To run this code in my project using the renv environment, run the following lines of code
install.packages("renv") #install the package on the new computer (may not be necessary if renv bootstraps itself as expected)
renv::restore() #reinstall all the package versions in the renv lockfile
library("ViSEAGO")
##
## Warning: replacing previous import 'data.table::set' by 'dendextend::set' when
## loading 'ViSEAGO'
## Warning: replacing previous import 'dendextend::cutree' by 'stats::cutree' when
## loading 'ViSEAGO'
## Warning: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when
## loading 'ViSEAGO'
require("topGO")
## Loading required package: topGO
## Loading required package: BiocGenerics
## Loading required package: generics
##
## Attaching package: 'generics'
## The following objects are masked from 'package:base':
##
## as.difftime, as.factor, as.ordered, intersect, is.element, setdiff,
## setequal, union
##
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:stats':
##
## IQR, mad, sd, var, xtabs
## The following objects are masked from 'package:base':
##
## anyDuplicated, aperm, append, as.data.frame, basename, cbind,
## colnames, dirname, do.call, duplicated, eval, evalq, Filter, Find,
## get, grep, grepl, is.unsorted, lapply, Map, mapply, match, mget,
## order, paste, pmax, pmax.int, pmin, pmin.int, Position, rank,
## rbind, Reduce, rownames, sapply, saveRDS, table, tapply, unique,
## unsplit, which.max, which.min
## Loading required package: graph
## Loading required package: Biobase
## Welcome to Bioconductor
##
## Vignettes contain introductory material; view with
## 'browseVignettes()'. To cite Bioconductor, see
## 'citation("Biobase")', and for packages 'citation("pkgname")'.
## Loading required package: GO.db
## Loading required package: AnnotationDbi
## Loading required package: stats4
## Loading required package: IRanges
## Loading required package: S4Vectors
##
## Attaching package: 'S4Vectors'
## The following object is masked from 'package:utils':
##
## findMatches
## The following objects are masked from 'package:base':
##
## expand.grid, I, unname
## Loading required package: SparseM
##
## groupGOTerms: GOBPTerm, GOMFTerm, GOCCTerm environments built.
##
## Attaching package: 'topGO'
## The following object is masked from 'package:IRanges':
##
## members
require("tidyverse")
## Loading required package: tidyverse
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.4 ✔ readr 2.1.5
## ✔ forcats 1.0.1 ✔ stringr 1.6.0
## ✔ ggplot2 4.0.0 ✔ tibble 3.3.0
## ✔ lubridate 1.9.4 ✔ tidyr 1.3.1
## ✔ purrr 1.2.0
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ lubridate::%within%() masks IRanges::%within%()
## ✖ ggplot2::annotate() masks ViSEAGO::annotate()
## ✖ stringr::boundary() masks graph::boundary()
## ✖ dplyr::collapse() masks IRanges::collapse()
## ✖ dplyr::combine() masks Biobase::combine(), BiocGenerics::combine()
## ✖ dplyr::desc() masks IRanges::desc()
## ✖ tidyr::expand() masks S4Vectors::expand()
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::first() masks S4Vectors::first()
## ✖ dplyr::lag() masks stats::lag()
## ✖ ggplot2::Position() masks BiocGenerics::Position(), base::Position()
## ✖ purrr::reduce() masks IRanges::reduce()
## ✖ dplyr::rename() masks S4Vectors::rename()
## ✖ lubridate::second() masks S4Vectors::second()
## ✖ lubridate::second<-() masks S4Vectors::second<-()
## ✖ dplyr::select() masks AnnotationDbi::select()
## ✖ dplyr::slice() masks IRanges::slice()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
#BiocManager::install("GO.db")
sessionInfo() #provides list of loaded packages and version of R.
## R version 4.5.2 (2025-10-31)
## Platform: aarch64-apple-darwin20
## Running under: macOS Tahoe 26.0.1
##
## Matrix products: default
## BLAS: /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; LAPACK version 3.12.1
##
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices datasets utils methods
## [8] base
##
## other attached packages:
## [1] lubridate_1.9.4 forcats_1.0.1 stringr_1.6.0
## [4] dplyr_1.1.4 purrr_1.2.0 readr_2.1.5
## [7] tidyr_1.3.1 tibble_3.3.0 ggplot2_4.0.0
## [10] tidyverse_2.0.0 topGO_2.62.0 SparseM_1.84-2
## [13] GO.db_3.22.0 AnnotationDbi_1.72.0 IRanges_2.44.0
## [16] S4Vectors_0.48.0 Biobase_2.70.0 graph_1.88.0
## [19] BiocGenerics_0.56.0 generics_0.1.4 ViSEAGO_1.24.0
##
## loaded via a namespace (and not attached):
## [1] RColorBrewer_1.1-3 rstudioapi_0.17.1 jsonlite_2.0.0
## [4] shape_1.4.6.1 magrittr_2.0.4 farver_2.1.2
## [7] rmarkdown_2.30 GlobalOptions_0.1.2 fs_1.6.6
## [10] vctrs_0.6.5 memoise_2.0.1 RCurl_1.98-1.17
## [13] webshot_0.5.5 htmltools_0.5.8.1 progress_1.2.3
## [16] dynamicTreeCut_1.63-1 curl_7.0.0 sass_0.4.10
## [19] bslib_0.9.0 htmlwidgets_1.6.4 plyr_1.8.9
## [22] httr2_1.2.1 plotly_4.11.0 cachem_1.1.0
## [25] igraph_2.2.1 lifecycle_1.0.4 iterators_1.0.14
## [28] pkgconfig_2.0.3 Matrix_1.7-4 R6_2.6.1
## [31] fastmap_1.2.0 clue_0.3-66 digest_0.6.37
## [34] colorspace_2.1-2 RSQLite_2.4.3 seriation_1.5.8
## [37] filelock_1.0.3 timechange_0.3.0 httr_1.4.7
## [40] compiler_4.5.2 bit64_4.6.0-1 withr_3.0.2
## [43] doParallel_1.0.17 S7_0.2.0 BiocParallel_1.44.0
## [46] viridis_0.6.5 DBI_1.2.3 UpSetR_1.4.0
## [49] heatmaply_1.6.0 dendextend_1.19.1 R.utils_2.13.0
## [52] biomaRt_2.66.0 rappdirs_0.3.3 rjson_0.2.23
## [55] tools_4.5.2 R.oo_1.27.1 glue_1.8.0
## [58] DiagrammeR_1.0.11 GOSemSim_2.36.0 grid_4.5.2
## [61] cluster_2.1.8.1 fgsea_1.36.0 gtable_0.3.6
## [64] tzdb_0.5.0 R.methodsS3_1.8.2 ca_0.71.1
## [67] data.table_1.17.8 hms_1.1.4 XVector_0.50.0
## [70] foreach_1.5.2 pillar_1.11.1 yulab.utils_0.2.1
## [73] circlize_0.4.16 BiocFileCache_3.0.0 lattice_0.22-7
## [76] renv_1.1.5 bit_4.6.0 tidyselect_1.2.1
## [79] registry_0.5-1 ComplexHeatmap_2.26.0 Biostrings_2.78.0
## [82] knitr_1.50 gridExtra_2.3 Seqinfo_1.0.0
## [85] xfun_0.54 matrixStats_1.5.0 DT_0.34.0
## [88] visNetwork_2.1.4 stringi_1.8.7 lazyeval_0.2.2
## [91] yaml_2.3.10 evaluate_1.0.5 codetools_0.2-20
## [94] BiocManager_1.30.26 cli_3.6.5 jquerylib_0.1.4
## [97] dichromat_2.0-0.1 Rcpp_1.1.0 dbplyr_2.5.1
## [100] png_0.1-8 XML_3.99-0.19 parallel_4.5.2
## [103] assertthat_0.2.1 blob_1.2.4 prettyunits_1.2.0
## [106] AnnotationForge_1.52.0 bitops_1.0-9 viridisLite_0.4.2
## [109] scales_1.4.0 crayon_1.5.3 GetoptLong_1.0.5
## [112] rlang_1.1.6 cowplot_1.2.0 fastmatch_1.1-6
## [115] KEGGREST_1.50.0 TSP_1.2-5
I am going to perform functional enrichment of GO terms using ViSEAGO.
I am following this vignette: http://bioconductor.unipi.it/packages/devel/bioc/vignettes/ViSEAGO/inst/doc/ViSEAGO.html.
In the next chunk I am loading in my DESeq data. These results are ordered by adjusted p-value. As a reminder, negative LFC = higher in Oral tissue, and positive LFC = higher in Aboral tissue.
#load in DESeq results
DESeq <- read.csv("../output_RNA/differential_expression/DESeq_results.csv", header = TRUE) %>% dplyr::rename("query" ="X")
#make dataframes of just differentially expressed genes for each LFC direction - filtering a little more stringent, abs(LFC) >2
DE_05_Aboral <- DESeq %>% filter(padj < 0.05 & log2FoldChange < -1)
DE_05_OralEpi <- DESeq %>% filter(padj < 0.05& log2FoldChange > 1)
#load in annotation data
annot_tab <- read.delim("../references/annotation/protein-GO.tsv") %>% dplyr::rename(GOs = GeneOntologyIDs)
#filter annotation data for just expressed genes with GO annotations
annot_tab <- annot_tab %>% filter(query %in% DESeq$query)
annot_tab$GOs <- gsub("; ", ";", annot_tab$GOs)
annot_tab$GOs[annot_tab$GOs==""] <- NA
annot_tab <- annot_tab %>% filter(!is.na(GOs))
nrow(annot_tab)
## [1] 10638
nrow(annot_tab)/nrow(DESeq)
## [1] 0.7354812
10638/14464 genes in our dataset have GO information in this file. That is 74%.
sum(annot_tab$query %in% DE_05_Aboral$query)
## [1] 376
sum(annot_tab$query %in% DE_05_Aboral$query)/nrow(DE_05_Aboral)
## [1] 0.6811594
sum(annot_tab$query %in% DE_05_OralEpi$query)
## [1] 826
sum(annot_tab$query %in% DE_05_OralEpi$query)/nrow(DE_05_OralEpi)
## [1] 0.6592179
379/558 genes that are significantly upregulated in the Aboral tissue have annotation information. That is 68% of the genes.
796/1216 genes that are significantly upregulated in the Oral Epidermis tissue have annotation information. That is 71% of the genes.
##Get a list of GO Terms for all genes
annots <- annot_tab %>% dplyr::select(query,GOs,ProteinNames) %>% dplyr::rename("GO.terms" = GOs)
# format into the format required by ViSEAGO for custom mappings
Custom_GOs <- annots %>%
# Separate GO terms into individual rows
separate_rows(GO.terms, sep = ";") %>%
# Add necessary columns
mutate(
taxid = "pacuta",
gene_symbol = ProteinNames,
evidence = "SwissProt"
) %>%
# Rename columns
dplyr::rename(
gene_id = query,
GOID = GO.terms
) %>%
dplyr::select(taxid, gene_id, gene_symbol, GOID, evidence)
Custom_GOs_valid <- Custom_GOs %>% filter(GOID %in% keys(GO.db))
write.table(Custom_GOs_valid, "../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt",row.names = FALSE, sep = "\t", quote = FALSE,col.names=TRUE)
length(unique(Custom_GOs$gene_id))
## [1] 10638
length(unique(Custom_GOs_valid$gene_id))
## [1] 10637
We seem to have lost one gene when filtering for valid GO terms, so I need to account for that below.
Custom_Pacuta <- ViSEAGO::Custom2GO("../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt")
## 'select()' returned 1:1 mapping between keys and columns
myGENE2GO_Pacuta <- ViSEAGO::annotate(
id="pacuta",
Custom_Pacuta
)
selection <- DESeq %>% filter(query %in% Custom_GOs_valid$gene_id) %>%
mutate(DE_05_Aboral = ifelse(query %in% DE_05_Aboral$query, 1,0)) %>%
mutate(DE_05_Oral = ifelse(query %in% DE_05_OralEpi$query, 1,0)) %>%
mutate(expressed = 1)
selection_Aboral <- selection %>% pull(DE_05_Aboral) %>% as.factor()
names(selection_Aboral) <- selection %>% pull(query)
selection_Oral <- selection %>% pull(DE_05_Oral) %>% as.factor()
names(selection_Oral) <- selection %>% pull(query)
expressed <- selection %>% pull(expressed) %>% as.factor()
names(expressed) <- selection %>% pull(query)
# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)
BP_Oral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="BP",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 8797 GO terms found. )
##
## Build GO DAG topology ..........
## ( 12496 GO terms and 27095 relations. )
##
## Annotating nodes ...............
## ( 9496 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
BP_Oral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 4469 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 19: 2 nodes to be scored (0 eliminated genes)
##
## Level 18: 2 nodes to be scored (0 eliminated genes)
##
## Level 17: 8 nodes to be scored (0 eliminated genes)
##
## Level 16: 18 nodes to be scored (0 eliminated genes)
##
## Level 15: 39 nodes to be scored (0 eliminated genes)
##
## Level 14: 42 nodes to be scored (61 eliminated genes)
##
## Level 13: 70 nodes to be scored (68 eliminated genes)
##
## Level 12: 158 nodes to be scored (96 eliminated genes)
##
## Level 11: 312 nodes to be scored (115 eliminated genes)
##
## Level 10: 469 nodes to be scored (382 eliminated genes)
##
## Level 9: 592 nodes to be scored (540 eliminated genes)
##
## Level 8: 646 nodes to be scored (699 eliminated genes)
##
## Level 7: 689 nodes to be scored (979 eliminated genes)
##
## Level 6: 638 nodes to be scored (1207 eliminated genes)
##
## Level 5: 444 nodes to be scored (1477 eliminated genes)
##
## Level 4: 244 nodes to be scored (1582 eliminated genes)
##
## Level 3: 79 nodes to be scored (1626 eliminated genes)
##
## Level 2: 16 nodes to be scored (1626 eliminated genes)
##
## Level 1: 1 nodes to be scored (1626 eliminated genes)
BP_Results <- ViSEAGO::merge_enrich_terms(
Input = list( Oral_elim = c("BP_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
## BP_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 67
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## Nontrivial_nodes: 4469
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 67 GO terms of 1 conditions.
## Oral_elim : 67 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
BP_Results,
"../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
## BP_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 67
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## Nontrivial_nodes: 4469
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 67 GO terms of 1 conditions.
## Oral_elim : 67 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## ℹ The deprecated feature was likely used in the dendextend package.
## Please report the issue at <https://github.com/talgalili/dendextend/issues>.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOterms")
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
height=1000,
width=700,
"GOterms", file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral_cluster_heatmap_Wang_wardD2.png")
## quartz_off_screen
## 2
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Oral,
"../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Oral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Oral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOclusters")
DE_05_SwissProt <- read.csv("../output_RNA/differential_expression/DE_05_SwissProt_annotation.csv")
DESeq_SwissProt <- read.csv("../output_RNA/differential_expression/DESeq_SwissProt_annotation.csv")
Oral_enriched_clustered <- Wang_clusters_wardD2_Oral@enrich_GOs@data
top_cluster <- Oral_enriched_clustered %>% arrange(Oral_elim.pvalue) %>% head(1) %>% pull(GO.cluster)
Oral_enriched_clustered %>% dplyr::filter(GO.cluster == top_cluster)
## GO.cluster IC GO.ID
## <char> <num> <char>
## 1: 7 9.45 GO:0006068
## 2: 7 6.37 GO:0009308
## 3: 7 9.11 GO:0009812
## 4: 7 8.86 GO:0051923
## 5: 7 9.11 GO:0050427
## 6: 7 8.11 GO:0009208
## 7: 7 6.36 GO:0017148
## 8: 7 8.11 GO:0016114
## 9: 7 6.43 GO:1901607
## 10: 7 9.27 GO:0046314
## term
## <char>
## 1: ethanol catabolic process
## 2: amine metabolic process
## 3: flavonoid metabolic process
## 4: sulfation
## 5: 3'-phosphoadenosine 5'-phosphosulfate metabolic process
## 6: pyrimidine ribonucleoside triphosphate metabolic process
## 7: negative regulation of translation
## 8: terpenoid biosynthetic process
## 9: alpha-amino acid biosynthetic process
## 10: phosphocreatine biosynthetic process
## definition
## <char>
## 1: The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
## 2: The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
## 3: The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.
## 4: The addition of a sulfate group to a molecule.
## 5: The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
## 6: The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.
## 7: Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
## 8: The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
## 9: <NA>
## 10: The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.
## Oral_elim.genes_frequency Oral_elim.pvalue Oral_elim.-log10_pvalue
## <char> <num> <num>
## 1: 60% (3/5) 3.742425e-03 2.43
## 2: 17.188% (11/64) 7.446749e-03 2.13
## 3: 71.429% (5/7) 4.321628e-05 4.36
## 4: 44.444% (4/9) 2.909709e-03 2.54
## 5: 85.714% (6/7) 1.141908e-06 5.94
## 6: 33.333% (4/12) 9.533181e-03 2.02
## 7: 15.476% (13/84) 9.327027e-03 2.03
## 8: 33.333% (4/12) 9.533181e-03 2.02
## 9: 17.105% (13/76) 3.948213e-03 2.40
## 10: 66.667% (4/6) 4.159939e-04 3.38
## Oral_elim.Significant_genes
## <char>
## 1: Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
## 2: Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g11785.t1;Pocillopora_acuta_HIv2___RNAseq.g15141.t1;Pocillopora_acuta_HIv2___RNAseq.g20712.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g21957.t1;Pocillopora_acuta_HIv2___RNAseq.g22120.t1;Pocillopora_acuta_HIv2___RNAseq.g26474.t1a;Pocillopora_acuta_HIv2___RNAseq.g27978.t1;Pocillopora_acuta_HIv2___RNAseq.g28398.t1;Pocillopora_acuta_HIv2___TS.g805.t1a
## 3: Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g12481.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9089.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
## 4: Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9090.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
## 5: Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g12481.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g25759.t1;Pocillopora_acuta_HIv2___RNAseq.g9089.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
## 6: Pocillopora_acuta_HIv2___RNAseq.g11840.t1;Pocillopora_acuta_HIv2___RNAseq.g21884.t1;Pocillopora_acuta_HIv2___RNAseq.g3911.t1;Pocillopora_acuta_HIv2___TS.g19040.t1
## 7: Pocillopora_acuta_HIv2___RNAseq.g10158.t1;Pocillopora_acuta_HIv2___RNAseq.g1103.t1;Pocillopora_acuta_HIv2___RNAseq.g16905.t1;Pocillopora_acuta_HIv2___RNAseq.g1800.t1;Pocillopora_acuta_HIv2___RNAseq.g18756.t2;Pocillopora_acuta_HIv2___RNAseq.g219.t1;Pocillopora_acuta_HIv2___RNAseq.g24051.t1;Pocillopora_acuta_HIv2___RNAseq.g24787.t1;Pocillopora_acuta_HIv2___RNAseq.g24800.t1;Pocillopora_acuta_HIv2___RNAseq.g28169.t1;Pocillopora_acuta_HIv2___RNAseq.g4938.t1;Pocillopora_acuta_HIv2___RNAseq.g763.t1;Pocillopora_acuta_HIv2___TS.g4312.t1
## 8: Pocillopora_acuta_HIv2___RNAseq.g28425.t1;Pocillopora_acuta_HIv2___RNAseq.g610.t1;Pocillopora_acuta_HIv2___RNAseq.g9824.t1;Pocillopora_acuta_HIv2___RNAseq.g9825.t1
## 9: Pocillopora_acuta_HIv2___RNAseq.g10854.t2;Pocillopora_acuta_HIv2___RNAseq.g12417.t1;Pocillopora_acuta_HIv2___RNAseq.g1504.t1;Pocillopora_acuta_HIv2___RNAseq.g16699.t1;Pocillopora_acuta_HIv2___RNAseq.g19367.t1;Pocillopora_acuta_HIv2___RNAseq.g23634.t1;Pocillopora_acuta_HIv2___RNAseq.g27978.t1;Pocillopora_acuta_HIv2___RNAseq.g28641.t1;Pocillopora_acuta_HIv2___RNAseq.g7498.t1;Pocillopora_acuta_HIv2___TS.g19253.t1;Pocillopora_acuta_HIv2___TS.g3401.t1;Pocillopora_acuta_HIv2___TS.g6241.t1e;Pocillopora_acuta_HIv2___TS.g7609.t1b
## 10: Pocillopora_acuta_HIv2___RNAseq.g15574.t1;Pocillopora_acuta_HIv2___RNAseq.g15577.t1;Pocillopora_acuta_HIv2___RNAseq.g15584.t1;Pocillopora_acuta_HIv2___RNAseq.g2258.t1
## Oral_elim.Significant_genes_symbol
## <char>
## 1: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 2: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain];Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3 (EC 3.2.2.n1) (Protein LONELY GUY 3);DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X);DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X);Ornithine decarboxylase (ODC) (EC 4.1.1.17);Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4);Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein);Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
## 3: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 4: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.1) (Sulfotransferase K2);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 5: Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPS synthetase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)];Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 6: CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1);Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42);Nucleoside diphosphate kinase homolog 5 (3'-5' exonuclease NME5) (EC 3.1.-.-);GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3)
## 7: Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2);Mitochondrial assembly of ribosomal large subunit protein 1;E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97);Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2);Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
## 8: Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3);Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1);Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H);Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
## 9: Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase);Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2);L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase);Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain];Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53);Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53);Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4);Protein TabA;Branched-chain-amino-acid aminotransferase (EC 2.6.1.42);Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)];Asparagine synthetase domain-containing protein 1;Glutamate dehydrogenase (GDH) (EC 1.4.1.3) (NAD(P)H-utilizing glutamate dehydrogenase);Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)
## 10: Creatine kinase, testis isozyme (EC 2.7.3.2);Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK);Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK);Arginine kinase (AK) (EC 2.7.3.3)
BP_go_terms <- BP_Oral@graph@nodes
genes_by_GO <- genesInTerm(BP_Oral, BP_go_terms)
cluster_8 <- Oral_enriched_clustered %>% dplyr::filter(GO.cluster == 8) %>% pull(GO.ID)
cluster_8_genes <- unique(unlist(genes_by_GO[cluster_8]))
write.csv(cluster_8_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Oral_enrich_BP_Sensory.csv",row.names=FALSE)
DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Oral_enriched_clustered %>% pull(GO.ID)])))
## X query baseMean log2FoldChange
## 1 3 Pocillopora_acuta_HIv2___RNAseq.g27038.t1 1882.71412 -16.920243
## 2 4 Pocillopora_acuta_HIv2___RNAseq.g2165.t1 1608.73918 -16.674695
## 3 5 Pocillopora_acuta_HIv2___TS.g18104.t1 1967.60901 -16.931827
## 4 9 Pocillopora_acuta_HIv2___RNAseq.g3832.t1 4681.36282 -12.478513
## 5 12 Pocillopora_acuta_HIv2___RNAseq.g14253.t1 1084.62611 -16.044514
## 6 25 Pocillopora_acuta_HIv2___TS.g18100.t1 8027.26641 -10.532544
## 7 43 Pocillopora_acuta_HIv2___RNAseq.g25759.t1 808.98861 14.778851
## 8 44 Pocillopora_acuta_HIv2___RNAseq.30415_t 893.17636 15.012329
## 9 48 Pocillopora_acuta_HIv2___TS.g4983.t1 908.84789 -15.756839
## 10 58 Pocillopora_acuta_HIv2___RNAseq.g1102.t1 682.41009 14.602337
## 11 68 Pocillopora_acuta_HIv2___RNAseq.22067_t 613.52482 14.107731
## 12 72 Pocillopora_acuta_HIv2___RNAseq.g11810.t1 633.24487 14.247818
## 13 76 Pocillopora_acuta_HIv2___RNAseq.g13400.t1 533.22375 14.107082
## 14 81 Pocillopora_acuta_HIv2___RNAseq.g17085.t1 542.20189 14.118241
## 15 85 Pocillopora_acuta_HIv2___TS.g22105.t1 586.45387 14.289758
## 16 97 Pocillopora_acuta_HIv2___RNAseq.g2813.t4 1653.40829 12.582278
## 17 104 Pocillopora_acuta_HIv2___RNAseq.g28971.t1a 1603.22813 -12.463466
## 18 105 Pocillopora_acuta_HIv2___RNAseq.g829.t1 2530.87773 -14.321435
## 19 108 Pocillopora_acuta_HIv2___RNAseq.g19042.t1 916.62147 11.472047
## 20 120 Pocillopora_acuta_HIv2___TS.g1253.t1 528.00964 13.646918
## 21 121 Pocillopora_acuta_HIv2___RNAseq.5883_t 372.24588 13.488005
## 22 124 Pocillopora_acuta_HIv2___RNAseq.g26586.t1 381.24714 13.667940
## 23 129 Pocillopora_acuta_HIv2___RNAseq.g10339.t1 392.04943 13.516463
## 24 137 Pocillopora_acuta_HIv2___RNAseq.g14366.t1 250.60207 -13.471894
## 25 140 Pocillopora_acuta_HIv2___RNAseq.g2995.t1 1190.36858 12.390397
## 26 141 Pocillopora_acuta_HIv2___RNAseq.g16699.t1 328.73878 13.386611
## 27 149 Pocillopora_acuta_HIv2___RNAseq.g17965.t1 339.14551 13.087614
## 28 152 Pocillopora_acuta_HIv2___RNAseq.g9466.t1 3868.10738 8.985654
## 29 153 Pocillopora_acuta_HIv2___RNAseq.g14817.t1 308.27793 13.131510
## 30 158 Pocillopora_acuta_HIv2___RNAseq.g28815.t1 448.84744 13.365085
## 31 178 Pocillopora_acuta_HIv2___RNAseq.g13056.t1 308.24224 13.021437
## 32 181 Pocillopora_acuta_HIv2___RNAseq.g24787.t1 282.08747 13.036363
## 33 190 Pocillopora_acuta_HIv2___RNAseq.g14871.t1 360.81188 7.613995
## 34 198 Pocillopora_acuta_HIv2___RNAseq.g6468.t1 936.24266 9.534804
## 35 206 Pocillopora_acuta_HIv2___RNAseq.g21265.t1 347.29673 12.936159
## 36 207 Pocillopora_acuta_HIv2___RNAseq.g28641.t1 1378.32284 12.260241
## 37 215 Pocillopora_acuta_HIv2___TS.g12304.t1 114980.25585 -5.890846
## 38 218 Pocillopora_acuta_HIv2___RNAseq.g9089.t1 319.56517 10.090590
## 39 219 Pocillopora_acuta_HIv2___TS.g4109.t3 319.81897 9.823642
## 40 224 Pocillopora_acuta_HIv2___RNAseq.g3837.t1a 978.54197 12.038054
## 41 230 Pocillopora_acuta_HIv2___TS.g15672.t1 261.98313 10.203702
## 42 247 Pocillopora_acuta_HIv2___TS.g6682.t1 2368.98413 9.996086
## 43 249 Pocillopora_acuta_HIv2___RNAseq.g19043.t1 733.86103 11.220600
## 44 258 Pocillopora_acuta_HIv2___RNAseq.g7241.t1 474.33368 10.238737
## 45 267 Pocillopora_acuta_HIv2___RNAseq.g14013.t1a 937.51551 11.885729
## 46 268 Pocillopora_acuta_HIv2___RNAseq.g28741.t1 193.97963 12.383304
## 47 271 Pocillopora_acuta_HIv2___RNAseq.g26057.t1 470.87061 -8.416140
## 48 275 Pocillopora_acuta_HIv2___TS.g23175.t1 218.46048 12.410051
## 49 286 Pocillopora_acuta_HIv2___RNAseq.g15097.t1 414.09800 8.776136
## 50 289 Pocillopora_acuta_HIv2___RNAseq.g30398.t1 1296.99952 12.153863
## 51 291 Pocillopora_acuta_HIv2___RNAseq.g710.t1 707.19309 11.544615
## 52 298 Pocillopora_acuta_HIv2___TS.g2952.t1 159.85802 12.121735
## 53 304 Pocillopora_acuta_HIv2___TS.g6681.t1 1375.40247 11.972496
## 54 308 Pocillopora_acuta_HIv2___TS.g19999.t1 1687.93854 9.056586
## 55 309 Pocillopora_acuta_HIv2___RNAseq.g9825.t1 4116.90824 6.816459
## 56 314 Pocillopora_acuta_HIv2___RNAseq.g25241.t1 922.27330 8.361412
## 57 321 Pocillopora_acuta_HIv2___RNAseq.g21572.t1a 170.49483 12.130633
## 58 322 Pocillopora_acuta_HIv2___RNAseq.g8217.t1 745.87324 8.570046
## 59 324 Pocillopora_acuta_HIv2___RNAseq.g30624.t2b 1458.34038 8.335606
## 60 330 Pocillopora_acuta_HIv2___RNAseq.g7628.t1 523.53570 10.355061
## 61 334 Pocillopora_acuta_HIv2___RNAseq.g3854.t1 848.16600 11.703962
## 62 335 Pocillopora_acuta_HIv2___RNAseq.g6379.t1 156.42142 12.081733
## 63 337 Pocillopora_acuta_HIv2___RNAseq.18284_t 232.50656 12.473251
## 64 347 Pocillopora_acuta_HIv2___TS.g4312.t1 138.82358 11.871756
## 65 350 Pocillopora_acuta_HIv2___RNAseq.g22644.t1 1223.76429 11.542686
## 66 352 Pocillopora_acuta_HIv2___RNAseq.10969_t 147.54454 11.959623
## 67 358 Pocillopora_acuta_HIv2___RNAseq.g11840.t1 608.42043 11.086288
## 68 364 Pocillopora_acuta_HIv2___RNAseq.g1200.t1 410.45697 10.657138
## 69 373 Pocillopora_acuta_HIv2___RNAseq.g26118.t1 743.19811 11.473173
## 70 376 Pocillopora_acuta_HIv2___RNAseq.g25689.t1 180.09581 11.823436
## 71 381 Pocillopora_acuta_HIv2___TS.g12848.t1 975.41006 -6.943136
## 72 382 Pocillopora_acuta_HIv2___RNAseq.g993.t1 2110.82545 4.512598
## 73 384 Pocillopora_acuta_HIv2___TS.g21128.t1 169.89170 12.046767
## 74 385 Pocillopora_acuta_HIv2___RNAseq.g17089.t1 175.08674 11.887646
## 75 392 Pocillopora_acuta_HIv2___RNAseq.g13403.t1 858.51979 11.443478
## 76 393 Pocillopora_acuta_HIv2___RNAseq.g29275.t1 140.77522 11.757686
## 77 397 Pocillopora_acuta_HIv2___RNAseq.g15159.t1 303.96922 9.722651
## 78 398 Pocillopora_acuta_HIv2___TS.g27807.t1 791.76609 1.092373
## 79 400 Pocillopora_acuta_HIv2___RNAseq.g6366.t1 214.07730 12.178680
## 80 401 Pocillopora_acuta_HIv2___TS.g9752.t3 593.72773 11.322083
## 81 405 Pocillopora_acuta_HIv2___TS.g5171.t1 295.19827 9.501609
## 82 406 Pocillopora_acuta_HIv2___TS.g19097.t2 208.31701 12.300252
## 83 409 Pocillopora_acuta_HIv2___RNAseq.g7553.t1 178.60661 12.051832
## 84 415 Pocillopora_acuta_HIv2___RNAseq.g14869.t1 277.22441 12.748483
## 85 417 Pocillopora_acuta_HIv2___RNAseq.g30992.t1 924.62680 11.281143
## 86 420 Pocillopora_acuta_HIv2___RNAseq.673_t 1356.35628 -7.994764
## 87 422 Pocillopora_acuta_HIv2___RNAseq.g13533.t1 410.70976 10.410129
## 88 423 Pocillopora_acuta_HIv2___RNAseq.g18966.t1 158.81942 11.903979
## 89 428 Pocillopora_acuta_HIv2___RNAseq.g9811.t1 280.13599 9.945244
## 90 436 Pocillopora_acuta_HIv2___RNAseq.g26672.t1 145.88874 11.591255
## 91 439 Pocillopora_acuta_HIv2___RNAseq.g15141.t1 178.38230 12.004217
## 92 441 Pocillopora_acuta_HIv2___RNAseq.g27413.t1 680.37380 10.783595
## 93 442 Pocillopora_acuta_HIv2___RNAseq.g9381.t1 374.19623 -9.829149
## 94 444 Pocillopora_acuta_HIv2___RNAseq.g21884.t1 182.22550 11.817460
## 95 448 Pocillopora_acuta_HIv2___RNAseq.g994.t1 1097.04685 6.071051
## 96 450 Pocillopora_acuta_HIv2___TS.g1768.t1 504.47765 10.807546
## 97 455 Pocillopora_acuta_HIv2___TS.g16482.t1 595.10274 10.203581
## 98 474 Pocillopora_acuta_HIv2___RNAseq.g29670.t2 209.21923 11.982910
## 99 475 Pocillopora_acuta_HIv2___RNAseq.g7243.t1 147.91088 11.671206
## 100 476 Pocillopora_acuta_HIv2___RNAseq.g14744.t1 298.31599 9.848812
## 101 480 Pocillopora_acuta_HIv2___RNAseq.g3580.t1 975.16996 6.836213
## 102 481 Pocillopora_acuta_HIv2___RNAseq.g21538.t1 130.20924 11.694403
## 103 484 Pocillopora_acuta_HIv2___RNAseq.g18756.t2 130.62969 11.513978
## 104 485 Pocillopora_acuta_HIv2___TS.g18947.t1 17030.60621 3.376772
## 105 497 Pocillopora_acuta_HIv2___RNAseq.g28213.t1 2856.05827 7.512964
## 106 500 Pocillopora_acuta_HIv2___RNAseq.g11785.t1 185.50046 11.898849
## 107 504 Pocillopora_acuta_HIv2___RNAseq.g22296.t1 560.58781 5.513365
## 108 510 Pocillopora_acuta_HIv2___RNAseq.25384_t 433.72434 10.357234
## 109 514 Pocillopora_acuta_HIv2___RNAseq.g17559.t1 552.61162 6.897249
## 110 520 Pocillopora_acuta_HIv2___RNAseq.g13552.t1 463.70755 10.099140
## 111 525 Pocillopora_acuta_HIv2___RNAseq.g4938.t1 145.73746 11.622478
## 112 529 Pocillopora_acuta_HIv2___RNAseq.g19152.t1 364.25795 9.906597
## 113 557 Pocillopora_acuta_HIv2___RNAseq.g16285.t1 1143.46418 -6.261819
## 114 561 Pocillopora_acuta_HIv2___RNAseq.g19392.t1 343.30899 10.113259
## 115 565 Pocillopora_acuta_HIv2___TS.g3401.t1 92.69481 11.155815
## 116 572 Pocillopora_acuta_HIv2___RNAseq.g1504.t1 415.22385 6.330544
## 117 578 Pocillopora_acuta_HIv2___RNAseq.g1103.t1 548.10380 9.746741
## 118 590 Pocillopora_acuta_HIv2___RNAseq.10010_t 685.38221 4.843496
## 119 594 Pocillopora_acuta_HIv2___RNAseq.g28466.t1 431.13150 1.151369
## 120 597 Pocillopora_acuta_HIv2___RNAseq.g14615.t1 376.11563 6.538480
## 121 603 Pocillopora_acuta_HIv2___RNAseq.2533_t 3992.17100 -5.969005
## 122 610 Pocillopora_acuta_HIv2___RNAseq.g20846.t1 519.71004 8.666834
## 123 611 Pocillopora_acuta_HIv2___RNAseq.g7881.t1 255.10125 9.392847
## 124 612 Pocillopora_acuta_HIv2___RNAseq.g17622.t1 186.93916 9.201601
## 125 613 Pocillopora_acuta_HIv2___RNAseq.g10343.t1 180.95669 -9.474330
## 126 621 Pocillopora_acuta_HIv2___RNAseq.g9093.t1 4489.42848 1.000144
## 127 630 Pocillopora_acuta_HIv2___RNAseq.g7452.t1 80.68499 10.705902
## 128 633 Pocillopora_acuta_HIv2___RNAseq.g12898.t1 423.47847 9.629377
## 129 636 Pocillopora_acuta_HIv2___RNAseq.g17047.t1 87.49373 8.600616
## 130 641 Pocillopora_acuta_HIv2___RNAseq.g28742.t1 119.78645 11.364056
## 131 644 Pocillopora_acuta_HIv2___RNAseq.g26058.t1 292.93529 7.819730
## 132 649 Pocillopora_acuta_HIv2___RNAseq.g21527.t1 228.33529 9.496081
## 133 653 Pocillopora_acuta_HIv2___RNAseq.g3723.t1 703.78472 1.047436
## 134 655 Pocillopora_acuta_HIv2___RNAseq.g8821.t1 15967.80052 -2.993156
## 135 656 Pocillopora_acuta_HIv2___RNAseq.g3911.t1 242.52436 9.346711
## 136 658 Pocillopora_acuta_HIv2___RNAseq.g7217.t1 250.82485 9.135807
## 137 660 Pocillopora_acuta_HIv2___RNAseq.g25869.t1 286.42014 9.437992
## 138 676 Pocillopora_acuta_HIv2___RNAseq.g24800.t1 329.33944 5.802163
## 139 678 Pocillopora_acuta_HIv2___RNAseq.g21637.t1 81.12761 7.989478
## 140 687 Pocillopora_acuta_HIv2___RNAseq.g11580.t1 148.09617 11.112030
## 141 692 Pocillopora_acuta_HIv2___RNAseq.g26341.t1 452.74167 7.144176
## 142 695 Pocillopora_acuta_HIv2___TS.g14960.t2 557.92530 1.201364
## 143 701 Pocillopora_acuta_HIv2___RNAseq.g28226.t2 750.90343 -5.444603
## 144 705 Pocillopora_acuta_HIv2___RNAseq.g219.t1 168.31613 5.110258
## 145 706 Pocillopora_acuta_HIv2___RNAseq.g17090.t1 5915.60173 5.828618
## 146 708 Pocillopora_acuta_HIv2___RNAseq.g4469.t1 556.81444 5.319428
## 147 719 Pocillopora_acuta_HIv2___RNAseq.g11547.t1 85.20667 10.755320
## 148 724 Pocillopora_acuta_HIv2___RNAseq.g7498.t1 335.77112 1.058537
## 149 727 Pocillopora_acuta_HIv2___RNAseq.g14060.t1 664.04192 1.147794
## 150 729 Pocillopora_acuta_HIv2___RNAseq.g9824.t1 3467.23763 5.617379
## 151 730 Pocillopora_acuta_HIv2___TS.g805.t1a 1602.31304 1.463693
## 152 731 Pocillopora_acuta_HIv2___RNAseq.g13784.t1 113.99787 -8.550451
## 153 735 Pocillopora_acuta_HIv2___RNAseq.g6559.t1 684.89771 -5.820409
## 154 736 Pocillopora_acuta_HIv2___RNAseq.g23181.t1 528.62485 8.941508
## 155 737 Pocillopora_acuta_HIv2___RNAseq.g9090.t1 169.71014 7.193983
## 156 741 Pocillopora_acuta_HIv2___TS.g28908.t1 330.89213 5.675045
## 157 751 Pocillopora_acuta_HIv2___RNAseq.g13970.t2 372.90592 8.583003
## 158 759 Pocillopora_acuta_HIv2___TS.g28111.t1 363.67741 4.386285
## 159 764 Pocillopora_acuta_HIv2___RNAseq.g7215.t1 116.66835 8.016421
## 160 777 Pocillopora_acuta_HIv2___RNAseq.g28425.t1 213.88314 1.615589
## 161 779 Pocillopora_acuta_HIv2___RNAseq.g898.t1b 482.16296 1.046302
## 162 784 Pocillopora_acuta_HIv2___RNAseq.g7625.t1 56.76602 10.073298
## 163 787 Pocillopora_acuta_HIv2___RNAseq.g12287.t1 160.93966 6.410081
## 164 788 Pocillopora_acuta_HIv2___TS.g19040.t1 79.63900 10.641704
## 165 791 Pocillopora_acuta_HIv2___RNAseq.g11548.t1 128.49271 8.040465
## 166 793 Pocillopora_acuta_HIv2___TS.g9513.t1 11530.17861 3.956219
## 167 796 Pocillopora_acuta_HIv2___RNAseq.g701.t1 129.22288 8.272886
## 168 798 Pocillopora_acuta_HIv2___RNAseq.g702.t1 58.20862 10.008556
## 169 806 Pocillopora_acuta_HIv2___RNAseq.g25708.t1 635.87560 1.268391
## 170 807 Pocillopora_acuta_HIv2___RNAseq.g28169.t1 119.66311 5.405765
## 171 822 Pocillopora_acuta_HIv2___RNAseq.g1217.t1 278.80456 4.868494
## 172 829 Pocillopora_acuta_HIv2___TS.g4466.t2 150.34533 7.921053
## 173 831 Pocillopora_acuta_HIv2___TS.g15668.t1 900.81727 4.845006
## 174 852 Pocillopora_acuta_HIv2___RNAseq.665_t 411.69240 1.072318
## 175 857 Pocillopora_acuta_HIv2___TS.g19253.t1 100.14541 7.285554
## 176 863 Pocillopora_acuta_HIv2___RNAseq.g13060.t1 7815.93678 5.228550
## 177 869 Pocillopora_acuta_HIv2___RNAseq.g26270.t1a 2780.75439 -4.737152
## 178 879 Pocillopora_acuta_HIv2___RNAseq.g2263.t1b 1355.99328 5.069863
## 179 880 Pocillopora_acuta_HIv2___RNAseq.g6094.t2 191.37227 7.837953
## 180 884 Pocillopora_acuta_HIv2___RNAseq.g16905.t1 276.17952 6.049125
## 181 902 Pocillopora_acuta_HIv2___TS.g14552.t1 1206.96542 4.269826
## 182 923 Pocillopora_acuta_HIv2___RNAseq.18788_t 50.28419 9.519608
## 183 927 Pocillopora_acuta_HIv2___RNAseq.g14489.t1 220.23037 1.018078
## 184 932 Pocillopora_acuta_HIv2___RNAseq.g5755.t1 258.53696 4.803600
## 185 935 Pocillopora_acuta_HIv2___RNAseq.g5181.t1 400.62919 -4.670589
## 186 937 Pocillopora_acuta_HIv2___RNAseq.g12292.t1 44.21671 9.326537
## 187 950 Pocillopora_acuta_HIv2___RNAseq.g19870.t1 593.27663 2.952445
## 188 951 Pocillopora_acuta_HIv2___TS.g16484.t1 154.45462 3.781709
## 189 954 Pocillopora_acuta_HIv2___RNAseq.g28398.t1 252.97119 6.656385
## 190 956 Pocillopora_acuta_HIv2___RNAseq.g28816.t1 119.34549 4.446159
## 191 964 Pocillopora_acuta_HIv2___RNAseq.g22964.t1 1389.15836 4.739693
## 192 975 Pocillopora_acuta_HIv2___RNAseq.g8520.t1 75.45588 9.702060
## 193 976 Pocillopora_acuta_HIv2___RNAseq.g565.t1 2194.07018 -4.487797
## 194 999 Pocillopora_acuta_HIv2___RNAseq.g12481.t1 34.11161 9.083646
## 195 1001 Pocillopora_acuta_HIv2___RNAseq.g7833.t1 316.00830 1.382589
## 196 1002 Pocillopora_acuta_HIv2___TS.g186.t2 1622.80560 -2.273752
## 197 1004 Pocillopora_acuta_HIv2___RNAseq.g27673.t1 3815.81336 4.308949
## 198 1026 Pocillopora_acuta_HIv2___RNAseq.g775.t1 686.76073 -4.039075
## 199 1040 Pocillopora_acuta_HIv2___RNAseq.g1838.t1 74.01631 6.181958
## 200 1043 Pocillopora_acuta_HIv2___RNAseq.g19452.t1 173.48522 3.937401
## 201 1053 Pocillopora_acuta_HIv2___TS.g305.t1 340.35457 1.166762
## 202 1063 Pocillopora_acuta_HIv2___RNAseq.g4959.t1 1090.45858 2.876880
## 203 1070 Pocillopora_acuta_HIv2___RNAseq.g30377.t2 463.55834 -2.018560
## 204 1076 Pocillopora_acuta_HIv2___RNAseq.g10158.t1 1479.44457 3.318070
## 205 1080 Pocillopora_acuta_HIv2___RNAseq.g4031.t1c 874.90040 1.493733
## 206 1095 Pocillopora_acuta_HIv2___RNAseq.g610.t1 104.25392 1.029751
## 207 1101 Pocillopora_acuta_HIv2___RNAseq.g8670.t1 5976.07967 -3.146682
## 208 1105 Pocillopora_acuta_HIv2___RNAseq.g7248.t1 34.88719 8.582062
## 209 1106 Pocillopora_acuta_HIv2___RNAseq.g26700.t1 3564.82512 2.876361
## 210 1110 Pocillopora_acuta_HIv2___RNAseq.g10777.t1 187.45508 1.190663
## 211 1113 Pocillopora_acuta_HIv2___RNAseq.g5711.t2 347.77617 1.461322
## 212 1119 Pocillopora_acuta_HIv2___RNAseq.g23414.t1 258.40788 3.285151
## 213 1134 Pocillopora_acuta_HIv2___RNAseq.g27609.t1 647.19584 3.462086
## 214 1136 Pocillopora_acuta_HIv2___RNAseq.g614.t1 2049.65501 -3.365559
## 215 1152 Pocillopora_acuta_HIv2___RNAseq.g11214.t1 286.00349 2.696417
## 216 1165 Pocillopora_acuta_HIv2___RNAseq.g15290.t1 2980.34602 -3.796695
## 217 1184 Pocillopora_acuta_HIv2___RNAseq.g243.t1 69.70758 3.238932
## 218 1185 Pocillopora_acuta_HIv2___RNAseq.g12374.t1 3131.42127 -3.728374
## 219 1196 Pocillopora_acuta_HIv2___RNAseq.g23588.t1 1186.73431 -2.434761
## 220 1197 Pocillopora_acuta_HIv2___RNAseq.g28270.t1 299.79990 6.448127
## 221 1199 Pocillopora_acuta_HIv2___RNAseq.g802.t1 510.71943 -3.277146
