Gene Ontology Analysis analysis of LCM RNA Data

Managing Packages Using Renv

To run this code in my project using the renv environment, run the following lines of code

install.packages("renv") #install the package on the new computer (may not be necessary if renv bootstraps itself as expected)
renv::restore() #reinstall all the package versions in the renv lockfile

Load packages

library("ViSEAGO")
## 
## Warning: replacing previous import 'data.table::set' by 'dendextend::set' when
## loading 'ViSEAGO'
## Warning: replacing previous import 'dendextend::cutree' by 'stats::cutree' when
## loading 'ViSEAGO'
## Warning: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when
## loading 'ViSEAGO'
require("topGO")
## Loading required package: topGO
## Loading required package: BiocGenerics
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## Attaching package: 'generics'
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##     order, paste, pmax, pmax.int, pmin, pmin.int, Position, rank,
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## Welcome to Bioconductor
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##     Vignettes contain introductory material; view with
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## Loading required package: GO.db
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## Loading required package: SparseM
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## groupGOTerms:    GOBPTerm, GOMFTerm, GOCCTerm environments built.
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## Attaching package: 'topGO'
## The following object is masked from 'package:IRanges':
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require("tidyverse")
## Loading required package: tidyverse
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
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## ✔ forcats   1.0.1     ✔ stringr   1.6.0
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## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
#BiocManager::install("GO.db")

sessionInfo() #provides list of loaded packages and version of R.
## R version 4.5.2 (2025-10-31)
## Platform: aarch64-apple-darwin20
## Running under: macOS Tahoe 26.0.1
## 
## Matrix products: default
## BLAS:   /System/Library/Frameworks/Accelerate.framework/Versions/A/Frameworks/vecLib.framework/Versions/A/libBLAS.dylib 
## LAPACK: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib;  LAPACK version 3.12.1
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## 
## time zone: America/New_York
## tzcode source: internal
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## attached base packages:
## [1] stats4    stats     graphics  grDevices datasets  utils     methods  
## [8] base     
## 
## other attached packages:
##  [1] lubridate_1.9.4      forcats_1.0.1        stringr_1.6.0       
##  [4] dplyr_1.1.4          purrr_1.2.0          readr_2.1.5         
##  [7] tidyr_1.3.1          tibble_3.3.0         ggplot2_4.0.0       
## [10] tidyverse_2.0.0      topGO_2.62.0         SparseM_1.84-2      
## [13] GO.db_3.22.0         AnnotationDbi_1.72.0 IRanges_2.44.0      
## [16] S4Vectors_0.48.0     Biobase_2.70.0       graph_1.88.0        
## [19] BiocGenerics_0.56.0  generics_0.1.4       ViSEAGO_1.24.0      
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Description of pipeline

I am going to perform functional enrichment of GO terms using ViSEAGO.

I am following this vignette: http://bioconductor.unipi.it/packages/devel/bioc/vignettes/ViSEAGO/inst/doc/ViSEAGO.html.

Load in reference files and differential expression data

In the next chunk I am loading in my DESeq data. These results are ordered by adjusted p-value. As a reminder, negative LFC = higher in Oral tissue, and positive LFC = higher in Aboral tissue.

#load in DESeq results
DESeq <- read.csv("../output_RNA/differential_expression/DESeq_results.csv", header = TRUE) %>% dplyr::rename("query" ="X")

#make dataframes of just differentially expressed genes for each LFC direction - filtering a little more stringent, abs(LFC) >2
DE_05_Aboral <- DESeq %>% filter(padj < 0.05 & log2FoldChange < -1)
DE_05_OralEpi <- DESeq %>% filter(padj < 0.05& log2FoldChange > 1)

#load in annotation data 
annot_tab <- read.delim("../references/annotation/protein-GO.tsv") %>% dplyr::rename(GOs = GeneOntologyIDs)

#filter annotation data for just expressed genes with GO annotations
annot_tab <- annot_tab %>% filter(query %in% DESeq$query) 

annot_tab$GOs <- gsub("; ", ";", annot_tab$GOs)
annot_tab$GOs[annot_tab$GOs==""] <- NA
annot_tab <- annot_tab %>% filter(!is.na(GOs))

nrow(annot_tab)
## [1] 10638
nrow(annot_tab)/nrow(DESeq)
## [1] 0.7354812

10638/14464 genes in our dataset have GO information in this file. That is 74%.

sum(annot_tab$query %in% DE_05_Aboral$query)
## [1] 376
sum(annot_tab$query %in% DE_05_Aboral$query)/nrow(DE_05_Aboral)
## [1] 0.6811594
sum(annot_tab$query %in% DE_05_OralEpi$query)
## [1] 826
sum(annot_tab$query %in% DE_05_OralEpi$query)/nrow(DE_05_OralEpi)
## [1] 0.6592179

379/558 genes that are significantly upregulated in the Aboral tissue have annotation information. That is 68% of the genes.

796/1216 genes that are significantly upregulated in the Oral Epidermis tissue have annotation information. That is 71% of the genes.

Create custom GO annotation file for ViSEAGO

##Get a list of GO Terms for all genes
annots <- annot_tab %>% dplyr::select(query,GOs,ProteinNames) %>% dplyr::rename("GO.terms" = GOs)

# format into the format required by ViSEAGO for custom mappings
Custom_GOs <- annots %>%
  # Separate GO terms into individual rows
  separate_rows(GO.terms, sep = ";") %>%
  # Add necessary columns
  mutate(
    taxid = "pacuta",
    gene_symbol = ProteinNames,
    evidence = "SwissProt"
  ) %>%
  # Rename columns
  dplyr::rename(
    gene_id = query,
    GOID = GO.terms
  ) %>%
  dplyr::select(taxid, gene_id, gene_symbol, GOID, evidence)

Custom_GOs_valid <- Custom_GOs %>% filter(GOID %in% keys(GO.db))

write.table(Custom_GOs_valid, "../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt",row.names = FALSE, sep = "\t", quote = FALSE,col.names=TRUE)

length(unique(Custom_GOs$gene_id))
## [1] 10638
length(unique(Custom_GOs_valid$gene_id))
## [1] 10637

We seem to have lost one gene when filtering for valid GO terms, so I need to account for that below.

load the file into ViSEAGO

Custom_Pacuta <- ViSEAGO::Custom2GO("../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt")
## 'select()' returned 1:1 mapping between keys and columns
myGENE2GO_Pacuta <- ViSEAGO::annotate(
    id="pacuta",
    Custom_Pacuta
)

Create gene lists for enrichment

selection <- DESeq %>% filter(query %in% Custom_GOs_valid$gene_id) %>% 
                       mutate(DE_05_Aboral = ifelse(query %in% DE_05_Aboral$query, 1,0)) %>%
                       mutate(DE_05_Oral = ifelse(query %in% DE_05_OralEpi$query, 1,0)) %>%
                       mutate(expressed = 1)

selection_Aboral <- selection %>% pull(DE_05_Aboral) %>% as.factor()
names(selection_Aboral) <- selection %>% pull(query)

selection_Oral <- selection %>% pull(DE_05_Oral) %>% as.factor()
names(selection_Oral) <- selection %>% pull(query)

expressed <- selection %>% pull(expressed) %>% as.factor()
names(expressed) <- selection %>% pull(query)

BP

Oral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)

BP_Oral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="BP",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 8797 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 12496 GO terms and 27095 relations. )
## 
## Annotating nodes ...............
##  ( 9496 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
    BP_Oral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 4469 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 19:  2 nodes to be scored    (0 eliminated genes)
## 
##   Level 18:  2 nodes to be scored    (0 eliminated genes)
## 
##   Level 17:  8 nodes to be scored    (0 eliminated genes)
## 
##   Level 16:  18 nodes to be scored   (0 eliminated genes)
## 
##   Level 15:  39 nodes to be scored   (0 eliminated genes)
## 
##   Level 14:  42 nodes to be scored   (61 eliminated genes)
## 
##   Level 13:  70 nodes to be scored   (68 eliminated genes)
## 
##   Level 12:  158 nodes to be scored  (96 eliminated genes)
## 
##   Level 11:  312 nodes to be scored  (115 eliminated genes)
## 
##   Level 10:  469 nodes to be scored  (382 eliminated genes)
## 
##   Level 9:   592 nodes to be scored  (540 eliminated genes)
## 
##   Level 8:   646 nodes to be scored  (699 eliminated genes)
## 
##   Level 7:   689 nodes to be scored  (979 eliminated genes)
## 
##   Level 6:   638 nodes to be scored  (1207 eliminated genes)
## 
##   Level 5:   444 nodes to be scored  (1477 eliminated genes)
## 
##   Level 4:   244 nodes to be scored  (1582 eliminated genes)
## 
##   Level 3:   79 nodes to be scored   (1626 eliminated genes)
## 
##   Level 2:   16 nodes to be scored   (1626 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (1626 eliminated genes)
BP_Results <- ViSEAGO::merge_enrich_terms(
    Input = list( Oral_elim = c("BP_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
##  Oral_elim
##       BP_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 67
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         Nontrivial_nodes: 4469 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 67 GO terms of 1 conditions.
##         Oral_elim : 67 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
    BP_Results,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01
  • enrich GOs (in at least one list): Oral_elim : 67 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
##       BP_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 67
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         Nontrivial_nodes: 4469 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 67 GO terms of 1 conditions.
##         Oral_elim : 67 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## ℹ The deprecated feature was likely used in the dendextend package.
##   Please report the issue at <https://github.com/talgalili/dendextend/issues>.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOterms")
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    height=1000,
    width=700,
    "GOterms", file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral_cluster_heatmap_Wang_wardD2.png")
## quartz_off_screen 
##                 2
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Oral,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Oral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Oral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOclusters")
DE_05_SwissProt <- read.csv("../output_RNA/differential_expression/DE_05_SwissProt_annotation.csv")
DESeq_SwissProt <- read.csv("../output_RNA/differential_expression/DESeq_SwissProt_annotation.csv")

Oral_enriched_clustered <- Wang_clusters_wardD2_Oral@enrich_GOs@data

top_cluster <- Oral_enriched_clustered %>% arrange(Oral_elim.pvalue) %>% head(1) %>% pull(GO.cluster)

Oral_enriched_clustered %>% dplyr::filter(GO.cluster == top_cluster)
##     GO.cluster    IC      GO.ID
##         <char> <num>     <char>
##  1:          7  9.45 GO:0006068
##  2:          7  6.37 GO:0009308
##  3:          7  9.11 GO:0009812
##  4:          7  8.86 GO:0051923
##  5:          7  9.11 GO:0050427
##  6:          7  8.11 GO:0009208
##  7:          7  6.36 GO:0017148
##  8:          7  8.11 GO:0016114
##  9:          7  6.43 GO:1901607
## 10:          7  9.27 GO:0046314
##                                                         term
##                                                       <char>
##  1:                                ethanol catabolic process
##  2:                                  amine metabolic process
##  3:                              flavonoid metabolic process
##  4:                                                sulfation
##  5:  3'-phosphoadenosine 5'-phosphosulfate metabolic process
##  6: pyrimidine ribonucleoside triphosphate metabolic process
##  7:                       negative regulation of translation
##  8:                           terpenoid biosynthetic process
##  9:                    alpha-amino acid biosynthetic process
## 10:                     phosphocreatine biosynthetic process
##                                                                                                                                                                                                                                                                                             definition
##                                                                                                                                                                                                                                                                                                 <char>
##  1:                                                                                                                           The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
##  2: The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
##  3:                                                                                               The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins.
##  4:                                                                                                                                                                                                                                                     The addition of a sulfate group to a molecule.
##  5:                                                                          The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
##  6:                                                                                               The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.
##  7:                                                                                                    Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
##  8:                                                                                                                                The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
##  9:                                                                                                                                                                                                                                                                                               <NA>
## 10:                                                                                                                        The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase.
##     Oral_elim.genes_frequency Oral_elim.pvalue Oral_elim.-log10_pvalue
##                        <char>            <num>                   <num>
##  1:                 60% (3/5)     3.742425e-03                    2.43
##  2:           17.188% (11/64)     7.446749e-03                    2.13
##  3:             71.429% (5/7)     4.321628e-05                    4.36
##  4:             44.444% (4/9)     2.909709e-03                    2.54
##  5:             85.714% (6/7)     1.141908e-06                    5.94
##  6:            33.333% (4/12)     9.533181e-03                    2.02
##  7:           15.476% (13/84)     9.327027e-03                    2.03
##  8:            33.333% (4/12)     9.533181e-03                    2.02
##  9:           17.105% (13/76)     3.948213e-03                    2.40
## 10:             66.667% (4/6)     4.159939e-04                    3.38
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Oral_elim.Significant_genes
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    <char>
##  1:                                                                                                                                                                                                                                                                                                                                                                                                                            Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
##  2:                                                                               Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g11785.t1;Pocillopora_acuta_HIv2___RNAseq.g15141.t1;Pocillopora_acuta_HIv2___RNAseq.g20712.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g21957.t1;Pocillopora_acuta_HIv2___RNAseq.g22120.t1;Pocillopora_acuta_HIv2___RNAseq.g26474.t1a;Pocillopora_acuta_HIv2___RNAseq.g27978.t1;Pocillopora_acuta_HIv2___RNAseq.g28398.t1;Pocillopora_acuta_HIv2___TS.g805.t1a
##  3:                                                                                                                                                                                                                                                                                                                                         Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g12481.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9089.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
##  4:                                                                                                                                                                                                                                                                                                                                                                                   Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g9090.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
##  5:                                                                                                                                                                                                                                                                                               Pocillopora_acuta_HIv2___RNAseq.10969_t;Pocillopora_acuta_HIv2___RNAseq.g12481.t1;Pocillopora_acuta_HIv2___RNAseq.g21538.t1;Pocillopora_acuta_HIv2___RNAseq.g25759.t1;Pocillopora_acuta_HIv2___RNAseq.g9089.t1;Pocillopora_acuta_HIv2___RNAseq.g9093.t1
##  6:                                                                                                                                                                                                                                                                                                                                                                                    Pocillopora_acuta_HIv2___RNAseq.g11840.t1;Pocillopora_acuta_HIv2___RNAseq.g21884.t1;Pocillopora_acuta_HIv2___RNAseq.g3911.t1;Pocillopora_acuta_HIv2___TS.g19040.t1
##  7: Pocillopora_acuta_HIv2___RNAseq.g10158.t1;Pocillopora_acuta_HIv2___RNAseq.g1103.t1;Pocillopora_acuta_HIv2___RNAseq.g16905.t1;Pocillopora_acuta_HIv2___RNAseq.g1800.t1;Pocillopora_acuta_HIv2___RNAseq.g18756.t2;Pocillopora_acuta_HIv2___RNAseq.g219.t1;Pocillopora_acuta_HIv2___RNAseq.g24051.t1;Pocillopora_acuta_HIv2___RNAseq.g24787.t1;Pocillopora_acuta_HIv2___RNAseq.g24800.t1;Pocillopora_acuta_HIv2___RNAseq.g28169.t1;Pocillopora_acuta_HIv2___RNAseq.g4938.t1;Pocillopora_acuta_HIv2___RNAseq.g763.t1;Pocillopora_acuta_HIv2___TS.g4312.t1
##  8:                                                                                                                                                                                                                                                                                                                                                                                   Pocillopora_acuta_HIv2___RNAseq.g28425.t1;Pocillopora_acuta_HIv2___RNAseq.g610.t1;Pocillopora_acuta_HIv2___RNAseq.g9824.t1;Pocillopora_acuta_HIv2___RNAseq.g9825.t1
##  9:        Pocillopora_acuta_HIv2___RNAseq.g10854.t2;Pocillopora_acuta_HIv2___RNAseq.g12417.t1;Pocillopora_acuta_HIv2___RNAseq.g1504.t1;Pocillopora_acuta_HIv2___RNAseq.g16699.t1;Pocillopora_acuta_HIv2___RNAseq.g19367.t1;Pocillopora_acuta_HIv2___RNAseq.g23634.t1;Pocillopora_acuta_HIv2___RNAseq.g27978.t1;Pocillopora_acuta_HIv2___RNAseq.g28641.t1;Pocillopora_acuta_HIv2___RNAseq.g7498.t1;Pocillopora_acuta_HIv2___TS.g19253.t1;Pocillopora_acuta_HIv2___TS.g3401.t1;Pocillopora_acuta_HIv2___TS.g6241.t1e;Pocillopora_acuta_HIv2___TS.g7609.t1b
## 10:                                                                                                                                                                                                                                                                                                                                                                                Pocillopora_acuta_HIv2___RNAseq.g15574.t1;Pocillopora_acuta_HIv2___RNAseq.g15577.t1;Pocillopora_acuta_HIv2___RNAseq.g15584.t1;Pocillopora_acuta_HIv2___RNAseq.g2258.t1
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Oral_elim.Significant_genes_symbol
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              <char>
##  1:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
##  2:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain];Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3 (EC 3.2.2.n1) (Protein LONELY GUY 3);DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X);DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X);Ornithine decarboxylase (ODC) (EC 4.1.1.17);Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4);Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein);Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
##  3:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
##  4:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.1) (Sulfotransferase K2);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
##  5:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase);Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPS synthetase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)];Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1);Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
##  6:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1);Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42);Nucleoside diphosphate kinase homolog 5 (3'-5' exonuclease NME5) (EC 3.1.-.-);GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3)
##  7: Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2);Mitochondrial assembly of ribosomal large subunit protein 1;E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97);Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2);Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22);Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
##  8:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3);Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1);Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H);Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
##  9:                                                                                  Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase);Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2);L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase);Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain];Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53);Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53);Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4);Protein TabA;Branched-chain-amino-acid aminotransferase (EC 2.6.1.42);Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)];Asparagine synthetase domain-containing protein 1;Glutamate dehydrogenase (GDH) (EC 1.4.1.3) (NAD(P)H-utilizing glutamate dehydrogenase);Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)
## 10:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Creatine kinase, testis isozyme (EC 2.7.3.2);Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK);Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK);Arginine kinase (AK) (EC 2.7.3.3)
BP_go_terms <- BP_Oral@graph@nodes
genes_by_GO <- genesInTerm(BP_Oral, BP_go_terms)


cluster_8 <- Oral_enriched_clustered %>% dplyr::filter(GO.cluster == 8) %>% pull(GO.ID)
cluster_8_genes <- unique(unlist(genes_by_GO[cluster_8]))

write.csv(cluster_8_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Oral_enrich_BP_Sensory.csv",row.names=FALSE)

DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Oral_enriched_clustered %>% pull(GO.ID)])))
##        X                                      query     baseMean log2FoldChange
## 1      3  Pocillopora_acuta_HIv2___RNAseq.g27038.t1   1882.71412     -16.920243
## 2      4   Pocillopora_acuta_HIv2___RNAseq.g2165.t1   1608.73918     -16.674695
## 3      5      Pocillopora_acuta_HIv2___TS.g18104.t1   1967.60901     -16.931827
## 4      9   Pocillopora_acuta_HIv2___RNAseq.g3832.t1   4681.36282     -12.478513
## 5     12  Pocillopora_acuta_HIv2___RNAseq.g14253.t1   1084.62611     -16.044514
## 6     25      Pocillopora_acuta_HIv2___TS.g18100.t1   8027.26641     -10.532544
## 7     43  Pocillopora_acuta_HIv2___RNAseq.g25759.t1    808.98861      14.778851
## 8     44    Pocillopora_acuta_HIv2___RNAseq.30415_t    893.17636      15.012329
## 9     48       Pocillopora_acuta_HIv2___TS.g4983.t1    908.84789     -15.756839
## 10    58   Pocillopora_acuta_HIv2___RNAseq.g1102.t1    682.41009      14.602337
## 11    68    Pocillopora_acuta_HIv2___RNAseq.22067_t    613.52482      14.107731
## 12    72  Pocillopora_acuta_HIv2___RNAseq.g11810.t1    633.24487      14.247818
## 13    76  Pocillopora_acuta_HIv2___RNAseq.g13400.t1    533.22375      14.107082
## 14    81  Pocillopora_acuta_HIv2___RNAseq.g17085.t1    542.20189      14.118241
## 15    85      Pocillopora_acuta_HIv2___TS.g22105.t1    586.45387      14.289758
## 16    97   Pocillopora_acuta_HIv2___RNAseq.g2813.t4   1653.40829      12.582278
## 17   104 Pocillopora_acuta_HIv2___RNAseq.g28971.t1a   1603.22813     -12.463466
## 18   105    Pocillopora_acuta_HIv2___RNAseq.g829.t1   2530.87773     -14.321435
## 19   108  Pocillopora_acuta_HIv2___RNAseq.g19042.t1    916.62147      11.472047
## 20   120       Pocillopora_acuta_HIv2___TS.g1253.t1    528.00964      13.646918
## 21   121     Pocillopora_acuta_HIv2___RNAseq.5883_t    372.24588      13.488005
## 22   124  Pocillopora_acuta_HIv2___RNAseq.g26586.t1    381.24714      13.667940
## 23   129  Pocillopora_acuta_HIv2___RNAseq.g10339.t1    392.04943      13.516463
## 24   137  Pocillopora_acuta_HIv2___RNAseq.g14366.t1    250.60207     -13.471894
## 25   140   Pocillopora_acuta_HIv2___RNAseq.g2995.t1   1190.36858      12.390397
## 26   141  Pocillopora_acuta_HIv2___RNAseq.g16699.t1    328.73878      13.386611
## 27   149  Pocillopora_acuta_HIv2___RNAseq.g17965.t1    339.14551      13.087614
## 28   152   Pocillopora_acuta_HIv2___RNAseq.g9466.t1   3868.10738       8.985654
## 29   153  Pocillopora_acuta_HIv2___RNAseq.g14817.t1    308.27793      13.131510
## 30   158  Pocillopora_acuta_HIv2___RNAseq.g28815.t1    448.84744      13.365085
## 31   178  Pocillopora_acuta_HIv2___RNAseq.g13056.t1    308.24224      13.021437
## 32   181  Pocillopora_acuta_HIv2___RNAseq.g24787.t1    282.08747      13.036363
## 33   190  Pocillopora_acuta_HIv2___RNAseq.g14871.t1    360.81188       7.613995
## 34   198   Pocillopora_acuta_HIv2___RNAseq.g6468.t1    936.24266       9.534804
## 35   206  Pocillopora_acuta_HIv2___RNAseq.g21265.t1    347.29673      12.936159
## 36   207  Pocillopora_acuta_HIv2___RNAseq.g28641.t1   1378.32284      12.260241
## 37   215      Pocillopora_acuta_HIv2___TS.g12304.t1 114980.25585      -5.890846
## 38   218   Pocillopora_acuta_HIv2___RNAseq.g9089.t1    319.56517      10.090590
## 39   219       Pocillopora_acuta_HIv2___TS.g4109.t3    319.81897       9.823642
## 40   224  Pocillopora_acuta_HIv2___RNAseq.g3837.t1a    978.54197      12.038054
## 41   230      Pocillopora_acuta_HIv2___TS.g15672.t1    261.98313      10.203702
## 42   247       Pocillopora_acuta_HIv2___TS.g6682.t1   2368.98413       9.996086
## 43   249  Pocillopora_acuta_HIv2___RNAseq.g19043.t1    733.86103      11.220600
## 44   258   Pocillopora_acuta_HIv2___RNAseq.g7241.t1    474.33368      10.238737
## 45   267 Pocillopora_acuta_HIv2___RNAseq.g14013.t1a    937.51551      11.885729
## 46   268  Pocillopora_acuta_HIv2___RNAseq.g28741.t1    193.97963      12.383304
## 47   271  Pocillopora_acuta_HIv2___RNAseq.g26057.t1    470.87061      -8.416140
## 48   275      Pocillopora_acuta_HIv2___TS.g23175.t1    218.46048      12.410051
## 49   286  Pocillopora_acuta_HIv2___RNAseq.g15097.t1    414.09800       8.776136
## 50   289  Pocillopora_acuta_HIv2___RNAseq.g30398.t1   1296.99952      12.153863
## 51   291    Pocillopora_acuta_HIv2___RNAseq.g710.t1    707.19309      11.544615
## 52   298       Pocillopora_acuta_HIv2___TS.g2952.t1    159.85802      12.121735
## 53   304       Pocillopora_acuta_HIv2___TS.g6681.t1   1375.40247      11.972496
## 54   308      Pocillopora_acuta_HIv2___TS.g19999.t1   1687.93854       9.056586
## 55   309   Pocillopora_acuta_HIv2___RNAseq.g9825.t1   4116.90824       6.816459
## 56   314  Pocillopora_acuta_HIv2___RNAseq.g25241.t1    922.27330       8.361412
## 57   321 Pocillopora_acuta_HIv2___RNAseq.g21572.t1a    170.49483      12.130633
## 58   322   Pocillopora_acuta_HIv2___RNAseq.g8217.t1    745.87324       8.570046
## 59   324 Pocillopora_acuta_HIv2___RNAseq.g30624.t2b   1458.34038       8.335606
## 60   330   Pocillopora_acuta_HIv2___RNAseq.g7628.t1    523.53570      10.355061
## 61   334   Pocillopora_acuta_HIv2___RNAseq.g3854.t1    848.16600      11.703962
## 62   335   Pocillopora_acuta_HIv2___RNAseq.g6379.t1    156.42142      12.081733
## 63   337    Pocillopora_acuta_HIv2___RNAseq.18284_t    232.50656      12.473251
## 64   347       Pocillopora_acuta_HIv2___TS.g4312.t1    138.82358      11.871756
## 65   350  Pocillopora_acuta_HIv2___RNAseq.g22644.t1   1223.76429      11.542686
## 66   352    Pocillopora_acuta_HIv2___RNAseq.10969_t    147.54454      11.959623
## 67   358  Pocillopora_acuta_HIv2___RNAseq.g11840.t1    608.42043      11.086288
## 68   364   Pocillopora_acuta_HIv2___RNAseq.g1200.t1    410.45697      10.657138
## 69   373  Pocillopora_acuta_HIv2___RNAseq.g26118.t1    743.19811      11.473173
## 70   376  Pocillopora_acuta_HIv2___RNAseq.g25689.t1    180.09581      11.823436
## 71   381      Pocillopora_acuta_HIv2___TS.g12848.t1    975.41006      -6.943136
## 72   382    Pocillopora_acuta_HIv2___RNAseq.g993.t1   2110.82545       4.512598
## 73   384      Pocillopora_acuta_HIv2___TS.g21128.t1    169.89170      12.046767
## 74   385  Pocillopora_acuta_HIv2___RNAseq.g17089.t1    175.08674      11.887646
## 75   392  Pocillopora_acuta_HIv2___RNAseq.g13403.t1    858.51979      11.443478
## 76   393  Pocillopora_acuta_HIv2___RNAseq.g29275.t1    140.77522      11.757686
## 77   397  Pocillopora_acuta_HIv2___RNAseq.g15159.t1    303.96922       9.722651
## 78   398      Pocillopora_acuta_HIv2___TS.g27807.t1    791.76609       1.092373
## 79   400   Pocillopora_acuta_HIv2___RNAseq.g6366.t1    214.07730      12.178680
## 80   401       Pocillopora_acuta_HIv2___TS.g9752.t3    593.72773      11.322083
## 81   405       Pocillopora_acuta_HIv2___TS.g5171.t1    295.19827       9.501609
## 82   406      Pocillopora_acuta_HIv2___TS.g19097.t2    208.31701      12.300252
## 83   409   Pocillopora_acuta_HIv2___RNAseq.g7553.t1    178.60661      12.051832
## 84   415  Pocillopora_acuta_HIv2___RNAseq.g14869.t1    277.22441      12.748483
## 85   417  Pocillopora_acuta_HIv2___RNAseq.g30992.t1    924.62680      11.281143
## 86   420      Pocillopora_acuta_HIv2___RNAseq.673_t   1356.35628      -7.994764
## 87   422  Pocillopora_acuta_HIv2___RNAseq.g13533.t1    410.70976      10.410129
## 88   423  Pocillopora_acuta_HIv2___RNAseq.g18966.t1    158.81942      11.903979
## 89   428   Pocillopora_acuta_HIv2___RNAseq.g9811.t1    280.13599       9.945244
## 90   436  Pocillopora_acuta_HIv2___RNAseq.g26672.t1    145.88874      11.591255
## 91   439  Pocillopora_acuta_HIv2___RNAseq.g15141.t1    178.38230      12.004217
## 92   441  Pocillopora_acuta_HIv2___RNAseq.g27413.t1    680.37380      10.783595
## 93   442   Pocillopora_acuta_HIv2___RNAseq.g9381.t1    374.19623      -9.829149
## 94   444  Pocillopora_acuta_HIv2___RNAseq.g21884.t1    182.22550      11.817460
## 95   448    Pocillopora_acuta_HIv2___RNAseq.g994.t1   1097.04685       6.071051
## 96   450       Pocillopora_acuta_HIv2___TS.g1768.t1    504.47765      10.807546
## 97   455      Pocillopora_acuta_HIv2___TS.g16482.t1    595.10274      10.203581
## 98   474  Pocillopora_acuta_HIv2___RNAseq.g29670.t2    209.21923      11.982910
## 99   475   Pocillopora_acuta_HIv2___RNAseq.g7243.t1    147.91088      11.671206
## 100  476  Pocillopora_acuta_HIv2___RNAseq.g14744.t1    298.31599       9.848812
## 101  480   Pocillopora_acuta_HIv2___RNAseq.g3580.t1    975.16996       6.836213
## 102  481  Pocillopora_acuta_HIv2___RNAseq.g21538.t1    130.20924      11.694403
## 103  484  Pocillopora_acuta_HIv2___RNAseq.g18756.t2    130.62969      11.513978
## 104  485      Pocillopora_acuta_HIv2___TS.g18947.t1  17030.60621       3.376772
## 105  497  Pocillopora_acuta_HIv2___RNAseq.g28213.t1   2856.05827       7.512964
## 106  500  Pocillopora_acuta_HIv2___RNAseq.g11785.t1    185.50046      11.898849
## 107  504  Pocillopora_acuta_HIv2___RNAseq.g22296.t1    560.58781       5.513365
## 108  510    Pocillopora_acuta_HIv2___RNAseq.25384_t    433.72434      10.357234
## 109  514  Pocillopora_acuta_HIv2___RNAseq.g17559.t1    552.61162       6.897249
## 110  520  Pocillopora_acuta_HIv2___RNAseq.g13552.t1    463.70755      10.099140
## 111  525   Pocillopora_acuta_HIv2___RNAseq.g4938.t1    145.73746      11.622478
## 112  529  Pocillopora_acuta_HIv2___RNAseq.g19152.t1    364.25795       9.906597
## 113  557  Pocillopora_acuta_HIv2___RNAseq.g16285.t1   1143.46418      -6.261819
## 114  561  Pocillopora_acuta_HIv2___RNAseq.g19392.t1    343.30899      10.113259
## 115  565       Pocillopora_acuta_HIv2___TS.g3401.t1     92.69481      11.155815
## 116  572   Pocillopora_acuta_HIv2___RNAseq.g1504.t1    415.22385       6.330544
## 117  578   Pocillopora_acuta_HIv2___RNAseq.g1103.t1    548.10380       9.746741
## 118  590    Pocillopora_acuta_HIv2___RNAseq.10010_t    685.38221       4.843496
## 119  594  Pocillopora_acuta_HIv2___RNAseq.g28466.t1    431.13150       1.151369
## 120  597  Pocillopora_acuta_HIv2___RNAseq.g14615.t1    376.11563       6.538480
## 121  603     Pocillopora_acuta_HIv2___RNAseq.2533_t   3992.17100      -5.969005
## 122  610  Pocillopora_acuta_HIv2___RNAseq.g20846.t1    519.71004       8.666834
## 123  611   Pocillopora_acuta_HIv2___RNAseq.g7881.t1    255.10125       9.392847
## 124  612  Pocillopora_acuta_HIv2___RNAseq.g17622.t1    186.93916       9.201601
## 125  613  Pocillopora_acuta_HIv2___RNAseq.g10343.t1    180.95669      -9.474330
## 126  621   Pocillopora_acuta_HIv2___RNAseq.g9093.t1   4489.42848       1.000144
## 127  630   Pocillopora_acuta_HIv2___RNAseq.g7452.t1     80.68499      10.705902
## 128  633  Pocillopora_acuta_HIv2___RNAseq.g12898.t1    423.47847       9.629377
## 129  636  Pocillopora_acuta_HIv2___RNAseq.g17047.t1     87.49373       8.600616
## 130  641  Pocillopora_acuta_HIv2___RNAseq.g28742.t1    119.78645      11.364056
## 131  644  Pocillopora_acuta_HIv2___RNAseq.g26058.t1    292.93529       7.819730
## 132  649  Pocillopora_acuta_HIv2___RNAseq.g21527.t1    228.33529       9.496081
## 133  653   Pocillopora_acuta_HIv2___RNAseq.g3723.t1    703.78472       1.047436
## 134  655   Pocillopora_acuta_HIv2___RNAseq.g8821.t1  15967.80052      -2.993156
## 135  656   Pocillopora_acuta_HIv2___RNAseq.g3911.t1    242.52436       9.346711
## 136  658   Pocillopora_acuta_HIv2___RNAseq.g7217.t1    250.82485       9.135807
## 137  660  Pocillopora_acuta_HIv2___RNAseq.g25869.t1    286.42014       9.437992
## 138  676  Pocillopora_acuta_HIv2___RNAseq.g24800.t1    329.33944       5.802163
## 139  678  Pocillopora_acuta_HIv2___RNAseq.g21637.t1     81.12761       7.989478
## 140  687  Pocillopora_acuta_HIv2___RNAseq.g11580.t1    148.09617      11.112030
## 141  692  Pocillopora_acuta_HIv2___RNAseq.g26341.t1    452.74167       7.144176
## 142  695      Pocillopora_acuta_HIv2___TS.g14960.t2    557.92530       1.201364
## 143  701  Pocillopora_acuta_HIv2___RNAseq.g28226.t2    750.90343      -5.444603
## 144  705    Pocillopora_acuta_HIv2___RNAseq.g219.t1    168.31613       5.110258
## 145  706  Pocillopora_acuta_HIv2___RNAseq.g17090.t1   5915.60173       5.828618
## 146  708   Pocillopora_acuta_HIv2___RNAseq.g4469.t1    556.81444       5.319428
## 147  719  Pocillopora_acuta_HIv2___RNAseq.g11547.t1     85.20667      10.755320
## 148  724   Pocillopora_acuta_HIv2___RNAseq.g7498.t1    335.77112       1.058537
## 149  727  Pocillopora_acuta_HIv2___RNAseq.g14060.t1    664.04192       1.147794
## 150  729   Pocillopora_acuta_HIv2___RNAseq.g9824.t1   3467.23763       5.617379
## 151  730       Pocillopora_acuta_HIv2___TS.g805.t1a   1602.31304       1.463693
## 152  731  Pocillopora_acuta_HIv2___RNAseq.g13784.t1    113.99787      -8.550451
## 153  735   Pocillopora_acuta_HIv2___RNAseq.g6559.t1    684.89771      -5.820409
## 154  736  Pocillopora_acuta_HIv2___RNAseq.g23181.t1    528.62485       8.941508
## 155  737   Pocillopora_acuta_HIv2___RNAseq.g9090.t1    169.71014       7.193983
## 156  741      Pocillopora_acuta_HIv2___TS.g28908.t1    330.89213       5.675045
## 157  751  Pocillopora_acuta_HIv2___RNAseq.g13970.t2    372.90592       8.583003
## 158  759      Pocillopora_acuta_HIv2___TS.g28111.t1    363.67741       4.386285
## 159  764   Pocillopora_acuta_HIv2___RNAseq.g7215.t1    116.66835       8.016421
## 160  777  Pocillopora_acuta_HIv2___RNAseq.g28425.t1    213.88314       1.615589
## 161  779   Pocillopora_acuta_HIv2___RNAseq.g898.t1b    482.16296       1.046302
## 162  784   Pocillopora_acuta_HIv2___RNAseq.g7625.t1     56.76602      10.073298
## 163  787  Pocillopora_acuta_HIv2___RNAseq.g12287.t1    160.93966       6.410081
## 164  788      Pocillopora_acuta_HIv2___TS.g19040.t1     79.63900      10.641704
## 165  791  Pocillopora_acuta_HIv2___RNAseq.g11548.t1    128.49271       8.040465
## 166  793       Pocillopora_acuta_HIv2___TS.g9513.t1  11530.17861       3.956219
## 167  796    Pocillopora_acuta_HIv2___RNAseq.g701.t1    129.22288       8.272886
## 168  798    Pocillopora_acuta_HIv2___RNAseq.g702.t1     58.20862      10.008556
## 169  806  Pocillopora_acuta_HIv2___RNAseq.g25708.t1    635.87560       1.268391
## 170  807  Pocillopora_acuta_HIv2___RNAseq.g28169.t1    119.66311       5.405765
## 171  822   Pocillopora_acuta_HIv2___RNAseq.g1217.t1    278.80456       4.868494
## 172  829       Pocillopora_acuta_HIv2___TS.g4466.t2    150.34533       7.921053
## 173  831      Pocillopora_acuta_HIv2___TS.g15668.t1    900.81727       4.845006
## 174  852      Pocillopora_acuta_HIv2___RNAseq.665_t    411.69240       1.072318
## 175  857      Pocillopora_acuta_HIv2___TS.g19253.t1    100.14541       7.285554
## 176  863  Pocillopora_acuta_HIv2___RNAseq.g13060.t1   7815.93678       5.228550
## 177  869 Pocillopora_acuta_HIv2___RNAseq.g26270.t1a   2780.75439      -4.737152
## 178  879  Pocillopora_acuta_HIv2___RNAseq.g2263.t1b   1355.99328       5.069863
## 179  880   Pocillopora_acuta_HIv2___RNAseq.g6094.t2    191.37227       7.837953
## 180  884  Pocillopora_acuta_HIv2___RNAseq.g16905.t1    276.17952       6.049125
## 181  902      Pocillopora_acuta_HIv2___TS.g14552.t1   1206.96542       4.269826
## 182  923    Pocillopora_acuta_HIv2___RNAseq.18788_t     50.28419       9.519608
## 183  927  Pocillopora_acuta_HIv2___RNAseq.g14489.t1    220.23037       1.018078
## 184  932   Pocillopora_acuta_HIv2___RNAseq.g5755.t1    258.53696       4.803600
## 185  935   Pocillopora_acuta_HIv2___RNAseq.g5181.t1    400.62919      -4.670589
## 186  937  Pocillopora_acuta_HIv2___RNAseq.g12292.t1     44.21671       9.326537
## 187  950  Pocillopora_acuta_HIv2___RNAseq.g19870.t1    593.27663       2.952445
## 188  951      Pocillopora_acuta_HIv2___TS.g16484.t1    154.45462       3.781709
## 189  954  Pocillopora_acuta_HIv2___RNAseq.g28398.t1    252.97119       6.656385
## 190  956  Pocillopora_acuta_HIv2___RNAseq.g28816.t1    119.34549       4.446159
## 191  964  Pocillopora_acuta_HIv2___RNAseq.g22964.t1   1389.15836       4.739693
## 192  975   Pocillopora_acuta_HIv2___RNAseq.g8520.t1     75.45588       9.702060
## 193  976    Pocillopora_acuta_HIv2___RNAseq.g565.t1   2194.07018      -4.487797
## 194  999  Pocillopora_acuta_HIv2___RNAseq.g12481.t1     34.11161       9.083646
## 195 1001   Pocillopora_acuta_HIv2___RNAseq.g7833.t1    316.00830       1.382589
## 196 1002        Pocillopora_acuta_HIv2___TS.g186.t2   1622.80560      -2.273752
## 197 1004  Pocillopora_acuta_HIv2___RNAseq.g27673.t1   3815.81336       4.308949
## 198 1026    Pocillopora_acuta_HIv2___RNAseq.g775.t1    686.76073      -4.039075
## 199 1040   Pocillopora_acuta_HIv2___RNAseq.g1838.t1     74.01631       6.181958
## 200 1043  Pocillopora_acuta_HIv2___RNAseq.g19452.t1    173.48522       3.937401
## 201 1053        Pocillopora_acuta_HIv2___TS.g305.t1    340.35457       1.166762
## 202 1063   Pocillopora_acuta_HIv2___RNAseq.g4959.t1   1090.45858       2.876880
## 203 1070  Pocillopora_acuta_HIv2___RNAseq.g30377.t2    463.55834      -2.018560
## 204 1076  Pocillopora_acuta_HIv2___RNAseq.g10158.t1   1479.44457       3.318070
## 205 1080  Pocillopora_acuta_HIv2___RNAseq.g4031.t1c    874.90040       1.493733
## 206 1095    Pocillopora_acuta_HIv2___RNAseq.g610.t1    104.25392       1.029751
## 207 1101   Pocillopora_acuta_HIv2___RNAseq.g8670.t1   5976.07967      -3.146682
## 208 1105   Pocillopora_acuta_HIv2___RNAseq.g7248.t1     34.88719       8.582062
## 209 1106  Pocillopora_acuta_HIv2___RNAseq.g26700.t1   3564.82512       2.876361
## 210 1110  Pocillopora_acuta_HIv2___RNAseq.g10777.t1    187.45508       1.190663
## 211 1113   Pocillopora_acuta_HIv2___RNAseq.g5711.t2    347.77617       1.461322
## 212 1119  Pocillopora_acuta_HIv2___RNAseq.g23414.t1    258.40788       3.285151
## 213 1134  Pocillopora_acuta_HIv2___RNAseq.g27609.t1    647.19584       3.462086
## 214 1136    Pocillopora_acuta_HIv2___RNAseq.g614.t1   2049.65501      -3.365559
## 215 1152  Pocillopora_acuta_HIv2___RNAseq.g11214.t1    286.00349       2.696417
## 216 1165  Pocillopora_acuta_HIv2___RNAseq.g15290.t1   2980.34602      -3.796695
## 217 1184    Pocillopora_acuta_HIv2___RNAseq.g243.t1     69.70758       3.238932
## 218 1185  Pocillopora_acuta_HIv2___RNAseq.g12374.t1   3131.42127      -3.728374
## 219 1196  Pocillopora_acuta_HIv2___RNAseq.g23588.t1   1186.73431      -2.434761
## 220 1197  Pocillopora_acuta_HIv2___RNAseq.g28270.t1    299.79990       6.448127
## 221 1199    Pocillopora_acuta_HIv2___RNAseq.g802.t1    510.71943      -3.277146
## 222 1205  Pocillopora_acuta_HIv2___RNAseq.g11589.t1     43.62564       4.419798
## 223 1218  Pocillopora_acuta_HIv2___RNAseq.g12286.t1    225.88497       2.888361
## 224 1221  Pocillopora_acuta_HIv2___RNAseq.g20688.t1   4154.69322       1.944529
## 225 1229   Pocillopora_acuta_HIv2___RNAseq.g4073.t1    505.37799      -2.615899
## 226 1231  Pocillopora_acuta_HIv2___RNAseq.g19367.t1   1104.62737       2.693734
## 227 1232  Pocillopora_acuta_HIv2___RNAseq.g27039.t1   5675.97668      -3.277390
## 228 1244  Pocillopora_acuta_HIv2___RNAseq.g10855.t1    430.37509      -2.846891
## 229 1247  Pocillopora_acuta_HIv2___RNAseq.g20712.t1    452.79544       1.055231
## 230 1249   Pocillopora_acuta_HIv2___RNAseq.g2519.t1   2787.36449       2.199689
## 231 1259  Pocillopora_acuta_HIv2___RNAseq.g22120.t1     26.03583       5.290266
## 232 1261  Pocillopora_acuta_HIv2___RNAseq.g11345.t1   1518.01744       1.165722
## 233 1264    Pocillopora_acuta_HIv2___RNAseq.g805.t1    877.33388      -3.112606
## 234 1265   Pocillopora_acuta_HIv2___RNAseq.g3016.t1   1002.55051       3.107115
## 235 1284   Pocillopora_acuta_HIv2___RNAseq.g8148.t1   2320.13158      -3.333232
## 236 1286  Pocillopora_acuta_HIv2___RNAseq.g11960.t1    114.82770       2.876785
## 237 1293   Pocillopora_acuta_HIv2___RNAseq.g6836.t1     25.21477       7.696885
## 238 1306    Pocillopora_acuta_HIv2___RNAseq.10263_t   3036.53536      -2.497755
## 239 1309       Pocillopora_acuta_HIv2___TS.g8131.t1    198.18930      -1.041336
## 240 1310   Pocillopora_acuta_HIv2___RNAseq.g2273.t1   3039.32436       1.876100
## 241 1319   Pocillopora_acuta_HIv2___RNAseq.g1315.t1    470.97654      -1.824525
## 242 1328  Pocillopora_acuta_HIv2___RNAseq.g15577.t1    225.94643       2.035708
## 243 1329    Pocillopora_acuta_HIv2___RNAseq.g763.t1     97.73460       2.980931
## 244 1333     Pocillopora_acuta_HIv2___TS.g18622.t1b   4572.98017      -3.302312
## 245 1347   Pocillopora_acuta_HIv2___RNAseq.g9589.t2   2396.75767      -2.895430
## 246 1348   Pocillopora_acuta_HIv2___RNAseq.g9334.t1   6238.79877       1.866734
## 247 1359 Pocillopora_acuta_HIv2___RNAseq.g30994.t1a   1228.79079       2.535507
## 248 1362 Pocillopora_acuta_HIv2___RNAseq.g25248.t1a    397.79734       1.391294
## 249 1368   Pocillopora_acuta_HIv2___RNAseq.g8890.t1     29.98779       1.504507
## 250 1370  Pocillopora_acuta_HIv2___RNAseq.g16957.t1    448.04585       1.016486
## 251 1390    Pocillopora_acuta_HIv2___RNAseq.g682.t1   2333.47091      -2.728555
## 252 1394   Pocillopora_acuta_HIv2___RNAseq.g2827.t1   2015.11451       1.328546
## 253 1395   Pocillopora_acuta_HIv2___RNAseq.g4028.t1   1336.23794       1.899472
## 254 1398  Pocillopora_acuta_HIv2___RNAseq.g27337.t1    784.20968      -2.891088
## 255 1409  Pocillopora_acuta_HIv2___RNAseq.g15584.t1   1587.90695       2.261018
## 256 1410   Pocillopora_acuta_HIv2___RNAseq.g1800.t1    103.53093       1.687979
## 257 1415  Pocillopora_acuta_HIv2___RNAseq.g12306.t1    727.11393      -1.100091
## 258 1418      Pocillopora_acuta_HIv2___TS.g7609.t1b    211.46026       2.356463
## 259 1421  Pocillopora_acuta_HIv2___RNAseq.g3142.t1a    165.53566       1.047763
## 260 1425  Pocillopora_acuta_HIv2___RNAseq.g21518.t1   1281.13794      -1.514914
## 261 1427      Pocillopora_acuta_HIv2___TS.g24662.t1     21.01564       3.227213
## 262 1429  Pocillopora_acuta_HIv2___RNAseq.g28818.t1   1048.18106      -1.830578
## 263 1450  Pocillopora_acuta_HIv2___RNAseq.g12088.t1    135.02634      -2.418641
## 264 1461  Pocillopora_acuta_HIv2___RNAseq.g13672.t1    133.71337       2.592185
## 265 1467   Pocillopora_acuta_HIv2___RNAseq.g3840.t1    611.16656       2.323684
## 266 1477      Pocillopora_acuta_HIv2___TS.g5006.t1b    819.97102      -2.004219
## 267 1491  Pocillopora_acuta_HIv2___RNAseq.g24761.t1   3524.03906       2.714320
## 268 1495  Pocillopora_acuta_HIv2___RNAseq.g16948.t1   2941.74849       2.117515
## 269 1497      Pocillopora_acuta_HIv2___TS.g15590.t1    303.51020      -3.159254
## 270 1499   Pocillopora_acuta_HIv2___RNAseq.g8004.t1    599.10553       2.046808
## 271 1502  Pocillopora_acuta_HIv2___RNAseq.g21957.t1    266.02201       2.547544
## 272 1507    Pocillopora_acuta_HIv2___RNAseq.26564_t   6653.23248       2.298868
## 273 1508   Pocillopora_acuta_HIv2___RNAseq.g3523.t1   2327.91634      -1.838200
## 274 1522  Pocillopora_acuta_HIv2___RNAseq.g29143.t2   4185.18788      -1.484992
## 275 1523  Pocillopora_acuta_HIv2___RNAseq.g12410.t1   6201.14924       1.904486
## 276 1553   Pocillopora_acuta_HIv2___RNAseq.g2258.t1   1914.01504       1.739834
## 277 1556      Pocillopora_acuta_HIv2___TS.g21857.t1    165.62274       1.977094
## 278 1562  Pocillopora_acuta_HIv2___RNAseq.g28252.t1   5381.46974      -2.184909
## 279 1565  Pocillopora_acuta_HIv2___RNAseq.g30836.t1    893.51261       1.157324
## 280 1566    Pocillopora_acuta_HIv2___RNAseq.g942.t1   2094.46904      -1.094885
## 281 1583  Pocillopora_acuta_HIv2___RNAseq.g23634.t1   3369.65393       2.134002
## 282 1590  Pocillopora_acuta_HIv2___RNAseq.g10854.t2   1353.64991       1.103598
## 283 1591  Pocillopora_acuta_HIv2___RNAseq.g12289.t1    169.18586       1.826114
## 284 1593  Pocillopora_acuta_HIv2___RNAseq.g15574.t1     34.16738       1.843892
## 285 1601  Pocillopora_acuta_HIv2___RNAseq.g24029.t1    216.49127       1.352660
## 286 1606  Pocillopora_acuta_HIv2___RNAseq.g15948.t1    179.21690      -2.052347
## 287 1612  Pocillopora_acuta_HIv2___RNAseq.g12223.t1   1942.75964       1.956525
## 288 1618   Pocillopora_acuta_HIv2___RNAseq.g4919.t1    187.63281       3.463306
## 289 1619 Pocillopora_acuta_HIv2___RNAseq.g26474.t1a  14692.89020       1.784435
## 290 1622    Pocillopora_acuta_HIv2___RNAseq.g562.t1    543.01090      -1.900843
## 291 1636       Pocillopora_acuta_HIv2___TS.g3024.t4   5769.89335       1.345575
## 292 1647  Pocillopora_acuta_HIv2___RNAseq.g27978.t1   1346.56743       1.001788
## 293 1659  Pocillopora_acuta_HIv2___RNAseq.g12290.t1    272.61929       1.396721
## 294 1667      Pocillopora_acuta_HIv2___TS.g24807.t1   6598.60730       1.321394
## 295 1673       Pocillopora_acuta_HIv2___TS.g3256.t1    295.29556       1.109164
## 296 1688  Pocillopora_acuta_HIv2___RNAseq.g30726.t1   3698.97199      -1.991751
## 297 1689   Pocillopora_acuta_HIv2___RNAseq.g3051.t1   4957.84106       1.432437
## 298 1695  Pocillopora_acuta_HIv2___RNAseq.g24196.t1    123.56332      -1.718484
## 299 1698  Pocillopora_acuta_HIv2___RNAseq.g22366.t1   2478.84738       1.737807
## 300 1705   Pocillopora_acuta_HIv2___RNAseq.g8093.t1   2555.99531       1.438195
## 301 1709   Pocillopora_acuta_HIv2___RNAseq.g7454.t2     22.44606       1.228765
## 302 1718      Pocillopora_acuta_HIv2___TS.g17199.t1   3983.64133      -1.572936
## 303 1720  Pocillopora_acuta_HIv2___RNAseq.g16928.t3   5447.65606      -1.783134
## 304 1722   Pocillopora_acuta_HIv2___RNAseq.g3094.t1    661.57875      -1.690762
## 305 1723   Pocillopora_acuta_HIv2___RNAseq.g3482.t1    140.22566       1.616148
## 306 1726  Pocillopora_acuta_HIv2___RNAseq.g15953.t1    211.50709      -1.632385
## 307 1733   Pocillopora_acuta_HIv2___RNAseq.g9027.t1   2280.97939       1.631564
## 308 1741   Pocillopora_acuta_HIv2___RNAseq.g3743.t1   1180.33307       1.729045
## 309 1744      Pocillopora_acuta_HIv2___TS.g6241.t1e   2993.39771       1.437186
## 310 1751  Pocillopora_acuta_HIv2___RNAseq.g18121.t1   6819.87418       1.880525
## 311 1755  Pocillopora_acuta_HIv2___RNAseq.g28251.t1   2338.02487       1.507841
## 312 1757  Pocillopora_acuta_HIv2___RNAseq.g16474.t1    150.76836       1.608725
## 313 1762  Pocillopora_acuta_HIv2___RNAseq.g12417.t1    170.56934       1.053248
## 314 1764      Pocillopora_acuta_HIv2___TS.g11002.t4    167.39786      -1.659866
## 315 1782   Pocillopora_acuta_HIv2___RNAseq.g3166.t1    575.39471       1.593229
## 316 1786  Pocillopora_acuta_HIv2___RNAseq.g26503.t1    559.87142       1.101889
## 317 1791  Pocillopora_acuta_HIv2___RNAseq.g24051.t1    302.81726       1.450521
## 318 1804      Pocillopora_acuta_HIv2___TS.g15134.t1   4469.94208       1.408270
##         lfcSE       pvalue         padj  blast_hit perc_ident    evalue
## 1   3.9804472 1.680854e-19 8.103957e-16     P24383     28.205  4.23e-13
## 2   3.9451894 3.935575e-19 1.229920e-15     Q9CXI3     31.818  9.57e-14
## 3   4.0005799 4.251661e-19 1.229920e-15     P51029     26.347  7.78e-22
## 4   2.3513750 5.406898e-18 8.336894e-15     Q566X8     69.663  1.47e-36
## 5   3.9062481 1.445915e-17 1.742810e-14     Q96RW7     23.873  2.16e-33
## 6   1.8496201 2.798837e-16 1.619295e-13     P51029     29.433  2.52e-27
## 7   3.6112381 2.413840e-15 7.934951e-13     Q27128     72.074  0.00e+00
## 8   3.6781444 3.114556e-15 9.945559e-13     Q6XYQ8     37.113  9.54e-39
## 9   4.0353343 6.230509e-15 1.828057e-12     Q9CZV8     25.397  7.00e-18
## 10  3.6778572 2.289682e-14 5.525163e-12     Q9EQD2     33.129  2.11e-45
## 11  3.5850266 6.568762e-14 1.376965e-11     Q98SN7     48.182 6.50e-110
## 12  3.6479384 1.069067e-13 2.118217e-11     P15508     33.852  2.41e-37
## 13  3.5841809 1.184752e-13 2.225488e-11     P51400     46.293  0.00e+00
## 14  3.6530708 1.421161e-13 2.506790e-11     G5EG78     35.727  2.82e-87
## 15  3.6906851 2.009348e-13 3.379443e-11     F1PZV2     33.610  2.55e-32
## 16  3.2988651 3.819062e-13 5.636624e-11     Q3UP38     33.410  3.52e-55
## 17  2.9212371 5.966435e-13 8.218907e-11     Q91X17     34.911  8.41e-23
## 18  3.3137235 6.429318e-13 8.772987e-11     P63253     40.947  6.37e-87
## 19  2.5153320 7.425805e-13 9.821870e-11     Q6IWH7     48.425  0.00e+00
## 20  3.5954255 1.654928e-12 1.978255e-10     Q91175     31.487  1.60e-45
## 21  3.5912730 1.779015e-12 2.109154e-10     Q5RCC4     38.828  2.53e-65
## 22  3.6264826 2.025007e-12 2.324579e-10     Q7TM99     24.157  4.51e-38
## 23  3.6169418 2.986256e-12 3.297191e-10     Q32ZE2     31.153  1.08e-33
## 24  3.7155788 3.543949e-12 3.687746e-10     Q5RFW0     52.381  7.91e-07
## 25  2.8932408 3.848449e-12 3.919998e-10     Q90Z12     46.269  2.22e-42
## 26  3.5911234 4.411236e-12 4.461827e-10     P19440     44.280 5.01e-149
## 27  3.5442430 7.553076e-12 7.224184e-10     O02824     35.475  5.16e-62
## 28  5.5223615 7.796371e-12 7.322513e-10     Q6RI86     29.548 1.07e-142
## 29  3.5464737 8.259408e-12 7.615830e-10     E7F6F9     26.552  7.72e-39
## 30  3.6407817 9.636208e-12 8.657026e-10     Q5R4J5     29.197  7.65e-31
## 31  3.5844958 2.391752e-11 1.890399e-09     Q18775     36.709  7.71e-07
## 32  3.5708979 2.674712e-11 2.068825e-09     E7FAM5     30.075  1.26e-34
## 33  1.4659682 3.356101e-11 2.476666e-09     P48442     31.726 1.34e-110
## 34  2.8485273 4.225953e-11 2.967193e-09     P11617     24.272  5.42e-18
## 35  3.6397053 4.930745e-11 3.317130e-09     Q9N126     44.643  8.65e-67
## 36  3.2204439 5.083411e-11 3.404002e-09     P31851     33.114  1.07e-85
## 37  1.2056184 6.319842e-11 4.044699e-09     P00918     36.842  2.04e-48
## 38  2.1111470 6.788153e-11 4.287504e-09 A0A2K5X3B6     35.484  1.25e-51
## 39  2.1766900 6.825609e-11 4.292418e-09     Q0ZLH3     26.455  8.77e-14
## 40  3.0746740 7.310161e-11 4.499326e-09     Q90268     69.930  1.29e-63
## 41  2.3205717 7.979410e-11 4.788970e-09     Q91VN0     32.852  1.90e-41
## 42  3.3217462 1.365619e-10 7.655934e-09     Q6GM82     47.292 2.43e-154
## 43  3.0841927 1.424577e-10 7.925030e-09     Q14AT5     50.494  0.00e+00
## 44  2.5445088 1.797157e-10 9.627438e-09     Q8WU66     32.550  1.99e-36
## 45  3.1298423 2.106768e-10 1.091067e-08     O42574     29.268  1.37e-29
## 46  3.4848297 2.112132e-10 1.091067e-08     P57695     32.536  2.29e-71
## 47  2.1852720 2.251819e-10 1.146842e-08     Q96P65     26.733  6.23e-25
## 48  3.5277856 2.530777e-10 1.269263e-08     Q96RW7     44.583  3.37e-66
## 49  2.2484694 3.096062e-10 1.487755e-08     Q16322     31.081  1.70e-08
## 50  3.3941001 3.302384e-10 1.571240e-08     P83858     30.033  2.55e-24
## 51  3.1381388 3.431226e-10 1.621871e-08     Q7TN88     32.143  1.00e-49
## 52  3.4625140 5.060383e-10 2.316246e-08     A6QLU6     37.069  7.47e-15
## 53  3.3917839 5.643947e-10 2.527370e-08     Q6NYL5     43.478 2.28e-110
## 54  3.3603398 5.874289e-10 2.598340e-08     O42357     38.428  1.98e-31
## 55  2.7779770 5.910658e-10 2.606456e-08     B8NHE3     25.899  6.07e-10
## 56  2.8261835 7.416875e-10 3.221552e-08     Q5HZE0     52.448  5.80e-99
## 