## 222 1205 Pocillopora_acuta_HIv2___RNAseq.g11589.t1 43.62564 4.419798
## 223 1218 Pocillopora_acuta_HIv2___RNAseq.g12286.t1 225.88497 2.888361
## 224 1221 Pocillopora_acuta_HIv2___RNAseq.g20688.t1 4154.69322 1.944529
## 225 1229 Pocillopora_acuta_HIv2___RNAseq.g4073.t1 505.37799 -2.615899
## 226 1231 Pocillopora_acuta_HIv2___RNAseq.g19367.t1 1104.62737 2.693734
## 227 1232 Pocillopora_acuta_HIv2___RNAseq.g27039.t1 5675.97668 -3.277390
## 228 1244 Pocillopora_acuta_HIv2___RNAseq.g10855.t1 430.37509 -2.846891
## 229 1247 Pocillopora_acuta_HIv2___RNAseq.g20712.t1 452.79544 1.055231
## 230 1249 Pocillopora_acuta_HIv2___RNAseq.g2519.t1 2787.36449 2.199689
## 231 1259 Pocillopora_acuta_HIv2___RNAseq.g22120.t1 26.03583 5.290266
## 232 1261 Pocillopora_acuta_HIv2___RNAseq.g11345.t1 1518.01744 1.165722
## 233 1264 Pocillopora_acuta_HIv2___RNAseq.g805.t1 877.33388 -3.112606
## 234 1265 Pocillopora_acuta_HIv2___RNAseq.g3016.t1 1002.55051 3.107115
## 235 1284 Pocillopora_acuta_HIv2___RNAseq.g8148.t1 2320.13158 -3.333232
## 236 1286 Pocillopora_acuta_HIv2___RNAseq.g11960.t1 114.82770 2.876785
## 237 1293 Pocillopora_acuta_HIv2___RNAseq.g6836.t1 25.21477 7.696885
## 238 1306 Pocillopora_acuta_HIv2___RNAseq.10263_t 3036.53536 -2.497755
## 239 1309 Pocillopora_acuta_HIv2___TS.g8131.t1 198.18930 -1.041336
## 240 1310 Pocillopora_acuta_HIv2___RNAseq.g2273.t1 3039.32436 1.876100
## 241 1319 Pocillopora_acuta_HIv2___RNAseq.g1315.t1 470.97654 -1.824525
## 242 1328 Pocillopora_acuta_HIv2___RNAseq.g15577.t1 225.94643 2.035708
## 243 1329 Pocillopora_acuta_HIv2___RNAseq.g763.t1 97.73460 2.980931
## 244 1333 Pocillopora_acuta_HIv2___TS.g18622.t1b 4572.98017 -3.302312
## 245 1347 Pocillopora_acuta_HIv2___RNAseq.g9589.t2 2396.75767 -2.895430
## 246 1348 Pocillopora_acuta_HIv2___RNAseq.g9334.t1 6238.79877 1.866734
## 247 1359 Pocillopora_acuta_HIv2___RNAseq.g30994.t1a 1228.79079 2.535507
## 248 1362 Pocillopora_acuta_HIv2___RNAseq.g25248.t1a 397.79734 1.391294
## 249 1368 Pocillopora_acuta_HIv2___RNAseq.g8890.t1 29.98779 1.504507
## 250 1370 Pocillopora_acuta_HIv2___RNAseq.g16957.t1 448.04585 1.016486
## 251 1390 Pocillopora_acuta_HIv2___RNAseq.g682.t1 2333.47091 -2.728555
## 252 1394 Pocillopora_acuta_HIv2___RNAseq.g2827.t1 2015.11451 1.328546
## 253 1395 Pocillopora_acuta_HIv2___RNAseq.g4028.t1 1336.23794 1.899472
## 254 1398 Pocillopora_acuta_HIv2___RNAseq.g27337.t1 784.20968 -2.891088
## 255 1409 Pocillopora_acuta_HIv2___RNAseq.g15584.t1 1587.90695 2.261018
## 256 1410 Pocillopora_acuta_HIv2___RNAseq.g1800.t1 103.53093 1.687979
## 257 1415 Pocillopora_acuta_HIv2___RNAseq.g12306.t1 727.11393 -1.100091
## 258 1418 Pocillopora_acuta_HIv2___TS.g7609.t1b 211.46026 2.356463
## 259 1421 Pocillopora_acuta_HIv2___RNAseq.g3142.t1a 165.53566 1.047763
## 260 1425 Pocillopora_acuta_HIv2___RNAseq.g21518.t1 1281.13794 -1.514914
## 261 1427 Pocillopora_acuta_HIv2___TS.g24662.t1 21.01564 3.227213
## 262 1429 Pocillopora_acuta_HIv2___RNAseq.g28818.t1 1048.18106 -1.830578
## 263 1450 Pocillopora_acuta_HIv2___RNAseq.g12088.t1 135.02634 -2.418641
## 264 1461 Pocillopora_acuta_HIv2___RNAseq.g13672.t1 133.71337 2.592185
## 265 1467 Pocillopora_acuta_HIv2___RNAseq.g3840.t1 611.16656 2.323684
## 266 1477 Pocillopora_acuta_HIv2___TS.g5006.t1b 819.97102 -2.004219
## 267 1491 Pocillopora_acuta_HIv2___RNAseq.g24761.t1 3524.03906 2.714320
## 268 1495 Pocillopora_acuta_HIv2___RNAseq.g16948.t1 2941.74849 2.117515
## 269 1497 Pocillopora_acuta_HIv2___TS.g15590.t1 303.51020 -3.159254
## 270 1499 Pocillopora_acuta_HIv2___RNAseq.g8004.t1 599.10553 2.046808
## 271 1502 Pocillopora_acuta_HIv2___RNAseq.g21957.t1 266.02201 2.547544
## 272 1507 Pocillopora_acuta_HIv2___RNAseq.26564_t 6653.23248 2.298868
## 273 1508 Pocillopora_acuta_HIv2___RNAseq.g3523.t1 2327.91634 -1.838200
## 274 1522 Pocillopora_acuta_HIv2___RNAseq.g29143.t2 4185.18788 -1.484992
## 275 1523 Pocillopora_acuta_HIv2___RNAseq.g12410.t1 6201.14924 1.904486
## 276 1553 Pocillopora_acuta_HIv2___RNAseq.g2258.t1 1914.01504 1.739834
## 277 1556 Pocillopora_acuta_HIv2___TS.g21857.t1 165.62274 1.977094
## 278 1562 Pocillopora_acuta_HIv2___RNAseq.g28252.t1 5381.46974 -2.184909
## 279 1565 Pocillopora_acuta_HIv2___RNAseq.g30836.t1 893.51261 1.157324
## 280 1566 Pocillopora_acuta_HIv2___RNAseq.g942.t1 2094.46904 -1.094885
## 281 1583 Pocillopora_acuta_HIv2___RNAseq.g23634.t1 3369.65393 2.134002
## 282 1590 Pocillopora_acuta_HIv2___RNAseq.g10854.t2 1353.64991 1.103598
## 283 1591 Pocillopora_acuta_HIv2___RNAseq.g12289.t1 169.18586 1.826114
## 284 1593 Pocillopora_acuta_HIv2___RNAseq.g15574.t1 34.16738 1.843892
## 285 1601 Pocillopora_acuta_HIv2___RNAseq.g24029.t1 216.49127 1.352660
## 286 1606 Pocillopora_acuta_HIv2___RNAseq.g15948.t1 179.21690 -2.052347
## 287 1612 Pocillopora_acuta_HIv2___RNAseq.g12223.t1 1942.75964 1.956525
## 288 1618 Pocillopora_acuta_HIv2___RNAseq.g4919.t1 187.63281 3.463306
## 289 1619 Pocillopora_acuta_HIv2___RNAseq.g26474.t1a 14692.89020 1.784435
## 290 1622 Pocillopora_acuta_HIv2___RNAseq.g562.t1 543.01090 -1.900843
## 291 1636 Pocillopora_acuta_HIv2___TS.g3024.t4 5769.89335 1.345575
## 292 1647 Pocillopora_acuta_HIv2___RNAseq.g27978.t1 1346.56743 1.001788
## 293 1659 Pocillopora_acuta_HIv2___RNAseq.g12290.t1 272.61929 1.396721
## 294 1667 Pocillopora_acuta_HIv2___TS.g24807.t1 6598.60730 1.321394
## 295 1673 Pocillopora_acuta_HIv2___TS.g3256.t1 295.29556 1.109164
## 296 1688 Pocillopora_acuta_HIv2___RNAseq.g30726.t1 3698.97199 -1.991751
## 297 1689 Pocillopora_acuta_HIv2___RNAseq.g3051.t1 4957.84106 1.432437
## 298 1695 Pocillopora_acuta_HIv2___RNAseq.g24196.t1 123.56332 -1.718484
## 299 1698 Pocillopora_acuta_HIv2___RNAseq.g22366.t1 2478.84738 1.737807
## 300 1705 Pocillopora_acuta_HIv2___RNAseq.g8093.t1 2555.99531 1.438195
## 301 1709 Pocillopora_acuta_HIv2___RNAseq.g7454.t2 22.44606 1.228765
## 302 1718 Pocillopora_acuta_HIv2___TS.g17199.t1 3983.64133 -1.572936
## 303 1720 Pocillopora_acuta_HIv2___RNAseq.g16928.t3 5447.65606 -1.783134
## 304 1722 Pocillopora_acuta_HIv2___RNAseq.g3094.t1 661.57875 -1.690762
## 305 1723 Pocillopora_acuta_HIv2___RNAseq.g3482.t1 140.22566 1.616148
## 306 1726 Pocillopora_acuta_HIv2___RNAseq.g15953.t1 211.50709 -1.632385
## 307 1733 Pocillopora_acuta_HIv2___RNAseq.g9027.t1 2280.97939 1.631564
## 308 1741 Pocillopora_acuta_HIv2___RNAseq.g3743.t1 1180.33307 1.729045
## 309 1744 Pocillopora_acuta_HIv2___TS.g6241.t1e 2993.39771 1.437186
## 310 1751 Pocillopora_acuta_HIv2___RNAseq.g18121.t1 6819.87418 1.880525
## 311 1755 Pocillopora_acuta_HIv2___RNAseq.g28251.t1 2338.02487 1.507841
## 312 1757 Pocillopora_acuta_HIv2___RNAseq.g16474.t1 150.76836 1.608725
## 313 1762 Pocillopora_acuta_HIv2___RNAseq.g12417.t1 170.56934 1.053248
## 314 1764 Pocillopora_acuta_HIv2___TS.g11002.t4 167.39786 -1.659866
## 315 1782 Pocillopora_acuta_HIv2___RNAseq.g3166.t1 575.39471 1.593229
## 316 1786 Pocillopora_acuta_HIv2___RNAseq.g26503.t1 559.87142 1.101889
## 317 1791 Pocillopora_acuta_HIv2___RNAseq.g24051.t1 302.81726 1.450521
## 318 1804 Pocillopora_acuta_HIv2___TS.g15134.t1 4469.94208 1.408270
## lfcSE pvalue padj blast_hit perc_ident evalue
## 1 3.9804472 1.680854e-19 8.103957e-16 P24383 28.205 4.23e-13
## 2 3.9451894 3.935575e-19 1.229920e-15 Q9CXI3 31.818 9.57e-14
## 3 4.0005799 4.251661e-19 1.229920e-15 P51029 26.347 7.78e-22
## 4 2.3513750 5.406898e-18 8.336894e-15 Q566X8 69.663 1.47e-36
## 5 3.9062481 1.445915e-17 1.742810e-14 Q96RW7 23.873 2.16e-33
## 6 1.8496201 2.798837e-16 1.619295e-13 P51029 29.433 2.52e-27
## 7 3.6112381 2.413840e-15 7.934951e-13 Q27128 72.074 0.00e+00
## 8 3.6781444 3.114556e-15 9.945559e-13 Q6XYQ8 37.113 9.54e-39
## 9 4.0353343 6.230509e-15 1.828057e-12 Q9CZV8 25.397 7.00e-18
## 10 3.6778572 2.289682e-14 5.525163e-12 Q9EQD2 33.129 2.11e-45
## 11 3.5850266 6.568762e-14 1.376965e-11 Q98SN7 48.182 6.50e-110
## 12 3.6479384 1.069067e-13 2.118217e-11 P15508 33.852 2.41e-37
## 13 3.5841809 1.184752e-13 2.225488e-11 P51400 46.293 0.00e+00
## 14 3.6530708 1.421161e-13 2.506790e-11 G5EG78 35.727 2.82e-87
## 15 3.6906851 2.009348e-13 3.379443e-11 F1PZV2 33.610 2.55e-32
## 16 3.2988651 3.819062e-13 5.636624e-11 Q3UP38 33.410 3.52e-55
## 17 2.9212371 5.966435e-13 8.218907e-11 Q91X17 34.911 8.41e-23
## 18 3.3137235 6.429318e-13 8.772987e-11 P63253 40.947 6.37e-87
## 19 2.5153320 7.425805e-13 9.821870e-11 Q6IWH7 48.425 0.00e+00
## 20 3.5954255 1.654928e-12 1.978255e-10 Q91175 31.487 1.60e-45
## 21 3.5912730 1.779015e-12 2.109154e-10 Q5RCC4 38.828 2.53e-65
## 22 3.6264826 2.025007e-12 2.324579e-10 Q7TM99 24.157 4.51e-38
## 23 3.6169418 2.986256e-12 3.297191e-10 Q32ZE2 31.153 1.08e-33
## 24 3.7155788 3.543949e-12 3.687746e-10 Q5RFW0 52.381 7.91e-07
## 25 2.8932408 3.848449e-12 3.919998e-10 Q90Z12 46.269 2.22e-42
## 26 3.5911234 4.411236e-12 4.461827e-10 P19440 44.280 5.01e-149
## 27 3.5442430 7.553076e-12 7.224184e-10 O02824 35.475 5.16e-62
## 28 5.5223615 7.796371e-12 7.322513e-10 Q6RI86 29.548 1.07e-142
## 29 3.5464737 8.259408e-12 7.615830e-10 E7F6F9 26.552 7.72e-39
## 30 3.6407817 9.636208e-12 8.657026e-10 Q5R4J5 29.197 7.65e-31
## 31 3.5844958 2.391752e-11 1.890399e-09 Q18775 36.709 7.71e-07
## 32 3.5708979 2.674712e-11 2.068825e-09 E7FAM5 30.075 1.26e-34
## 33 1.4659682 3.356101e-11 2.476666e-09 P48442 31.726 1.34e-110
## 34 2.8485273 4.225953e-11 2.967193e-09 P11617 24.272 5.42e-18
## 35 3.6397053 4.930745e-11 3.317130e-09 Q9N126 44.643 8.65e-67
## 36 3.2204439 5.083411e-11 3.404002e-09 P31851 33.114 1.07e-85
## 37 1.2056184 6.319842e-11 4.044699e-09 P00918 36.842 2.04e-48
## 38 2.1111470 6.788153e-11 4.287504e-09 A0A2K5X3B6 35.484 1.25e-51
## 39 2.1766900 6.825609e-11 4.292418e-09 Q0ZLH3 26.455 8.77e-14
## 40 3.0746740 7.310161e-11 4.499326e-09 Q90268 69.930 1.29e-63
## 41 2.3205717 7.979410e-11 4.788970e-09 Q91VN0 32.852 1.90e-41
## 42 3.3217462 1.365619e-10 7.655934e-09 Q6GM82 47.292 2.43e-154
## 43 3.0841927 1.424577e-10 7.925030e-09 Q14AT5 50.494 0.00e+00
## 44 2.5445088 1.797157e-10 9.627438e-09 Q8WU66 32.550 1.99e-36
## 45 3.1298423 2.106768e-10 1.091067e-08 O42574 29.268 1.37e-29
## 46 3.4848297 2.112132e-10 1.091067e-08 P57695 32.536 2.29e-71
## 47 2.1852720 2.251819e-10 1.146842e-08 Q96P65 26.733 6.23e-25
## 48 3.5277856 2.530777e-10 1.269263e-08 Q96RW7 44.583 3.37e-66
## 49 2.2484694 3.096062e-10 1.487755e-08 Q16322 31.081 1.70e-08
## 50 3.3941001 3.302384e-10 1.571240e-08 P83858 30.033 2.55e-24
## 51 3.1381388 3.431226e-10 1.621871e-08 Q7TN88 32.143 1.00e-49
## 52 3.4625140 5.060383e-10 2.316246e-08 A6QLU6 37.069 7.47e-15
## 53 3.3917839 5.643947e-10 2.527370e-08 Q6NYL5 43.478 2.28e-110
## 54 3.3603398 5.874289e-10 2.598340e-08 O42357 38.428 1.98e-31
## 55 2.7779770 5.910658e-10 2.606456e-08 B8NHE3 25.899 6.07e-10
## 56 2.8261835 7.416875e-10 3.221552e-08 Q5HZE0 52.448 5.80e-99
## 57 3.5747065 8.358525e-10 3.555815e-08 P63079 30.841 2.23e-50
## 58 2.4410753 8.542114e-10 3.623259e-08 Q16992 27.536 7.91e-09
## 59 4.1899269 8.661309e-10 3.652396e-08 Q99NH0 34.914 5.34e-66
## 60 2.9038227 9.867491e-10 4.077811e-08 Q704V6 32.000 2.62e-16
## 61 3.3454666 1.148341e-09 4.665620e-08 P30974 27.414 4.07e-26
## 62 3.5179055 1.210544e-09 4.904570e-08 A6QLU6 41.406 8.77e-21
## 63 3.7661239 1.291142e-09 5.187520e-08 Q21565 51.079 1.40e-128
## 64 3.4545212 1.453020e-09 5.664818e-08 O70277 22.846 5.42e-20
## 65 3.3558053 1.515378e-09 5.860540e-08 P31597 43.611 1.72e-126
## 66 3.5224344 1.587097e-09 6.105259e-08 O43704 37.755 1.12e-55
## 67 3.2079545 1.749576e-09 6.607277e-08 Q6PEI7 69.402 0.00e+00
## 68 3.0743137 1.940238e-09 7.214293e-08 P31649 55.882 0.00e+00
## 69 3.3183539 2.259957e-09 8.213070e-08 C9D7C2 47.898 0.00e+00
## 70 3.4754573 2.390312e-09 8.600367e-08 Q61184 24.088 3.00e-24
## 71 4.5763292 2.598137e-09 9.210651e-08 Q5RFW0 33.491 1.02e-17
## 72 5.2518526 2.620353e-09 9.266697e-08 P09917 28.151 2.26e-47
## 73 3.5860171 2.770869e-09 9.727634e-08 Q20JQ7 39.115 0.00e+00
## 74 3.4823937 2.951316e-09 1.033604e-07 G5EG78 35.577 1.90e-101
## 75 3.3448312 3.282924e-09 1.125218e-07 Q86SS6 32.867 1.79e-35
## 76 3.4735080 3.462091e-09 1.181030e-07 Q09081 45.729 1.11e-116
## 77 2.7390660 3.552823e-09 1.200655e-07 Q7TN88 24.546 1.45e-54
## 78 2.0688424 3.563308e-09 1.201391e-07 Q86UK0 32.646 0.00e+00
## 79 3.6319216 3.671780e-09 1.232219e-07 Q7SY09 31.595 4.76e-36
## 80 3.3165398 3.703303e-09 1.239921e-07 Q14517 33.143 4.66e-21
## 81 2.6339533 4.027512e-09 1.336099e-07 P52569 40.510 2.27e-146
## 82 3.7467033 4.296540e-09 1.418839e-07 Q94887 29.730 1.07e-14
## 83 3.6436353 4.540551e-09 1.482848e-07 Q14517 31.356 2.69e-09
## 84 3.8759797 4.794341e-09 1.544440e-07 Q9Y5X5 26.797 6.03e-26
## 85 3.6619797 5.102743e-09 1.632878e-07 Q9Z2J0 50.000 0.00e+00
## 86 3.4821481 5.230455e-09 1.662710e-07 Q7TSY2 34.615 9.23e-33
## 87 3.1997231 5.518053e-09 1.746458e-07 Q6V4S5 28.682 4.55e-54
## 88 3.6044973 5.845173e-09 1.837926e-07 P63142 52.284 1.56e-142
## 89 2.9093670 6.191427e-09 1.921734e-07 Q924H0 26.753 7.27e-29
## 90 3.4793258 7.240357e-09 2.200095e-07 P54131 36.441 1.59e-110
## 91 3.7519329 7.607090e-09 2.297055e-07 Q8L8B8 46.632 1.54e-56
## 92 3.3853784 7.852723e-09 2.361368e-07 P63079 34.722 4.11e-92
## 93 3.2676223 7.898303e-09 2.370146e-07 Q60928 40.820 3.76e-122
## 94 3.6283915 8.007842e-09 2.393087e-07 Q9Y227 48.846 2.93e-168
## 95 4.8157216 8.832363e-09 2.601860e-07 P09917 28.243 1.46e-46
## 96 3.3151038 8.935308e-09 2.621507e-07 P16621 28.169 2.14e-07
## 97 3.4126614 1.026446e-08 2.975254e-07 P31649 56.007 0.00e+00
## 98 3.7286917 1.393030e-08 3.867331e-07 Q16281 42.418 1.33e-122
## 99 3.6716524 1.397303e-08 3.871761e-07 Q8WU66 31.849 1.73e-32
## 100 3.1065245 1.400425e-08 3.872992e-07 Q7SC45 26.464 1.39e-33
## 101 5.3944915 1.630481e-08 4.466531e-07 Q7ZSX3 63.087 2.09e-57
## 102 3.6086575 1.634387e-08 4.468766e-07 O43704 38.095 2.35e-56
## 103 3.6159390 1.680309e-08 4.568419e-07 O75382 25.837 1.34e-10
## 104 0.6671773 1.706221e-08 4.630165e-07 Q9QWN8 42.532 4.06e-57
## 105 4.3104708 2.049182e-08 5.428457e-07 C3ZQF9 27.937 4.07e-23
## 106 3.6387289 2.128531e-08 5.607846e-07 P79888 51.099 7.01e-51
## 107 5.8894523 2.429209e-08 6.330824e-07 Q5DTY9 42.473 4.90e-43
## 108 3.4096303 2.732652e-08 7.032931e-07 B3TP03 36.289 7.71e-126
## 109 3.8734931 2.917305e-08 7.441958e-07 P34410 30.385 2.48e-29
## 110 3.3859111 3.560881e-08 8.941769e-07 P48547 42.222 3.35e-106
## 111 3.7426509 3.677053e-08 9.154026e-07 E7FAM5 30.959 1.12e-121
## 112 3.4249104 3.872466e-08 9.574589e-07 P30825 43.265 7.14e-165
## 113 2.0780951 5.426163e-08 1.259776e-06 Q01484 36.250 3.37e-06
## 114 3.3499700 6.097385e-08 1.397664e-06 A2AP18 44.169 8.20e-180
## 115 3.5495535 6.482654e-08 1.474294e-06 Q0V8E4 46.620 8.22e-94
## 116 3.9201733 7.268242e-08 1.632420e-06 Q9WYJ1 39.848 2.66e-76
## 117 3.6682250 8.496880e-08 1.882065e-06 Q96EH3 45.946 2.75e-24
## 118 5.9062800 1.003650e-07 2.166685e-06 O75762 28.650 6.47e-137
## 119 2.0903009 1.145959e-07 2.444712e-06 O73874 30.120 8.06e-14
## 120 3.6676254 1.200238e-07 2.538047e-06 Q7Z591 31.799 1.40e-16
## 121 3.9905622 1.312210e-07 2.746759e-06 Q96RW7 25.080 4.56e-34
## 122 3.1516655 1.434376e-07 2.972323e-06 Q80ZA4 35.060 0.00e+00
## 123 3.3016573 1.445378e-07 2.986564e-06 Q8IY21 34.420 1.62e-32
## 124 3.2255238 1.477322e-07 3.043873e-06 P35521 45.550 1.81e-42
## 125 3.3324379 1.500161e-07 3.086533e-06 Q8R508 38.542 1.12e-09
## 126 1.8187047 1.660932e-07 3.364668e-06 O75897 39.313 1.15e-54
## 127 3.5017338 1.974977e-07 3.923593e-06 P0CI65 30.928 3.08e-32
## 128 3.9320674 2.022318e-07 4.001479e-06 Q8NFF2 38.871 1.74e-134
## 129 2.7009288 2.087805e-07 4.102990e-06 P32456 24.068 2.12e-09
## 130 3.8154665 2.199496e-07 4.293322e-06 Q25060 49.342 2.23e-22
## 131 2.6437687 2.253844e-07 4.369920e-06 O15973 24.324 1.70e-18
## 132 3.5720034 2.488735e-07 4.774146e-06 Q6BZW3 31.017 8.15e-41
## 133 1.9066038 2.669248e-07 5.080001e-06 A6QLU6 24.034 3.82e-31
## 134 0.6544955 2.712874e-07 5.135997e-06 P01026 28.192 2.73e-170
## 135 3.3824295 2.734598e-07 5.170357e-06 Q6DGQ8 62.621 1.38e-96
## 136 3.4491355 2.849449e-07 5.373460e-06 Q3U481 36.207 1.02e-29
## 137 3.4885531 2.927700e-07 5.506666e-06 Q5RJA1 48.560 1.33e-153
## 138 1.9280430 3.655710e-07 6.667868e-06 E7FAM5 23.279 1.82e-11
## 139 2.3746450 3.844924e-07 6.977790e-06 A0A1D5PUP4 29.975 1.11e-24
## 140 3.9553653 4.351516e-07 7.745332e-06 Q96RW7 31.707 9.94e-21
## 141 3.1360492 4.532895e-07 7.995585e-06 Q8LAD0 43.320 4.32e-57
## 142 2.2966964 4.854949e-07 8.491171e-06 Q91755 31.502 4.95e-80
## 143 4.7892340 5.160336e-07 8.938814e-06 P07207 44.375 5.94e-69
## 144 1.3229849 5.484768e-07 9.421816e-06 A4IF63 32.743 8.41e-25
## 145 2.8809554 5.624860e-07 9.628162e-06 G5EG78 34.877 7.00e-92
## 146 3.5888905 5.680751e-07 9.700871e-06 Q5ZKY0 29.825 3.80e-54
## 147 3.7462922 6.432656e-07 1.076874e-05 Q96P65 26.271 8.58e-28
## 148 2.0063619 6.730121e-07 1.116336e-05 A7SLW1 70.635 0.00e+00
## 149 2.0509232 6.966087e-07 1.150200e-05 A7UKY7 48.077 9.87e-67
## 150 2.6249107 7.168730e-07 1.179619e-05 B8NHE3 27.338 6.70e-11
## 151 2.9973204 7.203152e-07 1.183936e-05 P19623 68.293 1.01e-149
## 152 3.4702885 7.226816e-07 1.185132e-05 Q04604 34.316 7.19e-103
## 153 2.3047378 8.045109e-07 1.305626e-05 A7RX26 71.571 0.00e+00
## 154 4.5947333 8.051844e-07 1.305626e-05 Q17LW0 35.849 7.15e-107
## 155 2.6741779 8.209762e-07 1.323813e-05 Q9WUW9 35.811 7.37e-52
## 156 1.9459116 8.520078e-07 1.364722e-05 Q0IIL7 42.857 7.88e-06
## 157 3.7872600 9.797935e-07 1.545445e-05 Q8TAM2 63.956 0.00e+00
## 158 4.8416528 1.113628e-06 1.726422e-05 Q7TPD1 59.049 0.00e+00
## 159 3.0040526 1.190073e-06 1.823801e-05 Q3U481 34.553 4.13e-30
## 160 6.1219286 1.549743e-06 2.306119e-05 O60678 49.811 2.98e-171
## 161 1.9351971 1.579126e-06 2.342613e-05 Q9WUA6 66.815 0.00e+00
## 162 3.5101464 1.678026e-06 2.466562e-05 Q15399 37.864 3.37e-10
## 163 3.0905745 1.737224e-06 2.545816e-05 P16621 30.380 3.33e-16
## 164 3.8146590 1.764177e-06 2.582697e-05 Q9UIJ7 50.000 1.38e-58
## 165 3.2572104 1.814656e-06 2.645885e-05 Q96P65 26.554 1.17e-28
## 166 3.6600897 1.893478e-06 2.738726e-05 Q9VIK2 28.154 1.18e-56
## 167 3.4939688 2.050597e-06 2.936617e-05 H2LRU7 27.626 3.96e-27
## 168 3.5437169 2.067450e-06 2.949921e-05 Q26627 24.005 2.92e-39
## 169 2.3298190 2.398212e-06 3.367741e-05 Q8IVV2 39.110 0.00e+00
## 170 1.5139153 2.436257e-06 3.414306e-05 F6QEU4 23.797 1.29e-49
## 171 5.3298345 2.815552e-06 3.845529e-05 P29274 28.483 2.79e-14
## 172 3.7702370 2.968553e-06 4.016571e-05 Q1RLY6 52.851 9.20e-175
## 173 1.7321229 3.299792e-06 4.420444e-05 A2TF48 36.082 3.83e-07
## 174 1.8989564 4.451371e-06 5.707857e-05 Q15319 61.943 1.61e-90
## 175 3.4980066 4.883081e-06 6.173854e-05 P54886 58.929 0.00e+00
## 176 2.0637231 5.433574e-06 6.786806e-05 O88572 30.834 1.08e-113
## 177 1.5819595 6.029436e-06 7.427833e-05 P55012 47.747 0.00e+00
## 178 2.4683443 6.887230e-06 8.329172e-05 P42893 36.091 6.72e-148
## 179 4.2373747 6.968825e-06 8.406763e-05 Q12791 45.255 0.00e+00
## 180 2.6964937 7.372550e-06 8.827531e-05 E7FAM5 25.627 1.96e-63
## 181 1.3681043 9.537625e-06 1.100097e-04 P58365 33.251 0.00e+00
## 182 3.6831017 1.158061e-05 1.298464e-04 P31422 30.478 1.26e-121
## 183 1.8721522 1.240899e-05 1.380643e-04 Q7TSH8 34.377 0.00e+00
## 184 4.2119525 1.295077e-05 1.432110e-04 Q9QX29 28.938 2.00e-47
## 185 2.0968122 1.381409e-05 1.512097e-04 Q9HCK4 31.724 3.69e-30
## 186 3.5380269 1.430307e-05 1.557828e-04 Q7SIC1 31.481 4.31e-15
## 187 4.0778747 1.728109e-05 1.839247e-04 Q9Z0U4 28.154 7.43e-73
## 188 4.1072820 1.778044e-05 1.881319e-04 P31649 55.862 0.00e+00
## 189 4.0725621 1.873303e-05 1.966289e-04 Q9Y6H5 33.491 2.51e-30
## 190 1.8568345 1.895173e-05 1.982052e-04 Q5I020 39.216 3.91e-74
## 191 2.5951008 2.045838e-05 2.118182e-04 Q6QNK2 31.734 6.08e-29
## 192 4.0550793 2.462882e-05 2.472058e-04 Q96RW7 28.814 2.26e-24
## 193 2.3967626 2.488525e-05 2.494388e-04 Q13467 59.398 4.39e-52
## 194 3.6038949 3.537869e-05 3.388857e-04 A0A2K5X3B6 35.254 1.03e-51
## 195 2.6959949 3.635986e-05 3.466770e-04 Q86U44 53.925 0.00e+00
## 196 0.6380319 3.645558e-05 3.473606e-04 Q6P2X9 26.765 7.06e-28
## 197 2.2697117 3.781426e-05 3.586528e-04 P63016 43.516 2.54e-98
## 198 3.2195131 5.083910e-05 4.651039e-04 Q924H0 28.150 2.76e-32
## 199 4.4838942 5.647047e-05 5.076376e-04 Q8WWC4 28.796 3.30e-13
## 200 3.5543247 5.783795e-05 5.176783e-04 Q8BX94 43.216 3.58e-45
## 201 1.8750225 6.597246e-05 5.829112e-04 O75899 32.645 4.30e-126
## 202 1.0190885 7.817652e-05 6.746690e-04 Q9QXE4 37.600 6.14e-15
## 203 3.5463172 8.353730e-05 7.128516e-04 O15973 24.398 9.93e-16
## 204 3.6991403 9.611706e-05 8.040701e-04 Q812E0 54.717 2.04e-137
## 205 2.3255087 1.015676e-04 8.423584e-04 Q5R4J5 33.457 3.68e-42
## 206 1.7946047 1.193115e-04 9.657091e-04 Q05609 28.428 7.44e-21
## 207 1.3280743 1.247856e-04 1.001560e-03 P02752 45.550 1.20e-55
## 208 3.8693118 1.310516e-04 1.046099e-03 Q8WU66 32.342 9.09e-34
## 209 1.0823840 1.313140e-04 1.047615e-03 E9PUL5 29.851 2.16e-08
## 210 2.0370673 1.354225e-04 1.073288e-03 Q8CAQ8 27.893 1.39e-70
## 211 2.9086113 1.377354e-04 1.087448e-03 Q8CGF6 54.711 1.70e-111
## 212 1.7553496 1.463885e-04 1.146380e-03 P35404 23.393 3.73e-12
## 213 1.9874319 1.643840e-04 1.260016e-03 Q01062 43.730 0.00e+00
## 214 1.8739604 1.685710e-04 1.287334e-03 Q61321 60.173 2.37e-90
## 215 4.2238744 1.951738e-04 1.458912e-03 P61752 26.814 1.54e-17
## 216 1.7930375 2.245844e-04 1.653124e-03 P00734 41.791 3.01e-53
## 217 1.3738192 2.521886e-04 1.822006e-03 P0CI65 26.531 5.90e-38
## 218 1.7695585 2.541226e-04 1.835062e-03 Q9VH14 31.507 3.51e-17
## 219 0.8966200 2.747590e-04 1.960975e-03 Q01484 31.495 3.68e-69
## 220 5.2269805 2.793921e-04 1.986788e-03 O08734 33.333 1.42e-26
## 221 1.4953282 2.832138e-04 2.009026e-03 Q90Z00 30.769 1.16e-08
## 222 1.7720118 3.032348e-04 2.132226e-03 Q86YH6 39.633 1.29e-83
## 223 1.1615533 3.338316e-04 2.318070e-03 Q9I928 35.374 1.20e-13
## 224 0.6452348 3.532561e-04 2.434253e-03 Q8WU66 32.714 2.96e-18
## 225 3.3338417 3.822199e-04 2.605292e-03 P17124 33.642 1.31e-44
## 226 1.2440002 3.924606e-04 2.667552e-03 Q9WU20 64.286 0.00e+00
## 227 1.5182934 3.927890e-04 2.668530e-03 P51029 28.881 9.02e-25
## 228 1.5185195 4.357000e-04 2.908152e-03 Q8HYN8 22.744 5.31e-09
## 229 1.7925462 4.418081e-04 2.942133e-03 Q08CS6 33.557 7.06e-17
## 230 4.6277366 4.455424e-04 2.964271e-03 O75899 28.317 1.20e-86
## 231 3.6045053 4.824608e-04 3.173403e-03 Q9CXI3 41.633 3.56e-117
## 232 1.7806683 4.923029e-04 3.229329e-03 P28289 41.243 4.12e-83
## 233 1.6939897 4.981992e-04 3.260612e-03 D3ZB51 27.347 2.71e-09
## 234 1.6050237 5.007928e-04 3.276104e-03 P07756 66.045 0.00e+00
## 235 1.7668049 5.788034e-04 3.707623e-03 Q96RW7 25.629 0.00e+00
## 236 1.2702072 5.885710e-04 3.761861e-03 Q1RLX4 56.379 9.93e-70
## 237 4.0316603 6.065785e-04 3.853119e-03 Q8WU66 42.202 5.46e-17
## 238 1.4370780 6.748503e-04 4.218252e-03 Q8IWU5 51.271 1.83e-153
## 239 2.0029127 6.937552e-04 4.315904e-03 Q8C419 27.213 2.94e-67
## 240 0.6694047 7.091851e-04 4.396297e-03 P54145 45.892 6.92e-138
## 241 2.8584754 7.448274e-04 4.574594e-03 Q0V9P1 25.795 3.74e-22
## 242 0.7692562 7.998511e-04 4.854824e-03 P05123 66.364 1.79e-103
## 243 1.6472178 8.061020e-04 4.882704e-03 O70277 23.596 2.65e-20
## 244 1.7669143 8.227743e-04 4.971014e-03 A2ASQ1 28.703 1.54e-86
## 245 1.9188959 9.308120e-04 5.526792e-03 Q91994 64.348 3.89e-37
## 246 0.6926413 9.351310e-04 5.545607e-03 P16621 40.588 0.00e+00
## 247 2.9169383 9.814741e-04 5.761513e-03 B0JZG0 52.817 0.00e+00
## 248 2.2106862 1.003792e-03 5.875695e-03 Q7SXM7 60.158 0.00e+00
## 249 2.8173030 1.020449e-03 5.953922e-03 Q7ZTV5 24.532 4.87e-16
## 250 1.6636187 1.023955e-03 5.969561e-03 Q06831 57.627 1.86e-37
## 251 1.7435652 1.164329e-03 6.672286e-03 O55005 32.000 1.77e-28
## 252 2.2954803 1.179347e-03 6.736995e-03 O43581 32.192 9.75e-12
## 253 2.9588305 1.204527e-03 6.863965e-03 O43581 44.828 5.45e-110
## 254 2.0336834 1.214432e-03 6.903764e-03 Q6PBD4 39.033 1.72e-41
## 255 1.4373909 1.339844e-03 7.514346e-03 P05123 73.025 0.00e+00
## 256 2.7693577 1.342687e-03 7.527376e-03 E7FAM5 24.843 2.92e-50
## 257 1.8495443 1.362684e-03 7.612925e-03 B7ZCC9 26.220 1.01e-57
## 258 2.6456168 1.454716e-03 8.080265e-03 Q5RB83 59.322 2.60e-75
## 259 1.6265450 1.470364e-03 8.142168e-03 Q7T2B9 40.909 6.59e-14
## 260 2.6270631 1.523136e-03 8.402225e-03 Q8JZQ5 37.709 0.00e+00
## 261 2.9879315 1.527400e-03 8.419326e-03 P97686 37.681 4.39e-08
## 262 0.7369535 1.533438e-03 8.445278e-03 Q6XYQ8 40.351 5.38e-20
## 263 2.8487861 1.809856e-03 9.782419e-03 Q9EQD2 29.677 2.18e-33
## 264 2.9527627 1.914116e-03 1.025399e-02 P43166 40.074 2.26e-47
## 265 1.4346135 1.991081e-03 1.062302e-02 O75366 41.916 0.00e+00
## 266 1.0085972 2.074748e-03 1.097227e-02 Q90Z00 61.481 2.94e-45
## 267 1.8697996 2.377677e-03 1.239752e-02 P79134 33.750 7.56e-108
## 268 1.1047899 2.432941e-03 1.263557e-02 P42325 86.631 2.16e-121
## 269 2.1708376 2.473954e-03 1.283299e-02 Q96RW7 24.498 2.07e-06
## 270 1.0618789 2.546351e-03 1.318197e-02 Q96EV8 27.536 1.80e-25
## 271 2.2284370 2.560759e-03 1.323287e-02 Q6UVY6 31.844 1.84e-14
## 272 2.3769551 2.653093e-03 1.362725e-02 P58197 69.608 8.90e-87
## 273 1.5676967 2.659415e-03 1.364759e-02 Q6DIV6 34.243 1.08e-72
## 274 0.5880945 3.020724e-03 1.525550e-02 Q9HCK4 31.373 1.34e-91
## 275 0.9361201 3.041363e-03 1.534788e-02 P43006 49.605 6.62e-159
## 276 1.6063769 3.545971e-03 1.739050e-02 O15992 74.860 0.00e+00
## 277 1.1507126 3.582582e-03 1.754180e-02 Q7Z443 31.579 2.58e-49
## 278 1.9569657 3.672661e-03 1.791615e-02 P30531 45.931 0.00e+00
## 279 1.8376173 3.744764e-03 1.821872e-02 Q9QWN8 50.215 9.69e-61
## 280 1.7750653 3.752806e-03 1.825171e-02 Q90481 56.489 1.26e-37
## 281 1.8770841 4.061439e-03 1.951001e-02 C3ZAH2 70.286 1.28e-88
## 282 1.7509826 4.144342e-03 1.982923e-02 Q2KIH7 61.312 0.00e+00
## 283 2.0247574 4.176294e-03 1.996230e-02 P16621 29.362 3.70e-13
## 284 2.4987247 4.184944e-03 1.998383e-02 P24722 71.818 4.44e-50
## 285 3.0615391 4.361290e-03 2.069610e-02 H1AFJ5 28.200 6.19e-57
## 286 1.6729402 4.571238e-03 2.153693e-02 Q923Y9 25.926 9.89e-08
## 287 2.0965058 4.745729e-03 2.222870e-02 P25228 76.023 3.56e-96
## 288 2.5968571 4.850806e-03 2.266216e-02 Q01484 26.037 1.12e-24
## 289 1.0157804 4.878893e-03 2.277132e-02 P09057 51.084 9.03e-160
## 290 1.5433837 4.975854e-03 2.317152e-02 Q8CHL0 58.696 1.31e-52
## 291 0.5609580 5.274476e-03 2.433493e-02 Q62770 32.710 1.10e-08
## 292 1.5904401 5.663686e-03 2.584119e-02 P23634 36.976 1.01e-131
## 293 1.8638516 6.125650e-03 2.767064e-02 Q7SIC1 34.416 1.31e-14
## 294 0.5679549 6.479885e-03 2.897220e-02 Q96RW7 32.287 1.03e-15
## 295 1.6423444 6.754106e-03 3.006814e-02 Q9I929 34.615 3.19e-13
## 296 1.9575026 7.211044e-03 3.176989e-02 O76082 31.957 1.84e-83
## 297 0.6698449 7.228704e-03 3.182830e-02 P02640 39.251 0.00e+00
## 298 1.1936763 7.442603e-03 3.263104e-02 P70115 26.786 2.37e-13
## 299 1.4934748 7.641264e-03 3.335040e-02 O43602 41.277 8.56e-46
## 300 0.6881318 7.905192e-03 3.435718e-02 Q06A37 52.760 0.00e+00
## 301 1.7823100 8.114492e-03 3.509885e-02 P0CI65 28.940 3.24e-37
## 302 0.8852068 8.453334e-03 3.622518e-02 P19137 22.266 9.77e-10
## 303 1.2643700 8.525161e-03 3.647241e-02 O70521 47.727 4.34e-40
## 304 1.2958602 8.658677e-03 3.696550e-02 P49288 28.763 2.49e-29
## 305 0.9272108 8.676269e-03 3.700783e-02 Q8JIR0 43.913 1.62e-57
## 306 0.9992270 8.746374e-03 3.725283e-02 Q923Y9 26.036 2.14e-06
## 307 1.9296822 8.993995e-03 3.810461e-02 P22004 34.409 2.50e-42
## 308 1.7209882 9.174541e-03 3.868821e-02 Q08E39 41.509 9.08e-18
## 309 0.7202075 9.359870e-03 3.940080e-02 P94598 64.384 0.00e+00
## 310 1.9780991 9.757966e-03 4.082708e-02 Q6K3R5 31.589 3.79e-66
## 311 0.8614981 1.007503e-02 4.196652e-02 P23978 46.211 1.73e-167
## 312 1.8642425 1.013214e-02 4.214877e-02 P55013 47.007 0.00e+00
## 313 1.5107143 1.019998e-02 4.233356e-02 Q60HG7 66.420 0.00e+00
## 314 1.3708181 1.026137e-02 4.253953e-02 P07207 40.852 6.79e-80
## 315 1.6702106 1.127829e-02 4.604266e-02 P09241 33.333 1.16e-26
## 316 1.5975481 1.147671e-02 4.672084e-02 Q99L13 58.544 1.87e-139
## 317 1.5914417 1.165298e-02 4.733186e-02 A4IF63 31.034 1.60e-06
## 318 0.7616722 1.216474e-02 4.903868e-02 Q27433 77.075 1.32e-128
## ProteinNames
## 1 Protein Wnt-7a
## 2 DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)
## 3 Protein Wnt-8b
## 4 Diencephalon/mesencephalon homeobox protein 1-B
## 5 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 6 Protein Wnt-8b
## 7 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPS synthetase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
## 8 Synaptotagmin-10 (Synaptotagmin X) (SytX)
## 9 F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)
## 10 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor)
## 11 Protein Wnt-2b
## 12 Spectrin beta chain, erythrocytic (Beta-I spectrin)
## 13 Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)
## 14 Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 15 Major facilitator superfamily domain-containing protein 12
## 16 EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
## 17 Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
## 18 Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
## 19 Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)
## 20 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (MAR1)
## 21 Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
## 22 Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)
## 23 Adenosine receptor A2b
## 24 Scavenger receptor class A member 5
## 25 Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a)
## 26 Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
## 27 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor)
## 28 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)
## 29 Kelch-like protein 3
## 30 Synaptotagmin-1 (Synaptotagmin I) (SytI)
## 31 Dopamine receptor 4
## 32 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 33 Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR)
## 34 Adenosine receptor A2a
## 35 Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase)
## 36 Protein TabA
## 37 Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69)
## 38 Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1)
## 39 Pejvakin (Autosomal recessive deafness type 59 protein)
## 40 Paired box protein Pax-2a (No isthmus protein) (Pax[Zf-b])
## 41 Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
## 42 Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
## 43 Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G)
## 44 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 45 Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (x-BETA1AR)
## 46 Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
## 47 Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 48 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 49 Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)
## 50 Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 51 Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)
## 52 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 53 Alanine aminotransferase 2-like (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
## 54 Retinal homeobox protein Rx2
## 55 Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
## 56 Mitochondrial basic amino acids transporter (Carnitine/acylcarnitine translocase-like) (CACT-like) (Mitochondrial carnitine/acylcarnitine carrier protein CACL) (Mitochondrial ornithine transporter 3) (Solute carrier family 25 member 29)
## 57 Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
## 58 LWamide neuropeptides [Cleaved into: LWamide I; Metamorphosin A (MMA) (LWamide II); LWamide III; LWamide IV; LWamide V; LWamide VI; LWamide VII; LWamide VIII; LWamide IX]
## 59 Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein)
## 60 Toll-like receptor 6 (CD antigen CD286)
## 61 Tachykinin-like peptides receptor 86C (NKD)
## 62 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 63 Putative ammonium transporter 3
## 64 Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
## 65 Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
## 66 Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
## 67 CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)
## 68 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 69 Voltage-dependent calcium channel type A subunit alpha-1 (Cacophony protein)
## 70 Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
## 71 Scavenger receptor class A member 5
## 72 Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
## 73 Sodium channel protein type 4 subunit alpha B (Voltage-gated sodium channel subunit alpha Nav1.4b)
## 74 Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 75 Synaptotagmin-9 (Synaptotagmin IX) (SytIX)
## 76 Potassium voltage-gated channel subfamily A member 2 (KC22) (Voltage-gated potassium channel subunit Kv1.2)
## 77 Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)
## 78 Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12)
## 79 Adhesion G protein-coupled receptor L4
## 80 Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
## 81 Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
## 82 Neurexin-4 (Neurexin IV)
## 83 Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
## 84 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
## 85 Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3)
## 86 LHFPL tetraspan subfamily member 4 protein (Lipoma HMGIC fusion partner-like 4 protein)
## 87 Protein sidekick-2
## 88 Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2)
## 89 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor)
## 90 Neuronal acetylcholine receptor subunit alpha-7
## 91 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3 (EC 3.2.2.n1) (Protein LONELY GUY 3)
## 92 Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
## 93 Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
## 94 Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42)
## 95 Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
## 96 Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 97 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 98 Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3)
## 99 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 100 Protein btn-1
## 101 Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48)
## 102 Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
## 103 Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
## 104 Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41)
## 105 QRFP-like peptide receptor
## 106 S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
## 107 BTB/POZ domain-containing protein KCTD16
## 108 Cationic amino acid transporter 2 (CAT-2) (CAT2) (cCAT-2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
## 109 TWiK family of potassium channels protein 7
## 110 Voltage-gated potassium channel KCNC1 (NGK2) (Potassium voltage-gated channel subfamily C member 1) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
## 111 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 112 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
## 113 Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 114 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)
## 115 Asparagine synthetase domain-containing protein 1
## 116 L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)
## 117 Mitochondrial assembly of ribosomal large subunit protein 1
## 118 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
## 119 Ephrin-B2a
## 120 Microtubule organization protein AKNA (AT-hook-containing transcription factor)
## 121 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 122 Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86)
## 123 Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60)
## 124 Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln))
## 125 Protocadherin Fat 3 (FAT tumor suppressor homolog 3)
## 126 Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 127 Nephrocystin-3
## 128 Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)
## 129 Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)
## 130 LWamide neuropeptides [Cleaved into: LWamide I; LWamide II; LWS]
## 131 Rhodopsin, GQ-coupled (GQ-rhodopsin)
## 132 Protein BTN1
## 133 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 134 Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
## 135 Nucleoside diphosphate kinase homolog 5 (3'-5' exonuclease NME5) (EC 3.1.-.-)
## 136 Major facilitator superfamily domain-containing protein 12 (Protein grizzled)
## 137 DNA-binding protein RFX6 (Regulatory factor X 6)
## 138 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 139 Reversion-inducing cysteine-rich protein with Kazal motifs
## 140 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 141 Probable pyridoxal 5'-phosphate synthase subunit PDX2 (AtPDX2) (EC 4.3.3.6) (Protein EMBRYO DEFECTIVE 2407) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2)
## 142 Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)
## 143 Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]
## 144 Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)
## 145 Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 146 Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175)
## 147 Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 148 Branched-chain-amino-acid aminotransferase (EC 2.6.1.42)
## 149 Insulinoma-associated protein 1 (Zinc finger protein IA-1)
## 150 Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
## 151 Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
## 152 Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase)
## 153 Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1 homolog)
## 154 Myosin-VIIa (Protein crinkled)
## 155 Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.1) (Sulfotransferase K2)
## 156 Complexin-1
## 157 Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)
## 158 F-box only protein 11
## 159 Major facilitator superfamily domain-containing protein 12 (Protein grizzled)
## 160 Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)
## 161 RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma)
## 162 Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
## 163 Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 164 GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3)
## 165 Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 166 Carcinine transporter
## 167 Polycystin-2 (Polycystic kidney disease 2 protein homolog)
## 168 Sperm receptor for egg jelly (suREJ)
## 169 Lipoxygenase homology domain-containing protein 1
## 170 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 171 Adenosine receptor A2a
## 172 Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)
## 173 Myeloid differentiation primary response protein MyD88
## 174 POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)
## 175 Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]
## 176 Low-density lipoprotein receptor-related protein 6 (LRP-6)
## 177 Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (mNKCC1)
## 178 Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)
## 179 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
## 180 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 181 Cadherin-23 (Otocadherin)
## 182 Metabotropic glutamate receptor 3 (mGluR3)
## 183 Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase)
## 184 Short transient receptor potential channel 5 (TrpC5) (Capacitative calcium entry channel 2) (CCE2) (Transient receptor protein 5) (TRP-5) (mTRP5) (Trp-related protein 5)
## 185 Roundabout homolog 2
## 186 Fucolectin
## 187 Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)
## 188 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 189 Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
## 190 Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8)
## 191 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25)
## 192 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 193 Frizzled-5 (Fz-5) (hFz5) (FzE5)
## 194 Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1)
## 195 N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)
## 196 Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)
## 197 Paired box protein Pax-6 (Oculorhombin)
## 198 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor)
## 199 m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1)
## 200 Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
## 201 Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)
## 202 Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
## 203 Rhodopsin, GQ-coupled (GQ-rhodopsin)
## 204 Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2)
## 205 Synaptotagmin-1 (Synaptotagmin I) (SytI)
## 206 Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1)
## 207 Riboflavin-binding protein (RBP) [Cleaved into: Riboflavin-binding protein, plasma form; Riboflavin-binding protein, yolk major form; Riboflavin-binding protein, yolk minor form]
## 208 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 209 Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
## 210 MICOS complex subunit Mic60 (Mitochondrial inner membrane protein) (Mitofilin)
## 211 WD repeat-containing protein 47 (Neuronal enriched MAP interacting protein) (Nemitin)
## 212 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B)
## 213 cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
## 214 Homeobox protein SIX4 (Sine oculis homeobox homolog 4) (Skeletal muscle-specific ARE-binding protein AREC3)
## 215 Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
## 216 Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
## 217 Nephrocystin-3
## 218 Tissue inhibitor of metalloproteinase
## 219 Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 220 Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
## 221 Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A)
## 222 All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2)
## 223 Fucolectin-4
## 224 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 225 Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
## 226 Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)
## 227 Protein Wnt-8b
## 228 Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
## 229 DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-)
## 230 Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)
## 231 DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)
## 232 Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
## 233 Protein turtle homolog B (Immunoglobulin superfamily member 9B)
## 234 Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)
## 235 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 236 Trafficking protein particle complex subunit 11 (Protein foie gras)
## 237 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 238 Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]
## 239 Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158)
## 240 Putative ammonium transporter 1
## 241 Histamine N-methyltransferase (HMT) (EC 2.1.1.8)
## 242 Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)
## 243 Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
## 244 Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]
## 245 Homeobox protein OTX1 B (zOtx1) (Orthodenticle homolog 1 B)
## 246 Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 247 Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)
## 248 U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31)
## 249 Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor)
## 250 Transcription factor SOX-4
## 251 Roundabout homolog 1
## 252 Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
## 253 Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
## 254 Transcription factor HES-4 (Hairy and enhancer of split 4) (Protein hairy-2)
## 255 Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)
## 256 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 257 Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112)
## 258 Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)
## 259 Myotrophin
## 260 Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amine oxidase copper domain-containing protein 1) (Histaminase)
## 261 Neuronal cell adhesion molecule (Nr-CAM) (Ankyrin-binding cell adhesion molecule NrCAM) (Neuronal surface protein Bravo) (rBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
## 262 Synaptotagmin-10 (Synaptotagmin X) (SytX)
## 263 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor)
## 264 Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)
## 265 Advillin (p92)
## 266 Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A)
## 267 Annexin A6 (Annexin VI) (Annexin-6)
## 268 Neurocalcin homolog (DrosNCa)
## 269 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 270 Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein)
## 271 DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)
## 272 Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
## 273 Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter)
## 274 Roundabout homolog 2
## 275 Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
## 276 Arginine kinase (AK) (EC 2.7.3.3)
## 277 Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3)
## 278 Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
## 279 Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41)
## 280 Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A)
## 281 Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53)
## 282 Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)
## 283 Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 284 Creatine kinase, testis isozyme (EC 2.7.3.2)
## 285 Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
## 286 Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
## 287 Ras-related protein Rab-3
## 288 Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 289 Ornithine decarboxylase (ODC) (EC 4.1.1.17)
## 290 Frizzled-5 (Fz-5)
## 291 Protein unc-13 homolog C (Munc13-3)
## 292 Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
## 293 Fucolectin
## 294 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 295 Fucolectin-3
## 296 Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5)
## 297 Villin-1
## 298 Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
## 299 Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)
## 300 Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7)
## 301 Nephrocystin-3
## 302 Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)
## 303 Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
## 304 Melatonin receptor type 1C (Mel-1C-R) (Mel1c receptor) (CKB)
## 305 Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A)
## 306 Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
## 307 Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
## 308 Protein sprouty homolog 2 (Spry-2)
## 309 Glutamate dehydrogenase (GDH) (EC 1.4.1.3) (NAD(P)H-utilizing glutamate dehydrogenase)
## 310 Sodium/calcium exchanger NCL2 (Na(+)/Ca(2+)-exchange protein NCL2) (OsEFCAX2) (Protein NCX-like 2) (OsNCL2)
## 311 Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
## 312 Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (NKCC1) (Na-K-CL symporter)
## 313 Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2)
## 314 Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]
## 315 Rhodopsin
## 316 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)
## 317 Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)
## 318 Mechanosensory protein 2
## BiologicalProcess
## 1 angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cell-cell signaling [GO:0007267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; limb development [GO:0060173]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; oviduct development [GO:0060066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon diameter [GO:0031133]; regulation of axonogenesis [GO:0050770]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; uterus development [GO:0060065]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]
## 2 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 3 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 4 midbrain development [GO:0030901]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]
## 5 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 6 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 7 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; sulfate assimilation [GO:0000103]
## 8 calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sensory perception of smell [GO:0007608]
## 9 behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]
## 10 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 11 camera-type eye photoreceptor cell differentiation [GO:0060219]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cornea development in camera-type eye [GO:0061303]; embryonic camera-type eye formation [GO:0060900]; embryonic forelimb morphogenesis [GO:0035115]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; limb development [GO:0060173]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of neuron differentiation [GO:0045665]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of fibroblast growth factor production [GO:0090270]; retina layer formation [GO:0010842]; Wnt signaling pathway [GO:0016055]
## 12 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; hemopoiesis [GO:0030097]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]
## 13 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of mRNA processing [GO:0050685]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965]
## 14 axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 15 carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 16 activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063]
## 17 antibacterial innate immune response [GO:0140367]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; calcium ion homeostasis [GO:0055074]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated protein folding [GO:0061077]; chemical homeostasis [GO:0048878]; chloride ion homeostasis [GO:0055064]; citric acid secretion [GO:0046720]; collecting duct development [GO:0072044]; connective tissue replacement [GO:0097709]; defense response to Gram-negative bacterium [GO:0050829]; endoplasmic reticulum organization [GO:0007029]; ERAD pathway [GO:0036503]; gene expression [GO:0010467]; glomerular filtration [GO:0003094]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; intracellular chloride ion homeostasis [GO:0030644]; intracellular phosphate ion homeostasis [GO:0030643]; intracellular sodium ion homeostasis [GO:0006883]; juxtaglomerular apparatus development [GO:0072051]; kidney development [GO:0001822]; leukocyte cell-cell adhesion [GO:0007159]; lipid metabolic process [GO:0006629]; loop of Henle development [GO:0072070]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; micturition [GO:0060073]; monoatomic ion homeostasis [GO:0050801]; multicellular organismal response to stress [GO:0033555]; multicellular organismal-level homeostasis [GO:0048871]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil migration [GO:1990266]; organ or tissue specific immune response [GO:0002251]; phosphate ion homeostasis [GO:0055062]; potassium ion homeostasis [GO:0055075]; protein localization to vacuole [GO:0072665]; protein transport into plasma membrane raft [GO:0044861]; regulation of blood pressure [GO:0008217]; regulation of protein transport [GO:0051223]; regulation of urine volume [GO:0035809]; renal sodium ion absorption [GO:0070294]; renal urate salt excretion [GO:0097744]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; response to lipopolysaccharide [GO:0032496]; response to unfolded protein [GO:0006986]; response to water deprivation [GO:0009414]; response to xenobiotic stimulus [GO:0009410]; RNA splicing [GO:0008380]; sodium ion homeostasis [GO:0055078]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; urate transport [GO:0015747]; urea transmembrane transport [GO:0071918]
## 18 cardiac muscle cell action potential involved in contraction [GO:0086002]; magnesium ion transport [GO:0015693]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of skeletal muscle contraction via regulation of action potential [GO:0014861]; relaxation of cardiac muscle [GO:0055119]; relaxation of skeletal muscle [GO:0090076]
## 19 calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]
## 20 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]
## 21 cellular response to interferon-beta [GO:0035458]; dendritic spine development [GO:0060996]; negative regulation of hydrolase activity [GO:0051346]; peptidyl-threonine autophosphorylation [GO:1990443]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of neuron migration [GO:2001222]
## 22 carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; monocarboxylic acid transport [GO:0015718]; urate metabolic process [GO:0046415]
## 23 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cGMP-mediated signaling [GO:0019934]; mast cell degranulation [GO:0043303]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; relaxation of vascular associated smooth muscle [GO:0060087]
## 24 endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]
## 25 BMP signaling pathway [GO:0030509]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]
## 26 amino acid metabolic process [GO:0006520]; cysteine biosynthetic process [GO:0019344]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]
## 27 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; cell growth involved in cardiac muscle cell development [GO:0061049]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; regulation of cardiac muscle contraction [GO:0055117]
## 28 calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; urinary bladder smooth muscle contraction [GO:0014832]
## 29 distal tubule morphogenesis [GO:0072156]; monoatomic ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; ubiquitin-dependent protein catabolic process [GO:0006511]
## 30 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]
## 31 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]
## 32 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 33 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; regulation of presynaptic membrane potential [GO:0099505]; response to calcium ion [GO:0051592]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; vasodilation [GO:0042311]
## 34 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic signaling pathway [GO:0097190]; eating behavior [GO:0042755]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of inflammatory response [GO:0050728]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; response to amphetamine [GO:0001975]; response to purine-containing compound [GO:0014074]; synaptic transmission, dopaminergic [GO:0001963]
## 35 estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]
## 36 lysine biosynthetic process via diaminopimelate [GO:0009089]
## 37 angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; morphogenesis of an epithelium [GO:0002009]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic anion transport [GO:0044070]; secretion [GO:0046903]
## 38 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; flavonoid metabolic process [GO:0009812]
## 39 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]
## 40 anterior/posterior pattern specification [GO:0009952]; anterior/posterior pattern specification involved in pronephros development [GO:0034672]; cell fate specification [GO:0001708]; cerebellum development [GO:0021549]; cerebellum formation [GO:0021588]; cilium assembly [GO:0060271]; closure of optic fissure [GO:0061386]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic pattern specification [GO:0009880]; hindbrain development [GO:0030902]; inner ear receptor cell differentiation [GO:0060113]; kidney development [GO:0001822]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; nervous system development [GO:0007399]; otic placode formation [GO:0043049]; peripheral nervous system development [GO:0007422]; pronephric glomerulus morphogenesis [GO:0035775]; pronephros development [GO:0048793]; pronephros morphogenesis [GO:0072114]; regulation of transcription by RNA polymerase II [GO:0006357]; thyroid gland development [GO:0030878]; vestibular receptor cell development [GO:0060118]
## 41 adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; blood vessel morphogenesis [GO:0048514]; bone development [GO:0060348]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retina vasculature development in camera-type eye [GO:0061298]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]
## 42 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]
## 43 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]
## 44 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 45 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of heart contraction [GO:0045823]
## 46 cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; response to alcohol [GO:0097305]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]
## 47 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 48 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 49 action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]
## 50 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 51 detection of mechanical stimulus [GO:0050982]
## 52 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 53 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]
## 54 camera-type eye photoreceptor cell differentiation [GO:0060219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]
## 55 methylation [GO:0032259]; terpenoid biosynthetic process [GO:0016114]
## 56 acyl carnitine transmembrane transport [GO:1902616]; acyl carnitine transport [GO:0006844]; L-arginine transmembrane transport [GO:1903826]; L-histidine transmembrane transport [GO:0089709]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; organic cation transport [GO:0015695]; ornithine transport [GO:0015822]
## 57 brain development [GO:0007420]; cellular response to histamine [GO:0071420]; cellular response to zinc ion [GO:0071294]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; chemical synaptic transmission, postsynaptic [GO:0099565]; chloride transmembrane transport [GO:1902476]; circadian sleep/wake cycle, REM sleep [GO:0042747]; cochlea development [GO:0090102]; exploration behavior [GO:0035640]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hard palate development [GO:0060022]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; learning [GO:0007612]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuron development [GO:0048666]; regulation of postsynaptic membrane potential [GO:0060078]; reproductive behavior [GO:0019098]; response to anesthetic [GO:0072347]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; social behavior [GO:0035176]; synaptic transmission, GABAergic [GO:0051932]
## 58 extracellular matrix organization [GO:0030198]; neuropeptide signaling pathway [GO:0007218]
## 59 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]
## 60 cellular response to diacyl bacterial lipopeptide [GO:0071726]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]
## 61 G protein-coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217]
## 62 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 63 ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]
## 64 negative regulation of translation [GO:0017148]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]
## 65 chloride transmembrane transport [GO:1902476]; cysteine transport [GO:0042883]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]
## 66 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]
## 67 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; notochord development [GO:0030903]; pyrimidine nucleobase biosynthetic process [GO:0019856]
## 68 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 69 calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]
## 70 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of insulin secretion [GO:0046676]
## 71 endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]
## 72 arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]
## 73 membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; sodium ion transmembrane transport [GO:0035725]
## 74 axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 75 calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; calcium-ion regulated exocytosis [GO:0017156]; regulation of calcium ion-dependent exocytosis [GO:0017158]
## 76 neuronal action potential [GO:0019228]; optic nerve structural organization [GO:0021633]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; sensory perception of pain [GO:0019233]
## 77 detection of mechanical stimulus [GO:0050982]
## 78 cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129]
## 79 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; animal organ development [GO:0048513]; cell surface receptor signaling pathway [GO:0007166]
## 80 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]
## 81 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]
## 82 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; cell-cell junction organization [GO:0045216]; dorsal closure [GO:0007391]; establishment of glial blood-brain barrier [GO:0060857]; heart process [GO:0003015]; nerve maturation [GO:0021682]; presynaptic membrane assembly [GO:0097105]; protein localization [GO:0008104]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synaptic target recognition [GO:0008039]; terminal button organization [GO:0072553]
## 83 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]
## 84 cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 85 brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transmembrane transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]
## 86 gamma-aminobutyric acid receptor clustering [GO:0097112]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of inhibitory synapse assembly [GO:1905702]; sensory perception of sound [GO:0007605]
## 87 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]
## 88 action potential [GO:0001508]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; neuronal action potential [GO:0019228]; optic nerve development [GO:0021554]; optic nerve structural organization [GO:0021633]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; sensory perception of pain [GO:0019233]
## 89 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 90 calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]
## 91 cytokinin biosynthetic process [GO:0009691]
## 92 brain development [GO:0007420]; cellular response to histamine [GO:0071420]; cellular response to zinc ion [GO:0071294]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; chemical synaptic transmission, postsynaptic [GO:0099565]; chloride transmembrane transport [GO:1902476]; circadian sleep/wake cycle, REM sleep [GO:0042747]; cochlea development [GO:0090102]; exploration behavior [GO:0035640]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hard palate development [GO:0060022]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; learning [GO:0007612]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuron development [GO:0048666]; regulation of postsynaptic membrane potential [GO:0060078]; reproductive behavior [GO:0019098]; response to anesthetic [GO:0072347]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; social behavior [GO:0035176]; synaptic transmission, GABAergic [GO:0051932]
## 93 cellular response to oxidative stress [GO:0034599]; cysteine biosynthetic process [GO:0019344]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; glutathione metabolic process [GO:0006749]; hepatoblast differentiation [GO:0061017]; hepatocyte differentiation [GO:0070365]; liver regeneration [GO:0097421]; peptide modification [GO:0031179]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; response to alcohol [GO:0097305]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]
## 94 CTP metabolic process [GO:0046036]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256]
## 95 arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]
## 96 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 97 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 98 inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]
## 99 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 100 L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; regulation of intracellular pH [GO:0051453]
## 101 amacrine cell differentiation [GO:0035881]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; hindbrain development [GO:0030902]; neuron development [GO:0048666]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]
## 102 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]
## 103 negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]
## 104 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cellular response to ethanol [GO:0071361]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; postsynapse organization [GO:0099173]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; vesicle-mediated transport [GO:0016192]
## 105 cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]
## 106 spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]
## 107 protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]
## 108 L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine transmembrane transport [GO:1903352]
## 109 potassium ion transmembrane transport [GO:0071805]; stabilization of membrane potential [GO:0030322]
## 110 action potential [GO:0001508]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; globus pallidus development [GO:0021759]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; response to amine [GO:0014075]; response to auditory stimulus [GO:0010996]; response to fibroblast growth factor [GO:0071774]; response to light intensity [GO:0009642]; response to nerve growth factor [GO:1990089]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]
## 111 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 112 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104]
## 113 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 114 lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209]
## 115 asparagine biosynthetic process [GO:0006529]; glutamine metabolic process [GO:0006541]
## 116 isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; threonine catabolic process [GO:0006567]
## 117 negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273]
## 118 calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]
## 119 angioblast cell migration involved in selective angioblast sprouting [GO:0035475]; anterior/posterior pattern specification [GO:0009952]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; optic vesicle morphogenesis [GO:0003404]; regulation of chemotaxis [GO:0050920]; rhombomere boundary formation [GO:0021654]; somitogenesis [GO:0001756]; synaptic target recognition [GO:0008039]
## 120 delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]
## 121 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 122 sensory perception of sound [GO:0007605]
## 123 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]
## 124 cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; mRNA cis splicing, via spliceosome [GO:0045292]; potassium ion transmembrane transport [GO:0071805]; spliceosomal snRNP assembly [GO:0000387]
## 125 cell morphogenesis involved in neuron differentiation [GO:0048667]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842]
## 126 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; doxorubicin metabolic process [GO:0044598]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]
## 127 cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 128 amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to high light intensity [GO:0009644]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]
## 129 activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein localization to nucleus [GO:0034504]
## 130 neuropeptide signaling pathway [GO:0007218]
## 131 cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 132 L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; regulation of intracellular pH [GO:0051453]
## 133 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 134 amyloid-beta clearance [GO:0097242]; chemotaxis [GO:0006935]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of developmental growth [GO:0048639]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; tolerance induction [GO:0002507]; vascular associated smooth muscle cell differentiation [GO:0035886]; vertebrate eye-specific patterning [GO:0150064]
## 135 cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; UTP biosynthetic process [GO:0006228]
## 136 carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 137 endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309]
## 138 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 139 blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; extracellular matrix organization [GO:0030198]; negative regulation of metalloendopeptidase activity [GO:1904684]; regulation of angiogenesis [GO:0045765]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]
## 140 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 141 glutamine metabolic process [GO:0006541]; pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819]
## 142 detection of cold stimulus involved in thermoception [GO:0120169]
## 143 actin filament organization [GO:0007015]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compartment boundary maintenance [GO:0060289]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; defense response to insect [GO:0002213]; determination of adult lifespan [GO:0008340]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; eye-antennal disc development [GO:0035214]; eye-antennal disc morphogenesis [GO:0007455]; female germ-line stem cell population maintenance [GO:0036099]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber migration [GO:0007297]; follicle cell of egg chamber stalk formation [GO:0030713]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germ-line stem cell population maintenance [GO:0030718]; germ-line stem-cell niche homeostasis [GO:0060250]; germarium-derived egg chamber formation [GO:0007293]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of an epithelial fold [GO:0060571]; motor neuron axon guidance [GO:0008045]; muscle cell cellular homeostasis [GO:0046716]; muscle cell fate determination [GO:0007521]; myoblast development [GO:0048627]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of gene expression [GO:0010629]; negative regulation of lamellocyte differentiation [GO:0035204]; negative regulation of neurogenesis [GO:0050768]; nervous system process [GO:0050877]; neuroblast development [GO:0014019]; neuroblast fate determination [GO:0007400]; neuroblast fate specification [GO:0014018]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; peripheral nervous system development [GO:0007422]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of crystal cell differentiation [GO:0042691]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell differentiation [GO:0048056]; R7 cell differentiation [GO:0045466]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of filopodium assembly [GO:0051489]; regulation of glycolytic process [GO:0006110]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of stem cell division [GO:2000035]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; stem cell differentiation [GO:0048863]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]
## 144 negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]
## 145 axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 146 lysosomal lumen pH elevation [GO:0035752]; neuron cellular homeostasis [GO:0070050]; phagosome-lysosome fusion [GO:0090385]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of lysosomal lumen pH [GO:0035751]
## 147 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 148 L-leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099]
## 149 endocrine pancreas development [GO:0031018]; endodermal cell differentiation [GO:0035987]; gland development [GO:0048732]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; pancreatic A cell differentiation [GO:0003310]; transdifferentiation [GO:0060290]; type B pancreatic cell differentiation [GO:0003309]
## 150 methylation [GO:0032259]; terpenoid biosynthetic process [GO:0016114]
## 151 cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]
## 152 melanin biosynthetic process from tyrosine [GO:0006583]
## 153 L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557]
## 154 actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605]
## 155 sulfation [GO:0051923]
## 156 regulation of neurotransmitter secretion [GO:0046928]; synaptic vesicle exocytosis [GO:0016079]
## 157 axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]
## 158 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511]
## 159 carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 160 chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]
## 161 brain morphogenesis [GO:0048854]; cellular response to insulin stimulus [GO:0032869]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]
## 162 cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]
## 163 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 164 ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; blood coagulation [GO:0007596]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; nucleoside triphosphate biosynthetic process [GO:0009142]; UTP metabolic process [GO:0046051]
## 165 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 166 carcinine import across plasma membrane [GO:1905130]; detection of light stimulus involved in visual perception [GO:0050908]; neurotransmitter