57  3.5747065 8.358525e-10 3.555815e-08     P63079     30.841  2.23e-50
## 58  2.4410753 8.542114e-10 3.623259e-08     Q16992     27.536  7.91e-09
## 59  4.1899269 8.661309e-10 3.652396e-08     Q99NH0     34.914  5.34e-66
## 60  2.9038227 9.867491e-10 4.077811e-08     Q704V6     32.000  2.62e-16
## 61  3.3454666 1.148341e-09 4.665620e-08     P30974     27.414  4.07e-26
## 62  3.5179055 1.210544e-09 4.904570e-08     A6QLU6     41.406  8.77e-21
## 63  3.7661239 1.291142e-09 5.187520e-08     Q21565     51.079 1.40e-128
## 64  3.4545212 1.453020e-09 5.664818e-08     O70277     22.846  5.42e-20
## 65  3.3558053 1.515378e-09 5.860540e-08     P31597     43.611 1.72e-126
## 66  3.5224344 1.587097e-09 6.105259e-08     O43704     37.755  1.12e-55
## 67  3.2079545 1.749576e-09 6.607277e-08     Q6PEI7     69.402  0.00e+00
## 68  3.0743137 1.940238e-09 7.214293e-08     P31649     55.882  0.00e+00
## 69  3.3183539 2.259957e-09 8.213070e-08     C9D7C2     47.898  0.00e+00
## 70  3.4754573 2.390312e-09 8.600367e-08     Q61184     24.088  3.00e-24
## 71  4.5763292 2.598137e-09 9.210651e-08     Q5RFW0     33.491  1.02e-17
## 72  5.2518526 2.620353e-09 9.266697e-08     P09917     28.151  2.26e-47
## 73  3.5860171 2.770869e-09 9.727634e-08     Q20JQ7     39.115  0.00e+00
## 74  3.4823937 2.951316e-09 1.033604e-07     G5EG78     35.577 1.90e-101
## 75  3.3448312 3.282924e-09 1.125218e-07     Q86SS6     32.867  1.79e-35
## 76  3.4735080 3.462091e-09 1.181030e-07     Q09081     45.729 1.11e-116
## 77  2.7390660 3.552823e-09 1.200655e-07     Q7TN88     24.546  1.45e-54
## 78  2.0688424 3.563308e-09 1.201391e-07     Q86UK0     32.646  0.00e+00
## 79  3.6319216 3.671780e-09 1.232219e-07     Q7SY09     31.595  4.76e-36
## 80  3.3165398 3.703303e-09 1.239921e-07     Q14517     33.143  4.66e-21
## 81  2.6339533 4.027512e-09 1.336099e-07     P52569     40.510 2.27e-146
## 82  3.7467033 4.296540e-09 1.418839e-07     Q94887     29.730  1.07e-14
## 83  3.6436353 4.540551e-09 1.482848e-07     Q14517     31.356  2.69e-09
## 84  3.8759797 4.794341e-09 1.544440e-07     Q9Y5X5     26.797  6.03e-26
## 85  3.6619797 5.102743e-09 1.632878e-07     Q9Z2J0     50.000  0.00e+00
## 86  3.4821481 5.230455e-09 1.662710e-07     Q7TSY2     34.615  9.23e-33
## 87  3.1997231 5.518053e-09 1.746458e-07     Q6V4S5     28.682  4.55e-54
## 88  3.6044973 5.845173e-09 1.837926e-07     P63142     52.284 1.56e-142
## 89  2.9093670 6.191427e-09 1.921734e-07     Q924H0     26.753  7.27e-29
## 90  3.4793258 7.240357e-09 2.200095e-07     P54131     36.441 1.59e-110
## 91  3.7519329 7.607090e-09 2.297055e-07     Q8L8B8     46.632  1.54e-56
## 92  3.3853784 7.852723e-09 2.361368e-07     P63079     34.722  4.11e-92
## 93  3.2676223 7.898303e-09 2.370146e-07     Q60928     40.820 3.76e-122
## 94  3.6283915 8.007842e-09 2.393087e-07     Q9Y227     48.846 2.93e-168
## 95  4.8157216 8.832363e-09 2.601860e-07     P09917     28.243  1.46e-46
## 96  3.3151038 8.935308e-09 2.621507e-07     P16621     28.169  2.14e-07
## 97  3.4126614 1.026446e-08 2.975254e-07     P31649     56.007  0.00e+00
## 98  3.7286917 1.393030e-08 3.867331e-07     Q16281     42.418 1.33e-122
## 99  3.6716524 1.397303e-08 3.871761e-07     Q8WU66     31.849  1.73e-32
## 100 3.1065245 1.400425e-08 3.872992e-07     Q7SC45     26.464  1.39e-33
## 101 5.3944915 1.630481e-08 4.466531e-07     Q7ZSX3     63.087  2.09e-57
## 102 3.6086575 1.634387e-08 4.468766e-07     O43704     38.095  2.35e-56
## 103 3.6159390 1.680309e-08 4.568419e-07     O75382     25.837  1.34e-10
## 104 0.6671773 1.706221e-08 4.630165e-07     Q9QWN8     42.532  4.06e-57
## 105 4.3104708 2.049182e-08 5.428457e-07     C3ZQF9     27.937  4.07e-23
## 106 3.6387289 2.128531e-08 5.607846e-07     P79888     51.099  7.01e-51
## 107 5.8894523 2.429209e-08 6.330824e-07     Q5DTY9     42.473  4.90e-43
## 108 3.4096303 2.732652e-08 7.032931e-07     B3TP03     36.289 7.71e-126
## 109 3.8734931 2.917305e-08 7.441958e-07     P34410     30.385  2.48e-29
## 110 3.3859111 3.560881e-08 8.941769e-07     P48547     42.222 3.35e-106
## 111 3.7426509 3.677053e-08 9.154026e-07     E7FAM5     30.959 1.12e-121
## 112 3.4249104 3.872466e-08 9.574589e-07     P30825     43.265 7.14e-165
## 113 2.0780951 5.426163e-08 1.259776e-06     Q01484     36.250  3.37e-06
## 114 3.3499700 6.097385e-08 1.397664e-06     A2AP18     44.169 8.20e-180
## 115 3.5495535 6.482654e-08 1.474294e-06     Q0V8E4     46.620  8.22e-94
## 116 3.9201733 7.268242e-08 1.632420e-06     Q9WYJ1     39.848  2.66e-76
## 117 3.6682250 8.496880e-08 1.882065e-06     Q96EH3     45.946  2.75e-24
## 118 5.9062800 1.003650e-07 2.166685e-06     O75762     28.650 6.47e-137
## 119 2.0903009 1.145959e-07 2.444712e-06     O73874     30.120  8.06e-14
## 120 3.6676254 1.200238e-07 2.538047e-06     Q7Z591     31.799  1.40e-16
## 121 3.9905622 1.312210e-07 2.746759e-06     Q96RW7     25.080  4.56e-34
## 122 3.1516655 1.434376e-07 2.972323e-06     Q80ZA4     35.060  0.00e+00
## 123 3.3016573 1.445378e-07 2.986564e-06     Q8IY21     34.420  1.62e-32
## 124 3.2255238 1.477322e-07 3.043873e-06     P35521     45.550  1.81e-42
## 125 3.3324379 1.500161e-07 3.086533e-06     Q8R508     38.542  1.12e-09
## 126 1.8187047 1.660932e-07 3.364668e-06     O75897     39.313  1.15e-54
## 127 3.5017338 1.974977e-07 3.923593e-06     P0CI65     30.928  3.08e-32
## 128 3.9320674 2.022318e-07 4.001479e-06     Q8NFF2     38.871 1.74e-134
## 129 2.7009288 2.087805e-07 4.102990e-06     P32456     24.068  2.12e-09
## 130 3.8154665 2.199496e-07 4.293322e-06     Q25060     49.342  2.23e-22
## 131 2.6437687 2.253844e-07 4.369920e-06     O15973     24.324  1.70e-18
## 132 3.5720034 2.488735e-07 4.774146e-06     Q6BZW3     31.017  8.15e-41
## 133 1.9066038 2.669248e-07 5.080001e-06     A6QLU6     24.034  3.82e-31
## 134 0.6544955 2.712874e-07 5.135997e-06     P01026     28.192 2.73e-170
## 135 3.3824295 2.734598e-07 5.170357e-06     Q6DGQ8     62.621  1.38e-96
## 136 3.4491355 2.849449e-07 5.373460e-06     Q3U481     36.207  1.02e-29
## 137 3.4885531 2.927700e-07 5.506666e-06     Q5RJA1     48.560 1.33e-153
## 138 1.9280430 3.655710e-07 6.667868e-06     E7FAM5     23.279  1.82e-11
## 139 2.3746450 3.844924e-07 6.977790e-06 A0A1D5PUP4     29.975  1.11e-24
## 140 3.9553653 4.351516e-07 7.745332e-06     Q96RW7     31.707  9.94e-21
## 141 3.1360492 4.532895e-07 7.995585e-06     Q8LAD0     43.320  4.32e-57
## 142 2.2966964 4.854949e-07 8.491171e-06     Q91755     31.502  4.95e-80
## 143 4.7892340 5.160336e-07 8.938814e-06     P07207     44.375  5.94e-69
## 144 1.3229849 5.484768e-07 9.421816e-06     A4IF63     32.743  8.41e-25
## 145 2.8809554 5.624860e-07 9.628162e-06     G5EG78     34.877  7.00e-92
## 146 3.5888905 5.680751e-07 9.700871e-06     Q5ZKY0     29.825  3.80e-54
## 147 3.7462922 6.432656e-07 1.076874e-05     Q96P65     26.271  8.58e-28
## 148 2.0063619 6.730121e-07 1.116336e-05     A7SLW1     70.635  0.00e+00
## 149 2.0509232 6.966087e-07 1.150200e-05     A7UKY7     48.077  9.87e-67
## 150 2.6249107 7.168730e-07 1.179619e-05     B8NHE3     27.338  6.70e-11
## 151 2.9973204 7.203152e-07 1.183936e-05     P19623     68.293 1.01e-149
## 152 3.4702885 7.226816e-07 1.185132e-05     Q04604     34.316 7.19e-103
## 153 2.3047378 8.045109e-07 1.305626e-05     A7RX26     71.571  0.00e+00
## 154 4.5947333 8.051844e-07 1.305626e-05     Q17LW0     35.849 7.15e-107
## 155 2.6741779 8.209762e-07 1.323813e-05     Q9WUW9     35.811  7.37e-52
## 156 1.9459116 8.520078e-07 1.364722e-05     Q0IIL7     42.857  7.88e-06
## 157 3.7872600 9.797935e-07 1.545445e-05     Q8TAM2     63.956  0.00e+00
## 158 4.8416528 1.113628e-06 1.726422e-05     Q7TPD1     59.049  0.00e+00
## 159 3.0040526 1.190073e-06 1.823801e-05     Q3U481     34.553  4.13e-30
## 160 6.1219286 1.549743e-06 2.306119e-05     O60678     49.811 2.98e-171
## 161 1.9351971 1.579126e-06 2.342613e-05     Q9WUA6     66.815  0.00e+00
## 162 3.5101464 1.678026e-06 2.466562e-05     Q15399     37.864  3.37e-10
## 163 3.0905745 1.737224e-06 2.545816e-05     P16621     30.380  3.33e-16
## 164 3.8146590 1.764177e-06 2.582697e-05     Q9UIJ7     50.000  1.38e-58
## 165 3.2572104 1.814656e-06 2.645885e-05     Q96P65     26.554  1.17e-28
## 166 3.6600897 1.893478e-06 2.738726e-05     Q9VIK2     28.154  1.18e-56
## 167 3.4939688 2.050597e-06 2.936617e-05     H2LRU7     27.626  3.96e-27
## 168 3.5437169 2.067450e-06 2.949921e-05     Q26627     24.005  2.92e-39
## 169 2.3298190 2.398212e-06 3.367741e-05     Q8IVV2     39.110  0.00e+00
## 170 1.5139153 2.436257e-06 3.414306e-05     F6QEU4     23.797  1.29e-49
## 171 5.3298345 2.815552e-06 3.845529e-05     P29274     28.483  2.79e-14
## 172 3.7702370 2.968553e-06 4.016571e-05     Q1RLY6     52.851 9.20e-175
## 173 1.7321229 3.299792e-06 4.420444e-05     A2TF48     36.082  3.83e-07
## 174 1.8989564 4.451371e-06 5.707857e-05     Q15319     61.943  1.61e-90
## 175 3.4980066 4.883081e-06 6.173854e-05     P54886     58.929  0.00e+00
## 176 2.0637231 5.433574e-06 6.786806e-05     O88572     30.834 1.08e-113
## 177 1.5819595 6.029436e-06 7.427833e-05     P55012     47.747  0.00e+00
## 178 2.4683443 6.887230e-06 8.329172e-05     P42893     36.091 6.72e-148
## 179 4.2373747 6.968825e-06 8.406763e-05     Q12791     45.255  0.00e+00
## 180 2.6964937 7.372550e-06 8.827531e-05     E7FAM5     25.627  1.96e-63
## 181 1.3681043 9.537625e-06 1.100097e-04     P58365     33.251  0.00e+00
## 182 3.6831017 1.158061e-05 1.298464e-04     P31422     30.478 1.26e-121
## 183 1.8721522 1.240899e-05 1.380643e-04     Q7TSH8     34.377  0.00e+00
## 184 4.2119525 1.295077e-05 1.432110e-04     Q9QX29     28.938  2.00e-47
## 185 2.0968122 1.381409e-05 1.512097e-04     Q9HCK4     31.724  3.69e-30
## 186 3.5380269 1.430307e-05 1.557828e-04     Q7SIC1     31.481  4.31e-15
## 187 4.0778747 1.728109e-05 1.839247e-04     Q9Z0U4     28.154  7.43e-73
## 188 4.1072820 1.778044e-05 1.881319e-04     P31649     55.862  0.00e+00
## 189 4.0725621 1.873303e-05 1.966289e-04     Q9Y6H5     33.491  2.51e-30
## 190 1.8568345 1.895173e-05 1.982052e-04     Q5I020     39.216  3.91e-74
## 191 2.5951008 2.045838e-05 2.118182e-04     Q6QNK2     31.734  6.08e-29
## 192 4.0550793 2.462882e-05 2.472058e-04     Q96RW7     28.814  2.26e-24
## 193 2.3967626 2.488525e-05 2.494388e-04     Q13467     59.398  4.39e-52
## 194 3.6038949 3.537869e-05 3.388857e-04 A0A2K5X3B6     35.254  1.03e-51
## 195 2.6959949 3.635986e-05 3.466770e-04     Q86U44     53.925  0.00e+00
## 196 0.6380319 3.645558e-05 3.473606e-04     Q6P2X9     26.765  7.06e-28
## 197 2.2697117 3.781426e-05 3.586528e-04     P63016     43.516  2.54e-98
## 198 3.2195131 5.083910e-05 4.651039e-04     Q924H0     28.150  2.76e-32
## 199 4.4838942 5.647047e-05 5.076376e-04     Q8WWC4     28.796  3.30e-13
## 200 3.5543247 5.783795e-05 5.176783e-04     Q8BX94     43.216  3.58e-45
## 201 1.8750225 6.597246e-05 5.829112e-04     O75899     32.645 4.30e-126
## 202 1.0190885 7.817652e-05 6.746690e-04     Q9QXE4     37.600  6.14e-15
## 203 3.5463172 8.353730e-05 7.128516e-04     O15973     24.398  9.93e-16
## 204 3.6991403 9.611706e-05 8.040701e-04     Q812E0     54.717 2.04e-137
## 205 2.3255087 1.015676e-04 8.423584e-04     Q5R4J5     33.457  3.68e-42
## 206 1.7946047 1.193115e-04 9.657091e-04     Q05609     28.428  7.44e-21
## 207 1.3280743 1.247856e-04 1.001560e-03     P02752     45.550  1.20e-55
## 208 3.8693118 1.310516e-04 1.046099e-03     Q8WU66     32.342  9.09e-34
## 209 1.0823840 1.313140e-04 1.047615e-03     E9PUL5     29.851  2.16e-08
## 210 2.0370673 1.354225e-04 1.073288e-03     Q8CAQ8     27.893  1.39e-70
## 211 2.9086113 1.377354e-04 1.087448e-03     Q8CGF6     54.711 1.70e-111
## 212 1.7553496 1.463885e-04 1.146380e-03     P35404     23.393  3.73e-12
## 213 1.9874319 1.643840e-04 1.260016e-03     Q01062     43.730  0.00e+00
## 214 1.8739604 1.685710e-04 1.287334e-03     Q61321     60.173  2.37e-90
## 215 4.2238744 1.951738e-04 1.458912e-03     P61752     26.814  1.54e-17
## 216 1.7930375 2.245844e-04 1.653124e-03     P00734     41.791  3.01e-53
## 217 1.3738192 2.521886e-04 1.822006e-03     P0CI65     26.531  5.90e-38
## 218 1.7695585 2.541226e-04 1.835062e-03     Q9VH14     31.507  3.51e-17
## 219 0.8966200 2.747590e-04 1.960975e-03     Q01484     31.495  3.68e-69
## 220 5.2269805 2.793921e-04 1.986788e-03     O08734     33.333  1.42e-26
## 221 1.4953282 2.832138e-04 2.009026e-03     Q90Z00     30.769  1.16e-08
## 222 1.7720118 3.032348e-04 2.132226e-03     Q86YH6     39.633  1.29e-83
## 223 1.1615533 3.338316e-04 2.318070e-03     Q9I928     35.374  1.20e-13
## 224 0.6452348 3.532561e-04 2.434253e-03     Q8WU66     32.714  2.96e-18
## 225 3.3338417 3.822199e-04 2.605292e-03     P17124     33.642  1.31e-44
## 226 1.2440002 3.924606e-04 2.667552e-03     Q9WU20     64.286  0.00e+00
## 227 1.5182934 3.927890e-04 2.668530e-03     P51029     28.881  9.02e-25
## 228 1.5185195 4.357000e-04 2.908152e-03     Q8HYN8     22.744  5.31e-09
## 229 1.7925462 4.418081e-04 2.942133e-03     Q08CS6     33.557  7.06e-17
## 230 4.6277366 4.455424e-04 2.964271e-03     O75899     28.317  1.20e-86
## 231 3.6045053 4.824608e-04 3.173403e-03     Q9CXI3     41.633 3.56e-117
## 232 1.7806683 4.923029e-04 3.229329e-03     P28289     41.243  4.12e-83
## 233 1.6939897 4.981992e-04 3.260612e-03     D3ZB51     27.347  2.71e-09
## 234 1.6050237 5.007928e-04 3.276104e-03     P07756     66.045  0.00e+00
## 235 1.7668049 5.788034e-04 3.707623e-03     Q96RW7     25.629  0.00e+00
## 236 1.2702072 5.885710e-04 3.761861e-03     Q1RLX4     56.379  9.93e-70
## 237 4.0316603 6.065785e-04 3.853119e-03     Q8WU66     42.202  5.46e-17
## 238 1.4370780 6.748503e-04 4.218252e-03     Q8IWU5     51.271 1.83e-153
## 239 2.0029127 6.937552e-04 4.315904e-03     Q8C419     27.213  2.94e-67
## 240 0.6694047 7.091851e-04 4.396297e-03     P54145     45.892 6.92e-138
## 241 2.8584754 7.448274e-04 4.574594e-03     Q0V9P1     25.795  3.74e-22
## 242 0.7692562 7.998511e-04 4.854824e-03     P05123     66.364 1.79e-103
## 243 1.6472178 8.061020e-04 4.882704e-03     O70277     23.596  2.65e-20
## 244 1.7669143 8.227743e-04 4.971014e-03     A2ASQ1     28.703  1.54e-86
## 245 1.9188959 9.308120e-04 5.526792e-03     Q91994     64.348  3.89e-37
## 246 0.6926413 9.351310e-04 5.545607e-03     P16621     40.588  0.00e+00
## 247 2.9169383 9.814741e-04 5.761513e-03     B0JZG0     52.817  0.00e+00
## 248 2.2106862 1.003792e-03 5.875695e-03     Q7SXM7     60.158  0.00e+00
## 249 2.8173030 1.020449e-03 5.953922e-03     Q7ZTV5     24.532  4.87e-16
## 250 1.6636187 1.023955e-03 5.969561e-03     Q06831     57.627  1.86e-37
## 251 1.7435652 1.164329e-03 6.672286e-03     O55005     32.000  1.77e-28
## 252 2.2954803 1.179347e-03 6.736995e-03     O43581     32.192  9.75e-12
## 253 2.9588305 1.204527e-03 6.863965e-03     O43581     44.828 5.45e-110
## 254 2.0336834 1.214432e-03 6.903764e-03     Q6PBD4     39.033  1.72e-41
## 255 1.4373909 1.339844e-03 7.514346e-03     P05123     73.025  0.00e+00
## 256 2.7693577 1.342687e-03 7.527376e-03     E7FAM5     24.843  2.92e-50
## 257 1.8495443 1.362684e-03 7.612925e-03     B7ZCC9     26.220  1.01e-57
## 258 2.6456168 1.454716e-03 8.080265e-03     Q5RB83     59.322  2.60e-75
## 259 1.6265450 1.470364e-03 8.142168e-03     Q7T2B9     40.909  6.59e-14
## 260 2.6270631 1.523136e-03 8.402225e-03     Q8JZQ5     37.709  0.00e+00
## 261 2.9879315 1.527400e-03 8.419326e-03     P97686     37.681  4.39e-08
## 262 0.7369535 1.533438e-03 8.445278e-03     Q6XYQ8     40.351  5.38e-20
## 263 2.8487861 1.809856e-03 9.782419e-03     Q9EQD2     29.677  2.18e-33
## 264 2.9527627 1.914116e-03 1.025399e-02     P43166     40.074  2.26e-47
## 265 1.4346135 1.991081e-03 1.062302e-02     O75366     41.916  0.00e+00
## 266 1.0085972 2.074748e-03 1.097227e-02     Q90Z00     61.481  2.94e-45
## 267 1.8697996 2.377677e-03 1.239752e-02     P79134     33.750 7.56e-108
## 268 1.1047899 2.432941e-03 1.263557e-02     P42325     86.631 2.16e-121
## 269 2.1708376 2.473954e-03 1.283299e-02     Q96RW7     24.498  2.07e-06
## 270 1.0618789 2.546351e-03 1.318197e-02     Q96EV8     27.536  1.80e-25
## 271 2.2284370 2.560759e-03 1.323287e-02     Q6UVY6     31.844  1.84e-14
## 272 2.3769551 2.653093e-03 1.362725e-02     P58197     69.608  8.90e-87
## 273 1.5676967 2.659415e-03 1.364759e-02     Q6DIV6     34.243  1.08e-72
## 274 0.5880945 3.020724e-03 1.525550e-02     Q9HCK4     31.373  1.34e-91
## 275 0.9361201 3.041363e-03 1.534788e-02     P43006     49.605 6.62e-159
## 276 1.6063769 3.545971e-03 1.739050e-02     O15992     74.860  0.00e+00
## 277 1.1507126 3.582582e-03 1.754180e-02     Q7Z443     31.579  2.58e-49
## 278 1.9569657 3.672661e-03 1.791615e-02     P30531     45.931  0.00e+00
## 279 1.8376173 3.744764e-03 1.821872e-02     Q9QWN8     50.215  9.69e-61
## 280 1.7750653 3.752806e-03 1.825171e-02     Q90481     56.489  1.26e-37
## 281 1.8770841 4.061439e-03 1.951001e-02     C3ZAH2     70.286  1.28e-88
## 282 1.7509826 4.144342e-03 1.982923e-02     Q2KIH7     61.312  0.00e+00
## 283 2.0247574 4.176294e-03 1.996230e-02     P16621     29.362  3.70e-13
## 284 2.4987247 4.184944e-03 1.998383e-02     P24722     71.818  4.44e-50
## 285 3.0615391 4.361290e-03 2.069610e-02     H1AFJ5     28.200  6.19e-57
## 286 1.6729402 4.571238e-03 2.153693e-02     Q923Y9     25.926  9.89e-08
## 287 2.0965058 4.745729e-03 2.222870e-02     P25228     76.023  3.56e-96
## 288 2.5968571 4.850806e-03 2.266216e-02     Q01484     26.037  1.12e-24
## 289 1.0157804 4.878893e-03 2.277132e-02     P09057     51.084 9.03e-160
## 290 1.5433837 4.975854e-03 2.317152e-02     Q8CHL0     58.696  1.31e-52
## 291 0.5609580 5.274476e-03 2.433493e-02     Q62770     32.710  1.10e-08
## 292 1.5904401 5.663686e-03 2.584119e-02     P23634     36.976 1.01e-131
## 293 1.8638516 6.125650e-03 2.767064e-02     Q7SIC1     34.416  1.31e-14
## 294 0.5679549 6.479885e-03 2.897220e-02     Q96RW7     32.287  1.03e-15
## 295 1.6423444 6.754106e-03 3.006814e-02     Q9I929     34.615  3.19e-13
## 296 1.9575026 7.211044e-03 3.176989e-02     O76082     31.957  1.84e-83
## 297 0.6698449 7.228704e-03 3.182830e-02     P02640     39.251  0.00e+00
## 298 1.1936763 7.442603e-03 3.263104e-02     P70115     26.786  2.37e-13
## 299 1.4934748 7.641264e-03 3.335040e-02     O43602     41.277  8.56e-46
## 300 0.6881318 7.905192e-03 3.435718e-02     Q06A37     52.760  0.00e+00
## 301 1.7823100 8.114492e-03 3.509885e-02     P0CI65     28.940  3.24e-37
## 302 0.8852068 8.453334e-03 3.622518e-02     P19137     22.266  9.77e-10
## 303 1.2643700 8.525161e-03 3.647241e-02     O70521     47.727  4.34e-40
## 304 1.2958602 8.658677e-03 3.696550e-02     P49288     28.763  2.49e-29
## 305 0.9272108 8.676269e-03 3.700783e-02     Q8JIR0     43.913  1.62e-57
## 306 0.9992270 8.746374e-03 3.725283e-02     Q923Y9     26.036  2.14e-06
## 307 1.9296822 8.993995e-03 3.810461e-02     P22004     34.409  2.50e-42
## 308 1.7209882 9.174541e-03 3.868821e-02     Q08E39     41.509  9.08e-18
## 309 0.7202075 9.359870e-03 3.940080e-02     P94598     64.384  0.00e+00
## 310 1.9780991 9.757966e-03 4.082708e-02     Q6K3R5     31.589  3.79e-66
## 311 0.8614981 1.007503e-02 4.196652e-02     P23978     46.211 1.73e-167
## 312 1.8642425 1.013214e-02 4.214877e-02     P55013     47.007  0.00e+00
## 313 1.5107143 1.019998e-02 4.233356e-02     Q60HG7     66.420  0.00e+00
## 314 1.3708181 1.026137e-02 4.253953e-02     P07207     40.852  6.79e-80
## 315 1.6702106 1.127829e-02 4.604266e-02     P09241     33.333  1.16e-26
## 316 1.5975481 1.147671e-02 4.672084e-02     Q99L13     58.544 1.87e-139
## 317 1.5914417 1.165298e-02 4.733186e-02     A4IF63     31.034  1.60e-06
## 318 0.7616722 1.216474e-02 4.903868e-02     Q27433     77.075 1.32e-128
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ProteinNames
## 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Protein Wnt-7a
## 2                                                                                                                                                                                                                                                                                                                                                                                           DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Protein Wnt-8b
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                   Diencephalon/mesencephalon homeobox protein 1-B
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                 Hemicentin-1 (Fibulin-6) (FIBL-6)
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Protein Wnt-8b
## 7                                     Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPS synthetase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                         Synaptotagmin-10 (Synaptotagmin X) (SytX)
## 9                                                                                                                                                                                                                                                                                                                                                                          F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like)
## 10                                                                                                                                                                                                                                                                                                                                                                             Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor)
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Protein Wnt-2b
## 12                                                                                                                                                                                                                                                                                                                                                                                                                              Spectrin beta chain, erythrocytic (Beta-I spectrin)
## 13                                                                                                                                                                                                                                                                                                                                                Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                          Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 15                                                                                                                                                                                                                                                                                                                                                                                                                       Major facilitator superfamily domain-containing protein 12
## 16                                                                                                                                                                                                                                                                                                                                               EF-hand calcium-binding domain-containing protein 4B (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
## 17                                                                                                                                                                                                                                                                                                                                                                                  Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]
## 18                                                                                                                                                                                                                                                                                   Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)
## 19                                                                                                                                                                                                                                                                                                Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)
## 20                                                                                                                                                                                                                                                                                                                                                                                            Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (MAR1)
## 21                                                                                                                                                                                                                                                                                                                                           Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
## 22                                                                                                                                                                                                                                                                                                                                                                                                        Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                           Adenosine receptor A2b
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                              Scavenger receptor class A member 5
## 25                                                                                                                                                                                                                                                                                                                                                         Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a)
## 26                                                                                                                                                                                       Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
## 27                                                                                                                                                                                                                                                                                                                                                                    Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor)
## 28                                                                                                                                                                                                                                                                                                                                           Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor)
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                             Kelch-like protein 3
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                         Synaptotagmin-1 (Synaptotagmin I) (SytI)
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                              Dopamine receptor 4
## 32                                                                                                                                                                                                                                                                                                                   E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 33                                                                                                                                                                                                                                                                                                                                                                       Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR)
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                           Adenosine receptor A2a
## 35                                                                                                                                                                                                                                                                                                                                                                             Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase)
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Protein TabA
## 37                                                                                                                                                                                                                                                                                                                Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69)
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                        Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1)