uptake [GO:0001504]; positive phototaxis [GO:0046956]; visual perception [GO:0007601]
## 167 calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; inorganic cation transmembrane transport [GO:0098662]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]; release of sequestered calcium ion into cytosol [GO:0051209]; Wnt signaling pathway [GO:0016055]
## 168 detection of mechanical stimulus [GO:0050982]
## 169 sensory perception of sound [GO:0007605]
## 170 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 171 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; central nervous system development [GO:0007417]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; sensory perception [GO:0007600]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]
## 172 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; kynurenine metabolic process [GO:0070189]; NAD metabolic process [GO:0019674]; podocyte development [GO:0072015]; quinolinate biosynthetic process [GO:0019805]; response to yeast [GO:0001878]; tryptophan catabolic process [GO:0006569]
## 173 defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]
## 174 axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]
## 175 citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266]
## 176 anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; mesenchymal cell proliferation [GO:0010463]; mesodermal cell migration [GO:0008078]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of developmental process [GO:0051093]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of morphogenesis of an epithelium [GO:1905331]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; Norrin signaling pathway [GO:0110135]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ossification [GO:0045778]; positive regulation of stem cell proliferation [GO:2000648]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of anatomical structure morphogenesis [GO:0022603]; regulation of cell development [GO:0060284]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]
## 177 ammonium transmembrane transport [GO:0072488]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; mammary duct terminal end bud growth [GO:0060763]; multicellular organism growth [GO:0035264]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; T cell chemotaxis [GO:0010818]
## 178 axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; blood vessel diameter maintenance [GO:0097746]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; gene expression [GO:0010467]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; neuron projection development [GO:0031175]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of blood pressure [GO:0008217]; regulation of ERK1 and ERK2 cascade [GO:0070372]; response to cadmium ion [GO:0046686]; response to hypoxia [GO:0001666]; response to muscle stretch [GO:0035994]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]
## 179 intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311]
## 180 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 181 adult locomotory behavior [GO:0008344]; auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; cell-cell adhesion [GO:0098609]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; righting reflex [GO:0060013]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]
## 182 G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]
## 183 embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transport from cytosol to endoplasmic reticulum [GO:0160176]
## 184 calcium ion transmembrane transport [GO:0070588]; negative regulation of dendrite morphogenesis [GO:0050774]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630]
## 185 aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]
## 186 regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 187 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of synaptic transmission [GO:0050805]; neuron-glial cell signaling [GO:0150099]; osteoblast differentiation [GO:0001649]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of growth hormone secretion [GO:0060124]; regulation of glutamate secretion [GO:0014048]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; synaptic transmission, GABAergic [GO:0051932]
## 188 amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 189 cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928]
## 190 zinc ion import into organelle [GO:0062111]
## 191 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 192 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 193 angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of mitophagy [GO:1901524]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]
## 194 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; flavonoid metabolic process [GO:0009812]
## 195 cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA destabilization [GO:0061157]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]
## 196 creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]
## 197 anterior/posterior pattern specification [GO:0009952]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; blood vessel development [GO:0001568]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epithelial cell development [GO:0002064]; establishment of mitotic spindle orientation [GO:0000132]; eye photoreceptor cell development [GO:0042462]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; hindbrain development [GO:0030902]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neural precursor cell proliferation [GO:0061351]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pallium development [GO:0021543]; pancreatic A cell development [GO:0003322]; pancreatic A cell differentiation [GO:0003310]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regionalization [GO:0003002]; regulation of asymmetric cell division [GO:0009786]; regulation of cell migration [GO:0030334]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]; regulation of neuron differentiation [GO:0045664]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; spinal cord development [GO:0021510]; telencephalon regionalization [GO:0021978]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]
## 198 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 199 calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]
## 200 intracellular cholesterol transport [GO:0032367]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]
## 201 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]
## 202 apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; response to heat [GO:0009408]
## 203 cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 204 cellular response to arsenic-containing substance [GO:0071243]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of translational elongation [GO:0045900]; regulation of translation at synapse, modulating synaptic transmission [GO:0099547]
## 205 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]
## 206 ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182]
## 207 negative regulation of sensory perception of bitter taste [GO:1904661]; negative regulation of sensory perception of sweet taste [GO:1904657]; riboflavin transport [GO:0032218]
## 208 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 209 negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]
## 210 cristae formation [GO:0042407]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]
## 211 adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; brain development [GO:0007420]; cerebral cortex development [GO:0021987]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; locomotory behavior [GO:0007626]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuron projection development [GO:0031175]; neuronal stem cell population maintenance [GO:0097150]
## 212 adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; negative regulation of serotonin secretion [GO:0014063]; regulation of behavior [GO:0050795]; vasoconstriction [GO:0042310]
## 213 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cardiac septum development [GO:0003279]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; coronary vasculature development [GO:0060976]; establishment of endothelial barrier [GO:0061028]; heart development [GO:0007507]; heart valve development [GO:0003170]; intracellular signal transduction [GO:0035556]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to hydrogen sulfide [GO:1904880]; ventricular septum development [GO:0003281]
## 214 embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]
## 215 chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907]
## 216 acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid kinase activity [GO:0090218]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]
## 217 cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 218 basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; delamination [GO:0060232]; imaginal disc-derived wing expansion [GO:0048526]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; oogenesis [GO:0048477]; phototaxis [GO:0042331]; tracheal outgrowth, open tracheal system [GO:0007426]; tracheal pit formation in open tracheal system [GO:0035202]; ventral cord development [GO:0007419]; wing disc morphogenesis [GO:0007472]
## 219 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 220 animal organ regeneration [GO:0031100]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to mechanical stimulus [GO:0071260]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; epithelial cell proliferation [GO:0050673]; establishment of localization in cell [GO:0051649]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; homeostasis of number of cells [GO:0048872]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; leukocyte homeostasis [GO:0001776]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]
## 221 anatomical structure homeostasis [GO:0060249]; cardiac muscle tissue development [GO:0048738]; cartilage development [GO:0051216]; cell migration in hindbrain [GO:0021535]; dorsal/ventral pattern formation [GO:0009953]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fin regeneration [GO:0031101]; liver development [GO:0001889]; mesoderm development [GO:0007498]; negative regulation of endodermal cell fate specification [GO:0042664]; olfactory nerve formation [GO:0021628]; olfactory placode morphogenesis [GO:0071699]; pectoral fin development [GO:0033339]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; post-anal tail morphogenesis [GO:0036342]; posterior lateral line development [GO:0048916]; response to ethanol [GO:0045471]; skin morphogenesis [GO:0043589]
## 222 cerebellum development [GO:0021549]; isoprenoid biosynthetic process [GO:0008299]; regulation of body fluid levels [GO:0050878]; ubiquinone biosynthetic process [GO:0006744]
## 223 regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 224 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 225 chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907]
## 226 methionine biosynthetic process [GO:0009086]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]
## 227 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 228 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]
## 229 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 230 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]
## 231 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 232 actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]
## 233 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; synaptic membrane adhesion [GO:0099560]
## 234 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to oleic acid [GO:0034201]; response to starvation [GO:0042594]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311]
## 235 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 236 Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; protein N-linked glycosylation [GO:0006487]; protein secretion [GO:0009306]; regulation of response to endoplasmic reticulum stress [GO:1905897]; retina development in camera-type eye [GO:0060041]; vesicle-mediated transport [GO:0016192]
## 237 hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 238 bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelin production [GO:1904472]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]
## 239 brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]
## 240 ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]
## 241 histamine catabolic process [GO:0001695]; methylation [GO:0032259]
## 242 phosphocreatine biosynthetic process [GO:0046314]; response to heat [GO:0009408]
## 243 negative regulation of translation [GO:0017148]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]
## 244 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; enzyme-linked receptor protein signaling pathway [GO:0007167]; motor neuron apoptotic process [GO:0097049]; negative regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903407]; negative regulation of sodium ion export across plasma membrane [GO:1903277]; neuromuscular junction development [GO:0007528]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein phosphorylation [GO:0001932]; regulation of synapse organization [GO:0050807]; regulation of synaptic activity [GO:0060025]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416]
## 245 inner ear morphogenesis [GO:0042472]; lateral semicircular canal development [GO:0060875]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal pigment epithelium development [GO:0003406]
## 246 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 247 sodium ion transport [GO:0006814]
## 248 mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]
## 249 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]
## 250 ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to glucose stimulus [GO:0071333]; endocrine pancreas development [GO:0031018]; gene expression [GO:0010467]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; hematopoietic stem cell homeostasis [GO:0061484]; kidney morphogenesis [GO:0060993]; mesenchyme development [GO:0060485]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412]
## 251 aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hypoxia [GO:0071456]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; coronary vasculature development [GO:0060976]; endocardial cushion formation [GO:0003272]; heart development [GO:0007507]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; neuron projection extension [GO:1990138]; olfactory bulb interneuron development [GO:0021891]; oligodendrocyte development [GO:0014003]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; regulation of dendrite morphogenesis [GO:0048814]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; ventricular septum morphogenesis [GO:0060412]
## 252 calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]
## 253 calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]
## 254 eye photoreceptor cell development [GO:0042462]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; Notch signaling pathway [GO:0007219]; photoreceptor cell maintenance [GO:0045494]; prechordal plate formation [GO:0021501]
## 255 phosphocreatine biosynthetic process [GO:0046314]; response to heat [GO:0009408]
## 256 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 257 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; neurogenesis [GO:0022008]
## 258 L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]
## 259 regulation of barbed-end actin filament capping [GO:2000812]
## 260 amine metabolic process [GO:0009308]; cellular response to copper ion starvation [GO:0035874]; putrescine metabolic process [GO:0009445]; response to antibiotic [GO:0046677]
## 261 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuronal action potential propagation [GO:0019227]; protein localization [GO:0008104]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]
## 262 calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sensory perception of smell [GO:0007608]
## 263 cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 264 neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]
## 265 actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]
## 266 anatomical structure homeostasis [GO:0060249]; cardiac muscle tissue development [GO:0048738]; cartilage development [GO:0051216]; cell migration in hindbrain [GO:0021535]; dorsal/ventral pattern formation [GO:0009953]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fin regeneration [GO:0031101]; liver development [GO:0001889]; mesoderm development [GO:0007498]; negative regulation of endodermal cell fate specification [GO:0042664]; olfactory nerve formation [GO:0021628]; olfactory placode morphogenesis [GO:0071699]; pectoral fin development [GO:0033339]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; post-anal tail morphogenesis [GO:0036342]; posterior lateral line development [GO:0048916]; response to ethanol [GO:0045471]; skin morphogenesis [GO:0043589]
## 267 apoptotic signaling pathway [GO:0097190]; biomineral tissue development [GO:0031214]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; growth plate cartilage chondrocyte differentiation [GO:0003418]; mitochondrial calcium ion homeostasis [GO:0051560]; negative regulation of sequestering of calcium ion [GO:0051283]; regulation of muscle contraction [GO:0006937]
## 268 negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]
## 269 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 270 actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; kidney development [GO:0001822]; melanosome organization [GO:0032438]; memory [GO:0007613]; negative regulation of dendritic spine morphogenesis [GO:0061002]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; protein transmembrane transport [GO:0071806]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041]
## 271 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 272 anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cell population proliferation [GO:0008283]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; fibroblast migration [GO:0010761]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]; trigeminal nerve development [GO:0021559]
## 273 beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]; neurotransmitter transport [GO:0006836]
## 274 aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]
## 275 adult behavior [GO:0030534]; cellular response to cocaine [GO:0071314]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transmembrane transport [GO:0098656]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; neurotransmitter reuptake [GO:0098810]; positive regulation of glucose import [GO:0046326]; protein homotrimerization [GO:0070207]; response to amino acid [GO:0043200]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; telencephalon development [GO:0021537]; visual behavior [GO:0007632]
## 276 phosphocreatine biosynthetic process [GO:0046314]
## 277 cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915]
## 278 amino acid transport [GO:0006865]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]
## 279 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cellular response to ethanol [GO:0071361]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; postsynapse organization [GO:0099173]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; vesicle-mediated transport [GO:0016192]
## 280 cell differentiation [GO:0030154]; endocrine pancreas development [GO:0031018]; floor plate development [GO:0033504]; floor plate formation [GO:0021508]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; Schwann cell development [GO:0014044]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; ventral spinal cord interneuron differentiation [GO:0021514]
## 281 L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555]
## 282 L-phenylalanine catabolic process [GO:0006559]; tyrosine biosynthetic process [GO:0006571]
## 283 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 284 phosphocreatine biosynthetic process [GO:0046314]
## 285 sodium ion transmembrane transport [GO:0035725]
## 286 G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]
## 287 cytoskeletal matrix organization at active zone [GO:0048789]; exocytosis [GO:0006887]; maintenance of presynaptic active zone structure [GO:0048790]; neurotransmitter secretion [GO:0007269]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; symbiont entry into host cell [GO:0046718]; vesicle-mediated transport [GO:0016192]
## 288 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 289 cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615]
## 290 angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye development [GO:0031076]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; presynapse assembly [GO:0099054]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; Spemann organizer formation [GO:0060061]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]
## 291 chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of neurotransmitter secretion [GO:0046928]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]
## 292 calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832]
## 293 regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 294 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 295 regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 296 (R)-carnitine transmembrane transport [GO:1902270]; (R)-carnitine transport [GO:1900749]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; response to symbiotic bacterium [GO:0009609]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]
## 297 actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]
## 298 adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]
## 299 axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041]
## 300 adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222]
## 301 cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 302 animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; branching involved in salivary gland morphogenesis [GO:0060445]; camera-type eye development [GO:0043010]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein phosphorylation [GO:0006468]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retina development in camera-type eye [GO:0060041]; retinal blood vessel morphogenesis [GO:0061304]; tissue development [GO:0009888]
## 303 negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to ethanol [GO:0045471]
## 304 G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of glucose import [GO:0046325]; negative regulation of glycolytic process [GO:0045820]
## 305 cerebellum development [GO:0021549]; chromatin remodeling [GO:0006338]; hematopoietic stem cell migration [GO:0035701]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primitive hemopoiesis [GO:0060215]
## 306 G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]
## 307 BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323]
## 308 animal organ development [GO:0048513]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]
## 309 glutamate biosynthetic process [GO:0006537]
## 310 calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814]
## 311 amino acid transport [GO:0006865]; associative learning [GO:0008306]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; inorganic anion import across plasma membrane [GO:0098658]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neurotransmitter reuptake [GO:0098810]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]
## 312 cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; inorganic cation import across plasma membrane [GO:0098659]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]
## 313 cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346]
## 314 actin filament organization [GO:0007015]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compartment boundary maintenance [GO:0060289]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; defense response to insect [GO:0002213]; determination of adult lifespan [GO:0008340]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; eye-antennal disc development [GO:0035214]; eye-antennal disc morphogenesis [GO:0007455]; female germ-line stem cell population maintenance [GO:0036099]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber migration [GO:0007297]; follicle cell of egg chamber stalk formation [GO:0030713]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germ-line stem cell population maintenance [GO:0030718]; germ-line stem-cell niche homeostasis [GO:0060250]; germarium-derived egg chamber formation [GO:0007293]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of an epithelial fold [GO:0060571]; motor neuron axon guidance [GO:0008045]; muscle cell cellular homeostasis [GO:0046716]; muscle cell fate determination [GO:0007521]; myoblast development [GO:0048627]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of gene expression [GO:0010629]; negative regulation of lamellocyte differentiation [GO:0035204]; negative regulation of neurogenesis [GO:0050768]; nervous system process [GO:0050877]; neuroblast development [GO:0014019]; neuroblast fate determination [GO:0007400]; neuroblast fate specification [GO:0014018]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; peripheral nervous system development [GO:0007422]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of crystal cell differentiation [GO:0042691]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell differentiation [GO:0048056]; R7 cell differentiation [GO:0045466]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of filopodium assembly [GO:0051489]; regulation of glycolytic process [GO:0006110]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of stem cell division [GO:2000035]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; stem cell differentiation [GO:0048863]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]
## 315 cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 316 valine catabolic process [GO:0006574]
## 317 negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]
## 318 detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; mechanosensory behavior [GO:0007638]; positive regulation of detection of mechanical stimulus involved in sensory perception of touch [GO:1905789]; positive regulation of mechanosensory behavior [GO:1905792]; potassium ion transport [GO:0006813]; response to mechanical stimulus [GO:0009612]
## GeneOntologyIDs
## 1 GO:0000578; GO:0001502; GO:0001525; GO:0002062; GO:0005102; GO:0005109; GO:0005125; GO:0005615; GO:0005788; GO:0006915; GO:0007165; GO:0007267; GO:0007269; GO:0007416; GO:0008284; GO:0009887; GO:0009953; GO:0009986; GO:0010595; GO:0010628; GO:0014719; GO:0014834; GO:0016055; GO:0021707; GO:0021846; GO:0022009; GO:0030010; GO:0030182; GO:0030326; GO:0031012; GO:0031133; GO:0032355; GO:0035019; GO:0035115; GO:0035116; GO:0035313; GO:0035567; GO:0042127; GO:0042733; GO:0043066; GO:0043627; GO:0045165; GO:0045167; GO:0045893; GO:0045944; GO:0046330; GO:0048103; GO:0048864; GO:0050678; GO:0050768; GO:0050770; GO:0050808; GO:0051216; GO:0051247; GO:0051965; GO:0060054; GO:0060065; GO:0060066; GO:0060070; GO:0060071; GO:0060173; GO:0060856; GO:0060997; GO:0061038; GO:0062009; GO:0071560; GO:0098685; GO:0098793; GO:0098978; GO:0099175; GO:1904891; GO:1905606; GO:2000300; GO:2000463
## 2 GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 3 GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 4 GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0007346; GO:0030901; GO:0050767; GO:0051726; GO:0060041; GO:0061074
## 5 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 6 GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 7 GO:0000103; GO:0004020; GO:0004781; GO:0005524; GO:0016779; GO:0050428
## 8 GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0007268; GO:0007608; GO:0017156; GO:0030276; GO:0030658; GO:0042803; GO:0045956; GO:0046982; GO:0070382; GO:0098793; GO:0098978
## 9 GO:0001662; GO:0005737; GO:0019005; GO:0031146; GO:0045202; GO:0098685; GO:0098793; GO:0098978; GO:0099575; GO:2000300
## 10 GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 11 GO:0002011; GO:0002088; GO:0003407; GO:0005109; GO:0005125; GO:0005615; GO:0008283; GO:0010842; GO:0016055; GO:0030182; GO:0035115; GO:0045165; GO:0045665; GO:0045686; GO:0045743; GO:0060070; GO:0060173; GO:0060219; GO:0060828; GO:0060900; GO:0061072; GO:0061303; GO:0090270; GO:0090271
## 12 GO:0003779; GO:0005200; GO:0005886; GO:0006779; GO:0007009; GO:0008091; GO:0014731; GO:0016020; GO:0030036; GO:0030054; GO:0030097; GO:0030863; GO:0030864; GO:0042995; GO:0051015; GO:0051693; GO:0098794; GO:0098978
## 13 GO:0003723; GO:0003725; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0006397; GO:0007274; GO:0008251; GO:0008285; GO:0016553; GO:0016556; GO:0021610; GO:0021618; GO:0021965; GO:0030336; GO:0035264; GO:0042802; GO:0044387; GO:0045070; GO:0045202; GO:0046872; GO:0050685; GO:0050884; GO:0051726; GO:0060384; GO:0060415; GO:0061744; GO:0097049
## 14 GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 15 GO:0005764; GO:0005765; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:1903712
## 16 GO:0000139; GO:0001772; GO:0002115; GO:0002250; GO:0003924; GO:0005509; GO:0005525; GO:0005737; GO:0005815; GO:0005886; GO:0016197; GO:0031982; GO:0032237; GO:0032588; GO:0033093; GO:0034776; GO:0045063; GO:0046330; GO:0051928
## 17 GO:0000922; GO:0001822; GO:0002251; GO:0003091; GO:0003094; GO:0005509; GO:0005615; GO:0005783; GO:0005886; GO:0005929; GO:0006629; GO:0006874; GO:0006883; GO:0006914; GO:0006915; GO:0006954; GO:0006986; GO:0007029; GO:0007157; GO:0007159; GO:0008217; GO:0008380; GO:0009410; GO:0009414; GO:0009986; GO:0010467; GO:0015747; GO:0016020; GO:0016323; GO:0016324; GO:0019864; GO:0030643; GO:0030644; GO:0032496; GO:0033209; GO:0033555; GO:0034620; GO:0034976; GO:0035809; GO:0036503; GO:0044861; GO:0045177; GO:0046720; GO:0048871; GO:0048878; GO:0050801; GO:0050829; GO:0050891; GO:0051223; GO:0055062; GO:0055064; GO:0055074; GO:0055075; GO:0055078; GO:0060073; GO:0060170; GO:0061077; GO:0070294; GO:0071918; GO:0072044; GO:0072051; GO:0072070; GO:0072218; GO:0072221; GO:0072233; GO:0072665; GO:0097190; GO:0097709; GO:0097744; GO:0098552; GO:0140367; GO:1990266
## 18 GO:0005242; GO:0005546; GO:0005886; GO:0006813; GO:0008076; GO:0014861; GO:0015693; GO:0016020; GO:0034765; GO:0042802; GO:0051289; GO:0055119; GO:0060306; GO:0086002; GO:0086008; GO:0086091; GO:0090076; GO:1990573
## 19 GO:0005229; GO:0005254; GO:0005783; GO:0005829; GO:0005886; GO:0034220; GO:0046983; GO:0061588; GO:0070161; GO:1902476
## 20 GO:0004937; GO:0005886; GO:0007200; GO:0007204; GO:0007267; GO:0043410; GO:0071880
## 21 GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005954; GO:0014069; GO:0035458; GO:0043197; GO:0046427; GO:0046872; GO:0051346; GO:0060996; GO:0106310; GO:1990443; GO:2000124; GO:2001222
## 22 GO:0005308; GO:0005886; GO:0008028; GO:0015226; GO:0015718; GO:0015881; GO:0046415; GO:1902603
## 23 GO:0001609; GO:0002882; GO:0005886; GO:0007189; GO:0010575; GO:0010753; GO:0019934; GO:0032722; GO:0032755; GO:0043303; GO:0043306; GO:0060087; GO:0098685; GO:0098793; GO:0098978; GO:0099171
## 24 GO:0005886; GO:0006879; GO:0006897; GO:0034755; GO:0070207; GO:0070287
## 25 GO:0000122; GO:0002088; GO:0005634; GO:0014029; GO:0021501; GO:0030509; GO:0033504; GO:0043066; GO:0043425; GO:0043565; GO:0045892; GO:0046983
## 26 GO:0000048; GO:0002682; GO:0002951; GO:0005615; GO:0005886; GO:0006508; GO:0006520; GO:0006536; GO:0006631; GO:0006691; GO:0006750; GO:0006751; GO:0007283; GO:0019344; GO:0031179; GO:0031638; GO:0036374; GO:0050727; GO:0070062; GO:0103068; GO:1901750
## 27 GO:0000165; GO:0001985; GO:0001994; GO:0001996; GO:0001997; GO:0004937; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005901; GO:0007200; GO:0007204; GO:0007512; GO:0010507; GO:0010613; GO:0031965; GO:0043410; GO:0045907; GO:0045987; GO:0046982; GO:0055117; GO:0061049; GO:0071880; GO:0097195; GO:0150099
## 28 GO:0005216; GO:0005245; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014070; GO:0014832; GO:0015267; GO:0015278; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042542; GO:0042802; GO:0046872; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071244; GO:0071313; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
## 29 GO:0003779; GO:0005829; GO:0005856; GO:0006511; GO:0016567; GO:0031463; GO:0050801; GO:0070294; GO:0070936; GO:0072156; GO:1990756
## 30 GO:0001786; GO:0005509; GO:0005544; GO:0005886; GO:0014059; GO:0019905; GO:0030154; GO:0030276; GO:0030424; GO:0030672; GO:0031045; GO:0042584; GO:0048488; GO:0048791; GO:0071277; GO:1903235
## 31 GO:0004952; GO:0004993; GO:0005886; GO:0007186; GO:0007187; GO:0007191; GO:0007268; GO:0030425; GO:0030594; GO:0045211
## 32 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 33 GO:0001503; GO:0002931; GO:0004930; GO:0005178; GO:0005509; GO:0005513; GO:0005886; GO:0006874; GO:0007186; GO:0007193; GO:0007200; GO:0007254; GO:0008284; GO:0009986; GO:0010038; GO:0010628; GO:0014070; GO:0016323; GO:0016324; GO:0016597; GO:0019901; GO:0030424; GO:0032024; GO:0032782; GO:0035729; GO:0042311; GO:0042734; GO:0042803; GO:0043025; GO:0043679; GO:0044325; GO:0045907; GO:0048754; GO:0050927; GO:0051592; GO:0051924; GO:0060613; GO:0070374; GO:0070509; GO:0071305; GO:0071333; GO:0071404; GO:0071456; GO:0071774; GO:0090280; GO:0098978; GO:0099505; GO:1901653; GO:1902476
## 34 GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005886; GO:0007189; GO:0007626; GO:0008289; GO:0014074; GO:0019899; GO:0032230; GO:0042755; GO:0042802; GO:0046636; GO:0050728; GO:0060080; GO:0097190; GO:0098794; GO:2001235
## 35 GO:0004303; GO:0004745; GO:0005829; GO:0006703; GO:0007601; GO:0042572; GO:0042622; GO:0052650
## 36 GO:0008836; GO:0009089
## 37 GO:0002009; GO:0004064; GO:0004089; GO:0005737; GO:0005829; GO:0005886; GO:0006730; GO:0008270; GO:0015670; GO:0018820; GO:0032230; GO:0032849; GO:0038166; GO:0043209; GO:0044070; GO:0045177; GO:0046903; GO:0051453; GO:0070050; GO:0070062; GO:2001150; GO:2001225
## 38 GO:0004062; GO:0005829; GO:0008146; GO:0009812; GO:0050427
## 39 GO:0000302; GO:0000425; GO:0005737; GO:0005778; GO:0007605; GO:0030864; GO:0035253; GO:0043025; GO:0050910; GO:0097468; GO:0120044; GO:0120045; GO:1900063
## 40 GO:0000978; GO:0000981; GO:0001708; GO:0001822; GO:0003677; GO:0003700; GO:0005634; GO:0006357; GO:0007399; GO:0007422; GO:0009880; GO:0009952; GO:0021549; GO:0021588; GO:0021703; GO:0030878; GO:0030901; GO:0030902; GO:0030917; GO:0034672; GO:0035775; GO:0043049; GO:0043565; GO:0048596; GO:0048793; GO:0060113; GO:0060118; GO:0060271; GO:0061386; GO:0072114
## 41 GO:0001702; GO:0001944; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006865; GO:0006897; GO:0007399; GO:0008078; GO:0008203; GO:0008217; GO:0009952; GO:0010467; GO:0015026; GO:0016055; GO:0017147; GO:0033687; GO:0033690; GO:0035019; GO:0035108; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0043434; GO:0045600; GO:0045668; GO:0045669; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0048514; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060348; GO:0060349; GO:0060444; GO:0060603; GO:0060612; GO:0060764; GO:0060856; GO:0061178; GO:0061298; GO:0061299; GO:0061304; GO:0098609; GO:0110135; GO:1902262; GO:1990963
## 42 GO:0004021; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853
## 43 GO:0005254; GO:0005783; GO:0005886; GO:0017128; GO:0046983; GO:0051649; GO:0061588; GO:0061589; GO:0061590; GO:0061591; GO:1902476
## 44 GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 45 GO:0004940; GO:0005769; GO:0005886; GO:0045823; GO:0071880
## 46 GO:0001964; GO:0004888; GO:0005886; GO:0006811; GO:0006821; GO:0006936; GO:0007218; GO:0008270; GO:0016594; GO:0016934; GO:0022824; GO:0030425; GO:0030594; GO:0030977; GO:0034707; GO:0043005; GO:0043025; GO:0043204; GO:0043231; GO:0045202; GO:0045211; GO:0051970; GO:0060012; GO:0060080; GO:0071230; GO:0071294; GO:0071361; GO:0097305; GO:1902476; GO:1902495
## 47 GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 48 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 49 GO:0001508; GO:0005221; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0016020; GO:0051260; GO:0071805
## 50 GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:0042277; GO:0097730
## 51 GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
## 52 GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 53 GO:0004021; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853
## 54 GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0045944; GO:0060219
## 55 GO:0008168; GO:0016114; GO:0032259; GO:0046872
## 56 GO:0005289; GO:0005292; GO:0005739; GO:0005743; GO:0006844; GO:0015174; GO:0015227; GO:0015695; GO:0015822; GO:0089709; GO:1902616; GO:1903401; GO:1903826; GO:1990575
## 57 