## 39                                                                                                                                                                                                                                                                                                                                                                                                                          Pejvakin (Autosomal recessive deafness type 59 protein)
## 40                                                                                                                                                                                                                                                                                                                                                                                                                       Paired box protein Pax-2a (No isthmus protein) (Pax[Zf-b])
## 41                                                                                                                                                                                                                                                                                                                                                          Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
## 42                                                                                                                                                                                                                                                                                                                 Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
## 43                                                                                                                                                                                                                                                                                                                                                                                                 Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G)
## 44                                                                                                                                                                                                                                                                                                                                                                                                 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 45                                                                                                                                                                                                                                                                                                                                                                                             Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (x-BETA1AR)
## 46                                                                                                                                                                                                                                                                                                                                                                 Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
## 47                                                                                                                                                                                                                                                                                                                                              Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                Hemicentin-1 (Fibulin-6) (FIBL-6)
## 49                                                                                                                                                                                                                                                                                                                                                                            Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8)
## 50                                                                                                                                                                                                                                                                                                                                              Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 51                                                                                                                                                                                                                                                                                                                                                                   Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)
## 52                                                                                                                                                                                                                                                                                                                                                                                                          Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 53                                                                                                                                                                                                                                                                                                            Alanine aminotransferase 2-like (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                     Retinal homeobox protein Rx2
## 55                                                                                                                                                                                                                                                                                                                                                                                                Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
## 56                                                                                                                                                                                                                                     Mitochondrial basic amino acids transporter (Carnitine/acylcarnitine translocase-like) (CACT-like) (Mitochondrial carnitine/acylcarnitine carrier protein CACL) (Mitochondrial ornithine transporter 3) (Solute carrier family 25 member 29)
## 57                                                                                                                                                                                                                                                                                                                                                                        Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
## 58                                                                                                                                                                                                                                                                                                       LWamide neuropeptides [Cleaved into: LWamide I; Metamorphosin A (MMA) (LWamide II); LWamide III; LWamide IV; LWamide V; LWamide VI; LWamide VII; LWamide VIII; LWamide IX]
## 59                                                                                                                                                                                                                                                                                                                                                    Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein)
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                          Toll-like receptor 6 (CD antigen CD286)
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                      Tachykinin-like peptides receptor 86C (NKD)
## 62                                                                                                                                                                                                                                                                                                                                                                                                          Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                  Putative ammonium transporter 3
## 64                                                                                                                                                                                                                                                                                                                                                               Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
## 65                                                                                                                                                                                                                                                                                                                    Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
## 66                                                                                                                                                                                                                                                                                                                              Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
## 67                                                                                                                                                                                                                                                                                                                                                                                                           CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)
## 68                                                                                                                                                                                                                                                                                                                        Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 69                                                                                                                                                                                                                                                                                                                                                                                                     Voltage-dependent calcium channel type A subunit alpha-1 (Cacophony protein)
## 70                                                                                                                                                                                                                                                                                                                                                                                                                           Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                              Scavenger receptor class A member 5
## 72                                                                                                                                                                                                                                                                                                                                                   Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
## 73                                                                                                                                                                                                                                                                                                                                                                               Sodium channel protein type 4 subunit alpha B (Voltage-gated sodium channel subunit alpha Nav1.4b)
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                          Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                       Synaptotagmin-9 (Synaptotagmin IX) (SytIX)
## 76                                                                                                                                                                                                                                                                                                                                                                      Potassium voltage-gated channel subfamily A member 2 (KC22) (Voltage-gated potassium channel subunit Kv1.2)
## 77                                                                                                                                                                                                                                                                                                                                                                   Polycystin-1-like protein 2 (Polycystin-1L2) (PC1-like 2 protein) (Polycystic kidney disease protein 1-like 2)
## 78                                                                                                                                                                                                                                                                                                                   Glucosylceramide transporter ABCA12 (EC 7.6.2.1) (ATP-binding cassette sub-family A member 12) (ATP-binding cassette transporter 12) (ATP-binding cassette 12)
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                           Adhesion G protein-coupled receptor L4
## 80                                                                                                                                                                                                                                                                                                               Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
## 81                                                                                                                                                                                                                                                                                                                                             Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                         Neurexin-4 (Neurexin IV)
## 83                                                                                                                                                                                                                                                                                                               Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
## 84                                                                                                                                                                                                                                                                                                                                        Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor)
## 85                                                                                                                                                                                                                                                                                                                           Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3)
## 86                                                                                                                                                                                                                                                                                                                                                                                          LHFPL tetraspan subfamily member 4 protein (Lipoma HMGIC fusion partner-like 4 protein)
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                               Protein sidekick-2
## 88                                                                                                                                                                                                                                                                                                                                                         Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2)
## 89                                                                                                                                                                                                                                                                                                                                                                                          Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor)
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                  Neuronal acetylcholine receptor subunit alpha-7
## 91                                                                                                                                                                                                                                                                                                                                                                               Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3 (EC 3.2.2.n1) (Protein LONELY GUY 3)
## 92                                                                                                                                                                                                                                                                                                                                                                        Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3)
## 93                                                                                                                                                                                       Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
## 94                                                                                                                                                                                                                                                                                 Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.15) (EC 3.6.1.6) (Golgi UDPase) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase) (EC 3.6.1.42)
## 95                                                                                                                                                                                                                                                                                                                                                   Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
## 96                                                                                                                                                                                                                                                                                                                                                                              Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 97                                                                                                                                                                                                                                                                                                                        Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 98                                                                                                                                                                                                                                                                                                                                             Cyclic nucleotide-gated channel alpha-3 (CNG channel alpha-3) (CNG-3) (CNG3) (Cone photoreceptor cGMP-gated channel subunit alpha-3)
## 99                                                                                                                                                                                                                                                                                                                                                                                                 Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Protein btn-1
## 101                                                                                                                                                                                                                                                                                                                                                       Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48)
## 102                                                                                                                                                                                                                                                                                                                             Sulfotransferase 1B1 (ST1B1) (EC 2.8.2.1) (Sulfotransferase 1B2) (Sulfotransferase family cytosolic 1B member 1) (Thyroid hormone sulfotransferase)
## 103                                                                                                                                                                                                                                                                                                                                     Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97)
## 104                                                                                                                                                                                                                                                                                                   Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41)
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                      QRFP-like peptide receptor
## 106                                                                                                                                                                                                                                                                                     S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                        BTB/POZ domain-containing protein KCTD16
## 108                                                                                                                                                                                                                                                                                                                                   Cationic amino acid transporter 2 (CAT-2) (CAT2) (cCAT-2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                     TWiK family of potassium channels protein 7
## 110                                                                                                                                                                                                                                                                               Voltage-gated potassium channel KCNC1 (NGK2) (Potassium voltage-gated channel subfamily C member 1) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4)
## 111                                                                                                                                                                                                                                                                                                                  E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 112                                                                                                                                                                                                                                             High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)
## 113                                                                                                                                                                                                                                                                                                                                                                                                           Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 114                                                                                                                                                                                                                                   1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)
## 115                                                                                                                                                                                                                                                                                                                                                                                                                               Asparagine synthetase domain-containing protein 1
## 116                                                                                                                                                                                                                                                                                                                                                                          L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine dehydratase)
## 117                                                                                                                                                                                                                                                                                                                                                                                                                     Mitochondrial assembly of ribosomal large subunit protein 1
## 118                                                                                                                                                                                                                                                                                           Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Ephrin-B2a
## 120                                                                                                                                                                                                                                                                                                                                                                                                 Microtubule organization protein AKNA (AT-hook-containing transcription factor)
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 122                                                                                                                                                                                                                                                                                                                                                                     Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86)
## 123                                                                                                                                                                                                                                                                                                                                                                                                   Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60)
## 124                                                                                                                                                                                                                                                                                                                                                   Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln))
## 125                                                                                                                                                                                                                                                                                                                                                                                                                            Protocadherin Fat 3 (FAT tumor suppressor homolog 3)
## 126                                                                                                                                                                                                                                                                                                                                                                                                     Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1) (Sulfotransferase 1C2) (SULT1C#2)
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Nephrocystin-3
## 128                                                                                                                                                                                                                                                                                                                                                                 Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)
## 129                                                                                                                                                                                                                                                                                                      Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)
## 130                                                                                                                                                                                                                                                                                                                                                                                                                LWamide neuropeptides [Cleaved into: LWamide I; LWamide II; LWS]
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                            Rhodopsin, GQ-coupled (GQ-rhodopsin)