GO:0004890; GO:0005216; GO:0005254; GO:0005886; GO:0007214; GO:0007268; GO:0007399; GO:0007420; GO:0007612; GO:0007613; GO:0009410; GO:0009986; GO:0019098; GO:0021549; GO:0022851; GO:0030594; GO:0030659; GO:0034220; GO:0034707; GO:0035176; GO:0035612; GO:0035640; GO:0042747; GO:0042802; GO:0043005; GO:0043195; GO:0045202; GO:0045211; GO:0048666; GO:0051932; GO:0060021; GO:0060022; GO:0060077; GO:0060078; GO:0060080; GO:0060119; GO:0060384; GO:0061744; GO:0071294; GO:0071420; GO:0072347; GO:0090102; GO:0098982; GO:0099565; GO:0099634; GO:1902476; GO:1902495; GO:1902711; GO:1904315; GO:1904862
## 58 GO:0005615; GO:0007218; GO:0030020; GO:0030198; GO:0062023
## 59 GO:0000785; GO:0001673; GO:0001955; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006275; GO:0007492; GO:0031965; GO:0042742; GO:0043123; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246
## 60 GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0038023; GO:0042802; GO:0045087; GO:0045121; GO:0061809; GO:0071723; GO:0071726; GO:1900227
## 61 GO:0002121; GO:0004995; GO:0005886; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016020
## 62 GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 63 GO:0005886; GO:0008519; GO:0072488; GO:0097272
## 64 GO:0000209; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0015031; GO:0016567; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
## 65 GO:0005313; GO:0005314; GO:0005886; GO:0015108; GO:0015501; GO:0015813; GO:0016324; GO:0031901; GO:0031902; GO:0033229; GO:0042883; GO:0043005; GO:0045202; GO:0046872; GO:0055038; GO:0070779; GO:0098712; GO:0140009; GO:1902476
## 66 GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
## 67 GO:0003883; GO:0005524; GO:0005737; GO:0006241; GO:0006541; GO:0019856; GO:0030903; GO:0042802; GO:0044210; GO:0097268
## 68 GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 69 GO:0005509; GO:0005891; GO:0007268; GO:0008331; GO:0045202; GO:0098703
## 70 GO:0004930; GO:0005886; GO:0007186; GO:0007193; GO:0007623; GO:0008502; GO:0042562; GO:0043025; GO:0043235; GO:0046676; GO:0097159
## 71 GO:0005886; GO:0006879; GO:0006897; GO:0034755; GO:0070207; GO:0070287
## 72 GO:0001937; GO:0002232; GO:0002523; GO:0002540; GO:0004051; GO:0004052; GO:0005506; GO:0005576; GO:0005615; GO:0005635; GO:0005641; GO:0005654; GO:0005829; GO:0006691; GO:0006959; GO:0016363; GO:0016525; GO:0016787; GO:0019369; GO:0019370; GO:0019372; GO:0030501; GO:0031965; GO:0034440; GO:0034774; GO:0036336; GO:0036403; GO:0042593; GO:0042759; GO:0045598; GO:0048471; GO:0050727; GO:0050728; GO:0050796; GO:0061044; GO:0061045; GO:0106014; GO:1900015; GO:1900407; GO:1901753; GO:1903426; GO:1903573; GO:1903671; GO:1904813; GO:1904999; GO:2001301
## 73 GO:0001518; GO:0005248; GO:0019228; GO:0030424; GO:0035725; GO:0086010
## 74 GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 75 GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0017156; GO:0017158; GO:0030276; GO:0030669; GO:0030672; GO:0031045; GO:0042802; GO:0070382; GO:0098686; GO:0099502
## 76 GO:0005249; GO:0005251; GO:0005789; GO:0005886; GO:0008076; GO:0014059; GO:0019228; GO:0019233; GO:0021633; GO:0030027; GO:0030424; GO:0030425; GO:0031258; GO:0032809; GO:0033010; GO:0042734; GO:0043194; GO:0043204; GO:0043679; GO:0044224; GO:0045188; GO:0051260; GO:0071805
## 77 GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
## 78 GO:0000139; GO:0003336; GO:0005102; GO:0005319; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006672; GO:0006869; GO:0006886; GO:0010875; GO:0016020; GO:0016887; GO:0019725; GO:0030658; GO:0031424; GO:0032379; GO:0032940; GO:0033344; GO:0033700; GO:0034040; GO:0034191; GO:0035627; GO:0042626; GO:0043129; GO:0043231; GO:0045055; GO:0045616; GO:0048286; GO:0055088; GO:0061178; GO:0061436; GO:0072659; GO:0097209; GO:0097234; GO:0140326; GO:0140359; GO:2000010
## 79 GO:0004930; GO:0005509; GO:0005886; GO:0007166; GO:0007189; GO:0048513
## 80 GO:0002088; GO:0003382; GO:0003412; GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016324; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062; GO:0098609; GO:1904385; GO:1904754
## 81 GO:0000064; GO:0005886; GO:0006865; GO:0015171; GO:0015174; GO:0015179; GO:0015189; GO:0015807; GO:0030054; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1902475; GO:1903352; GO:1903826
## 82 GO:0003015; GO:0005886; GO:0005919; GO:0007391; GO:0008039; GO:0008104; GO:0008366; GO:0019991; GO:0021682; GO:0035151; GO:0045202; GO:0045216; GO:0048786; GO:0060857; GO:0061343; GO:0072553; GO:0097105
## 83 GO:0002088; GO:0003382; GO:0003412; GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016324; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062; GO:0098609; GO:1904385; GO:1904754
## 84 GO:0004930; GO:0005886; GO:0007186; GO:0008188; GO:0009582; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 85 GO:0005737; GO:0005886; GO:0005903; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015143; GO:0015229; GO:0015882; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070837
## 86 GO:0005886; GO:0007605; GO:0030425; GO:0045211; GO:0050811; GO:0060077; GO:0097112; GO:0098982; GO:0099572; GO:0099645; GO:1905702
## 87 GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0045202; GO:0060219
## 88 GO:0001508; GO:0005249; GO:0005251; GO:0005768; GO:0005789; GO:0005886; GO:0008076; GO:0014059; GO:0015271; GO:0016020; GO:0019228; GO:0019233; GO:0019894; GO:0021554; GO:0021633; GO:0021987; GO:0022038; GO:0030027; GO:0030424; GO:0030425; GO:0031258; GO:0032809; GO:0033010; GO:0034705; GO:0042734; GO:0043194; GO:0043204; GO:0043679; GO:0044224; GO:0044305; GO:0045188; GO:0045211; GO:0051260; GO:0071805; GO:0097623; GO:0098978; GO:0099508; GO:1905030
## 89 GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 90 GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0032720; GO:0035094; GO:0042166; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890
## 91 GO:0005634; GO:0005829; GO:0009691; GO:0016799; GO:0102682
## 92 GO:0004890; GO:0005216; GO:0005254; GO:0005886; GO:0007214; GO:0007268; GO:0007399; GO:0007420; GO:0007612; GO:0007613; GO:0009410; GO:0009986; GO:0019098; GO:0021549; GO:0022851; GO:0030594; GO:0030659; GO:0034220; GO:0034707; GO:0035176; GO:0035612; GO:0035640; GO:0042747; GO:0042802; GO:0043005; GO:0043195; GO:0045202; GO:0045211; GO:0048666; GO:0051932; GO:0060021; GO:0060022; GO:0060077; GO:0060078; GO:0060080; GO:0060119; GO:0060384; GO:0061744; GO:0071294; GO:0071420; GO:0072347; GO:0090102; GO:0098982; GO:0099565; GO:0099634; GO:1902476; GO:1902495; GO:1902711; GO:1904315; GO:1904862
## 93 GO:0002682; GO:0002951; GO:0005615; GO:0005886; GO:0006536; GO:0006749; GO:0006750; GO:0006751; GO:0007283; GO:0016755; GO:0019344; GO:0031179; GO:0031638; GO:0031982; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374; GO:0050727; GO:0061017; GO:0070365; GO:0097305; GO:0097421; GO:0103068
## 94 GO:0000139; GO:0000421; GO:0003924; GO:0004382; GO:0005765; GO:0005794; GO:0006256; GO:0016020; GO:0017110; GO:0017111; GO:0031410; GO:0034656; GO:0036384; GO:0043273; GO:0045134; GO:0046036; GO:0046712
## 95 GO:0001937; GO:0002232; GO:0002523; GO:0002540; GO:0004051; GO:0004052; GO:0005506; GO:0005576; GO:0005615; GO:0005635; GO:0005641; GO:0005654; GO:0005829; GO:0006691; GO:0006959; GO:0016363; GO:0016525; GO:0016787; GO:0019369; GO:0019370; GO:0019372; GO:0030501; GO:0031965; GO:0034440; GO:0034774; GO:0036336; GO:0036403; GO:0042593; GO:0042759; GO:0045598; GO:0048471; GO:0050727; GO:0050728; GO:0050796; GO:0061044; GO:0061045; GO:0106014; GO:1900015; GO:1900407; GO:1901753; GO:1903426; GO:1903573; GO:1903671; GO:1904813; GO:1904999; GO:2001301
## 96 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 97 GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 98 GO:0005222; GO:0005223; GO:0005262; GO:0005272; GO:0005886; GO:0006812; GO:0007165; GO:0007601; GO:0015276; GO:0017022; GO:0017071; GO:0030425; GO:0030553; GO:0032026; GO:0043194; GO:0043204; GO:0044877; GO:0045296; GO:0051591; GO:0097386; GO:0098655; GO:0098659; GO:1902495
## 99 GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 100 GO:0000324; GO:0005773; GO:0005774; GO:0015819; GO:0051453; GO:1903826
## 101 GO:0000977; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0009887; GO:0009888; GO:0030154; GO:0030902; GO:0031016; GO:0031017; GO:0032502; GO:0035881; GO:0043565; GO:0045893; GO:0046983; GO:0048384; GO:0048666; GO:0048699
## 102 GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
## 103 GO:0000209; GO:0005737; GO:0005769; GO:0005794; GO:0007399; GO:0008270; GO:0015031; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534
## 104 GO:0000139; GO:0005200; GO:0005543; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0007416; GO:0008021; GO:0008091; GO:0016079; GO:0016081; GO:0016192; GO:0016324; GO:0016363; GO:0017158; GO:0021692; GO:0030036; GO:0030054; GO:0030534; GO:0030864; GO:0033010; GO:0035264; GO:0042995; GO:0043025; GO:0048471; GO:0051015; GO:0051693; GO:0071361; GO:0098688; GO:0098793; GO:0098918; GO:0098978; GO:0099150; GO:0099173; GO:0099186; GO:0099189
## 105 GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:0042277; GO:1901653
## 106 GO:0004014; GO:0006597; GO:0008295
## 107 GO:0008277; GO:0042734; GO:0042995; GO:0043235; GO:0045211; GO:0051260
## 108 GO:0000064; GO:0005737; GO:0005794; GO:0005886; GO:0015189; GO:0031410; GO:0061459; GO:0097638; GO:0097639; GO:1903352
## 109 GO:0005886; GO:0015271; GO:0022841; GO:0030322; GO:0071805
## 110 GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0009636; GO:0009642; GO:0009986; GO:0010996; GO:0014075; GO:0019894; GO:0021549; GO:0021554; GO:0021759; GO:0022038; GO:0030673; GO:0032590; GO:0032809; GO:0035864; GO:0042734; GO:0043679; GO:0044305; GO:0044325; GO:0045211; GO:0051260; GO:0051262; GO:0071466; GO:0071774; GO:0071805; GO:0099508; GO:1901381; GO:1990089
## 111 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 112 GO:0000064; GO:0001618; GO:0005290; GO:0005886; GO:0006865; GO:0009925; GO:0015171; GO:0015174; GO:0015189; GO:0015807; GO:0015819; GO:0015822; GO:0016020; GO:0016323; GO:0016324; GO:0032991; GO:0042102; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1903352; GO:1903810; GO:1903826
## 113 GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 114 GO:0004435; GO:0004629; GO:0005509; GO:0005737; GO:0005886; GO:0007200; GO:0016042; GO:0046488; GO:0048015; GO:0051209
## 115 GO:0004066; GO:0006529; GO:0006541
## 116 GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0009097; GO:0030170
## 117 GO:0005739; GO:0005759; GO:0005829; GO:0017148; GO:0042273; GO:0043023; GO:0070130; GO:0090071; GO:0140978
## 118 GO:0005262; GO:0005886; GO:0006811; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014070; GO:0015267; GO:0015278; GO:0019233; GO:0032421; GO:0042802; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0051289; GO:0070301; GO:0070588; GO:0097604
## 119 GO:0001568; GO:0001756; GO:0002042; GO:0003404; GO:0005886; GO:0007155; GO:0007411; GO:0007412; GO:0008039; GO:0009952; GO:0021654; GO:0035475; GO:0042734; GO:0046875; GO:0048013; GO:0048514; GO:0050920; GO:0098978
## 120 GO:0001650; GO:0001837; GO:0003677; GO:0005654; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0016020; GO:0021849; GO:0043231; GO:0045944; GO:0050727; GO:0060232; GO:0060234
## 121 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 122 GO:0007605; GO:0016020; GO:0032426; GO:0120234
## 123 GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005737; GO:0005829; GO:0009615; GO:0016887; GO:0045087; GO:0045111; GO:0051607; GO:1900245; GO:1900246
## 124 GO:0000387; GO:0005229; GO:0005267; GO:0005634; GO:0005681; GO:0005829; GO:0005856; GO:0005886; GO:0006884; GO:0008289; GO:0016020; GO:0032991; GO:0034709; GO:0034715; GO:0036094; GO:0045292; GO:0071805; GO:1902476; GO:1990935
## 125 GO:0005509; GO:0005886; GO:0007156; GO:0010842; GO:0016358; GO:0030425; GO:0048667; GO:0098609; GO:1904936; GO:2000171
## 126 GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006805; GO:0008146; GO:0009812; GO:0044598; GO:0050427; GO:0051923
## 127 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 128 GO:0005262; GO:0005516; GO:0005737; GO:0005886; GO:0006811; GO:0006874; GO:0007602; GO:0007608; GO:0008273; GO:0008277; GO:0009644; GO:0010628; GO:0015293; GO:0016020; GO:0016324; GO:0021630; GO:0031982; GO:0035725; GO:0036368; GO:0042756; GO:0048306; GO:0050849; GO:0050911; GO:0055074; GO:0070166; GO:0070588; GO:0071486; GO:0071805; GO:0086009; GO:0097186; GO:0098703; GO:0120199; GO:1903998; GO:1990034; GO:1990680; GO:1990834
## 129 GO:0000139; GO:0002218; GO:0003924; GO:0004866; GO:0005525; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006955; GO:0030659; GO:0031410; GO:0034504; GO:0042742; GO:0042802; GO:0042803; GO:0042832; GO:0048471; GO:0050830; GO:0051607; GO:0051715; GO:0071222; GO:0071346; GO:0071347; GO:0071356; GO:0140639; GO:0140678; GO:0140973
## 130 GO:0005576; GO:0007218
## 131 GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0071482
## 132 GO:0000324; GO:0005773; GO:0005774; GO:0015819; GO:0022857; GO:0051453; GO:1903826
## 133 GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 134 GO:0001798; GO:0001934; GO:0001970; GO:0002430; GO:0002507; GO:0004866; GO:0005576; GO:0005615; GO:0006631; GO:0006935; GO:0006954; GO:0006956; GO:0006957; GO:0006958; GO:0008289; GO:0009410; GO:0009617; GO:0009986; GO:0010575; GO:0010828; GO:0010866; GO:0010884; GO:0016322; GO:0031715; GO:0032026; GO:0032355; GO:0032570; GO:0032991; GO:0035846; GO:0035886; GO:0043627; GO:0045745; GO:0045766; GO:0048260; GO:0048639; GO:0050766; GO:0051384; GO:0060041; GO:0060100; GO:0070374; GO:0097242; GO:0097278; GO:0150062; GO:0150064; GO:2000427
## 135 GO:0003341; GO:0004550; GO:0005929; GO:0006183; GO:0006228; GO:0006241; GO:0008408; GO:1902176
## 136 GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:0048022; GO:1903712
## 137 GO:0000976; GO:0000978; GO:0000981; GO:0003309; GO:0003310; GO:0003311; GO:0005634; GO:0006357; GO:0031018; GO:0035774; GO:0042593; GO:0045893; GO:0045944; GO:0050796; GO:0090104
## 138 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 139 GO:0001955; GO:0002040; GO:0004866; GO:0004867; GO:0005615; GO:0005886; GO:0008191; GO:0015026; GO:0030198; GO:0045765; GO:0060070; GO:0090210; GO:0098552; GO:1904684; GO:1990909
## 140 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 141 GO:0004359; GO:0005829; GO:0006541; GO:0036381; GO:0042819; GO:0042823; GO:0046982
## 142 GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0045211; GO:0120169
## 143 GO:0001745; GO:0002052; GO:0002213; GO:0003682; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005783; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006110; GO:0007015; GO:0007219; GO:0007293; GO:0007297; GO:0007298; GO:0007346; GO:0007391; GO:0007400; GO:0007403; GO:0007405; GO:0007411; GO:0007422; GO:0007423; GO:0007440; GO:0007455; GO:0007474; GO:0007476; GO:0007478; GO:0007480; GO:0007498; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009950; GO:0009986; GO:0010001; GO:0010628; GO:0010629; GO:0014018; GO:0014019; GO:0016020; GO:0016318; GO:0016324; GO:0016330; GO:0016348; GO:0016360; GO:0022416; GO:0030139; GO:0030154; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0032991; GO:0035035; GO:0035153; GO:0035162; GO:0035167; GO:0035171; GO:0035172; GO:0035204; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042686; GO:0042688; GO:0042691; GO:0043525; GO:0043697; GO:0045165; GO:0045316; GO:0045466; GO:0045595; GO:0045893; GO:0045944; GO:0046331; GO:0046666; GO:0046667; GO:0046716; GO:0046843; GO:0048052; GO:0048056; GO:0048190; GO:0048477; GO:0048542; GO:0048627; GO:0048664; GO:0048665; GO:0048749; GO:0048803; GO:0048863; GO:0050699; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060289; GO:0060571; GO:0061331; GO:0061382; GO:0097150; GO:1900087; GO:1902692; GO:1990433; GO:2000035; GO:2000048
## 144 GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0017148; GO:0030371; GO:0043161; GO:0043523; GO:0061630
## 145 GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 146 GO:0005267; GO:0005764; GO:0005765; GO:0005768; GO:0010008; GO:0015252; GO:0022841; GO:0035751; GO:0035752; GO:0050544; GO:0070050; GO:0071805; GO:0090385; GO:1902600
## 147 GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 148 GO:0004084; GO:0005739; GO:0009098; GO:0009099; GO:0050048; GO:0052654; GO:0052655; GO:0052656
## 149 GO:0000122; GO:0000978; GO:0003309; GO:0003310; GO:0003700; GO:0005634; GO:0007399; GO:0017053; GO:0031018; GO:0031490; GO:0035987; GO:0046872; GO:0048732; GO:0060290
## 150 GO:0008168; GO:0016114; GO:0032259; GO:0046872
## 151 GO:0004766; GO:0005829; GO:0006595; GO:0008295; GO:0042802; GO:0042803; GO:1990830
## 152 GO:0004503; GO:0005507; GO:0006583; GO:0033162; GO:0042470
## 153 GO:0005737; GO:0006548; GO:0019556; GO:0019557; GO:0046872; GO:0050480
## 154 GO:0000146; GO:0003779; GO:0005524; GO:0005737; GO:0007605; GO:0008407; GO:0016459; GO:0030048; GO:0032027; GO:0035317; GO:0048800; GO:0071944; GO:0120025
## 155 GO:0004062; GO:0005737; GO:0005764; GO:0008146; GO:0051923
## 156 GO:0000149; GO:0005829; GO:0016079; GO:0019905; GO:0031201; GO:0043195; GO:0043204; GO:0046928
## 157 GO:0001736; GO:0005813; GO:0005829; GO:0005929; GO:0007411; GO:0007608; GO:0015031; GO:0021772; GO:0032391; GO:0032880; GO:0034451; GO:0034464; GO:0035264; GO:0036064; GO:0045198; GO:0045444; GO:0048560; GO:0050893; GO:0051492; GO:0060122; GO:0060170; GO:0060219; GO:0060271; GO:0061326; GO:0061629; GO:0072659; GO:0097730; GO:1903251; GO:1905515
## 158 GO:0004842; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006511; GO:0007605; GO:0008270; GO:0010719; GO:0016274; GO:0016567; GO:0042981; GO:0043161; GO:0045732; GO:1904878; GO:1990756
## 159 GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:0048022; GO:1903712
## 160 GO:0005634; GO:0005737; GO:0005829; GO:0006338; GO:0008168; GO:0016274; GO:0031397; GO:0032259; GO:0035241; GO:0035242; GO:0042054; GO:0043022; GO:0046872; GO:1900053
## 161 GO:0000002; GO:0004672; GO:0004674; GO:0005080; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0010765; GO:0032008; GO:0032869; GO:0035556; GO:0045766; GO:0045793; GO:0048854; GO:0048873; GO:0090050; GO:0106310; GO:1905564; GO:1905653; GO:2000773
## 162 GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0016020; GO:0030670; GO:0032755; GO:0032757; GO:0032760; GO:0034137; GO:0035354; GO:0035663; GO:0038023; GO:0042116; GO:0042495; GO:0042802; GO:0043235; GO:0045087; GO:0045121; GO:0061809; GO:0071723; GO:0071727
## 163 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 164 GO:0005524; GO:0005525; GO:0005737; GO:0005739; GO:0005759; GO:0006172; GO:0007596; GO:0009142; GO:0046033; GO:0046039; GO:0046041; GO:0046051; GO:0046899
## 165 GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 166 GO:0001504; GO:0005326; GO:0005886; GO:0007601; GO:0043679; GO:0046956; GO:0050908; GO:1905130; GO:1905131
## 167 GO:0003127; GO:0005102; GO:0005245; GO:0005248; GO:0005261; GO:0005262; GO:0005267; GO:0005509; GO:0005789; GO:0005886; GO:0005929; GO:0007166; GO:0015271; GO:0016020; GO:0016055; GO:0016323; GO:0030659; GO:0034703; GO:0050982; GO:0051209; GO:0051262; GO:0051290; GO:0051371; GO:0060170; GO:0070588; GO:0071277; GO:0071805; GO:0098662
## 168 GO:0005262; GO:0005509; GO:0005886; GO:0016020; GO:0030246; GO:0050982
## 169 GO:0007605; GO:0032420
## 170 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 171 GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005882; GO:0005886; GO:0006355; GO:0006909; GO:0006915; GO:0006954; GO:0006968; GO:0007188; GO:0007189; GO:0007205; GO:0007267; GO:0007271; GO:0007417; GO:0007596; GO:0007600; GO:0007626; GO:0008015; GO:0008285; GO:0008289; GO:0009410; GO:0014049; GO:0014057; GO:0014061; GO:0014074; GO:0016020; GO:0019899; GO:0030425; GO:0030673; GO:0031000; GO:0031802; GO:0032230; GO:0032279; GO:0035249; GO:0035810; GO:0042311; GO:0042734; GO:0042755; GO:0042802; GO:0043025; GO:0043116; GO:0043524; GO:0044877; GO:0045211; GO:0045938; GO:0046636; GO:0048143; GO:0048786; GO:0048812; GO:0050714; GO:0050728; GO:0051393; GO:0051881; GO:0051899; GO:0051924; GO:0051968; GO:0060079; GO:0060080; GO:0060134; GO:0097190; GO:0098978; GO:0099171; GO:1900273; GO:2001235
## 172 GO:0001878; GO:0004502; GO:0005741; GO:0006569; GO:0019674; GO:0019805; GO:0034354; GO:0043420; GO:0070189; GO:0071949; GO:0072015
## 173 GO:0002755; GO:0005634; GO:0005737; GO:0005886; GO:0006954; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
## 174 GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007601; GO:0007605; GO:0021562; GO:0031290; GO:0042472; GO:0042491; GO:0045944; GO:0048675; GO:0050885; GO:0051402; GO:1990837
## 175 GO:0003723; GO:0004349; GO:0004350; GO:0005524; GO:0005739; GO:0005743; GO:0006536; GO:0006561; GO:0006592; GO:0009266; GO:0019240; GO:0042802; GO:0055129
## 176 GO:0001702; GO:0001756; GO:0001843; GO:0001947; GO:0002053; GO:0003151; GO:0003344; GO:0003401; GO:0005041; GO:0005769; GO:0005783; GO:0005886; GO:0006355; GO:0007204; GO:0007268; GO:0007399; GO:0008078; GO:0009880; GO:0009950; GO:0009952; GO:0010463; GO:0010976; GO:0016020; GO:0017147; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0022603; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0034185; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042475; GO:0042733; GO:0042813; GO:0043025; GO:0043065; GO:0045121; GO:0045202; GO:0045444; GO:0045599; GO:0045778; GO:0045780; GO:0045893; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050678; GO:0050680; GO:0051091; GO:0051093; GO:0051593; GO:0055008; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060412; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0060856; GO:0071542; GO:0072089; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0098609; GO:0110135; GO:1905331; GO:1990963; GO:2000051; GO:2000149; GO:2000151; GO:2000164; GO:2000166; GO:2000168; GO:2000648
## 177 GO:0006813; GO:0006814; GO:0006821; GO:0006883; GO:0006884; GO:0006972; GO:0007214; GO:0008511; GO:0008519; GO:0010818; GO:0015079; GO:0016323; GO:0016324; GO:0030007; GO:0030644; GO:0035264; GO:0035633; GO:0035725; GO:0035865; GO:0042995; GO:0043025; GO:0044297; GO:0045795; GO:0050910; GO:0055064; GO:0055075; GO:0055078; GO:0060444; GO:0060763; GO:0061044; GO:0071222; GO:0071944; GO:0072488; GO:0098658; GO:0098719; GO:0150003; GO:1902476; GO:1904450; GO:1904464; GO:1990573; GO:1990869
## 178 GO:0001666; GO:0001921; GO:0004175; GO:0004222; GO:0005768; GO:0005769; GO:0005886; GO:0007411; GO:0007507; GO:0008217; GO:0008270; GO:0009410; GO:0009897; GO:0010467; GO:0010613; GO:0010814; GO:0010815; GO:0010816; GO:0016020; GO:0016485; GO:0016486; GO:0030141; GO:0031175; GO:0031982; GO:0033093; GO:0034959; GO:0035050; GO:0035994; GO:0042447; GO:0042733; GO:0042802; GO:0042803; GO:0043583; GO:0043950; GO:0045745; GO:0046686; GO:0048471; GO:0060037; GO:0060385; GO:0070372; GO:0097492; GO:0097746; GO:1902287
## 179 GO:0001666; GO:0003779; GO:0005249; GO:0005886; GO:0005901; GO:0006813; GO:0006970; GO:0008076; GO:0015269; GO:0016020; GO:0016324; GO:0030007; GO:0034465; GO:0042311; GO:0042391; GO:0042802; GO:0043065; GO:0045211; GO:0045794; GO:0046872; GO:0051592; GO:0060072; GO:0060073; GO:0060083; GO:0071805
## 180 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 181 GO:0001917; GO:0005509; GO:0005813; GO:0005886; GO:0005911; GO:0006816; GO:0007156; GO:0007605; GO:0007626; GO:0008344; GO:0032420; GO:0032426; GO:0042472; GO:0042491; GO:0045177; GO:0045202; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0051480; GO:0060013; GO:0060088; GO:0060091; GO:0060122; GO:0090102; GO:0098609; GO:0098683; GO:0098684
## 182 GO:0001641; GO:0005246; GO:0005886; GO:0007216; GO:0010467; GO:0014069; GO:0019233; GO:0030424; GO:0042734; GO:0043005; GO:0043197; GO:0045211; GO:0050804; GO:0051966; GO:0097110; GO:0097449; GO:0098978; GO:0099170
## 183 GO:0005789; GO:0010961; GO:0015444; GO:0035050; GO:0160176; GO:1990403
## 184 GO:0003779; GO:0005886; GO:0007204; GO:0008284; GO:0010800; GO:0015279; GO:0030182; GO:0030276; GO:0030425; GO:0030426; GO:0034703; GO:0034704; GO:0042805; GO:0043025; GO:0045666; GO:0045773; GO:0050774; GO:0051117; GO:0051402; GO:0051480; GO:0070588; GO:0070679; GO:0070782; GO:0098793; GO:1902630
## 185 GO:0001656; GO:0001657; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0005886; GO:0006935; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035904; GO:0042802; GO:0045747; GO:0050772; GO:0050925; GO:0051964; GO:0060412; GO:0061364; GO:0070062; GO:0098609
## 186 GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 187 GO:0001649; GO:0004965; GO:0005615; GO:0005737; GO:0005789; GO:0005886; GO:0007193; GO:0007214; GO:0008021; GO:0008285; GO:0014048; GO:0014049; GO:0014053; GO:0016020; GO:0030673; GO:0031966; GO:0032811; GO:0033602; GO:0035094; GO:0038037; GO:0038039; GO:0042734; GO:0043025; GO:0043197; GO:0043198; GO:0043204; GO:0045211; GO:0045471; GO:0046982; GO:0050805; GO:0051932; GO:0060124; GO:0097060; GO:0098685; GO:0098793; GO:0098978; GO:0098982; GO:0099579; GO:0150047; GO:0150099; GO:1902710; GO:1902712; GO:1990430
## 188 GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 189 GO:0005654; GO:0005737; GO:0005829; GO:0008021; GO:0008219; GO:0031625; GO:0036464; GO:0042417; GO:0042734; GO:0042802; GO:0043025; GO:0046928; GO:0090083
## 190 GO:0005886; GO:0030658; GO:0030667; GO:0046872; GO:0062111; GO:0140826
## 191 GO:0004930; GO:0005654; GO:0005829; GO:0005886; GO:0007166; GO:0007186; GO:0007189; GO:0016020; GO:0016607
## 192 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 193 GO:0000139; GO:0000578; GO:0001525; GO:0001540; GO:0001654; GO:0002071; GO:0002726; GO:0004930; GO:0005886; GO:0005923; GO:0007416; GO:0008285; GO:0008289; GO:0008595; GO:0009986; GO:0017147; GO:0019901; GO:0030182; GO:0030424; GO:0030425; GO:0030669; GO:0031077; GO:0031625; GO:0031901; GO:0032729; GO:0032731; GO:0032760; GO:0033077; GO:0035567; GO:0042813; GO:0043204; GO:0044877; GO:0045202; GO:0045944; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060561; GO:0060574; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0071219; GO:1901382; GO:1901524; GO:1903955; GO:2000810
## 194 GO:0004062; GO:0005829; GO:0008146; GO:0009812; GO:0050427
## 195 GO:0000398; GO:0001510; GO:0001734; GO:0003729; GO:0005634; GO:0005654; GO:0005794; GO:0005829; GO:0006397; GO:0006974; GO:0007283; GO:0007623; GO:0008173; GO:0009048; GO:0016556; GO:0016604; GO:0016607; GO:0019827; GO:0021861; GO:0031053; GO:0034644; GO:0036396; GO:0042063; GO:0045087; GO:0045580; GO:0045727; GO:0045746; GO:0046982; GO:0048477; GO:0051445; GO:0060339; GO:0061157; GO:0098508; GO:1902036; GO:1903679; GO:1904047; GO:1990204
## 196 GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
## 197 GO:0000122; GO:0000132; GO:0000785; GO:0000976; GO:0000978; GO:0000979; GO:0000981; GO:0001221; GO:0001227; GO:0001228; GO:0001568; GO:0001709; GO:0001755; GO:0001764; GO:0001933; GO:0002052; GO:0002064; GO:0002067; GO:0002088; GO:0003002; GO:0003309; GO:0003310; GO:0003322; GO:0003677; GO:0003680; GO:0003682; GO:0003690; GO:0003700; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006357; GO:0006366; GO:0007224; GO:0007399; GO:0007405; GO:0007406; GO:0007409; GO:0007411; GO:0007420; GO:0007435; GO:0008283; GO:0009611; GO:0009786; GO:0009950; GO:0009952; GO:0009953; GO:0010467; GO:0010468; GO:0010628; GO:0010975; GO:0019901; GO:0021510; GO:0021517; GO:0021543; GO:0021549; GO:0021593; GO:0021772; GO:0021778; GO:0021796; GO:0021798; GO:0021902; GO:0021905; GO:0021978; GO:0021983; GO:0021986; GO:0021987; GO:0022027; GO:0023019; GO:0030154; GO:0030182; GO:0030216; GO:0030334; GO:0030858; GO:0030900; GO:0030902; GO:0031490; GO:0031625; GO:0032808; GO:0032869; GO:0033365; GO:0035035; GO:0042462; GO:0042593; GO:0042660; GO:0043010; GO:0043565; GO:0044344; GO:0045165; GO:0045471; GO:0045664; GO:0045665; GO:0045893; GO:0045944; GO:0048505; GO:0048596; GO:0048708; GO:0050680; GO:0050767; GO:0060041; GO:0061034; GO:0061072; GO:0061303; GO:0061351; GO:0070410; GO:0070412; GO:0071333; GO:0071380; GO:0071466; GO:0071837; GO:0098598; GO:0120008; GO:1901142; GO:1902895; GO:1904798; GO:1904937; GO:1990830; GO:1990837; GO:2000178; GO:2001224
## 198 GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 199 GO:0005743; GO:0005759; GO:0032979; GO:0036444; GO:0043022; GO:0051204; GO:0051560
## 200 GO:0005546; GO:0005811; GO:0005829; GO:0005886; GO:0007009; GO:0008526; GO:0009898; GO:0015485; GO:0032367; GO:0051289; GO:0097038; GO:0098831; GO:0098978; GO:0099509; GO:0120020
## 201 GO:0004888; GO:0004965; GO:0005737; GO:0005886; GO:0007186; GO:0007193; GO:0007194; GO:0007214; GO:0007268; GO:0038039; GO:0043005; GO:0045211; GO:0046982; GO:0051932; GO:0150099; GO:1902710; GO:1902712
## 202 GO:0000045; GO:0005634; GO:0005776; GO:0005829; GO:0006915; GO:0008285; GO:0009408; GO:0010508; GO:0010628; GO:0010629; GO:0016209; GO:0016605; GO:0030336; GO:0031410; GO:0034644; GO:0043065; GO:0045893; GO:0048102; GO:0048147; GO:0071361; GO:0071447; GO:0072703; GO:1904761
## 203 GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0071482
## 204 GO:0000900; GO:0003730; GO:0005095; GO:0005634; GO:0005737; GO:0005840; GO:0008135; GO:0008187; GO:0032869; GO:0034599; GO:0035925; GO:0043005; GO:0043022; GO:0043023; GO:0043024; GO:0045202; GO:0045900; GO:0071243; GO:0071456; GO:0098978; GO:0099547; GO:1900248; GO:1990124; GO:2000766
## 205 GO:0001786; GO:0005509; GO:0005544; GO:0005886; GO:0014059; GO:0019905; GO:0030154; GO:0030276; GO:0030424; GO:0030672; GO:0031045; GO:0042584; GO:0048488; GO:0048791; GO:0071277; GO:1903235
## 206 GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0106310; GO:2000035; GO:2000069
## 207 GO:0009897; GO:0032217; GO:0032218; GO:0038023; GO:1902444; GO:1904657; GO:1904661
## 208 GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 209 GO:0005886; GO:0008021; GO:0016020; GO:0017075; GO:0017124; GO:0030672; GO:0031629; GO:0031982; GO:0035544; GO:0042734; GO:0043005; GO:0043197; GO:0043679; GO:0050884; GO:0098793; GO:0098839; GO:0098978; GO:0150037; GO:1905513
## 210 GO:0005739; GO:0005743; GO:0005758; GO:0042407; GO:0043209; GO:0051560; GO:0061617; GO:0070050
## 211 GO:0000226; GO:0005737; GO:0005874; GO:0006914; GO:0007026; GO:0007420; GO:0007626; GO:0008344; GO:0021801; GO:0021960; GO:0021987; GO:0022038; GO:0030424; GO:0030425; GO:0030426; GO:0031175; GO:0043005; GO:0043025; GO:0044877; GO:0061351; GO:0061744; GO:0097150; GO:0120168
## 212 GO:0004993; GO:0005886; GO:0007198; GO:0007268; GO:0014063; GO:0042310; GO:0045202; GO:0046849; GO:0050795; GO:0071312; GO:0071466
## 213 GO:0000122; GO:0000287; GO:0003170; GO:0003279; GO:0003281; GO:0004115; GO:0004118; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0007193; GO:0007507; GO:0008270; GO:0010628; GO:0010749; GO:0010752; GO:0010754; GO:0010821; GO:0019933; GO:0019934; GO:0030424; GO:0030425; GO:0030552; GO:0030553; GO:0030911; GO:0035556; GO:0035904; GO:0036004; GO:0036006; GO:0042301; GO:0042734; GO:0042802; GO:0042803; GO:0043116; GO:0043117; GO:0043949; GO:0043951; GO:0046069; GO:0047555; GO:0048471; GO:0050729; GO:0060976; GO:0061028; GO:0071222; GO:0071260; GO:0071320; GO:0071321; GO:0071560; GO:0090324; GO:0097011; GO:0097060; GO:0097457; GO:0106072; GO:1904613; GO:1904880
## 214 GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006357; GO:0007519; GO:0008582; GO:0008584; GO:0010468; GO:0030238; GO:0030910; GO:0032880; GO:0034504; GO:0042472; GO:0043066; GO:0043524; GO:0043565; GO:0043586; GO:0045214; GO:0045892; GO:0045893; GO:0045944; GO:0046661; GO:0048538; GO:0048699; GO:0048701; GO:0048704; GO:0050678; GO:0051451; GO:0060037; GO:0061055; GO:0061197; GO:0061551; GO:0072075; GO:0072095; GO:0072107; GO:0090190; GO:0098528; GO:1902725
## 215 GO:0001696; GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007268; GO:0030425; GO:0030594; GO:0045202; GO:0045907
## 216 GO:0001530; GO:0001934; GO:0004252; GO:0005102; GO:0005509; GO:0005576; GO:0005615; GO:0005788; GO:0005796; GO:0005886; GO:0006508; GO:0006953; GO:0007166; GO:0007186; GO:0007596; GO:0008083; GO:0008201; GO:0008284; GO:0008360; GO:0009611; GO:0010544; GO:0030168; GO:0030193; GO:0030194; GO:0030307; GO:0032024; GO:0032967; GO:0042730; GO:0045861; GO:0046427; GO:0048712; GO:0051281; GO:0051480; GO:0051838; GO:0051897; GO:0051918; GO:0061844; GO:0062023; GO:0070053; GO:0070062; GO:0070945; GO:0072562; GO:0090218; GO:1900016; GO:1900182; GO:1900738; GO:1990806; GO:2000379
## 217 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 218 GO:0002020; GO:0005615; GO:0007155; GO:0007419; GO:0007426; GO:0007472; GO:0008191; GO:0008270; GO:0030425; GO:0031012; GO:0035202; GO:0042331; GO:0048477; GO:0048526; GO:0051045; GO:0060232; GO:0071711
## 219 GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 220 GO:0001776; GO:0001782; GO:0001783; GO:0001836; GO:0001974; GO:0002262; GO:0002352; GO:0005739; GO:0005741; GO:0005783; GO:0005829; GO:0008053; GO:0008285; GO:0008630; GO:0009410; GO:0009620; GO:0010046; GO:0010225; GO:0010248; GO:0010332; GO:0010524; GO:0010629; GO:0014070; GO:0015288; GO:0031018; GO:0031072; GO:0031100; GO:0031334; GO:0031966; GO:0032471; GO:0033137; GO:0034644; GO:0035108; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0044325; GO:0044346; GO:0044877; GO:0045471; GO:0045862; GO:0046872; GO:0046902; GO:0046930; GO:0046982; GO:0048597; GO:0048872; GO:0050673; GO:0051087; GO:0051400; GO:0051649; GO:0051726; GO:0051881; GO:0060068; GO:0060402; GO:0070059; GO:0070242; GO:0071260; GO:0090200; GO:0090201; GO:0097145; GO:0097192; GO:1900103; GO:1901029; GO:1901030; GO:1902262
## 221 GO:0001889; GO:0005007; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0007498; GO:0008201; GO:0008284; GO:0008543; GO:0009953; GO:0017134; GO:0018108; GO:0021535; GO:0021628; GO:0031101; GO:0031410; GO:0033339; GO:0036342; GO:0042664; GO:0043235; GO:0043406; GO:0043589; GO:0045471; GO:0045597; GO:0048738; GO:0048916; GO:0051216; GO:0060249; GO:0071699
## 222 GO:0004659; GO:0005759; GO:0005829; GO:0006744; GO:0008299; GO:0021549; GO:0032478; GO:0046982; GO:0050878; GO:0052923; GO:0097269; GO:1990234
## 223 GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 224 GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 225 GO:0001696; GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007268; GO:0030425; GO:0030594; GO:0045202; GO:0045907
## 226 GO:0004489; GO:0009086; GO:0035999; GO:0046653; GO:0050660; GO:0050661; GO:0071949; GO:0106313
## 227 GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 228 GO:0004930; GO:0004978; GO:0005737; GO:0005886; GO:0007189; GO:0019222
## 229 GO:0004500; GO:0005507; GO:0005615; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 230 GO:0004888; GO:0004965; GO:0005737; GO:0005886; GO:0007186; GO:0007193; GO:0007194; GO:0007214; GO:0007268; GO:0038039; GO:0043005; GO:0045211; GO:0046982; GO:0051932; GO:0150099; GO:1902710; GO:1902712
## 231 GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 232 GO:0003779; GO:0005523; GO:0005829; GO:0005856; GO:0005865; GO:0005884; GO:0006936; GO:0007015; GO:0008344; GO:0016020; GO:0030016; GO:0030017; GO:0030239; GO:0030863; GO:0051694; GO:0070307
## 233 GO:0007156; GO:0007399; GO:0014069; GO:0019900; GO:0030425; GO:0043005; GO:0043025; GO:0045211; GO:0060077; GO:0097151; GO:0098982; GO:0099560; GO:0099629
## 234 GO:0000050; GO:0001889; GO:0004087; GO:0004088; GO:0004175; GO:0005509; GO:0005524; GO:0005543; GO:0005730; GO:0005737; GO:0005739; GO:0005743; GO:0005886; GO:0006207; GO:0006541; GO:0007494; GO:0009410; GO:0009636; GO:0010043; GO:0014075; GO:0016595; GO:0019433; GO:0030955; GO:0032094; GO:0032496; GO:0032991; GO:0033762; GO:0034201; GO:0036094; GO:0042311; GO:0042594; GO:0042645; GO:0043200; GO:0044344; GO:0044877; GO:0046209; GO:0046872; GO:0048545; GO:0050667; GO:0051384; GO:0051591; GO:0055081; GO:0060416; GO:0070365; GO:0070409; GO:0071242; GO:0071320; GO:0071377; GO:0071400; GO:0071548; GO:0072341
## 235 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 236 GO:0001889; GO:0005794; GO:0006487; GO:0007030; GO:0009306; GO:0016192; GO:0055088; GO:0060041; GO:1905897
## 237 GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 238 GO:0001822; GO:0002063; GO:0003094; GO:0004065; GO:0005509; GO:0005539; GO:0005576; GO:0005615; GO:0005783; GO:0005795; GO:0005886; GO:0008449; GO:0009611; GO:0009986; GO:0010575; GO:0014846; GO:0030177; GO:0030201; GO:0032836; GO:0035860; GO:0040037; GO:0048706; GO:0051216; GO:0060348; GO:0060384; GO:0090263; GO:0097421; GO:1904472; GO:2000345
## 239 GO:0001956; GO:0004888; GO:0005634; GO:0005886; GO:0007186; GO:0007420; GO:0008047; GO:0008277; GO:0016020; GO:0042734; GO:0042995; GO:0045211; GO:0050807; GO:0050890; GO:0072659; GO:0098839; GO:0160079
## 240 GO:0005886; GO:0008519; GO:0072488; GO:0097272
## 241 GO:0001695; GO:0005737; GO:0032259; GO:0046539
## 242 