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Protein BTN1
## 133                                                                                                                                                                                                                                                                                                                                                                                                         Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133)
## 134 Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
## 135                                                                                                                                                                                                                                                                                                                                                                                                   Nucleoside diphosphate kinase homolog 5 (3'-5' exonuclease NME5) (EC 3.1.-.-)
## 136                                                                                                                                                                                                                                                                                                                                                                                                   Major facilitator superfamily domain-containing protein 12 (Protein grizzled)
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                DNA-binding protein RFX6 (Regulatory factor X 6)
## 138                                                                                                                                                                                                                                                                                                                  E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 139                                                                                                                                                                                                                                                                                                                                                                                                                      Reversion-inducing cysteine-rich protein with Kazal motifs
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 141                                                                                                                                                                                                                                                                                                  Probable pyridoxal 5'-phosphate synthase subunit PDX2 (AtPDX2) (EC 4.3.3.6) (Protein EMBRYO DEFECTIVE 2407) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2)
## 142                                                                                                                                                                                                                                                                                                                                                                                        Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)
## 143                                                                                                                                                                                                                                                                                                                                                                                         Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]
## 144                                                                                                                                                                                                                                                                                                                                              Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                         Peroxidasin homolog pxn-2 (EC 1.11.2.-)
## 146                                                                                                                                                                                                                                                                                                                                                                              Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175)
## 147                                                                                                                                                                                                                                                                                                                                             Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 148                                                                                                                                                                                                                                                                                                                                                                                                                        Branched-chain-amino-acid aminotransferase (EC 2.6.1.42)
## 149                                                                                                                                                                                                                                                                                                                                                                                                                      Insulinoma-associated protein 1 (Zinc finger protein IA-1)
## 150                                                                                                                                                                                                                                                                                                                                                                                               Methyltransferase flvH (EC 2.1.1.-) (Flavunoidine biosynthesis cluster protein H)
## 151                                                                                                                                                                                                                                                                                                                                                                                                   Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
## 152                                                                                                                                                                                                                                                                                                                                                                                                                            Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase)
## 153                                                                                                                                                                                                                                                                                                                                                                                Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1 homolog)
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                  Myosin-VIIa (Protein crinkled)
## 155                                                                                                                                                                                                                                                                                                                                                                                                   Sulfotransferase 1C2A (ST1C2A) (rSULT1C2A) (EC 2.8.2.1) (Sulfotransferase K2)
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Complexin-1
## 157                                                                                                                                                                                                                                                                                                                                                                                     Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                           F-box only protein 11
## 159                                                                                                                                                                                                                                                                                                                                                                                                   Major facilitator superfamily domain-containing protein 12 (Protein grizzled)
## 160                                                                                                                                                                                                                                                                                                                                                Protein arginine N-methyltransferase 3 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)
## 161                                                                                                                                                                                                                                                                                                                                              RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma)
## 162                                                                                                                                                                                                                                                                                                                                                                                        Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
## 163                                                                                                                                                                                                                                                                                                                                                                             Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 164                                                                                                                                                                                                                                                                                                                                 GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (Adenylate kinase 3 alpha-like 1) (Adenylate kinase isozyme 3)
## 165                                                                                                                                                                                                                                                                                                                                             Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                           Carcinine transporter
## 167                                                                                                                                                                                                                                                                                                                                                                                                                      Polycystin-2 (Polycystic kidney disease 2 protein homolog)
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                            Sperm receptor for egg jelly (suREJ)
## 169                                                                                                                                                                                                                                                                                                                                                                                                                               Lipoxygenase homology domain-containing protein 1
## 170                                                                                                                                                                                                                                                                                                                  E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 171                                                                                                                                                                                                                                                                                                                                                                                                                                                          Adenosine receptor A2a
## 172                                                                                                                                                                                                                                                                                                                                                                                                            Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)
## 173                                                                                                                                                                                                                                                                                                                                                                                                                          Myeloid differentiation primary response protein MyD88
## 174                                                                                                                                                                                                                                                                                                                                                                 POU domain, class 4, transcription factor 3 (Brain-specific homeobox/POU domain protein 3C) (Brain-3C) (Brn-3C)
## 175                                                                                                                                                             Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]
## 176                                                                                                                                                                                                                                                                                                                                                                                                                      Low-density lipoprotein receptor-related protein 6 (LRP-6)
## 177                                                                                                                                                                                                                                                                                                 Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (mNKCC1)
## 178                                                                                                                                                                                                                                                                                                                                                                                                                           Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)
## 179                                                                                                                                                                                                                     Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
## 180                                                                                                                                                                                                                                                                                                                  E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 181                                                                                                                                                                                                                                                                                                                                                                                                                                                       Cadherin-23 (Otocadherin)
## 182                                                                                                                                                                                                                                                                                                                                                                                                                                      Metabotropic glutamate receptor 3 (mGluR3)
## 183                                                                                                                                                                                                                                                                                                                                                                                                               Transmembrane protein 94 (Endoplasmic reticulum magnesium ATPase)
## 184                                                                                                                                                                                                                                                                                                       Short transient receptor potential channel 5 (TrpC5) (Capacitative calcium entry channel 2) (CCE2) (Transient receptor protein 5) (TRP-5) (mTRP5) (Trp-related protein 5)
## 185                                                                                                                                                                                                                                                                                                                                                                                                                                                            Roundabout homolog 2
## 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Fucolectin
## 187                                                                                                                                                                                                                                                                                                                                                                    Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1)
## 188                                                                                                                                                                                                                                                                                                                       Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13)
## 189                                                                                                                                                                                                                                                                                                                                                                                                                        Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)
## 190                                                                                                                                                                                                                                                                                                                                                                         Proton-coupled zinc antiporter SLC30A8 (Solute carrier family 30 member 8) (Zinc transporter 8) (ZnT-8)
## 191                                                                                                                                                                                                                                                                                                                                                                      Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25)
## 192                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 193                                                                                                                                                                                                                                                                                                                                                                                                                                                 Frizzled-5 (Fz-5) (hFz5) (FzE5)
## 194                                                                                                                                                                                                                                                                                                                                                                                                                                       Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.1)
## 195                                                                                                                                                                                                                                                                                                           N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)
## 196                                                                                                                                                                                                                                                                                                                                                                                                    Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12)
## 197                                                                                                                                                                                                                                                                                                                                                                                                                                         Paired box protein Pax-6 (Oculorhombin)
## 198                                                                                                                                                                                                                                                                                                                                                                                         Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor)
## 199                                                                                                                                                                                                                                                                                                                                                                                m-AAA protease-interacting protein 1, mitochondrial (Matrix AAA peptidase-interacting protein 1)
## 200                                                                                                                                                                                                                                                                                                                                                                                                    Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
## 201                                                                                                                                                                                                                                                                                                                             Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)
## 202                                                                                                                                                                                                                                                                                                   Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
## 203                                                                                                                                                                                                                                                                                                                                                                                                                                            Rhodopsin, GQ-coupled (GQ-rhodopsin)
## 204                                                                                                                                                                                                                                                                                                                                                                               Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2)
## 205                                                                                                                                                                                                                                                                                                                                                                                                                                        Synaptotagmin-1 (Synaptotagmin I) (SytI)
## 206                                                                                                                                                                                                                                                                                                                                                                                      Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1)
## 207                                                                                                                                                                                                                                                                                              Riboflavin-binding protein (RBP) [Cleaved into: Riboflavin-binding protein, plasma form; Riboflavin-binding protein, yolk major form; Riboflavin-binding protein, yolk minor form]
## 208                                                                                                                                                                                                                                                                                                                                                                                                Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 209                                                                                                                                                                                                                                                                                                                                                                                                    Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
## 210                                                                                                                                                                                                                                                                                                                                                                                                  MICOS complex subunit Mic60 (Mitochondrial inner membrane protein) (Mitofilin)
## 211                                                                                                                                                                                                                                                                                                                                                                                           WD repeat-containing protein 47 (Neuronal enriched MAP interacting protein) (Nemitin)
## 212                                                                                                                                                                                                                                                                                                                                                                                                      5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B)
## 213                                                                                                                                                                                                                                                                                                                                                        cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)
## 214                                                                                                                                                                                                                                                                                                                                                                     Homeobox protein SIX4 (Sine oculis homeobox homolog 4) (Skeletal muscle-specific ARE-binding protein AREC3)
## 215                                                                                                                                                                                                                                                                                                                                                                                                                         Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
## 216                                                                                                                                                                                                                                                                                                      Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
## 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Nephrocystin-3
## 218                                                                                                                                                                                                                                                                                                                                                                                                                                           Tissue inhibitor of metalloproteinase
## 219                                                                                                                                                                                                                                                                                                                                                                                                           Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 220                                                                                                                                                                                                                                                                                                                                                                                                                    Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK)
## 221                                                                                                                                                                                                                                                                                                                                                       Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A)
## 222                                                                                                                                                                                   All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2)
## 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Fucolectin-4
## 224                                                                                                                                                                                                                                                                                                                                                                                                Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 225                                                                                                                                                                                                                                                                                                                                                                                                                         Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
## 226                                                                                                                                                                                                                                                                                                                                                                                                                       Methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.53)
## 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Protein Wnt-8b
## 228                                                                                                                                                                                                                                                                                                                                                  Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
## 229                                                                                                                                                                                                                                                                                                                                                                                                                         DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-)
## 230                                                                                                                                                                                                                                                                                                                             Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)
## 231                                                                                                                                                                                                                                                                                                                                                                                         DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X)
## 232                                                                                                                                                                                                                                                                                                                                                                                                                              Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
## 233                                                                                                                                                                                                                                                                                                                                                                                                                 Protein turtle homolog B (Immunoglobulin superfamily member 9B)
## 234                                                                                                                                                                                                                                                                                                                                                               Carbamoyl-phosphate synthase [ammonia], mitochondrial (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I)
## 235                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 236                                                                                                                                                                                                                                                                                                                                                                                                             Trafficking protein particle complex subunit 11 (Protein foie gras)
## 237                                                                                                                                                                                                                                                                                                                                                                                                Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
## 238                                                                                                                                                                                                                                                                                              Extracellular sulfatase Sulf-2 (hSulf-2) (Arylsulfatase) (EC 3.1.6.1) (N-acetylglucosamine-6-sulfatase) (EC 3.1.6.14) [Cleaved into: Extracellular sulfatase Sulf-2 secreted form]
## 239                                                                                                                                                                                                                                                                                                                                                                                                          Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158)
## 240                                                                                                                                                                                                                                                                                                                                                                                                                                                 Putative ammonium transporter 1
## 241                                                                                                                                                                                                                                                                                                                                                                                                                                Histamine N-methyltransferase (HMT) (EC 2.1.1.8)
## 242                                                                                                                                                                                                                                                                                                                                                                    Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)
## 243                                                                                                                                                                                                                                                                                                                                                              Tripartite motif-containing protein 3 (EC 2.3.2.27) (Brain-expressed RING finger protein) (RING finger protein 22)
## 244                                                                                                                                                                                                                                                                                                        Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]
## 245                                                                                                                                                                                                                                                                                                                                                                                                                     Homeobox protein OTX1 B (zOtx1) (Orthodenticle homolog 1 B)
## 246                                                                                                                                                                                                                                                                                                                                                                             Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 247                                                                                                                                                                                                                                                                                                                                                              Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2)
## 248                                                                                                                                                                                                                                                                                                                                                                                                     U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31)
## 249                                                                                                                                                                                                                                                                                                                                                                                                            Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor)
## 250                                                                                                                                                                                                                                                                                                                                                                                                                                                      Transcription factor SOX-4
## 251                                                                                                                                                                                                                                                                                                                                                                                                                                                            Roundabout homolog 1
## 252                                                                                                                                                                                                                                                                                                                                                                                    Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
## 253                                                                                                                                                                                                                                                                                                                                                                                    Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
## 254                                                                                                                                                                                                                                                                                                                                                                                                    Transcription factor HES-4 (Hairy and enhancer of split 4) (Protein hairy-2)
## 255                                                                                                                                                                                                                                                                                                                                                                    Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (Creatine phosphokinase M-type) (CPK-M) (M-CK)
## 256                                                                                                                                                                                                                                                                                                                  E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
## 257                                                                                                                                                                                                                                                                                                                                                                                                         Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112)
## 258                                                                                                                                                                                                                                                                                                                                                                                        Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase)
## 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Myotrophin
## 260                                                                                                                                                                                                                                                                                                                                            Diamine oxidase [copper-containing] (Diamine oxidase) (EC 1.4.3.22) (Amine oxidase copper domain-containing protein 1) (Histaminase)
## 261                                                                                                                                                                                                                                                                                       Neuronal cell adhesion molecule (Nr-CAM) (Ankyrin-binding cell adhesion molecule NrCAM) (Neuronal surface protein Bravo) (rBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
## 262                                                                                                                                                                                                                                                                                                                                                                                                                                       Synaptotagmin-10 (Synaptotagmin X) (SytX)
## 263                                                                                                                                                                                                                                                                                                                                                                            Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor)
## 264                                                                                                                                                                                                                                                                                                                                                                                 Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)
## 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Advillin (p92)
## 266                                                                                                                                                                                                                                                                                                                                                       Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A)
## 267                                                                                                                                                                                                                                                                                                                                                                                                                                             Annexin A6 (Annexin VI) (Annexin-6)
## 268                                                                                                                                                                                                                                                                                                                                                                                                                                                   Neurocalcin homolog (DrosNCa)
## 269                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 270                                                                                                                                                                                                                                                                                Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein)
## 271                                                                                                                                                                                                                                                                                                                                                                                                               DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)
## 272                                                                                                                                                                                                                                                                                                                              Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
## 273                                                                                                                                                                                                                                                                                                                                     Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter)
## 274                                                                                                                                                                                                                                                                                                                                                                                                                                                            Roundabout homolog 2
## 275                                                                                                                                                                                                                                                                                                                                             Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
## 276                                                                                                                                                                                                                                                                                                                                                                                                                                               Arginine kinase (AK) (EC 2.7.3.3)
## 277                                                                                                                                                                                                                                                                                                                                                                  Polycystin-1-like protein 3 (Polycystin-1L3) (PC1-like 3 protein) (Polycystic kidney disease protein 1-like 3)
## 278                                                                                                                                                                                                                                                                                                                                                                                    Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
## 279                                                                                                                                                                                                                                                                                                   Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41)
## 280                                                                                                                                                                                                                                                                                                                                                                                                                   Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A)
## 281                                                                                                                                                                                                                                                                                             Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53)
## 282                                                                                                                                                                                                                                                                                                                                                                                                          Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase)
## 283                                                                                                                                                                                                                                                                                                                                                                             Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR)
## 284                                                                                                                                                                                                                                                                                                                                                                                                                                    Creatine kinase, testis isozyme (EC 2.7.3.2)
## 285                                                                                                                                                                                                                                                                                                   Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
## 286                                                                                                                                                                                                                                                                                                                                                                                                              Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
## 287                                                                                                                                                                                                                                                                                                                                                                                                                                                       Ras-related protein Rab-3
## 288                                                                                                                                                                                                                                                                                                                                                                                                           Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)
## 289                                                                                                                                                                                                                                                                                                                                                                                                                                     Ornithine decarboxylase (ODC) (EC 4.1.1.17)
## 290                                                                                                                                                                                                                                                                                                                                                                                                                                                               Frizzled-5 (Fz-5)
## 291                                                                                                                                                                                                                                                                                                                                                                                                                                             Protein unc-13 homolog C (Munc13-3)
## 292                                                                                                                                                                                                                                                                                Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
## 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Fucolectin
## 294                                                                                                                                                                                                                                                                                                                                                                                                                                               Hemicentin-1 (Fibulin-6) (FIBL-6)
## 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Fucolectin-3
## 296                                                                                                                                                                                                                                                                                                                                             Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5)
## 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Villin-1
## 298                                                                                                                                                                                                                                                                                                                                                  Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R)
## 299                                                                                                                                                                                                                                                                                                                                                                                                    Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)
## 300                                                                                                                                                                                                                                                                                                                                                                                 Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7)
## 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Nephrocystin-3
## 302                                                                                                                                                                                                                                                                                                                                           Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)
## 303                                                                                                                                                                                                                                                                                                                                                                                                Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
## 304                                                                                                                                                                                                                                                                                                                                                                                                                    Melatonin receptor type 1C (Mel-1C-R) (Mel1c receptor) (CKB)
## 305                                                                                                                                                                                                                                                                                                                                                                                                       Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A)
## 306                                                                                                                                                                                                                                                                                                                                                                                                              Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1)
## 307                                                                                                                                                                                                                                                                                                                                                                                                    Bone morphogenetic protein 6 (BMP-6) (VG-1-related protein) (VG-1-R) (VGR-1)
## 308                                                                                                                                                                                                                                                                                                                                                                                                                                              Protein sprouty homolog 2 (Spry-2)
## 309                                                                                                                                                                                                                                                                                                                                                                                          Glutamate dehydrogenase (GDH) (EC 1.4.1.3) (NAD(P)H-utilizing glutamate dehydrogenase)
## 310                                                                                                                                                                                                                                                                                                                                                                     Sodium/calcium exchanger NCL2 (Na(+)/Ca(2+)-exchange protein NCL2) (OsEFCAX2) (Protein NCX-like 2) (OsNCL2)
## 311                                                                                                                                                                                                                                                                                                                                                                                    Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
## 312                                                                                                                                                                                                                                                                                                              Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (NKCC1) (Na-K-CL symporter)
## 313                                                                                                                                                                                                                                                                                                      Cystathionine gamma-lyase (CGL) (CSE) (EC 4.4.1.1) (Cysteine desulfhydrase) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) (Homocysteine desulfhydrase) (EC 4.4.1.2)
## 314                                                                                                                                                                                                                                                                                                                                                                                         Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]
## 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Rhodopsin
## 316                                                                                                                                                                                                                                                                                                                                                                                                        3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)
## 317                                                                                                                                                                                                                                                                                                                                              Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2)
## 318                                                                                                                                                                                                                                                                                                                                                                                                                                                        Mechanosensory protein 2
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     BiologicalProcess
## 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; apoptotic process [GO:0006915]; asymmetric protein localization involved in cell fate determination [GO:0045167]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cell-cell signaling [GO:0007267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; establishment of blood-brain barrier [GO:0060856]; establishment of cell polarity [GO:0030010]; limb development [GO:0060173]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; non-canonical Wnt signaling pathway [GO:0035567]; oviduct development [GO:0060066]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of axon diameter [GO:0031133]; regulation of axonogenesis [GO:0050770]; regulation of cell population proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; signal transduction [GO:0007165]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; uterus development [GO:0060065]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]
## 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           midbrain development [GO:0030901]; regulation of cell cycle [GO:0051726]; regulation of mitotic cell cycle [GO:0007346]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; regulation of transcription by RNA polymerase II [GO:0006357]; retina development in camera-type eye [GO:0060041]
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; sulfate assimilation [GO:0000103]
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sensory perception of smell [GO:0007608]
## 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           behavioral fear response [GO:0001662]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]; regulation of synaptic vesicle exocytosis [GO:2000300]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]
## 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             camera-type eye photoreceptor cell differentiation [GO:0060219]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell population proliferation [GO:0008283]; cornea development in camera-type eye [GO:0061303]; embryonic camera-type eye formation [GO:0060900]; embryonic forelimb morphogenesis [GO:0035115]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; limb development [GO:0060173]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of neuron differentiation [GO:0045665]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of fibroblast growth factor production [GO:0090270]; retina layer formation [GO:0010842]; Wnt signaling pathway [GO:0016055]
## 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; hemopoiesis [GO:0030097]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]
## 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; facial nerve morphogenesis [GO:0021610]; hypoglossal nerve morphogenesis [GO:0021618]; innervation [GO:0060384]; motor behavior [GO:0061744]; motor neuron apoptotic process [GO:0097049]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; muscle tissue morphogenesis [GO:0060415]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; neuromuscular process controlling posture [GO:0050884]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of mRNA processing [GO:0050685]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396]; spinal cord ventral commissure morphogenesis [GO:0021965]
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               activation of store-operated calcium channel activity [GO:0032237]; adaptive immune response [GO:0002250]; endosomal transport [GO:0016197]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of JNK cascade [GO:0046330]; response to histamine [GO:0034776]; store-operated calcium entry [GO:0002115]; T-helper 1 cell differentiation [GO:0045063]
## 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    antibacterial innate immune response [GO:0140367]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; calcium ion homeostasis [GO:0055074]; cellular response to unfolded protein [GO:0034620]; chaperone-mediated protein folding [GO:0061077]; chemical homeostasis [GO:0048878]; chloride ion homeostasis [GO:0055064]; citric acid secretion [GO:0046720]; collecting duct development [GO:0072044]; connective tissue replacement [GO:0097709]; defense response to Gram-negative bacterium [GO:0050829]; endoplasmic reticulum organization [GO:0007029]; ERAD pathway [GO:0036503]; gene expression [GO:0010467]; glomerular filtration [GO:0003094]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; inflammatory response [GO:0006954]; intracellular calcium ion homeostasis [GO:0006874]; intracellular chloride ion homeostasis [GO:0030644]; intracellular phosphate ion homeostasis [GO:0030643]; intracellular sodium ion homeostasis [GO:0006883]; juxtaglomerular apparatus development [GO:0072051]; kidney development [GO:0001822]; leukocyte cell-cell adhesion [GO:0007159]; lipid metabolic process [GO:0006629]; loop of Henle development [GO:0072070]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; micturition [GO:0060073]; monoatomic ion homeostasis [GO:0050801]; multicellular organismal response to stress [GO:0033555]; multicellular organismal-level homeostasis [GO:0048871]; multicellular organismal-level water homeostasis [GO:0050891]; neutrophil migration [GO:1990266]; organ or tissue specific immune response [GO:0002251]; phosphate ion homeostasis [GO:0055062]; potassium ion homeostasis [GO:0055075]; protein localization to vacuole [GO:0072665]; protein transport into plasma membrane raft [GO:0044861]; regulation of blood pressure [GO:0008217]; regulation of protein transport [GO:0051223]; regulation of urine volume [GO:0035809]; renal sodium ion absorption [GO:0070294]; renal urate salt excretion [GO:0097744]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; response to lipopolysaccharide [GO:0032496]; response to unfolded protein [GO:0006986]; response to water deprivation [GO:0009414]; response to xenobiotic stimulus [GO:0009410]; RNA splicing [GO:0008380]; sodium ion homeostasis [GO:0055078]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; urate transport [GO:0015747]; urea transmembrane transport [GO:0071918]
## 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cardiac muscle cell action potential involved in contraction [GO:0086002]; magnesium ion transport [GO:0015693]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of monoatomic ion transmembrane transport [GO:0034765]; regulation of skeletal muscle contraction via regulation of action potential [GO:0014861]; relaxation of cardiac muscle [GO:0055119]; relaxation of skeletal muscle [GO:0090076]
## 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; monoatomic ion transmembrane transport [GO:0034220]
## 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]
## 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cellular response to interferon-beta [GO:0035458]; dendritic spine development [GO:0060996]; negative regulation of hydrolase activity [GO:0051346]; peptidyl-threonine autophosphorylation [GO:1990443]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of neuron migration [GO:2001222]
## 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    carnitine transmembrane transport [GO:1902603]; creatine transmembrane transport [GO:0015881]; monocarboxylic acid transport [GO:0015718]; urate metabolic process [GO:0046415]
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cGMP-mediated signaling [GO:0019934]; mast cell degranulation [GO:0043303]; positive regulation of cGMP-mediated signaling [GO:0010753]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; relaxation of vascular associated smooth muscle [GO:0060087]
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]
## 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           BMP signaling pathway [GO:0030509]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]
## 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                amino acid metabolic process [GO:0006520]; cysteine biosynthetic process [GO:0019344]; fatty acid metabolic process [GO:0006631]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; leukotriene D4 biosynthetic process [GO:1901750]; leukotriene metabolic process [GO:0006691]; peptide modification [GO:0031179]; proteolysis [GO:0006508]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]
## 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adult heart development [GO:0007512]; cell growth involved in cardiac muscle cell development [GO:0061049]; MAPK cascade [GO:0000165]; negative regulation of autophagy [GO:0010507]; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure [GO:0001985]; neuron-glial cell signaling [GO:0150099]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; pilomotor reflex [GO:0097195]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of heart rate by epinephrine-norepinephrine [GO:0001996]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of the force of heart contraction by epinephrine-norepinephrine [GO:0001997]; positive regulation of vasoconstriction [GO:0045907]; regulation of cardiac muscle contraction [GO:0055117]
## 28                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; cellular response to caffeine [GO:0071313]; cellular response to carbon dioxide [GO:0071244]; cellular response to cold [GO:0070417]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of monoatomic anion transport [GO:1903793]; protein homotetramerization [GO:0051289]; regulation of blood circulation [GO:1903522]; regulation of neuronal action potential [GO:0098908]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]; urinary bladder smooth muscle contraction [GO:0014832]
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       distal tubule morphogenesis [GO:0072156]; monoatomic ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; renal sodium ion absorption [GO:0070294]; ubiquitin-dependent protein catabolic process [GO:0006511]
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]
## 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; bile acid secretion [GO:0032782]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion import [GO:0070509]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hypoxia [GO:0071456]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to peptide [GO:1901653]; cellular response to vitamin D [GO:0071305]; chloride transmembrane transport [GO:1902476]; detection of calcium ion [GO:0005513]; fat pad development [GO:0060613]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular calcium ion homeostasis [GO:0006874]; JNK cascade [GO:0007254]; ossification [GO:0001503]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of insulin secretion [GO:0032024]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of vasoconstriction [GO:0045907]; regulation of calcium ion transport [GO:0051924]; regulation of presynaptic membrane potential [GO:0099505]; response to calcium ion [GO:0051592]; response to fibroblast growth factor [GO:0071774]; response to ischemia [GO:0002931]; response to metal ion [GO:0010038]; response to organic cyclic compound [GO:0014070]; vasodilation [GO:0042311]
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; apoptotic signaling pathway [GO:0097190]; eating behavior [GO:0042755]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of inflammatory response [GO:0050728]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; response to amphetamine [GO:0001975]; response to purine-containing compound [GO:0014074]; synaptic transmission, dopaminergic [GO:0001963]
## 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 estrogen biosynthetic process [GO:0006703]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       lysine biosynthetic process via diaminopimelate [GO:0009089]
## 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; morphogenesis of an epithelium [GO:0002009]; neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of monoatomic anion transport [GO:0044070]; secretion [GO:0046903]
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; flavonoid metabolic process [GO:0009812]
## 39                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; pexophagy [GO:0000425]; programmed cell death in response to reactive oxygen species [GO:0097468]; regulation of peroxisome organization [GO:1900063]; response to reactive oxygen species [GO:0000302]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]
## 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      anterior/posterior pattern specification [GO:0009952]; anterior/posterior pattern specification involved in pronephros development [GO:0034672]; cell fate specification [GO:0001708]; cerebellum development [GO:0021549]; cerebellum formation [GO:0021588]; cilium assembly [GO:0060271]; closure of optic fissure [GO:0061386]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic pattern specification [GO:0009880]; hindbrain development [GO:0030902]; inner ear receptor cell differentiation [GO:0060113]; kidney development [GO:0001822]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; nervous system development [GO:0007399]; otic placode formation [GO:0043049]; peripheral nervous system development [GO:0007422]; pronephric glomerulus morphogenesis [GO:0035775]; pronephros development [GO:0048793]; pronephros morphogenesis [GO:0072114]; regulation of transcription by RNA polymerase II [GO:0006357]; thyroid gland development [GO:0030878]; vestibular receptor cell development [GO:0060118]
## 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          adipose tissue development [GO:0060612]; amino acid transport [GO:0006865]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; blood vessel morphogenesis [GO:0048514]; bone development [GO:0060348]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cell-cell signaling involved in mammary gland development [GO:0060764]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; gene expression [GO:0010467]; glucose catabolic process [GO:0006007]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mesodermal cell migration [GO:0008078]; negative regulation of osteoblast differentiation [GO:0045668]; nervous system development [GO:0007399]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; osteoblast proliferation [GO:0033687]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; response to peptide hormone [GO:0043434]; retina morphogenesis in camera-type eye [GO:0060042]; retina vasculature development in camera-type eye [GO:0061298]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; retinal blood vessel morphogenesis [GO:0061304]; somatic stem cell population maintenance [GO:0035019]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]
## 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]
## 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; calcium activated phospholipid scrambling [GO:0061588]; chloride transmembrane transport [GO:1902476]; establishment of localization in cell [GO:0051649]
## 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of heart contraction [GO:0045823]
## 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; monoatomic ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; response to alcohol [GO:0097305]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]
## 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 49                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  action potential [GO:0001508]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]
## 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      detection of mechanical stimulus [GO:0050982]
## 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851]
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             camera-type eye photoreceptor cell differentiation [GO:0060219]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]
## 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              methylation [GO:0032259]; terpenoid biosynthetic process [GO:0016114]
## 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              acyl carnitine transmembrane transport [GO:1902616]; acyl carnitine transport [GO:0006844]; L-arginine transmembrane transport [GO:1903826]; L-histidine transmembrane transport [GO:0089709]; L-lysine transmembrane transport [GO:1903401]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; organic cation transport [GO:0015695]; ornithine transport [GO:0015822]
## 57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   brain development [GO:0007420]; cellular response to histamine [GO:0071420]; cellular response to zinc ion [GO:0071294]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; chemical synaptic transmission, postsynaptic [GO:0099565]; chloride transmembrane transport [GO:1902476]; circadian sleep/wake cycle, REM sleep [GO:0042747]; cochlea development [GO:0090102]; exploration behavior [GO:0035640]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hard palate development [GO:0060022]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; learning [GO:0007612]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuron development [GO:0048666]; regulation of postsynaptic membrane potential [GO:0060078]; reproductive behavior [GO:0019098]; response to anesthetic [GO:0072347]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; social behavior [GO:0035176]; synaptic transmission, GABAergic [GO:0051932]
## 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        extracellular matrix organization [GO:0030198]; neuropeptide signaling pathway [GO:0007218]
## 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cellular response to diacyl bacterial lipopeptide [GO:0071726]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; toll-like receptor signaling pathway [GO:0002224]
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G protein-coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217]
## 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]
## 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        negative regulation of translation [GO:0017148]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]
## 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           chloride transmembrane transport [GO:1902476]; cysteine transport [GO:0042883]; D-aspartate import across plasma membrane [GO:0070779]; L-aspartate import across plasma membrane [GO:0140009]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]
## 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]
## 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; notochord development [GO:0030903]; pyrimidine nucleobase biosynthetic process [GO:0019856]
## 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion import across plasma membrane [GO:0098703]; chemical synaptic transmission [GO:0007268]
## 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; circadian rhythm [GO:0007623]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of insulin secretion [GO:0046676]
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   endocytosis [GO:0006897]; intracellular iron ion homeostasis [GO:0006879]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]