GO:0004111; GO:0005524; GO:0005615; GO:0005737; GO:0009408; GO:0046314
## 243 GO:0000209; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0015031; GO:0016567; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
## 244 GO:0001932; GO:0001934; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0007009; GO:0007167; GO:0007268; GO:0007416; GO:0007528; GO:0007623; GO:0009986; GO:0015031; GO:0030154; GO:0030548; GO:0032092; GO:0033691; GO:0035022; GO:0035374; GO:0036122; GO:0042030; GO:0042383; GO:0043083; GO:0043087; GO:0043113; GO:0043395; GO:0043547; GO:0044295; GO:0044325; GO:0045202; GO:0045887; GO:0045944; GO:0048018; GO:0050431; GO:0050731; GO:0050807; GO:0051491; GO:0055117; GO:0060025; GO:0061098; GO:0062023; GO:0070507; GO:0071340; GO:0086036; GO:0097049; GO:0098978; GO:1902667; GO:1903277; GO:1903407; GO:1904395; GO:2000541; GO:2000673
## 245 GO:0000978; GO:0000981; GO:0003406; GO:0005634; GO:0006357; GO:0042472; GO:0060875
## 246 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 247 GO:0005886; GO:0006814; GO:0015293
## 248 GO:0000244; GO:0000381; GO:0000398; GO:0005634; GO:0005687; GO:0005690; GO:0015030; GO:0016607; GO:0030622; GO:0046540; GO:0060041; GO:0071005; GO:0071011; GO:0071339; GO:0097526
## 249 GO:0004963; GO:0005886; GO:0007186; GO:0007189; GO:0008528; GO:0008584; GO:0009755; GO:0010738; GO:0016020; GO:0042699; GO:0043235; GO:0051897; GO:0070374; GO:0071372
## 250 GO:0000122; GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0001666; GO:0002328; GO:0003183; GO:0003215; GO:0003289; GO:0003357; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005739; GO:0006355; GO:0007399; GO:0007420; GO:0007507; GO:0008284; GO:0008285; GO:0010467; GO:0014009; GO:0021510; GO:0021782; GO:0030182; GO:0030217; GO:0031018; GO:0031397; GO:0031647; GO:0032024; GO:0035019; GO:0035198; GO:0035910; GO:0042593; GO:0043065; GO:0043516; GO:0045588; GO:0045662; GO:0045663; GO:0045727; GO:0045893; GO:0045944; GO:0048485; GO:0048593; GO:0050821; GO:0060412; GO:0060485; GO:0060563; GO:0060993; GO:0061484; GO:0071333; GO:0090263; GO:2000761
## 251 GO:0001822; GO:0002042; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0003281; GO:0005737; GO:0005886; GO:0007156; GO:0007411; GO:0007507; GO:0008046; GO:0008285; GO:0009986; GO:0010628; GO:0010629; GO:0014003; GO:0016199; GO:0021510; GO:0021836; GO:0021891; GO:0030275; GO:0030336; GO:0030424; GO:0030425; GO:0030673; GO:0030949; GO:0033116; GO:0033600; GO:0035025; GO:0035385; GO:0035904; GO:0042802; GO:0043025; GO:0045747; GO:0048814; GO:0050772; GO:0050808; GO:0050925; GO:0051964; GO:0060412; GO:0060763; GO:0060976; GO:0070100; GO:0071456; GO:1900748; GO:1990138
## 252 GO:0000149; GO:0001778; GO:0001786; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0019905; GO:0030276; GO:0030424; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0045202; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0070062; GO:0070092; GO:0090119; GO:0090385; GO:0098686; GO:1900242; GO:1990926; GO:1990927
## 253 GO:0000149; GO:0001778; GO:0001786; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0019905; GO:0030276; GO:0030424; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0045202; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0070062; GO:0070092; GO:0090119; GO:0090385; GO:0098686; GO:1900242; GO:1990926; GO:1990927
## 254 GO:0000122; GO:0002088; GO:0005634; GO:0007219; GO:0007517; GO:0014029; GO:0021501; GO:0033504; GO:0042462; GO:0043066; GO:0043565; GO:0045494; GO:0045892; GO:0046982; GO:0048642; GO:0050768
## 255 GO:0004111; GO:0005524; GO:0005615; GO:0005737; GO:0009408; GO:0046314
## 256 GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 257 GO:0004930; GO:0005886; GO:0007166; GO:0007189; GO:0022008
## 258 GO:0000287; GO:0005829; GO:0006563; GO:0006564; GO:0036424
## 259 GO:0005634; GO:0005737; GO:0048471; GO:2000812
## 260 GO:0005507; GO:0005615; GO:0005886; GO:0005923; GO:0008131; GO:0008201; GO:0009308; GO:0009445; GO:0035874; GO:0046677; GO:0048038; GO:0050232; GO:0052597; GO:0052598; GO:0052599; GO:0052600; GO:0097159
## 261 GO:0001525; GO:0005576; GO:0005886; GO:0007155; GO:0007156; GO:0007411; GO:0007417; GO:0008104; GO:0010975; GO:0019227; GO:0030424; GO:0030506; GO:0031290; GO:0033268; GO:0043194; GO:0045162; GO:0045202; GO:0045211; GO:0070593; GO:0086080; GO:0098609; GO:0098632; GO:0098839; GO:0098978; GO:0099175
## 262 GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0007268; GO:0007608; GO:0017156; GO:0030276; GO:0030658; GO:0042803; GO:0045956; GO:0046982; GO:0070382; GO:0098793; GO:0098978
## 263 GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 264 GO:0004089; GO:0005737; GO:0005829; GO:0006730; GO:0008270; GO:0032230; GO:0032849; GO:0051453; GO:0070050; GO:2001225
## 265 GO:0003779; GO:0005546; GO:0005737; GO:0005884; GO:0005925; GO:0007015; GO:0007399; GO:0008154; GO:0010592; GO:0010976; GO:0015629; GO:0030027; GO:0030424; GO:0042995; GO:0043005; GO:0051014; GO:0051015; GO:0051016; GO:0060271; GO:0071933; GO:1900480
## 266 GO:0001889; GO:0005007; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0007498; GO:0008201; GO:0008284; GO:0008543; GO:0009953; GO:0017134; GO:0018108; GO:0021535; GO:0021628; GO:0031101; GO:0031410; GO:0033339; GO:0036342; GO:0042664; GO:0043235; GO:0043406; GO:0043589; GO:0045471; GO:0045597; GO:0048738; GO:0048916; GO:0051216; GO:0060249; GO:0071699
## 267 GO:0001725; GO:0001786; GO:0003418; GO:0005262; GO:0005509; GO:0005544; GO:0005737; GO:0005886; GO:0005925; GO:0006816; GO:0006937; GO:0008201; GO:0012506; GO:0016020; GO:0019899; GO:0030061; GO:0031214; GO:0031982; GO:0035374; GO:0038024; GO:0042383; GO:0042470; GO:0042584; GO:0048306; GO:0048471; GO:0051015; GO:0051283; GO:0051560; GO:0070509; GO:0070588; GO:0097190
## 268 GO:0005509; GO:0045938; GO:1902848
## 269 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 270 GO:0001822; GO:0001934; GO:0001956; GO:0002092; GO:0005634; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0007596; GO:0007613; GO:0008089; GO:0010008; GO:0010628; GO:0014059; GO:0014069; GO:0015630; GO:0016528; GO:0030036; GO:0030424; GO:0030426; GO:0030496; GO:0030672; GO:0031083; GO:0031175; GO:0032438; GO:0033162; GO:0042383; GO:0043005; GO:0043025; GO:0043197; GO:0045211; GO:0048490; GO:0048812; GO:0048813; GO:0060041; GO:0060155; GO:0060159; GO:0060271; GO:0061002; GO:0061646; GO:0071806; GO:0098685; GO:0098686; GO:0098978; GO:1904115; GO:2000300
## 271 GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 272 GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005905; GO:0006355; GO:0006357; GO:0006366; GO:0007173; GO:0007399; GO:0007423; GO:0007605; GO:0008283; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010761; GO:0010763; GO:0010842; GO:0010944; GO:0014032; GO:0014044; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0051402; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:0140536; GO:1990837; GO:2000378
## 273 GO:0001762; GO:0006836; GO:0008021; GO:0015185; GO:0015187; GO:0015812; GO:0015816; GO:0030659; GO:0042995; GO:0051939; GO:0098793; GO:0140799; GO:0140800
## 274 GO:0001656; GO:0001657; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0005886; GO:0006935; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035904; GO:0042802; GO:0045747; GO:0050772; GO:0050925; GO:0051964; GO:0060412; GO:0061364; GO:0070062; GO:0098609
## 275 GO:0005313; GO:0005314; GO:0005886; GO:0006750; GO:0007399; GO:0007632; GO:0008509; GO:0009410; GO:0009416; GO:0009611; GO:0009986; GO:0015175; GO:0015501; GO:0015813; GO:0016020; GO:0021537; GO:0030424; GO:0030534; GO:0030673; GO:0031982; GO:0033229; GO:0035264; GO:0042734; GO:0043197; GO:0043198; GO:0043200; GO:0044297; GO:0044306; GO:0045121; GO:0045202; GO:0046326; GO:0046872; GO:0070207; GO:0070778; GO:0070779; GO:0071314; GO:0097449; GO:0098656; GO:0098712; GO:0098796; GO:0098810; GO:0098978; GO:0140009
## 276 GO:0004054; GO:0004111; GO:0005524; GO:0046314
## 277 GO:0001581; GO:0005262; GO:0005886; GO:0006812; GO:0016020; GO:0030246; GO:0034703; GO:0043235; GO:0050915; GO:0050982; GO:0070062; GO:0071468
## 278 GO:0005332; GO:0005886; GO:0006865; GO:0007268; GO:0007613; GO:0008306; GO:0009636; GO:0009744; GO:0009986; GO:0010288; GO:0014054; GO:0014074; GO:0015185; GO:0015378; GO:0016020; GO:0030424; GO:0032229; GO:0032355; GO:0035725; GO:0042220; GO:0042734; GO:0042802; GO:0043025; GO:0045211; GO:0046872; GO:0050808; GO:0051592; GO:0051936; GO:0051939; GO:0098658; GO:0098719; GO:0098982; GO:0150104; GO:1902476
## 279 GO:0000139; GO:0005200; GO:0005543; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0007416; GO:0008021; GO:0008091; GO:0016079; GO:0016081; GO:0016192; GO:0016324; GO:0016363; GO:0017158; GO:0021692; GO:0030036; GO:0030054; GO:0030534; GO:0030864; GO:0033010; GO:0035264; GO:0042995; GO:0043025; GO:0048471; GO:0051015; GO:0051693; GO:0071361; GO:0098688; GO:0098793; GO:0098918; GO:0098978; GO:0099150; GO:0099173; GO:0099186; GO:0099189
## 280 GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0008045; GO:0008347; GO:0014044; GO:0021508; GO:0021514; GO:0021529; GO:0021530; GO:0030154; GO:0031018; GO:0033504; GO:0045893
## 281 GO:0005506; GO:0005634; GO:0005737; GO:0006555; GO:0010308; GO:0010309; GO:0016151; GO:0019509
## 282 GO:0004505; GO:0005506; GO:0006559; GO:0006571
## 283 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 284 GO:0004111; GO:0005524; GO:0046314
## 285 GO:0001669; GO:0005737; GO:0015280; GO:0016324; GO:0031514; GO:0034706; GO:0035725
## 286 GO:0001594; GO:0004930; GO:0005886; GO:0007186; GO:0008227; GO:0043950
## 287 GO:0000287; GO:0003924; GO:0005525; GO:0005768; GO:0005886; GO:0006887; GO:0007269; GO:0008021; GO:0009306; GO:0016192; GO:0031489; GO:0031630; GO:0031982; GO:0032482; GO:0045202; GO:0046718; GO:0046928; GO:0048172; GO:0048786; GO:0048789; GO:0048790
## 288 GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 289 GO:0001822; GO:0004586; GO:0005737; GO:0005829; GO:0006595; GO:0008283; GO:0008284; GO:0009446; GO:0009615; GO:0033387; GO:0042176; GO:0042803; GO:0048471
## 290 GO:0000139; GO:0000578; GO:0001525; GO:0001540; GO:0001654; GO:0001944; GO:0002071; GO:0002726; GO:0004930; GO:0005769; GO:0005794; GO:0005886; GO:0005923; GO:0008285; GO:0008289; GO:0008595; GO:0009986; GO:0016055; GO:0017147; GO:0019901; GO:0030424; GO:0030425; GO:0031076; GO:0031077; GO:0031625; GO:0032729; GO:0032731; GO:0032760; GO:0033077; GO:0035567; GO:0042813; GO:0043204; GO:0044877; GO:0045202; GO:0045944; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060561; GO:0060574; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0071219; GO:0098978; GO:0099054; GO:1901382; GO:2000810
## 291 GO:0005509; GO:0005516; GO:0005543; GO:0005886; GO:0007268; GO:0016079; GO:0016081; GO:0016082; GO:0017075; GO:0019905; GO:0019992; GO:0030672; GO:0031594; GO:0031914; GO:0035249; GO:0042734; GO:0043195; GO:0044305; GO:0046928; GO:0061789; GO:0098688; GO:0098793; GO:0098831; GO:0099525
## 292 GO:0003407; GO:0005388; GO:0005516; GO:0005524; GO:0005886; GO:0005901; GO:0006357; GO:0006874; GO:0007283; GO:0010629; GO:0014832; GO:0015085; GO:0016020; GO:0016323; GO:0016525; GO:0016887; GO:0017080; GO:0019901; GO:0021766; GO:0030018; GO:0030165; GO:0030315; GO:0030317; GO:0030346; GO:0032991; GO:0034220; GO:0036126; GO:0036487; GO:0038060; GO:0043231; GO:0043537; GO:0045019; GO:0045121; GO:0046872; GO:0048787; GO:0050998; GO:0051001; GO:0051480; GO:0051599; GO:0070588; GO:0070885; GO:0071872; GO:0071878; GO:0097110; GO:0097228; GO:0097553; GO:0098703; GO:0098736; GO:0098978; GO:0150104; GO:1900082; GO:1901660; GO:1902083; GO:1902305; GO:1902548; GO:1902806; GO:1903078; GO:1903243; GO:1903249; GO:1903779; GO:1905145
## 293 GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 294 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 295 GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 296 GO:0005524; GO:0005737; GO:0005783; GO:0005829; GO:0005886; GO:0006814; GO:0009609; GO:0009925; GO:0015199; GO:0015226; GO:0015293; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031526; GO:0034341; GO:0034612; GO:0042910; GO:0060731; GO:0070062; GO:0070715; GO:0150104; GO:1900749; GO:1901235; GO:1902270; GO:1902603; GO:1990961
## 297 GO:0001726; GO:0005509; GO:0005546; GO:0005737; GO:0005902; GO:0007173; GO:0008154; GO:0008360; GO:0009617; GO:0010634; GO:0015629; GO:0030027; GO:0030041; GO:0030042; GO:0030175; GO:0030335; GO:0032233; GO:0032432; GO:0032433; GO:0035727; GO:0035729; GO:0042803; GO:0043027; GO:0051014; GO:0051015; GO:0051016; GO:0051125; GO:0051693; GO:0060327; GO:0061041; GO:0071364; GO:2000392
## 298 GO:0004978; GO:0005737; GO:0005886; GO:0007189; GO:0019222
## 299 GO:0001764; GO:0005829; GO:0005856; GO:0005874; GO:0005875; GO:0007399; GO:0007417; GO:0008017; GO:0019901; GO:0035082; GO:0035556; GO:0043005; GO:0060041
## 300 GO:0000785; GO:0000978; GO:0001501; GO:0001974; GO:0003007; GO:0003222; GO:0003226; GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006338; GO:0006364; GO:0006366; GO:0007417; GO:0007512; GO:0007605; GO:0007628; GO:0008015; GO:0009617; GO:0010468; GO:0010880; GO:0016887; GO:0021545; GO:0021553; GO:0021772; GO:0030217; GO:0030540; GO:0035116; GO:0035909; GO:0036302; GO:0040018; GO:0042048; GO:0042393; GO:0042472; GO:0043009; GO:0043584; GO:0045944; GO:0048752; GO:0050767; GO:0050890; GO:0060041; GO:0060123; GO:0060324; GO:0060384; GO:0060411; GO:0060429; GO:0062009; GO:0140658; GO:1990841
## 301 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 302 GO:0002011; GO:0005102; GO:0005201; GO:0005576; GO:0005604; GO:0005606; GO:0005608; GO:0005615; GO:0005911; GO:0006468; GO:0007155; GO:0007166; GO:0007411; GO:0009887; GO:0009888; GO:0016020; GO:0030334; GO:0031012; GO:0031175; GO:0043010; GO:0043208; GO:0043256; GO:0045198; GO:0045785; GO:0045995; GO:0048514; GO:0051149; GO:0060041; GO:0060441; GO:0060445; GO:0061304; GO:0062023; GO:0098637; GO:0110011; GO:2001046
## 303 GO:0000139; GO:0001965; GO:0005096; GO:0005903; GO:0008277; GO:0009968; GO:0030136; GO:0045471
## 304 GO:0004930; GO:0005654; GO:0005886; GO:0007186; GO:0008502; GO:0045820; GO:0046325; GO:1904408
## 305 GO:0000122; GO:0006338; GO:0021549; GO:0031519; GO:0035102; GO:0035701; GO:0045814; GO:0046872; GO:0060215; GO:1990841
## 306 GO:0001594; GO:0004930; GO:0005886; GO:0007186; GO:0008227; GO:0043950
## 307 GO:0000122; GO:0001501; GO:0001649; GO:0001654; GO:0001822; GO:0001938; GO:0001958; GO:0003323; GO:0005125; GO:0005615; GO:0006879; GO:0006954; GO:0006955; GO:0008083; GO:0008284; GO:0010628; GO:0014823; GO:0030182; GO:0030501; GO:0030509; GO:0030539; GO:0031666; GO:0031982; GO:0032026; GO:0032332; GO:0032349; GO:0032526; GO:0043117; GO:0045603; GO:0045666; GO:0045669; GO:0045944; GO:0046982; GO:0050679; GO:0050714; GO:0050731; GO:0051216; GO:0051384; GO:0060348; GO:0060391; GO:0060586; GO:0070700; GO:0071260; GO:0071281; GO:0071773; GO:1903392; GO:2000048; GO:2000860
## 308 GO:0005829; GO:0005874; GO:0010719; GO:0030512; GO:0031397; GO:0032587; GO:0040037; GO:0046580; GO:0048513; GO:0070373; GO:1902747
## 309 GO:0004352; GO:0004354; GO:0005829; GO:0006537
## 310 GO:0005509; GO:0005774; GO:0005886; GO:0006814; GO:0006874; GO:0015369; GO:0070588
## 311 GO:0005283; GO:0005332; GO:0005886; GO:0006865; GO:0007612; GO:0007613; GO:0008306; GO:0009636; GO:0009744; GO:0009986; GO:0010288; GO:0014054; GO:0014070; GO:0014074; GO:0015185; GO:0015378; GO:0030424; GO:0032229; GO:0032355; GO:0035725; GO:0042220; GO:0042734; GO:0042802; GO:0043025; GO:0045211; GO:0046872; GO:0050808; GO:0051592; GO:0051939; GO:0098658; GO:0098719; GO:0098793; GO:0098810; GO:0098982; GO:1902476
## 312 GO:0006884; GO:0008511; GO:0008519; GO:0016323; GO:0016324; GO:0046873; GO:0055064; GO:0055075; GO:0055078; GO:0071944; GO:0098659; GO:1990573
## 313 GO:0004123; GO:0005516; GO:0005737; GO:0006629; GO:0018272; GO:0019344; GO:0019346; GO:0030170; GO:0043066; GO:0043123; GO:0044524; GO:0044540; GO:0047982; GO:0051092; GO:0070814; GO:0080146; GO:0098606
## 314 GO:0001745; GO:0002052; GO:0002213; GO:0003682; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005783; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006110; GO:0007015; GO:0007219; GO:0007293; GO:0007297; GO:0007298; GO:0007346; GO:0007391; GO:0007400; GO:0007403; GO:0007405; GO:0007411; GO:0007422; GO:0007423; GO:0007440; GO:0007455; GO:0007474; GO:0007476; GO:0007478; GO:0007480; GO:0007498; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009950; GO:0009986; GO:0010001; GO:0010628; GO:0010629; GO:0014018; GO:0014019; GO:0016020; GO:0016318; GO:0016324; GO:0016330; GO:0016348; GO:0016360; GO:0022416; GO:0030139; GO:0030154; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0032991; GO:0035035; GO:0035153; GO:0035162; GO:0035167; GO:0035171; GO:0035172; GO:0035204; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042686; GO:0042688; GO:0042691; GO:0043525; GO:0043697; GO:0045165; GO:0045316; GO:0045466; GO:0045595; GO:0045893; GO:0045944; GO:0046331; GO:0046666; GO:0046667; GO:0046716; GO:0046843; GO:0048052; GO:0048056; GO:0048190; GO:0048477; GO:0048542; GO:0048627; GO:0048664; GO:0048665; GO:0048749; GO:0048803; GO:0048863; GO:0050699; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060289; GO:0060571; GO:0061331; GO:0061382; GO:0097150; GO:1900087; GO:1902692; GO:1990433; GO:2000035; GO:2000048
## 315 GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0016020; GO:0016918; GO:0033583; GO:0071482
## 316 GO:0005739; GO:0006574; GO:0008442; GO:0050661; GO:0051287
## 317 GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0017148; GO:0030371; GO:0043161; GO:0043523; GO:0061630
## 318 GO:0005272; GO:0005886; GO:0006813; GO:0007638; GO:0009612; GO:0015485; GO:0032589; GO:0043005; GO:0050976; GO:1905789; GO:1905792
## CellularComponent
## 1 cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]
## 2 endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 3 extracellular space [GO:0005615]
## 4 nucleus [GO:0005634]
## 5 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 6 extracellular space [GO:0005615]
## 7
## 8 exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]
## 9 cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]
## 10 actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 11 extracellular space [GO:0005615]
## 12 cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cortical cytoskeleton [GO:0030863]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]
## 13 cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]
## 14 basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 15 lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 16 cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]
## 17 apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; spindle pole [GO:0000922]
## 18 membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]
## 19 anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]
## 20 plasma membrane [GO:0005886]
## 21 calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]
## 22 plasma membrane [GO:0005886]
## 23 glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]
## 24 plasma membrane [GO:0005886]
## 25 nucleus [GO:0005634]
## 26 extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]
## 27 caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 28 apical plasma membrane [GO:0016324]; axon [GO:0030424]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]
## 29 Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]
## 30 axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 31 dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 32 P-body [GO:0000932]
## 33 apical plasma membrane [GO:0016324]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]
## 34 plasma membrane [GO:0005886]; postsynapse [GO:0098794]
## 35 cytosol [GO:0005829]; photoreceptor outer segment membrane [GO:0042622]
## 36
## 37 apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]
## 38 cytosol [GO:0005829]
## 39 ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044]
## 40 nucleus [GO:0005634]
## 41 endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 42
## 43 endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]
## 44 cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 45 early endosome [GO:0005769]; plasma membrane [GO:0005886]
## 46 chloride channel complex [GO:0034707]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]
## 47 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 48 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 49 membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]
## 50 non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]
## 51 membrane [GO:0016020]
## 52 plasma membrane [GO:0005886]
## 53
## 54 nucleus [GO:0005634]
## 55
## 56 mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]
## 57 cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]
## 58 collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]
## 59 chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 60 Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]
## 61 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 62 plasma membrane [GO:0005886]
## 63 plasma membrane [GO:0005886]
## 64 cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]
## 65 apical plasma membrane [GO:0016324]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]
## 66 cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 67 cytoophidium [GO:0097268]; cytoplasm [GO:0005737]
## 68 basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 69 synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]
## 70 neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 71 plasma membrane [GO:0005886]
## 72 cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]
## 73 axon [GO:0030424]; voltage-gated sodium channel complex [GO:0001518]
## 74 basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 75 clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 76 axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 77 membrane [GO:0016020]
## 78 cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]
## 79 plasma membrane [GO:0005886]
## 80 apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]
## 81 cell junction [GO:0030054]; plasma membrane [GO:0005886]
## 82 plasma membrane [GO:0005886]; pleated septate junction [GO:0005919]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]
## 83 apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]
## 84 actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 85 apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]
## 86 dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]
## 87 plasma membrane [GO:0005886]; synapse [GO:0045202]
## 88 axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; potassium channel complex [GO:0034705]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 89 actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 90 acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]
## 91 cytosol [GO:0005829]; nucleus [GO:0005634]
## 92 cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]
## 93 extracellular space [GO:0005615]; plasma membrane [GO:0005886]; vesicle [GO:0031982]
## 94 autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]
## 95 cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]
## 96 axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 97 basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 98 axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]
## 99 cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 100 fungal-type vacuole [GO:0000324]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]
## 101 cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 102 cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 103 cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]
## 104 apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; synaptic vesicle [GO:0008021]
## 105 plasma membrane [GO:0005886]
## 106
## 107 cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]
## 108 cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]
## 109 plasma membrane [GO:0005886]
## 110 axolemma [GO:0030673]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 111 P-body [GO:0000932]
## 112 apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 113 A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 114 cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 115
## 116
## 117 cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
## 118 plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]
## 119 glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]
## 120 centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]
## 121 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 122 membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium tip [GO:0032426]
## 123 cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]
## 124 cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; methylosome [GO:0034709]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]
## 125 dendrite [GO:0030425]; plasma membrane [GO:0005886]
## 126 cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 127 ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 128 apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]
## 129 cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]
## 130 extracellular region [GO:0005576]
## 131 plasma membrane [GO:0005886]
## 132 fungal-type vacuole [GO:0000324]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]
## 133 plasma membrane [GO:0005886]
## 134 cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]
## 135 cilium [GO:0005929]
## 136 late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 137 nucleus [GO:0005634]
## 138 P-body [GO:0000932]
## 139 extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; Wnt signalosome [GO:1990909]
## 140 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 141 cytosol [GO:0005829]
## 142 plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 143 adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; CSL-Notch-Mastermind transcription factor complex [GO:1990433]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 144 cytoplasm [GO:0005737]
## 145 basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 146 endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]
## 147 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 148 mitochondrion [GO:0005739]
## 149 nucleus [GO:0005634]; transcription repressor complex [GO:0017053]
## 150
## 151 cytosol [GO:0005829]
## 152 melanosome [GO:0042470]; melanosome membrane [GO:0033162]
## 153 cytoplasm [GO:0005737]
## 154 cell periphery [GO:0071944]; cytoplasm [GO:0005737]; myosin complex [GO:0016459]; plasma membrane bounded cell projection [GO:0120025]
## 155 cytoplasm [GO:0005737]; lysosome [GO:0005764]
## 156 cytosol [GO:0005829]; perikaryon [GO:0043204]; SNARE complex [GO:0031201]; terminal bouton [GO:0043195]
## 157 BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]
## 158 chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]
## 159 late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 160 cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]
## 161 cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 162 Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]
## 163 axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 164 cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
## 165 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 166 axon terminus [GO:0043679]; plasma membrane [GO:0005886]
## 167 basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]
## 168 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 169 stereocilium [GO:0032420]
## 170 P-body [GO:0000932]
## 171 asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]
## 172 mitochondrial outer membrane [GO:0005741]
## 173 cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 174 chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 175 mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]
## 176 early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 177 apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; neuronal cell body [GO:0043025]
## 178 early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]
## 179 apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]
## 180 P-body [GO:0000932]
## 181 apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]
## 182 astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 183 endoplasmic reticulum membrane [GO:0005789]
## 184 calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]
## 185 axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 186 extracellular region [GO:0005576]
## 187 axolemma [GO:0030673]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]
## 188 basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 189 cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]
## 190 plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]
## 191 cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
## 192 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 193 axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 194 cytosol [GO:0005829]
## 195 cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]
## 196 basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]
## 197 chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 198 actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 199 mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]
## 200 cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; presynaptic active zone cytoplasmic component [GO:0098831]
## 201 cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 202 autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]
## 203 plasma membrane [GO:0005886]
## 204 cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202]
## 205 axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 206 endoplasmic reticulum membrane [GO:0005789]
## 207 external side of plasma membrane [GO:0009897]
## 208 cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 209 axon terminus [GO:0043679]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]
## 210 MICOS complex [GO:0061617]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]
## 211 axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]
## 212 plasma membrane [GO:0005886]; synapse [GO:0045202]
## 213 axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber [GO:0097457]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]
## 214 cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 215 dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 216 blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]
## 217 ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 218 dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]
## 219 A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 220 BAK complex [GO:0097145]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]
## 221 cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 222 cytosol [GO:0005829]; heterotetrameric polyprenyl diphosphate synthase complex [GO:0032478]; mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]
## 223 extracellular space [GO:0005615]
## 224 cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 225 dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 226
## 227 extracellular space [GO:0005615]
## 228 cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 229 extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 230 cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 231 endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 232 actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]
## 233 dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629]
## 234 cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 235 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 236 Golgi apparatus [GO:0005794]
## 237 cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 238 cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]
## 239 cell projection [GO:0042995]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 240 plasma membrane [GO:0005886]
## 241 cytoplasm [GO:0005737]
## 242 cytoplasm [GO:0005737]; extracellular space [GO:0005615]
## 243 cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]
## 244 axonal growth cone [GO:0044295]; basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; sarcolemma [GO:0042383]; synapse [GO:0045202]; synaptic cleft [GO:0043083]
## 245 nucleus [GO:0005634]
## 246 axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 247 plasma membrane [GO:0005886]
## 248 Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]
## 249 membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 250 cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 251 axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]
## 252 axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]
## 253 axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]
## 254 nucleus [GO:0005634]
## 255 cytoplasm [GO:0005737]; extracellular space [GO:0005615]
## 256 P-body [GO:0000932]
## 257 plasma membrane [GO:0005886]
## 258 cytosol [GO:0005829]
## 259 cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]
## 260 bicellular tight junction [GO:0005923]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]
## 261 axon [GO:0030424]; axon initial segment [GO:0043194]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]
## 262 exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]
## 263 actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 264 cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 265 actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]
## 266 cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 267 chromaffin granule membrane [GO:0042584]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrial crista [GO:0030061]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; stress fiber [GO:0001725]; vesicle [GO:0031982]; vesicle membrane [GO:0012506]
## 268
## 269 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 270 axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]
## 271 endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 272 clathrin-coated pit [GO:0005905]; nucleus [GO:0005634]
## 273 cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]
## 274 axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 275 astrocyte projection [GO:0097449]; axolemma [GO:0030673]; axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; vesicle [GO:0031982]
## 276
## 277 cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 278 axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 279 apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; synaptic vesicle [GO:0008021]
## 280 nucleus [GO:0005634]
## 281 cytoplasm [GO:0005737]; nucleus [GO:0005634]
## 282
## 283 axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 284
## 285 acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; sodium channel complex [GO:0034706]
## 286 plasma membrane [GO:0005886]
## 287 endosome [GO:0005768]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]
## 288 A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 289 cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]
## 290 axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 291 calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]
## 292 basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 293 extracellular region [GO:0005576]
## 294 adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 295 extracellular space [GO:0005615]
## 296 apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 297 actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; ruffle [GO:0001726]
## 298 cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 299 cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]
## 300 chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 301 ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 302 basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin complex [GO:0043256]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637]
## 303 brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi membrane [GO:0000139]
## 304 nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
## 305 PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]
## 306 plasma membrane [GO:0005886]
## 307 extracellular space [GO:0005615]; vesicle [GO:0031982]
## 308 cytosol [GO:0005829]; microtubule [GO:0005874]; ruffle membrane [GO:0032587]
## 309 cytosol [GO:0005829]
## 310 plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]
## 311 axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]
## 312 apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]
## 313 cytoplasm [GO:0005737]
## 314 adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; CSL-Notch-Mastermind transcription factor complex [GO:1990433]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 315 membrane [GO:0016020]; plasma membrane [GO:0005886]; rhabdomere membrane [GO:0033583]
## 316 mitochondrion [GO:0005739]
## 317 cytoplasm [GO:0005737]
## 318 neuron projection [GO:0043005]; neuron projection membrane [GO:0032589]; plasma membrane [GO:0005886]
## MolecularFunction
## 1 cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]
## 2 copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 3 cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 4 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]
## 5 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 6 cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 7 adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]
## 8 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]
## 9
## 10 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 11 cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 12 actin binding [GO:0003779]; actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]
## 13 double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]
## 14 heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 15 cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 16 calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]
## 17 calcium ion binding [GO:0005509]; IgG binding [GO:0019864]
## 18 identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]
## 19 chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]
## 20 alpha1-adrenergic receptor activity [GO:0004937]
## 21 ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
## 22 carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]
## 23 G protein-coupled adenosine receptor activity [GO:0001609]
## 24 ferritin receptor activity [GO:0070287]
## 25 bHLH transcription factor binding [GO:0043425]; protein dimerization activity [GO:0046983]; sequence-specific DNA binding [GO:0043565]
## 26 glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]
## 27 alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]
## 28 calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]
## 29 actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]
## 30 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]
## 31 dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]
## 32 miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 33 amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]
## 34 calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]
## 35 all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]
## 36 diaminopimelate decarboxylase activity [GO:0008836]
## 37 arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; zinc ion binding [GO:0008270]
## 38 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 39
## 40 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]
## 41 coreceptor activity [GO:0015026]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 42 L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]
## 43 chloride channel activity [GO:0005254]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]
## 44
## 45 beta1-adrenergic receptor activity [GO:0004940]
## 46 extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; neurotransmitter receptor activity [GO:0030594]; taurine binding [GO:0030977]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824]; zinc ion binding [GO:0008270]
## 47 G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 48 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 49 delayed rectifier potassium channel activity [GO:0005251]; intracellularly cyclic nucleotide-activated monoatomic cation channel activity [GO:0005221]; voltage-gated potassium channel activity [GO:0005249]
## 50 G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 51 calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]
## 52 G protein-coupled receptor activity [GO:0004930]
## 53 L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]
## 54 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 55 metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]
## 56 acyl carnitine transmembrane transporter activity [GO:0015227]; basic amino acid transmembrane transporter activity [GO:0015174]; high-affinity L-arginine transmembrane transporter activity [GO:0005289]; high-affinity lysine transmembrane transporter activity [GO:0005292]
## 57 AP-2 adaptor complex binding [GO:0035612]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; monoatomic ion channel activity [GO:0005216]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]
## 58 extracellular matrix structural constituent conferring tensile strength [GO:0030020]
## 59 chromatin binding [GO:0003682]; RNA binding [GO:0003723]
## 60 identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]
## 61 neuropeptide receptor activity [GO:0008188]; tachykinin receptor activity [GO:0004995]
## 62 G protein-coupled receptor activity [GO:0004930]
## 63 ammonium channel activity [GO:0008519]
## 64 identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 65 chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]
## 66 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 67 ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]
## 68 amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 69 calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]
## 70 G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159]
## 71 ferritin receptor activity [GO:0070287]
## 72 arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]
## 73 voltage-gated sodium channel activity [GO:0005248]
## 74 heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 75 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]
## 76 delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]
## 77 calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]
## 78 ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]
## 79 calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]
## 80 calcium ion binding [GO:0005509]
## 81 amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]
## 82
## 83 calcium ion binding [GO:0005509]
## 84 G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 85 dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; sodium ion transmembrane transporter activity [GO:0015081]; urate transmembrane transporter activity [GO:0015143]
## 86 GABA receptor binding [GO:0050811]
## 87
## 88 delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; outward rectifier potassium channel activity [GO:0015271]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]
## 89 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 90 acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]
## 91 cytokinin riboside 5'-monophosphate phosphoribohydrolase activity [GO:0102682]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]
## 92 AP-2 adaptor complex binding [GO:0035612]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; monoatomic ion channel activity [GO:0005216]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]
## 93 aminoacyltransferase activity [GO:0016755]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]
## 94 CDP phosphatase activity [GO:0036384]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]
## 95 arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]
## 96 heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 97 amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 98 cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272]
## 99
## 100
## 101 DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]
## 102 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 103 identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]
## 104 actin filament binding [GO:0051015]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]
## 105 G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 106 adenosylmethionine decarboxylase activity [GO:0004014]
## 107
## 108 L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]
## 109 outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]
## 110 delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]
## 111 miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 112 amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618]
## 113 ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 114 calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]
## 115 asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]
## 116 L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]
## 117 mitochondrial large ribosomal subunit binding [GO:0140978]; ribosomal large subunit binding [GO:0043023]
## 118 calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; temperature-gated cation channel activity [GO:0097604]
## 119 ephrin receptor binding [GO:0046875]
## 120 DNA binding [GO:0003677]
## 121 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 122
## 123 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]
## 124 intracellularly calcium-gated chloride channel activity [GO:0005229]; lipid binding [GO:0008289]; potassium channel activity [GO:0005267]; small molecule binding [GO:0036094]; splicing factor binding [GO:1990935]
## 125 calcium ion binding [GO:0005509]
## 126 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 127
## 128 calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; symporter activity [GO:0015293]
## 129 endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]
## 130
## 131 G protein-coupled photoreceptor activity [GO:0008020]
## 132 transmembrane transporter activity [GO:0022857]
## 133 G protein-coupled receptor activity [GO:0004930]
## 134 C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; lipid binding [GO:0008289]
## 135 3'-5' exonuclease activity [GO:0008408]; nucleoside diphosphate kinase activity [GO:0004550]
## 136 cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 137 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]
## 138 miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 139 coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]
## 140 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 141 glutaminase activity [GO:0004359]; protein heterodimerization activity [GO:0046982]; pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [GO:0036381]
## 142 extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]
## 143 calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]; WW domain binding [GO:0050699]
## 144 translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 145 heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 146 arachidonic acid binding [GO:0050544]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; proton channel activity [GO:0015252]
## 147 G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 148 branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]
## 149 chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 150 metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]
## 151 identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]
## 152 copper ion binding [GO:0005507]; tyrosinase activity [GO:0004503]
## 153 imidazolonepropionase activity [GO:0050480]; metal ion binding [GO:0046872]
## 154 actin binding [GO:0003779]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]
## 155 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 156 SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 157 RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]
## 158 protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 159 cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 160 histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022]
## 161 ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
## 162 identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]
## 163 heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 164 ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899]
## 165 G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 166 carcinine transmembrane transporter activity [GO:1905131]; neurotransmitter transmembrane transporter activity [GO:0005326]
## 167 calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; signaling receptor binding [GO:0005102]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated sodium channel activity [GO:0005248]
## 168 calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]
## 169
## 170 miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 171 alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]
## 172 FAD binding [GO:0071949]; kynurenine 3-monooxygenase activity [GO:0004502]
## 173 TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]
## 174 DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]
## 175 ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]
## 176 apolipoprotein binding [GO:0034185]; low-density lipoprotein particle receptor activity [GO:0005041]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 177 ammonium channel activity [GO:0008519]; potassium ion transmembrane transporter activity [GO:0015079]; sodium:potassium:chloride symporter activity [GO:0008511]
## 178 endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]
## 179 actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249]
## 180 miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 181 calcium ion binding [GO:0005509]
## 182 calcium channel regulator activity [GO:0005246]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]
## 183 P-type magnesium transporter activity [GO:0015444]
## 184 actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]
## 185 axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]
## 186 calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 187 extracellular matrix protein binding [GO:1990430]; G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; protein heterodimerization activity [GO:0046982]
## 188 amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 189 identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]
## 190 metal ion binding [GO:0046872]; zinc:proton antiporter activity [GO:0140826]
## 191 G protein-coupled receptor activity [GO:0004930]
## 192 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 193 amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 194 aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 195 mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]
## 196 creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]
## 197 chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]
## 198 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 199 ribosome binding [GO:0043022]
## 200 cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]
## 201 G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]
## 202 antioxidant activity [GO:0016209]
## 203 G protein-coupled photoreceptor activity [GO:0008020]
## 204 GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; poly-pyrimidine tract binding [GO:0008187]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]
## 205 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]
## 206 ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]
## 207 riboflavin binding [GO:1902444]; riboflavin transmembrane transporter activity [GO:0032217]; signaling receptor activity [GO:0038023]
## 208
## 209 SH3 domain binding [GO:0017124]; syntaxin-1 binding [GO:0017075]
## 210
## 211 protein-containing complex binding [GO:0044877]
## 212 G protein-coupled serotonin receptor activity [GO:0004993]
## 213 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; GAF domain binding [GO:0036004]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]
## 214 DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]
## 215 G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]
## 216 calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053]
## 217
## 218 metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]
## 219 ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 220 BH domain binding [GO:0051400]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]
## 221 ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]
## 222 all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]
## 223 calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 224
## 225 G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]
## 226 FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]; NADP binding [GO:0050661]
## 227 cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 228 corticotropin receptor activity [GO:0004978]; G protein-coupled receptor activity [GO:0004930]
## 229 copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 230 G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]
## 231 copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 232 actin binding [GO:0003779]; tropomyosin binding [GO:0005523]
## 233 kinase binding [GO:0019900]
## 234 ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094]
## 235 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 236
## 237
## 238 arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]
## 239 enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]
## 240 ammonium channel activity [GO:0008519]
## 241 histamine N-methyltransferase activity [GO:0046539]
## 242 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 243 identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 244 acetylcholine receptor regulator activity [GO:0030548]; ATPase inhibitor activity [GO:0042030]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; receptor ligand activity [GO:0048018]; sialic acid binding [GO:0033691]; transforming growth factor beta binding [GO:0050431]; transmembrane transporter binding [GO:0044325]
## 245 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 246 heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 247 symporter activity [GO:0015293]
## 248 U4atac snRNA binding [GO:0030622]
## 249 follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528]
## 250 DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]
## 251 axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275]
## 252 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 253 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 254 protein heterodimerization activity [GO:0046982]; sequence-specific DNA binding [GO:0043565]
## 255 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 256 miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 257 G protein-coupled receptor activity [GO:0004930]
## 258 L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]
## 259
## 260 copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; methylputrescine oxidase activity [GO:0052599]; organic cyclic compound binding [GO:0097159]; primary amine oxidase activity [GO:0008131]; propane-1,3-diamine oxidase activity [GO:0052600]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038]
## 261 ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]
## 262 calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]
## 263 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 264 carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]
## 265 actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]
## 266 ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]
## 267 actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; chondroitin sulfate binding [GO:0035374]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; phosphatidylserine binding [GO:0001786]
## 268 calcium ion binding [GO:0005509]
## 269 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 270
## 271 copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 272 chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]
## 273 gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799]
## 274 axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]
## 275 cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]
## 276 arginine kinase activity [GO:0004054]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 277 calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]
## 278 gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]
## 279 actin filament binding [GO:0051015]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]
## 280 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 281 acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]
## 282 iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505]
## 283 heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 284 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 285 ligand-gated sodium channel activity [GO:0015280]
## 286 G protein-coupled amine receptor activity [GO:0008227]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]
## 287 GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; myosin V binding [GO:0031489]
## 288 ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 289 ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803]
## 290 amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 291 calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]
## 292 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]
## 293 calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 294 calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 295 calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 296 (R)-carnitine transmembrane transporter activity [GO:1901235]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; xenobiotic transmembrane transporter activity [GO:0042910]
## 297 actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]
## 298 corticotropin receptor activity [GO:0004978]
## 299 microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]
## 300 ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 301
## 302 extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102]
## 303 G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]
## 304 G protein-coupled receptor activity [GO:0004930]; melatonin binding [GO:1904408]; melatonin receptor activity [GO:0008502]
## 305 metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]
## 306 G protein-coupled amine receptor activity [GO:0008227]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]
## 307 BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein heterodimerization activity [GO:0046982]
## 308
## 309 glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]
## 310 calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]
## 311 amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]
## 312 ammonium channel activity [GO:0008519]; metal ion transmembrane transporter activity [GO:0046873]; sodium:potassium:chloride symporter activity [GO:0008511]
## 313 calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606]
## 314 calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]; WW domain binding [GO:0050699]
## 315 G protein-coupled photoreceptor activity [GO:0008020]; retinal binding [GO:0016918]
## 316 3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661]
## 317 translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 318 cholesterol binding [GO:0015485]; sodium channel activity [GO:0005272]
cluster_1_3 <- Oral_enriched_clustered %>% dplyr::filter(GO.cluster == 1|
GO.cluster == 2|
GO.cluster == 3) %>% pull(GO.ID)
showSigOfNodes(BP_Oral, score(elim_Oral)[names(score(elim_Oral)) %in% cluster_1_3], firstSigNodes = length(cluster_1_3), useInfo = 'all')
## Loading required package: Rgraphviz
## Loading required package: grid
##
## Attaching package: 'grid'
## The following object is masked from 'package:topGO':
##
## depth
##
## Attaching package: 'Rgraphviz'
## The following objects are masked from 'package:IRanges':
##
## from, to
## The following objects are masked from 'package:S4Vectors':
##
## from, to
## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 52
## Number of Edges = 87
##
## $complete.dag
## [1] "A graph with 52 nodes."
cluster_1_3_genes <- unique(unlist(genes_by_GO[cluster_1_3]))
write.csv(cluster_1_3_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Oral_enrich_BP_transport.csv",row.names=FALSE)
cluster_1_3_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_1_3_genes)
#DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Aboral_enriched_clustered %>% pull(GO.ID)])))
# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)
BP_Aboral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="BP",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 8797 GO terms found. )
##
## Build GO DAG topology ..........
## ( 12496 GO terms and 27095 relations. )
##
## Annotating nodes ...............
## ( 9496 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
BP_Aboral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 3092 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 17: 1 nodes to be scored (0 eliminated genes)
##
## Level 16: 6 nodes to be scored (0 eliminated genes)
##
## Level 15: 21 nodes to be scored (0 eliminated genes)
##
## Level 14: 24 nodes to be scored (0 eliminated genes)
##
## Level 13: 44 nodes to be scored (175 eliminated genes)
##
## Level 12: 85 nodes to be scored (236 eliminated genes)
##
## Level 11: 184 nodes to be scored (238 eliminated genes)
##
## Level 10: 284 nodes to be scored (291 eliminated genes)
##
## Level 9: 377 nodes to be scored (334 eliminated genes)
##
## Level 8: 450 nodes to be scored (625 eliminated genes)
##
## Level 7: 472 nodes to be scored (816 eliminated genes)
##
## Level 6: 489 nodes to be scored (1092 eliminated genes)
##
## Level 5: 366 nodes to be scored (1921 eliminated genes)
##
## Level 4: 194 nodes to be scored (2391 eliminated genes)
##
## Level 3: 78 nodes to be scored (2465 eliminated genes)
##
## Level 2: 16 nodes to be scored (2583 eliminated genes)
##
## Level 1: 1 nodes to be scored (2583 eliminated genes)
BP_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Aboral_elim = c("BP_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
## Aboral_elim
## BP_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 118
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## Nontrivial_nodes: 3092
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 118 GO terms of 1 conditions.
## Aboral_elim : 118 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
BP_Results,
"../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Aboral_elim
## BP_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 118
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## Nontrivial_nodes: 3092
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 118 GO terms of 1 conditions.
## Aboral_elim : 118 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 1,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Aboral,
"../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
height=1500,
width=700,
"GOterms", file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral_cluster_heatmap_Wang_wardD2.png")
## quartz_off_screen
## 2
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Aboral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Aboral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOclusters")
Aboral_enriched_clustered <- Wang_clusters_wardD2_Aboral@enrich_GOs@data
top_cluster <- Aboral_enriched_clustered %>% arrange(Aboral_elim.pvalue) %>% head(1) %>% pull(GO.cluster)
Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == top_cluster)
## GO.cluster IC GO.ID
## <char> <num> <char>
## 1: 9 6.30 GO:0007160
## 2: 9 4.14 GO:0007155
## 3: 9 8.23 GO:0016339
## 4: 9 6.32 GO:0007156
## 5: 9 7.39 GO:0007157
## term
## <char>
## 1: cell-matrix adhesion
## 2: cell adhesion
## 3: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
## 4: homophilic cell adhesion via plasma membrane adhesion molecules
## 5: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
## definition
## <char>
## 1: The binding of a cell to the extracellular matrix via adhesion molecules.
## 2: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
## 3: The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
## 4: The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
## 5: The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
## Aboral_elim.genes_frequency Aboral_elim.pvalue Aboral_elim.-log10_pvalue
## <char> <num> <num>
## 1: 8.738% (9/103) 9.829966e-03 2.01
## 2: 10.423% (69/662) 3.718063e-03 2.43
## 3: 29.412% (5/17) 2.216604e-04 3.65
## 4: 20.175% (23/114) 6.027593e-12 11.22
## 5: 30.769% (12/39) 4.576971e-09 8.34
## Aboral_elim.Significant_genes
## <char>
## 1: Pocillopora_acuta_HIv2___RNAseq.g11876.t1;Pocillopora_acuta_HIv2___RNAseq.g12272.t1;Pocillopora_acuta_HIv2___RNAseq.g12278.t1;Pocillopora_acuta_HIv2___RNAseq.g13823.t1;Pocillopora_acuta_HIv2___RNAseq.g25351.t1;Pocillopora_acuta_HIv2___RNAseq.g28502.t1;Pocillopora_acuta_HIv2___RNAseq.g5342.t1;Pocillopora_acuta_HIv2___RNAseq.g7895.t1;Pocillopora_acuta_HIv2___TS.g10825.t1
## 2: Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.6832_t;Pocillopora_acuta_HIv2___RNAseq.g10343.t1;Pocillopora_acuta_HIv2___RNAseq.g10385.t1;Pocillopora_acuta_HIv2___RNAseq.g1119.t1;Pocillopora_acuta_HIv2___RNAseq.g11876.t1;Pocillopora_acuta_HIv2___RNAseq.g12258.t1;Pocillopora_acuta_HIv2___RNAseq.g12272.t1;Pocillopora_acuta_HIv2___RNAseq.g12278.t1;Pocillopora_acuta_HIv2___RNAseq.g12281.t1;Pocillopora_acuta_HIv2___RNAseq.g12374.t1;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g13823.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g14347.t1;Pocillopora_acuta_HIv2___RNAseq.g14375.t1;Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___RNAseq.g18125.t1;Pocillopora_acuta_HIv2___RNAseq.g18385.t1;Pocillopora_acuta_HIv2___RNAseq.g19085.t1;Pocillopora_acuta_HIv2___RNAseq.g20876.t1;Pocillopora_acuta_HIv2___RNAseq.g21477.t1;Pocillopora_acuta_HIv2___RNAseq.g21479.t1;Pocillopora_acuta_HIv2___RNAseq.g21481.t1;Pocillopora_acuta_HIv2___RNAseq.g23178.t1;Pocillopora_acuta_HIv2___RNAseq.g23210.t1;Pocillopora_acuta_HIv2___RNAseq.g23886.t1;Pocillopora_acuta_HIv2___RNAseq.g24688.t1;Pocillopora_acuta_HIv2___RNAseq.g25351.t1;Pocillopora_acuta_HIv2___RNAseq.g25739.t1;Pocillopora_acuta_HIv2___RNAseq.g25761.t1;Pocillopora_acuta_HIv2___RNAseq.g27031.t1;Pocillopora_acuta_HIv2___RNAseq.g28109.t1;Pocillopora_acuta_HIv2___RNAseq.g28196.t1;Pocillopora_acuta_HIv2___RNAseq.g28226.t2;Pocillopora_acuta_HIv2___RNAseq.g28502.t1;Pocillopora_acuta_HIv2___RNAseq.g28971.t1a;Pocillopora_acuta_HIv2___RNAseq.g29143.t2;Pocillopora_acuta_HIv2___RNAseq.g29795.t1;Pocillopora_acuta_HIv2___RNAseq.g3826.t1;Pocillopora_acuta_HIv2___RNAseq.g3939.t1;Pocillopora_acuta_HIv2___RNAseq.g5181.t1;Pocillopora_acuta_HIv2___RNAseq.g5342.t1;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g5896.t1;Pocillopora_acuta_HIv2___RNAseq.g682.t1;Pocillopora_acuta_HIv2___RNAseq.g7895.t1;Pocillopora_acuta_HIv2___RNAseq.g805.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___RNAseq.g9049.t1;Pocillopora_acuta_HIv2___RNAseq.g9253.t1;Pocillopora_acuta_HIv2___TS.g10825.t1;Pocillopora_acuta_HIv2___TS.g11002.t4;Pocillopora_acuta_HIv2___TS.g12860.t1;Pocillopora_acuta_HIv2___TS.g14528.t1a;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g17199.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g24030.t1;Pocillopora_acuta_HIv2___TS.g24743.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g30914.t1;Pocillopora_acuta_HIv2___TS.g3265.t1;Pocillopora_acuta_HIv2___TS.g5115.t2;Pocillopora_acuta_HIv2___TS.g5308.t2;Pocillopora_acuta_HIv2___TS.g8258.t1;Pocillopora_acuta_HIv2___TS.g8259.t1b
## 3: Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g5308.t2
## 4: Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.g10343.t1;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___RNAseq.g19085.t1;Pocillopora_acuta_HIv2___RNAseq.g23178.t1;Pocillopora_acuta_HIv2___RNAseq.g23210.t1;Pocillopora_acuta_HIv2___RNAseq.g29143.t2;Pocillopora_acuta_HIv2___RNAseq.g5181.t1;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g682.t1;Pocillopora_acuta_HIv2___RNAseq.g805.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g24743.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g5308.t2;Pocillopora_acuta_HIv2___TS.g8258.t1;Pocillopora_acuta_HIv2___TS.g8259.t1b
## 5: Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g28971.t1a;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___RNAseq.g9253.t1;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g30914.t1;Pocillopora_acuta_HIv2___TS.g3265.t1
## Aboral_elim.Significant_genes_symbol
## <char>
## 1: Mucin-like protein;Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Mucin-like protein;Mammalian ependymin-related protein 1 (MERP-1);Mucin-like protein;Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339);Protein jagged-1 (Jagged1) (CD antigen CD339);Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module)
## 2: Hemicentin-1 (Fibulin-6) (FIBL-6);Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B);Protocadherin Fat 3 (FAT tumor suppressor homolog 3);Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5);Collagen alpha-6(VI) chain;Mucin-like protein;Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Chick receptor tyrosine phosphatase alpha) (CRYP alpha) (CRYPalpha);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR);Tissue inhibitor of metalloproteinase;Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Mucin-like protein;Hemicentin-1 (Fibulin-6) (FIBL-6);Collagen alpha-4(VI) chain;Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Melanotransferrin (Membrane-bound transferrin-like protein p97) (MTf) (CD antigen CD228);BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains);Halomucin;Melanotransferrin (Membrane-bound transferrin-like protein p97) (MTf) (CD antigen CD228);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Hemicentin-2;Hemicentin-2;Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta);Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha);Mammalian ependymin-related protein 1 (MERP-1);Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L);Collagen alpha-6(VI) chain;Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2);Fibulin-2 (FIBL-2);Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2];Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein];Mucin-like protein;Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form];Roundabout homolog 2;Zonadhesin;Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2);Spondin-1 (F-spondin);Roundabout homolog 2;Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339);Hemicentin-1 (Fibulin-6) (FIBL-6);Probable N-acetyltransferase camello (EC 2.3.1.-) (Xcml);Roundabout homolog 1;Protein jagged-1 (Jagged1) (CD antigen CD339);Protein turtle homolog B (Immunoglobulin superfamily member 9B);Hemicentin-1 (Fibulin-6) (FIBL-6);Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module);Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein];Collagen alpha-1(VI) chain;Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment];Hemicentin-1 (Fibulin-6) (FIBL-6);Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12);Hemicentin-2;Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Hemicentin-2;Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1)
## 3: Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14)
## 4: Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 3 (FAT tumor suppressor homolog 3);Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-1 (Fibulin-6) (FIBL-6);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Halomucin;Hemicentin-2;Hemicentin-2;Roundabout homolog 2;Roundabout homolog 2;Hemicentin-1 (Fibulin-6) (FIBL-6);Roundabout homolog 1;Protein turtle homolog B (Immunoglobulin superfamily member 9B);Hemicentin-1 (Fibulin-6) (FIBL-6);Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-2;Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Hemicentin-2;Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1)
## 5: Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-1 (Fibulin-6) (FIBL-6);Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form];Hemicentin-1 (Fibulin-6) (FIBL-6);Hemicentin-1 (Fibulin-6) (FIBL-6);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOterms")
BP_go_terms <- BP_Aboral@graph@nodes
genes_by_GO <- genesInTerm(BP_Aboral, BP_go_terms)
cluster_6_9 <- Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == 6|GO.cluster == 9) %>% pull(GO.ID)
showSigOfNodes(BP_Aboral, score(elim_Aboral)[names(score(elim_Aboral)) %in% cluster_6_9], firstSigNodes = length(cluster_6_9), useInfo = 'all')
## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 20
## Number of Edges = 22
##
## $complete.dag
## [1] "A graph with 20 nodes."
cluster_6_9_genes <- unique(unlist(genes_by_GO[cluster_6_9]))
write.csv(cluster_6_9_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Aboral_enrich_BP_adhesion.csv",row.names=FALSE)
cluster_6_9_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_6_9_genes)
cluster_1_5 <- Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == 1|
GO.cluster == 2|
GO.cluster == 3|
GO.cluster == 4|
GO.cluster == 5) %>% pull(GO.ID)
showSigOfNodes(BP_Aboral, score(elim_Aboral)[names(score(elim_Aboral)) %in% cluster_1_5], firstSigNodes = length(cluster_1_5), useInfo = 'all')
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
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## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 309
## Number of Edges = 601
##
## $complete.dag
## [1] "A graph with 309 nodes."
cluster_1_5_genes <- unique(unlist(genes_by_GO[cluster_1_5]))
write.csv(cluster_1_5_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Aboral_enrich_BP_development.csv",row.names=FALSE)
cluster_1_5_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_1_5_genes)
#DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Aboral_enriched_clustered %>% pull(GO.ID)])))
clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
dplyr::select(cluster, Cluster.name)
clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Oral")
clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Aboral")
clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
dplyr::select(-contains("Oral")),
clustered_Aboral_DEGs_enrichedGO %>%
dplyr::select(-contains("Aboral")))
library(ggdendro)
library(patchwork)
dist_mat <- slot(Wang_clusters_wardD2_Oral, "clusters_dist")[["BMA"]]
hc <- hclust(dist_mat, method = "ward.D2")
dend <- as.dendrogram(hc)
dend_data <- ggdendro::dendro_data(dend, type = "rectangle")
dend_labels <- dend_data$labels %>%
mutate(
cluster = str_extract(label, "\\d+"),
Cluster.name = str_replace(label,".*?_.*?_",""),
Cluster.term = str_replace(label,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name))
bar_plot <- clustered_allDEGs_enrichedGO %>%
filter(Tissue == "Oral") %>%
arrange(as.numeric(GO.cluster)) %>%
mutate(Cluster_label = factor(Cluster.name, levels = rev(dend_labels$Cluster.name))) %>%
ggplot(aes(x = Cluster_label)) +
stat_count(width = .8, fill="#FD8D3C", alpha = 0.8) +
coord_flip() +
theme_classic(base_size = 9) +
scale_y_continuous(
breaks = scales::breaks_width(2),
expand = c(0, 0),
limits = c(0, NA)
) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Oral epidermis", y = "Terms in Cluster")
dend_plot <- ggplot() +
geom_segment(
data = dend_data$segments,
aes(x = y, y = x, xend = yend, yend = xend),
linewidth = 0.6,
color = "#2C3E50"
) +
scale_y_reverse(
breaks = seq_along(dend_labels$Cluster.name),
expand = c(0.02, 0.02)
) +
scale_x_reverse(expand = c(0.02, 0)) +
theme_void() +
theme(
plot.margin = margin(t = 30, r = 0, b = 22, l = 5)
)
# Combine plots with better proportions
final <- dend_plot + bar_plot +
plot_layout(widths = c(0.8, 3.5))
Wang_clusters_wardD2_Oral@heatmap$GOclusters_static
ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Dend_Clusters_Oral.png", final, width = 5, height = 6.5, dpi = 300)
library(ggdendro)
dist_mat <- slot(Wang_clusters_wardD2_Aboral, "clusters_dist")[["BMA"]]
hc <- hclust(dist_mat, method = "ward.D2")
dend <- as.dendrogram(hc)
dend_data <- ggdendro::dendro_data(dend, type = "rectangle")
dend_labels <- dend_data$labels %>%
mutate(
cluster = str_extract(label, "\\d+"),
Cluster.name = str_replace(label,".*?_.*?_",""),
Cluster.term = str_replace(label,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name))
bar_plot <- clustered_allDEGs_enrichedGO %>%
filter(Tissue == "Aboral") %>%
arrange(as.numeric(GO.cluster)) %>%
mutate(Cluster_label = factor(Cluster.name, levels = rev(dend_labels$Cluster.name))) %>%
ggplot(aes(x = Cluster_label)) +
stat_count(width = .8, fill="#756BB1", alpha = 0.8) +
coord_flip() +
theme_classic(base_size = 9) +
scale_y_continuous(
breaks = scales::breaks_width(2),
expand = c(0, 0),
limits = c(0, NA)
) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Aboral", y = "Terms in Cluster")
dend_plot <- ggplot() +
geom_segment(
data = dend_data$segments,
aes(x = y, y = x, xend = yend, yend = xend),
linewidth = 0.6,
color = "#2C3E50"
) +
scale_y_reverse(
breaks = seq_along(dend_labels$Cluster.name),
expand = c(0.02, 0.02)
) +
scale_x_reverse(expand = c(0.02, 0)) +
theme_void() +
theme(
plot.margin = margin(t = 30, r = 0, b = 22, l = 5)
)
# Combine plots with better proportions
final <- dend_plot + bar_plot +
plot_layout(widths = c(0.8, 3.5))
Wang_clusters_wardD2_Oral@heatmap$GOclusters_static
ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Dend_Clusters_Aboral.png", final, width = 5, height = 6.5, dpi = 300)
p1 <- clustered_allDEGs_enrichedGO %>%
filter(Tissue == "Aboral") %>%
arrange(as.numeric(GO.cluster)) %>%
mutate(Cluster_label = factor(Cluster.name, levels = rev(unique(Cluster.name)))) %>%
ggplot(aes(x = Cluster_label)) +
stat_count(width = .8, fill="#756BB1", alpha = 0.8) +
coord_flip() +
scale_y_continuous(breaks = scales::breaks_width(2)) +
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Aboral", y = "Terms in Cluster")
p2 <- clustered_allDEGs_enrichedGO %>%
filter(Tissue == "Oral") %>%
arrange(as.numeric(GO.cluster)) %>%
mutate(Cluster_label = factor(Cluster.name, levels = rev(unique(Cluster.name)))) %>%
ggplot(aes(x = Cluster_label)) +
stat_count(width = .8, fill="#FD8D3C", alpha = 0.8) +
coord_flip() +
theme_bw(base_size = 9) +
scale_y_continuous(breaks = scales::breaks_width(2)) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Oral epidermis", y = "Terms in Cluster")
plot <- p1 + p2 +
plot_annotation(
title = "Semantic Similarity Clusters of All Enriched (p < 0.01) BP GO Terms",
theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Clusters.png", plot, width = 7, height = 6.5, dpi = 300)
top_Oral_per_Cluster <- clustered_Oral_DEGs_enrichedGO %>% group_by(GO.cluster) %>% arrange(Oral_elim.pvalue) %>% slice(1) %>% ungroup() %>% dplyr::select(GO.cluster,GO.ID,term) %>% rename("top_sig_GO" = `GO.ID`,"top_sig_term" = `term`)
plotting_oral <- left_join(clustered_Oral_DEGs_enrichedGO,top_Oral_per_Cluster) %>%
arrange(as.numeric(GO.cluster)) %>%
mutate(is_top = GO.ID == top_sig_GO,
pvalue = Oral_elim.pvalue,
term_wrapped = str_wrap(`term`, width = 25),
cluster_label = factor(str_wrap(Cluster.name,
width = 20), levels = unique(str_wrap(Cluster.name,
width = 20)))) %>%
add_count(GO.cluster, name = "n_terms")
## Joining with `by = join_by(GO.cluster)`
top_Aboral_per_Cluster <- clustered_Aboral_DEGs_enrichedGO %>% group_by(GO.cluster) %>% arrange(Aboral_elim.pvalue) %>% slice(1) %>% ungroup() %>% dplyr::select(GO.cluster,GO.ID,term) %>% rename("top_sig_GO" = `GO.ID`,"top_sig_term" = `term`)
plotting_aboral <- left_join(clustered_Aboral_DEGs_enrichedGO,top_Aboral_per_Cluster)%>%
arrange(as.numeric(GO.cluster)) %>%
mutate(is_top = GO.ID == top_sig_GO,
pvalue = Aboral_elim.pvalue,
term_wrapped = str_wrap(`term`, width = 25),
cluster_label = factor(str_wrap(Cluster.name,
width = 20), levels = unique(str_wrap(Cluster.name,
width = 20)))) %>%
add_count(GO.cluster, name = "n_terms")
## Joining with `by = join_by(GO.cluster)`
combined_plotting <- rbind(plotting_oral %>%
dplyr::select(-contains("Oral")),
plotting_aboral %>%
dplyr::select(-contains("Aboral")))
library(ggrepel)
p_oral <- ggplot(plotting_oral,
aes(x = `Oral_elim.-log10_pvalue`,
y = reorder(GO.ID, `Oral_elim.-log10_pvalue`),
color = factor(GO.cluster),
size = `Oral_elim.-log10_pvalue`)) +
geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Oral_elim.-log10_pvalue`)),
alpha = 0.5, linewidth = 0.8) +
geom_point(alpha = 0.8) +
facet_grid(cluster_label ~ .,
scales = "free_y", space = "free_y") +
geom_text_repel(data = plotting_oral %>% filter(is_top),
aes(label = term_wrapped),
size = 2.5,
hjust = 0,
nudge_x = 0.3,
direction = "y",
color = "black",
fontface = "bold",
segment.color = "gray40",
segment.size = 0.3,
box.padding = 0.3,
max.overlaps = 30) +
labs(title = "Oral Epidermis Tissue",
x = "-log10(p-value)",
y = NULL) +
theme_minimal(base_size = 10) +
theme(plot.title = element_text(face = "bold", size = 12),
axis.text.y = element_text(size = 7.5),
strip.text.y = element_text(size = 8.5, angle = 0, hjust = 0, face = "bold"),
legend.position = "none",
panel.spacing = unit(0.5, "lines"),
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank()) +
scale_size_continuous(range = c(2, 5))
p_aboral <- ggplot(plotting_aboral,
aes(x = `Aboral_elim.-log10_pvalue`,
y = reorder(GO.ID, `Aboral_elim.-log10_pvalue`),
color = factor(GO.cluster),
size = `Aboral_elim.-log10_pvalue`)) +
geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Aboral_elim.-log10_pvalue`)),
alpha = 0.5, linewidth = 0.8) +
geom_point(alpha = 0.8) +
facet_grid(cluster_label ~ .,
scales = "free_y", space = "free_y") +
geom_text_repel(data = plotting_aboral %>% filter(is_top),
aes(label = term_wrapped),
size = 2.5,
hjust = 0,
nudge_x = 0.3,
direction = "y",
color = "black",
fontface = "bold",
segment.color = "gray40",
segment.size = 0.3,
box.padding = 0.3,
max.overlaps = 30) +
labs(title = "Aboral Tissue",
x = "-log10(p-value)",
y = NULL) +
theme_minimal(base_size = 10) +
theme(plot.title = element_text(face = "bold", size = 12),
axis.text.y = element_text(size = 7.5),
strip.text.y = element_text(size = 8.5, angle = 0, hjust = 0, face = "bold"),
legend.position = "none",
panel.spacing = unit(0.5, "lines"),
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank()) +
scale_size_continuous(range = c(2, 5))
library(patchwork)
p2 <- p_oral + p_aboral +
plot_annotation(
title = "Enriched GO Terms by Semantic Cluster",
subtitle = "Diamond = most significant term per cluster | Size = significance",
theme = theme(plot.title = element_text(face = "bold", size = 14))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster.pdf", p2, width = 14, height = 16)
p_oral <-ggplot(plotting_oral,
aes(x = `Oral_elim.-log10_pvalue`,
y = reorder(GO.ID, `Oral_elim.-log10_pvalue`),
size = `Oral_elim.-log10_pvalue`)) +
geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Oral_elim.-log10_pvalue`)),
alpha = 0.4, linewidth = 0.6, color = "#FD8D3C") +
geom_point(alpha = 0.7, color = "#FD8D3C") +
facet_grid(cluster_label ~ .,
scales = "free_y", space = "free_y") +
geom_text_repel(data = plotting_oral %>% filter(is_top),
aes(label = str_wrap(term, width = 20)),
size = 2,
hjust = 0,
nudge_x = 0.5,
nudge_y = -0.5,
direction = "y",
color = "black",
segment.color = "gray50",
segment.size = 0.5,
max.overlaps = 30) +
labs(title = "Oral Epidermis Tissue",
x = "-log10(p-value)",
y = NULL) +
theme_minimal(base_size = 11) +
theme(plot.title = element_text(face = "bold", size = 12),
axis.text.y = element_text(size = 7.5),
strip.text.y = element_text(size = 7.5, angle = 0, hjust = 0, face = "bold"),
legend.position = "none",
panel.spacing = unit(.15, "lines"),
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank()) +
scale_size_continuous(range = c(2, 5))
p_aboral <- ggplot(plotting_aboral,
aes(x = `Aboral_elim.-log10_pvalue`,
y = reorder(GO.ID, `Aboral_elim.-log10_pvalue`),
color = factor(GO.cluster),
size = `Aboral_elim.-log10_pvalue`)) +
geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Aboral_elim.-log10_pvalue`)),
alpha = 0.4, linewidth = 0.6, color = "#756BB1") +
geom_point(alpha = 0.7, color = "#756BB1") +
facet_grid(cluster_label ~ .,
scales = "free_y", space = "free_y") +
geom_text_repel(data = plotting_aboral %>% filter(is_top),
aes(label = str_wrap(term, width = 20)),
size = 2,
hjust = 0,
nudge_x = 0.5,
nudge_y = -0.5,
direction = "y",
color = "black",
segment.color = "gray50",
segment.size = 0.5,
max.overlaps = 30) +
labs(title = "Aboral Tissue",
x = "-log10(p-value)",
y = NULL) +
theme_minimal(base_size = 11) +
theme(plot.title = element_text(face = "bold", size = 12),
axis.text.y = element_text(size = 7.5),
strip.text.y = element_text(size = 7.5, angle = 0, hjust = 0, face = "bold"),
legend.position = "none",
panel.spacing = unit(.15, "lines"),
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank()) +
scale_size_continuous(range = c(2, 5))
p2 <- p_oral + p_aboral +
plot_annotation(
title = "Tissue-specific GO term enrichment patterns",
theme = theme(plot.title = element_text(face = "bold", size = 14))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster_colored.pdf", p2, width = 14, height = 16)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster_colored2.png", p2, width = 8, height = 12, dpi = 300)
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
dplyr::select(Cluster.name, Tissue) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Tissue=="Oral"),
Aboral_terms = sum(Tissue=="Aboral"),
.groups = "drop"
) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)
BP_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Oral_elim = c("BP_Oral", "elim_Oral"),
Aboral_elim = c("BP_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
## BP_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 67
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## Nontrivial_nodes: 4469
## Aboral_elim
## BP_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 118
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## Nontrivial_nodes: 3092
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 185 GO terms of 2 conditions.
## Oral_elim : 67 terms
## Aboral_elim : 118 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
BP_Results,
"../output_RNA/differential_expression/semantic-enrichment/DE_05.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
## BP_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 67
## feasible_genes: 9496
## feasible_genes_significant: 712
## genes_nodeSize: 5
## Nontrivial_nodes: 4469
## Aboral_elim
## BP_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## nodes_number: 6675
## edges_number: 14047
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 6675
## GO_significant: 118
## feasible_genes: 9496
## feasible_genes_significant: 332
## genes_nodeSize: 5
## Nontrivial_nodes: 3092
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 185 GO terms of 2 conditions.
## Oral_elim : 67 terms
## Aboral_elim : 118 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 4
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2,
"../output_RNA/differential_expression/semantic-enrichment/DE_05_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOclusters")
clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
dplyr::select(cluster, Cluster.name)
cluster_map
## cluster Cluster.name
## 1 1 Cluster 1: neuron projection development
## 2 2 Cluster 2: cell differentiation
## 3 3 Cluster 3: anatomical structure development
## 4 4 Cluster 4: anatomical structure development
## 5 5 Cluster 5: multicellular organism development
## 6 6 Cluster 6: sensory organ development
## 7 7 Cluster 7: anatomical structure development
## 8 8 Cluster 8: transport
## 9 9 Cluster 9: transport
## 10 10 Cluster 10: external encapsulating structure organization
## 11 11 Cluster 11: biological_process
## 12 12 Cluster 12: regulation of cell adhesion
## 13 13 Cluster 13: cell adhesion
## 14 14 Cluster 14: secretion by cell
## 15 15 Cluster 15: cell-cell signaling
## 16 16 Cluster 16: regulation of biological process
## 17 17 Cluster 17: metabolic process
## 18 18 Cluster 18: metabolic process
## 19 19 Cluster 19: multicellular organismal process
## 20 20 Cluster 20: nervous system process
## 21 21 Cluster 21: response to stimulus
## 22 22 Cluster 22: immune effector process
## 23 23 Cluster 23: biological_process
cluster_map_fixed <- cluster_map #%>%
# mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
# Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
# Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
# Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
# Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
# Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
# Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
# Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
# )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))
write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/DE_05_clusters_named.csv")
library(DT)
# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
dplyr::select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
mutate(
# Clean cluster names
#Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Oral_terms),
Aboral_terms = sum(Aboral_terms),
.groups = "drop"
) %>%
filter(Oral_terms + Aboral_terms > 0) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
datatable(cluster_data,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12, hjust=0)
) +
scale_y_continuous(labels = abs) +
scale_x_discrete(position = "top") +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
#coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "right",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
p
ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)
# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)
CC_Oral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="CC",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 1542 GO terms found. )
##
## Build GO DAG topology ..........
## ( 1765 GO terms and 2911 relations. )
##
## Annotating nodes ...............
## ( 10052 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
CC_Oral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 611 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 12: 1 nodes to be scored (0 eliminated genes)
##
## Level 11: 21 nodes to be scored (0 eliminated genes)
##
## Level 10: 60 nodes to be scored (0 eliminated genes)
##
## Level 9: 85 nodes to be scored (24 eliminated genes)
##
## Level 8: 95 nodes to be scored (30 eliminated genes)
##
## Level 7: 97 nodes to be scored (61 eliminated genes)
##
## Level 6: 96 nodes to be scored (342 eliminated genes)
##
## Level 5: 67 nodes to be scored (601 eliminated genes)
##
## Level 4: 43 nodes to be scored (601 eliminated genes)
##
## Level 3: 43 nodes to be scored (2500 eliminated genes)
##
## Level 2: 2 nodes to be scored (3424 eliminated genes)
##
## Level 1: 1 nodes to be scored (3424 eliminated genes)
CC_Results <- ViSEAGO::merge_enrich_terms(
Input = list( Oral_elim = c("CC_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
## CC_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 17
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## Nontrivial_nodes: 611
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 17 GO terms of 1 conditions.
## Oral_elim : 17 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
CC_Results,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
## CC_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 17
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## Nontrivial_nodes: 611
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 17 GO terms of 1 conditions.
## Oral_elim : 17 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Oral,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Oral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Oral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOclusters")
# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)
CC_Aboral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="CC",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 1542 GO terms found. )
##
## Build GO DAG topology ..........
## ( 1765 GO terms and 2911 relations. )
##
## Annotating nodes ...............
## ( 10052 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
CC_Aboral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 351 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 11: 6 nodes to be scored (0 eliminated genes)
##
## Level 10: 26 nodes to be scored (0 eliminated genes)
##
## Level 9: 40 nodes to be scored (0 eliminated genes)
##
## Level 8: 51 nodes to be scored (7 eliminated genes)
##
## Level 7: 57 nodes to be scored (19 eliminated genes)
##
## Level 6: 58 nodes to be scored (431 eliminated genes)
##
## Level 5: 49 nodes to be scored (850 eliminated genes)
##
## Level 4: 29 nodes to be scored (1101 eliminated genes)
##
## Level 3: 32 nodes to be scored (3129 eliminated genes)
##
## Level 2: 2 nodes to be scored (3481 eliminated genes)
##
## Level 1: 1 nodes to be scored (3481 eliminated genes)
CC_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Aboral_elim = c("CC_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
## Aboral_elim
## CC_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 23
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## Nontrivial_nodes: 351
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 23 GO terms of 1 conditions.
## Aboral_elim : 23 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
CC_Results,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Aboral_elim
## CC_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 23
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## Nontrivial_nodes: 351
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 23 GO terms of 1 conditions.
## Aboral_elim : 23 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Aboral,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Aboral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Aboral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOclusters")
clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) #%>%
#mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
#dplyr::select(cluster, Cluster.name)
clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Oral")
clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) #%>%
#mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
#dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Aboral")
clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
dplyr::select(-contains("Oral")),
clustered_Aboral_DEGs_enrichedGO %>%
dplyr::select(-contains("Aboral")))
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
dplyr::select(Cluster.name, Tissue) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Tissue=="Oral"),
Aboral_terms = sum(Tissue=="Aboral"),
.groups = "drop"
) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)
CC_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Oral_elim = c("CC_Oral", "elim_Oral"),
Aboral_elim = c("CC_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
## CC_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 17
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## Nontrivial_nodes: 611
## Aboral_elim
## CC_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 23
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## Nontrivial_nodes: 351
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 38 GO terms of 2 conditions.
## Oral_elim : 17 terms
## Aboral_elim : 23 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
CC_Results,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
## CC_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 17
## feasible_genes: 10052
## feasible_genes_significant: 762
## genes_nodeSize: 5
## Nontrivial_nodes: 611
## Aboral_elim
## CC_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## nodes_number: 967
## edges_number: 1615
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 967
## GO_significant: 23
## feasible_genes: 10052
## feasible_genes_significant: 364
## genes_nodeSize: 5
## Nontrivial_nodes: 351
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 38 GO terms of 2 conditions.
## Oral_elim : 17 terms
## Aboral_elim : 23 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 4
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2,
"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOclusters")
clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
select(cluster, Cluster.name)
cluster_map
## cluster Cluster.name
## 1 1 Cluster 1: extracellular matrix
## 2 2 Cluster 2: cellular anatomical structure
## 3 3 Cluster 3: intracellular organelle
## 4 4 Cluster 4: cellular_component
## 5 5 Cluster 5: cell junction
cluster_map_fixed <- cluster_map #%>%
# mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
# Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
# Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
# Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
# Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
# Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
# Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
# Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
# )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))
write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_clusters_named.csv")
library(DT)
# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
mutate(
# Clean cluster names
#Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Oral_terms),
Aboral_terms = sum(Aboral_terms),
.groups = "drop"
) %>%
filter(Oral_terms + Aboral_terms > 0) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
datatable(cluster_data,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12, hjust=0)
) +
scale_y_continuous(labels = abs) +
scale_x_discrete(position = "top") +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
#coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "right",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
p
ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)
# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)
MF_Oral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="MF",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 3360 GO terms found. )
##
## Build GO DAG topology ..........
## ( 3929 GO terms and 5138 relations. )
##
## Annotating nodes ...............
## ( 9061 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
MF_Oral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 949 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 12: 2 nodes to be scored (0 eliminated genes)
##
## Level 11: 8 nodes to be scored (0 eliminated genes)
##
## Level 10: 15 nodes to be scored (9 eliminated genes)
##
## Level 9: 40 nodes to be scored (35 eliminated genes)
##
## Level 8: 82 nodes to be scored (62 eliminated genes)
##
## Level 7: 132 nodes to be scored (563 eliminated genes)
##
## Level 6: 198 nodes to be scored (1099 eliminated genes)
##
## Level 5: 217 nodes to be scored (1184 eliminated genes)
##
## Level 4: 184 nodes to be scored (1485 eliminated genes)
##
## Level 3: 52 nodes to be scored (1485 eliminated genes)
##
## Level 2: 18 nodes to be scored (1562 eliminated genes)
##
## Level 1: 1 nodes to be scored (1605 eliminated genes)
MF_Results <- ViSEAGO::merge_enrich_terms(
Input = list( Oral_elim = c("MF_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
## MF_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 31
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## Nontrivial_nodes: 949
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 31 GO terms of 1 conditions.
## Oral_elim : 31 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
MF_Results,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
## MF_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 31
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## Nontrivial_nodes: 949
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## - enrich GOs (in at least one list): 31 GO terms of 1 conditions.
## Oral_elim : 31 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Oral,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Oral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Oral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Oral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Oral,
"GOclusters")
# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)
MF_Aboral <- ViSEAGO::create_topGOdata(
geneSel=selection,
allGenes=background,
gene2GO=myGENE2GO_Pacuta,
ont="MF",
nodeSize=5
)
##
## Building most specific GOs .....
## ( 3360 GO terms found. )
##
## Build GO DAG topology ..........
## ( 3929 GO terms and 5138 relations. )
##
## Annotating nodes ...............
## ( 9061 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
MF_Aboral,
algorithm ="elim",
statistic = "fisher"
)
##
## -- Elim Algorithm --
##
## the algorithm is scoring 577 nontrivial nodes
## parameters:
## test statistic: fisher
## cutOff: 0.01
##
## Level 11: 3 nodes to be scored (0 eliminated genes)
##
## Level 10: 5 nodes to be scored (0 eliminated genes)
##
## Level 9: 17 nodes to be scored (0 eliminated genes)
##
## Level 8: 40 nodes to be scored (30 eliminated genes)
##
## Level 7: 78 nodes to be scored (142 eliminated genes)
##
## Level 6: 119 nodes to be scored (704 eliminated genes)
##
## Level 5: 136 nodes to be scored (957 eliminated genes)
##
## Level 4: 121 nodes to be scored (1045 eliminated genes)
##
## Level 3: 41 nodes to be scored (1102 eliminated genes)
##
## Level 2: 16 nodes to be scored (1571 eliminated genes)
##
## Level 1: 1 nodes to be scored (1571 eliminated genes)
MF_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Aboral_elim = c("MF_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
## Aboral_elim
## MF_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 28
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## Nontrivial_nodes: 577
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 28 GO terms of 1 conditions.
## Aboral_elim : 28 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
MF_Results,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Aboral_elim
## MF_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 28
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## Nontrivial_nodes: 577
## - enrichment pvalue cutoff:
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 28 GO terms of 1 conditions.
## Aboral_elim : 28 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 2
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2_Aboral,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2_Aboral,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2_Aboral,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2_Aboral,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2_Aboral,
"GOclusters")
clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) #%>%
#mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
#dplyr::select(cluster, Cluster.name)
clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Oral")
clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
Cluster.term = str_replace(cluster_full,"^\\d+_",""),
Cluster.term = str_replace(Cluster.term,"_.*$","")
) #%>%
#mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
#dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
mutate(Tissue="Aboral")
clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
dplyr::select(-contains("Oral")),
clustered_Aboral_DEGs_enrichedGO %>%
dplyr::select(-contains("Aboral")))
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
dplyr::select(Cluster.name, Tissue) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Tissue=="Oral"),
Aboral_terms = sum(Tissue=="Aboral"),
.groups = "drop"
) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)
MF_Results <- ViSEAGO::merge_enrich_terms(
Input = list(Oral_elim = c("MF_Oral", "elim_Oral"),
Aboral_elim = c("MF_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns
# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
## MF_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 31
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## Nontrivial_nodes: 949
## Aboral_elim
## MF_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 28
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## Nontrivial_nodes: 577
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 58 GO terms of 2 conditions.
## Oral_elim : 31 terms
## Aboral_elim : 28 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
MF_Results,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05.tsv"
)
# initialize
myGOs<-ViSEAGO::build_GO_SS(
gene2GO=myGENE2GO_Pacuta,
enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
myGOs,
distance=c("Wang")
)
myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
## MF_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 826
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Oral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 31
## feasible_genes: 9061
## feasible_genes_significant: 700
## genes_nodeSize: 5
## Nontrivial_nodes: 949
## Aboral_elim
## MF_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## available_genes: 10637
## available_genes_significant: 376
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## nodes_number: 1460
## edges_number: 1914
## elim_Aboral
## description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
## test_name: fisher p<0.01
## algorithm_name: elim
## GO_scored: 1460
## GO_significant: 28
## feasible_genes: 9061
## feasible_genes_significant: 329
## genes_nodeSize: 5
## Nontrivial_nodes: 577
## - enrichment pvalue cutoff:
## Oral_elim : 0.01
## Aboral_elim : 0.01
## - enrich GOs (in at least one list): 58 GO terms of 2 conditions.
## Oral_elim : 31 terms
## Aboral_elim : 28 terms
## - terms distances: Wang
# display MDSplot
ViSEAGO::MDSplot(myGOs,
"GOterms")
# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
myGOs,
showIC = TRUE,
showGOlabels = TRUE,
GO.tree = list(
tree = list(distance = "Wang", aggreg.method = "ward.D2"),
cut = list(
dynamic = list(
pamStage = TRUE,
pamRespectsDendro = TRUE,
deepSplit = 2,
minClusterSize = 4
)
)
),
samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
Wang_clusters_wardD2,
"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_cluster_heatmap_Wang_wardD2.tsv"
)
# display colored MDSplot
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOterms")
# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
Wang_clusters_wardD2,
distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
Wang_clusters_wardD2,
"GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
Wang_clusters_wardD2,
tree=list(
distance="BMA",
aggreg.method="ward.D2"
)
)
## 'magick' package is suggested to install to give better rasterization.
##
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
Wang_clusters_wardD2,
"GOclusters")
clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)
cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>%
mutate(
cluster = str_extract(cluster_full, "\\d+"),
Cluster.name = str_replace(cluster_full,".*?_.*?_","")
) %>%
mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
select(cluster, Cluster.name)
cluster_map
## cluster Cluster.name
## 1 1 Cluster 1: transmembrane transporter activity
## 2 2 Cluster 2: monoatomic ion channel activity
## 3 3 Cluster 3: protein binding
## 4 4 Cluster 4: carbohydrate derivative binding
## 5 5 Cluster 5: molecular_function
## 6 6 Cluster 6: binding
## 7 7 Cluster 7: signaling receptor activity
## 8 8 Cluster 8: hydrolase activity
## 9 9 Cluster 9: catalytic activity
cluster_map_fixed <- cluster_map #%>%
# mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
# Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
# Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
# Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
# Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
# Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
# Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
# Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
# Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
# )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))
write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_clusters_named.csv")
library(DT)
# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
library(dplyr)
library(tidyr)
library(ggplot2)
# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
mutate(
# Clean cluster names
#Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
) %>%
group_by(Cluster.name) %>%
summarise(
Oral_terms = sum(Oral_terms),
Aboral_terms = sum(Aboral_terms),
.groups = "drop"
) %>%
filter(Oral_terms + Aboral_terms > 0) %>%
mutate(
deviation = Aboral_terms - Oral_terms,
Oral_terms = -Oral_terms # Make negative for bidirectional plot
) %>%
pivot_longer(cols = c("Oral_terms", "Aboral_terms"),
names_to = "Tissue", values_to = "n_terms") %>%
mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))
datatable(cluster_data,
options = list(
pageLength = 10, # rows per page
scrollX = TRUE, # horizontal scroll if wide
scrollY = "400px" # vertical scroll
))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
distinct(Cluster.name, deviation) %>%
arrange(deviation)
oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "bottom",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12),
axis.text.y = element_text(size = 12, hjust=0)
) +
scale_y_continuous(labels = abs) +
scale_x_discrete(position = "top") +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)
print(p)
# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
geom_col(width = 0.7, alpha = 0.8) +
geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
geom_vline(xintercept = c(oral_to_equal, equal_to_aboral),
color = "grey60", linetype = "dashed", linewidth = 0.6) +
scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
#coord_flip() +
theme_minimal() +
theme(
panel.grid.major.y = element_blank(),
panel.grid.minor = element_blank(),
legend.position = "right",
legend.title = element_text(face = "bold"),
axis.title = element_text(face = "bold"),
axis.text = element_text(color = "black"),
axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
axis.text.y = element_text(size = 12)
) +
scale_y_continuous(labels = abs) +
labs(
x = "Gene clusters",
y = "Number of enriched GO terms",
title = "Tissue-specific GO term enrichment patterns",
subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
)
p
ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)
BP_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral.tsv") %>% mutate(ontology="BP")
MF_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral.tsv") %>% mutate(ontology="MF")
CC_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral.tsv") %>% mutate(ontology="CC")
BP_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral.tsv") %>% mutate(ontology="BP")
MF_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral.tsv") %>% mutate(ontology="MF")
CC_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral.tsv") %>% mutate(ontology="CC")
oral_combined <- rbind(BP_GOs_Oral,MF_GOs_Oral,CC_GOs_Oral) %>%
rename_with(~ str_replace_all(.x, "Oral_elim|\\.", "")) %>% mutate(Tissue="Oral")
aboral_combined <- rbind(BP_GOs_Aboral,MF_GOs_Aboral,CC_GOs_Aboral) %>%
rename_with(~ str_replace_all(.x, "Aboral_elim|\\.", "")) %>% mutate(Tissue="Aboral")
tissues_combined <- rbind(oral_combined,aboral_combined) %>%
mutate(freq = as.numeric(str_remove(genes_frequency,pattern="\\%.*")))
aboral_cols <- c(
BP = "#756BB1",
CC = "#9E9AC8",
MF = "#CBC9E2"
)
oral_cols <- c(
BP = "#FD8D3C",
CC = "#FDAE6B",
MF = "#FDD0A2"
)
top10_pval <- tissues_combined %>%
filter(ontology=="BP") %>%
group_by(Tissue,ontology) %>%
slice_max(order_by = desc(pvalue), n = 30, with_ties = FALSE) %>%
arrange(Tissue, ontology, log10_pvalue) %>%
ungroup() %>%
mutate(term=str_wrap(`term`, width = 40))
p1 <- top10_pval %>% filter(Tissue == "Aboral") %>%
mutate(term = fct_reorder(term, log10_pvalue)) %>%
ggplot(aes(x = term, y = log10_pvalue, fill = ontology)) +
geom_col(width = .8, fill="#756BB1", alpha = 0.8) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
# scale_fill_manual(values = aboral_cols) +
theme_bw(base_size = 9) +
#scale_y_continuous(limits = c(0, 35), expand = expansion(mult = c(0, 0.05)))+
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Aboral", y = "-log10(p-value)")
p2 <- top10_pval %>% filter(Tissue == "Oral") %>%
mutate(term = fct_reorder(term, log10_pvalue)) %>%
ggplot(aes(x = term, y = log10_pvalue, fill = ontology)) +
geom_col(width = .8, fill="#FD8D3C", alpha = 0.8) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
# scale_fill_manual(values = oral_cols) +
# scale_y_continuous(limits = c(0, 35), expand = expansion(mult = c(0, 0.05)))+
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Oral epidermis", y = "-log10(p-value)")
plot <- p1 + p2 +
plot_annotation(
title = "Top 30 enriched GO terms by p-value",
theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/Top_BP_30.png", plot, width = 7, height = 6.5, dpi = 300)
top10_freq <- tissues_combined %>% group_by(Tissue,ontology) %>%
slice_max(order_by = freq, n = 10, with_ties = FALSE) %>%
arrange(Tissue, ontology, log10_pvalue) %>%
ungroup() %>%
mutate(term=str_wrap(`term`, width = 40))
p1 <- top10_freq %>% filter(Tissue == "Aboral") %>%
mutate(term = fct_reorder(term, freq)) %>%
ggplot(aes(x = term, y = freq, fill = ontology)) +
geom_col(width = 0.7, alpha = 0.85) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
scale_fill_manual(values = aboral_cols) +
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Aboral", y = "% DEGs with GO term of\nall genes with GO term")
p2 <- top10_freq %>% filter(Tissue == "Oral") %>%
mutate(term = fct_reorder(term, freq)) %>%
ggplot(aes(x = term, y = freq, fill = ontology)) +
geom_col(width = 0.7, alpha = 0.85) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
scale_fill_manual(values = oral_cols) +
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "none",
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Oral epidermis", y = "% DEGs with GO term of\nall genes with GO term")
plot <- p1 + p2 +
plot_annotation(
title = "Top 10 enriched GO terms by frequency in tissue DEGs",
theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_Onts_frq.png", plot, width = 7, height = 6.5, dpi = 300)
# Create gradient scales for each tissue
aboral_gradient <- colorRampPalette(c("#CBC9E2", "#756BB1"))(100)
oral_gradient <- colorRampPalette(c("#FDD0A2", "#FD8D3C"))(100)
p1 <- top10_freq %>% filter(Tissue == "Aboral") %>%
mutate(term = fct_reorder(term, freq)) %>%
ggplot(aes(x = term, y = freq, fill = log10_pvalue)) +
geom_col(width = 0.7, alpha = 0.85) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
scale_fill_gradientn(colors = aboral_gradient, name = "-log10(p-value)") +
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7, color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "right",
legend.key.height = unit(0.8, "cm"),
legend.key.width = unit(0.3, "cm"),
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Aboral", y = "% DEGs with GO term of\nall genes with GO term")
p2 <- top10_freq %>% filter(Tissue == "Oral") %>%
mutate(term = fct_reorder(term, freq)) %>%
ggplot(aes(x = term, y = freq, fill = log10_pvalue)) +
geom_col(width = 0.7, alpha = 0.85) +
facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
coord_flip() +
scale_fill_gradientn(colors = oral_gradient, name = "-log10(p-value)") +
theme_bw(base_size = 9) +
theme(
panel.grid.major.y = element_blank(),
panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
axis.title.y = element_blank(),
axis.text.y = element_text(size = 7, lineheight = 0.7, color = "black"),
strip.text = element_text(face = "bold", size = 9),
strip.background = element_rect(fill = "white", color = "black"),
legend.position = "right",
legend.key.height = unit(0.8, "cm"),
legend.key.width = unit(0.3, "cm"),
plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
panel.spacing.y = unit(0.2, "lines")
) + labs(subtitle = "Oral epidermis", y = "% DEGs with GO term of\nall genes with GO term")
plot <- p1 + p2 +
plot_annotation(
title = "Top 10 enriched GO terms by frequency in tissue DEGs",
theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_Onts_freq_pval.png", plot, width = 8, height = 6.5, dpi = 300)