## 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]
## 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; sodium ion transmembrane transport [GO:0035725]
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   calcium-dependent activation of synaptic vesicle fusion [GO:0099502]; calcium-ion regulated exocytosis [GO:0017156]; regulation of calcium ion-dependent exocytosis [GO:0017158]
## 76                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               neuronal action potential [GO:0019228]; optic nerve structural organization [GO:0021633]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; sensory perception of pain [GO:0019233]
## 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      detection of mechanical stimulus [GO:0050982]
## 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cellular homeostasis [GO:0019725]; ceramide metabolic process [GO:0006672]; ceramide transport [GO:0035627]; cholesterol efflux [GO:0033344]; corneocyte desquamation [GO:0003336]; establishment of skin barrier [GO:0061436]; intracellular protein transport [GO:0006886]; keratinization [GO:0031424]; lipid homeostasis [GO:0055088]; lipid transport [GO:0006869]; lung alveolus development [GO:0048286]; phospholipid efflux [GO:0033700]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of intracellular lipid transport [GO:0032379]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to plasma membrane [GO:0072659]; regulated exocytosis [GO:0045055]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of keratinocyte differentiation [GO:0045616]; secretion by cell [GO:0032940]; surfactant homeostasis [GO:0043129]
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; animal organ development [GO:0048513]; cell surface receptor signaling pathway [GO:0007166]
## 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]
## 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-alpha-amino acid transmembrane transport [GO:1902475]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-ornithine transmembrane transport [GO:1903352]; transport across blood-brain barrier [GO:0150104]
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; cell-cell junction organization [GO:0045216]; dorsal closure [GO:0007391]; establishment of glial blood-brain barrier [GO:0060857]; heart process [GO:0003015]; nerve maturation [GO:0021682]; presynaptic membrane assembly [GO:0097105]; protein localization [GO:0008104]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synaptic target recognition [GO:0008039]; terminal button organization [GO:0072553]
## 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to angiotensin [GO:1904385]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis [GO:0003412]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lens development in camera-type eye [GO:0002088]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]
## 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cellular response to hormone stimulus [GO:0032870]; detection of abiotic stimulus [GO:0009582]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transmembrane transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]
## 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            gamma-aminobutyric acid receptor clustering [GO:0097112]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; regulation of inhibitory synapse assembly [GO:1905702]; sensory perception of sound [GO:0007605]
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416]
## 88                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            action potential [GO:0001508]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; neuronal action potential [GO:0019228]; optic nerve development [GO:0021554]; optic nerve structural organization [GO:0021633]; potassium ion export across plasma membrane [GO:0097623]; potassium ion transmembrane transport [GO:0071805]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, non-REM sleep [GO:0045188]; regulation of dopamine secretion [GO:0014059]; sensory perception of pain [GO:0019233]
## 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 calcium ion transport [GO:0006816]; cognition [GO:0050890]; intracellular calcium ion homeostasis [GO:0006874]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAPK cascade [GO:0043410]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]
## 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        cytokinin biosynthetic process [GO:0009691]
## 92                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   brain development [GO:0007420]; cellular response to histamine [GO:0071420]; cellular response to zinc ion [GO:0071294]; cerebellum development [GO:0021549]; chemical synaptic transmission [GO:0007268]; chemical synaptic transmission, postsynaptic [GO:0099565]; chloride transmembrane transport [GO:1902476]; circadian sleep/wake cycle, REM sleep [GO:0042747]; cochlea development [GO:0090102]; exploration behavior [GO:0035640]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hard palate development [GO:0060022]; inhibitory postsynaptic potential [GO:0060080]; inhibitory synapse assembly [GO:1904862]; inner ear receptor cell development [GO:0060119]; innervation [GO:0060384]; learning [GO:0007612]; memory [GO:0007613]; monoatomic ion transmembrane transport [GO:0034220]; motor behavior [GO:0061744]; nervous system development [GO:0007399]; neuron development [GO:0048666]; regulation of postsynaptic membrane potential [GO:0060078]; reproductive behavior [GO:0019098]; response to anesthetic [GO:0072347]; response to xenobiotic stimulus [GO:0009410]; roof of mouth development [GO:0060021]; social behavior [GO:0035176]; synaptic transmission, GABAergic [GO:0051932]
## 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cellular response to oxidative stress [GO:0034599]; cysteine biosynthetic process [GO:0019344]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; glutathione metabolic process [GO:0006749]; hepatoblast differentiation [GO:0061017]; hepatocyte differentiation [GO:0070365]; liver regeneration [GO:0097421]; peptide modification [GO:0031179]; regulation of immune system process [GO:0002682]; regulation of inflammatory response [GO:0050727]; response to alcohol [GO:0097305]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; spermatogenesis [GO:0007283]; zymogen activation [GO:0031638]
## 94                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    CTP metabolic process [GO:0046036]; GDP catabolic process [GO:0046712]; nucleobase-containing small molecule catabolic process [GO:0034656]; UDP catabolic process [GO:0006256]
## 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           arachidonic acid metabolic process [GO:0019369]; dendritic cell migration [GO:0036336]; glucose homeostasis [GO:0042593]; humoral immune response [GO:0006959]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; leukocyte migration involved in inflammatory response [GO:0002523]; leukotriene A4 biosynthetic process [GO:1901753]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipid oxidation [GO:0034440]; lipoxin biosynthetic process [GO:2001301]; lipoxygenase pathway [GO:0019372]; long-chain fatty acid biosynthetic process [GO:0042759]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of inflammatory response [GO:0050728]; negative regulation of response to endoplasmic reticulum stress [GO:1903573]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; positive regulation of bone mineralization [GO:0030501]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of fat cell differentiation [GO:0045598]; regulation of inflammatory response [GO:0050727]; regulation of inflammatory response to wounding [GO:0106014]; regulation of insulin secretion [GO:0050796]; regulation of reactive oxygen species biosynthetic process [GO:1903426]
## 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             inorganic cation import across plasma membrane [GO:0098659]; monoatomic cation transmembrane transport [GO:0098655]; monoatomic cation transport [GO:0006812]; response to cAMP [GO:0051591]; response to magnesium ion [GO:0032026]; signal transduction [GO:0007165]; visual perception [GO:0007601]
## 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; regulation of intracellular pH [GO:0051453]
## 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                amacrine cell differentiation [GO:0035881]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; developmental process [GO:0032502]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; hindbrain development [GO:0030902]; neuron development [GO:0048666]; pancreas development [GO:0031016]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of DNA-templated transcription [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]
## 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]
## 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     negative regulation of translation [GO:0017148]; nervous system development [GO:0007399]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]
## 104                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cellular response to ethanol [GO:0071361]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; postsynapse organization [GO:0099173]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; vesicle-mediated transport [GO:0016192]
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cellular response to hormone stimulus [GO:0032870]; cellular response to peptide [GO:1901653]; G protein-coupled receptor signaling pathway [GO:0007186]
## 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597]
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 protein homooligomerization [GO:0051260]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]
## 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      L-arginine import across plasma membrane [GO:0097638]; L-lysine import across plasma membrane [GO:0097639]; L-ornithine transmembrane transport [GO:1903352]
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              potassium ion transmembrane transport [GO:0071805]; stabilization of membrane potential [GO:0030322]
## 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 action potential [GO:0001508]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; corpus callosum development [GO:0022038]; globus pallidus development [GO:0021759]; optic nerve development [GO:0021554]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; protein tetramerization [GO:0051262]; response to amine [GO:0014075]; response to auditory stimulus [GO:0010996]; response to fibroblast growth factor [GO:0071774]; response to light intensity [GO:0009642]; response to nerve growth factor [GO:1990089]; response to potassium ion [GO:0035864]; response to toxic substance [GO:0009636]
## 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; L-arginine import across plasma membrane [GO:0097638]; L-arginine transmembrane transport [GO:1903826]; L-histidine import across plasma membrane [GO:1903810]; L-ornithine transmembrane transport [GO:1903352]; lysine transport [GO:0015819]; ornithine transport [GO:0015822]; positive regulation of T cell proliferation [GO:0042102]; transport across blood-brain barrier [GO:0150104]
## 113                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               lipid catabolic process [GO:0016042]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; release of sequestered calcium ion into cytosol [GO:0051209]
## 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            asparagine biosynthetic process [GO:0006529]; glutamine metabolic process [GO:0006541]
## 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; threonine catabolic process [GO:0006567]
## 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273]
## 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hydrogen peroxide [GO:0070301]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to xenobiotic stimulus [GO:0009410]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         angioblast cell migration involved in selective angioblast sprouting [GO:0035475]; anterior/posterior pattern specification [GO:0009952]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; blood vessel development [GO:0001568]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; optic vesicle morphogenesis [GO:0003404]; regulation of chemotaxis [GO:0050920]; rhombomere boundary formation [GO:0021654]; somitogenesis [GO:0001756]; synaptic target recognition [GO:0008039]
## 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             delamination [GO:0060232]; epithelial to mesenchymal transition [GO:0001837]; neuroblast delamination [GO:0060234]; neuroblast division in subventricular zone [GO:0021849]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of inflammatory response [GO:0050727]
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sensory perception of sound [GO:0007605]
## 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]
## 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cell volume homeostasis [GO:0006884]; chloride transmembrane transport [GO:1902476]; mRNA cis splicing, via spliceosome [GO:0045292]; potassium ion transmembrane transport [GO:0071805]; spliceosomal snRNP assembly [GO:0000387]
## 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           cell morphogenesis involved in neuron differentiation [GO:0048667]; cell-cell adhesion [GO:0098609]; dendrite development [GO:0016358]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; interneuron migration [GO:1904936]; negative regulation of dendrite development [GO:2000171]; retina layer formation [GO:0010842]
## 126                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; doxorubicin metabolic process [GO:0044598]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         amelogenesis [GO:0097186]; calcium ion export across plasma membrane [GO:1990034]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cellular response to high light intensity [GO:0071486]; cone photoresponse recovery [GO:0036368]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; drinking behavior [GO:0042756]; enamel mineralization [GO:0070166]; intracellular calcium ion homeostasis [GO:0006874]; membrane repolarization [GO:0086009]; monoatomic ion transport [GO:0006811]; negative regulation of calcium-mediated signaling [GO:0050849]; olfactory nerve maturation [GO:0021630]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; potassium ion transmembrane transport [GO:0071805]; regulation of eating behavior [GO:1903998]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to high light intensity [GO:0009644]; response to melanocyte-stimulating hormone [GO:1990680]; response to odorant [GO:1990834]; sensory perception of smell [GO:0007608]; sodium ion transmembrane transport [GO:0035725]
## 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           activation of innate immune response [GO:0002218]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to type II interferon [GO:0071346]; cytolysis in another organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response [GO:0006955]; positive regulation of AIM2 inflammasome complex assembly [GO:0140973]; positive regulation of pyroptotic inflammatory response [GO:0140639]; protein localization to nucleus [GO:0034504]
## 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       neuropeptide signaling pathway [GO:0007218]
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       L-arginine transmembrane transport [GO:1903826]; lysine transport [GO:0015819]; regulation of intracellular pH [GO:0051453]
## 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                amyloid-beta clearance [GO:0097242]; chemotaxis [GO:0006935]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; complement receptor mediated signaling pathway [GO:0002430]; complement-dependent cytotoxicity [GO:0097278]; complement-mediated synapse pruning [GO:0150062]; fatty acid metabolic process [GO:0006631]; inflammatory response [GO:0006954]; neuron remodeling [GO:0016322]; oviduct epithelium development [GO:0035846]; positive regulation of activation of membrane attack complex [GO:0001970]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of developmental growth [GO:0048639]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of glucose transmembrane transport [GO:0010828]; positive regulation of lipid storage [GO:0010884]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of triglyceride biosynthetic process [GO:0010866]; response to bacterium [GO:0009617]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to progesterone [GO:0032570]; response to xenobiotic stimulus [GO:0009410]; retina development in camera-type eye [GO:0060041]; tolerance induction [GO:0002507]; vascular associated smooth muscle cell differentiation [GO:0035886]; vertebrate eye-specific patterning [GO:0150064]
## 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cilium movement [GO:0003341]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; UTP biosynthetic process [GO:0006228]
## 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription by RNA polymerase II [GO:0006357]; type B pancreatic cell differentiation [GO:0003309]
## 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              blood vessel maturation [GO:0001955]; canonical Wnt signaling pathway [GO:0060070]; extracellular matrix organization [GO:0030198]; negative regulation of metalloendopeptidase activity [GO:1904684]; regulation of angiogenesis [GO:0045765]; regulation of establishment of blood-brain barrier [GO:0090210]; sprouting angiogenesis [GO:0002040]
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     glutamine metabolic process [GO:0006541]; pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819]
## 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 detection of cold stimulus involved in thermoception [GO:0120169]
## 143 actin filament organization [GO:0007015]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compartment boundary maintenance [GO:0060289]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; defense response to insect [GO:0002213]; determination of adult lifespan [GO:0008340]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; eye-antennal disc development [GO:0035214]; eye-antennal disc morphogenesis [GO:0007455]; female germ-line stem cell population maintenance [GO:0036099]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber migration [GO:0007297]; follicle cell of egg chamber stalk formation [GO:0030713]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germ-line stem cell population maintenance [GO:0030718]; germ-line stem-cell niche homeostasis [GO:0060250]; germarium-derived egg chamber formation [GO:0007293]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of an epithelial fold [GO:0060571]; motor neuron axon guidance [GO:0008045]; muscle cell cellular homeostasis [GO:0046716]; muscle cell fate determination [GO:0007521]; myoblast development [GO:0048627]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of gene expression [GO:0010629]; negative regulation of lamellocyte differentiation [GO:0035204]; negative regulation of neurogenesis [GO:0050768]; nervous system process [GO:0050877]; neuroblast development [GO:0014019]; neuroblast fate determination [GO:0007400]; neuroblast fate specification [GO:0014018]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; peripheral nervous system development [GO:0007422]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of crystal cell differentiation [GO:0042691]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell differentiation [GO:0048056]; R7 cell differentiation [GO:0045466]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of filopodium assembly [GO:0051489]; regulation of glycolytic process [GO:0006110]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of stem cell division [GO:2000035]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; stem cell differentiation [GO:0048863]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]
## 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; embryonic body morphogenesis [GO:0010172]; muscle attachment [GO:0016203]; negative regulation of axon regeneration [GO:0048681]; regulation of basement membrane organization [GO:0110011]; response to oxidative stress [GO:0006979]
## 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       lysosomal lumen pH elevation [GO:0035752]; neuron cellular homeostasis [GO:0070050]; phagosome-lysosome fusion [GO:0090385]; potassium ion transmembrane transport [GO:0071805]; proton transmembrane transport [GO:1902600]; regulation of lysosomal lumen pH [GO:0035751]
## 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             L-leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099]
## 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                endocrine pancreas development [GO:0031018]; endodermal cell differentiation [GO:0035987]; gland development [GO:0048732]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; pancreatic A cell differentiation [GO:0003310]; transdifferentiation [GO:0060290]; type B pancreatic cell differentiation [GO:0003309]
## 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             methylation [GO:0032259]; terpenoid biosynthetic process [GO:0016114]
## 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              cellular response to leukemia inhibitory factor [GO:1990830]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]
## 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           melanin biosynthetic process from tyrosine [GO:0006583]
## 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            L-histidine catabolic process [GO:0006548]; L-histidine catabolic process to glutamate and formamide [GO:0019556]; L-histidine catabolic process to glutamate and formate [GO:0019557]
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605]
## 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            sulfation [GO:0051923]
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   regulation of neurotransmitter secretion [GO:0046928]; synaptic vesicle exocytosis [GO:0016079]
## 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        axon guidance [GO:0007411]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cilium assembly [GO:0060271]; establishment of anatomical structure orientation [GO:0048560]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; fat cell differentiation [GO:0045444]; inner ear receptor cell stereocilium organization [GO:0060122]; multi-ciliated epithelial cell differentiation [GO:1903251]; multicellular organism growth [GO:0035264]; non-motile cilium assembly [GO:1905515]; olfactory bulb development [GO:0021772]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; regulation of stress fiber assembly [GO:0051492]; renal tubule development [GO:0061326]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904878]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; positive regulation of protein catabolic process [GO:0045732]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511]
## 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         carbohydrate transport [GO:0008643]; cysteine transmembrane transport [GO:1903712]; melanin biosynthetic process [GO:0042438]; negative regulation of melanin biosynthetic process [GO:0048022]; pigment metabolic process involved in pigmentation [GO:0043474]; regulation of melanin biosynthetic process [GO:0048021]
## 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   chromatin remodeling [GO:0006338]; methylation [GO:0032259]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of retinoic acid biosynthetic process [GO:1900053]
## 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             brain morphogenesis [GO:0048854]; cellular response to insulin stimulus [GO:0032869]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; mitochondrial genome maintenance [GO:0000002]; negative regulation of cellular senescence [GO:2000773]; positive regulation of angiogenesis [GO:0045766]; positive regulation of artery morphogenesis [GO:1905653]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell size [GO:0045793]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of TOR signaling [GO:0032008]; positive regulation of vascular endothelial cell proliferation [GO:1905564]
## 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor production [GO:0032760]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]
## 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; blood coagulation [GO:0007596]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; nucleoside triphosphate biosynthetic process [GO:0009142]; UTP metabolic process [GO:0046051]
## 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              carcinine import across plasma membrane [GO:1905130]; detection of light stimulus involved in visual perception [GO:0050908]; neurotransmitter uptake [GO:0001504]; positive phototaxis [GO:0046956]; visual perception [GO:0007601]
## 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; inorganic cation transmembrane transport [GO:0098662]; potassium ion transmembrane transport [GO:0071805]; protein heterotetramerization [GO:0051290]; protein tetramerization [GO:0051262]; release of sequestered calcium ion into cytosol [GO:0051209]; Wnt signaling pathway [GO:0016055]
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     detection of mechanical stimulus [GO:0050982]
## 169                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          sensory perception of sound [GO:0007605]
## 170                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 171                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; astrocyte activation [GO:0048143]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; central nervous system development [GO:0007417]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled adenosine receptor signaling pathway [GO:0001973]; inflammatory response [GO:0006954]; inhibitory postsynaptic potential [GO:0060080]; locomotory behavior [GO:0007626]; membrane depolarization [GO:0051899]; negative regulation of alpha-beta T cell activation [GO:0046636]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909]; positive regulation of acetylcholine secretion, neurotransmission [GO:0014057]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein secretion [GO:0050714]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of urine volume [GO:0035810]; prepulse inhibition [GO:0060134]; presynaptic modulation of chemical synaptic transmission [GO:0099171]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of calcium ion transport [GO:0051924]; regulation of DNA-templated transcription [GO:0006355]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of norepinephrine secretion [GO:0014061]; response to amphetamine [GO:0001975]; response to caffeine [GO:0031000]; response to purine-containing compound [GO:0014074]; response to xenobiotic stimulus [GO:0009410]; sensory perception [GO:0007600]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; vasodilation [GO:0042311]
## 172                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; kynurenine metabolic process [GO:0070189]; NAD metabolic process [GO:0019674]; podocyte development [GO:0072015]; quinolinate biosynthetic process [GO:0019805]; response to yeast [GO:0001878]; tryptophan catabolic process [GO:0006569]
## 173                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; Toll signaling pathway [GO:0008063]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 8 signaling pathway [GO:0034158]
## 174                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              axon extension [GO:0048675]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; neuron apoptotic process [GO:0051402]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of sound [GO:0007605]; vestibulocochlear nerve development [GO:0021562]; visual perception [GO:0007601]
## 175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; response to temperature stimulus [GO:0009266]
## 176                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue morphogenesis [GO:0055008]; cell migration involved in gastrulation [GO:0042074]; cell-cell adhesion [GO:0098609]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; establishment of blood-brain barrier [GO:0060856]; establishment of blood-retinal barrier [GO:1990963]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; mesenchymal cell proliferation [GO:0010463]; mesodermal cell migration [GO:0008078]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of developmental process [GO:0051093]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of morphogenesis of an epithelium [GO:1905331]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; nervous system development [GO:0007399]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; Norrin signaling pathway [GO:0110135]; odontogenesis of dentin-containing tooth [GO:0042475]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ossification [GO:0045778]; positive regulation of stem cell proliferation [GO:2000648]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; receptor-mediated endocytosis involved in cholesterol transport [GO:0090118]; regulation of anatomical structure morphogenesis [GO:0022603]; regulation of cell development [GO:0060284]; regulation of DNA-templated transcription [GO:0006355]; regulation of epithelial cell proliferation [GO:0050678]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; roof of mouth development [GO:0060021]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; stem cell proliferation [GO:0072089]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]
## 177                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ammonium transmembrane transport [GO:0072488]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to potassium ion [GO:0035865]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; inorganic anion import across plasma membrane [GO:0098658]; intracellular chloride ion homeostasis [GO:0030644]; intracellular potassium ion homeostasis [GO:0030007]; intracellular sodium ion homeostasis [GO:0006883]; maintenance of blood-brain barrier [GO:0035633]; mammary duct terminal end bud growth [GO:0060763]; multicellular organism growth [GO:0035264]; negative regulation of vascular wound healing [GO:0061044]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; potassium ion transport [GO:0006813]; regulation of matrix metallopeptidase secretion [GO:1904464]; regulation of spontaneous synaptic transmission [GO:0150003]; sodium ion homeostasis [GO:0055078]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; T cell chemotaxis [GO:0010818]
## 178                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                axon guidance [GO:0007411]; axonogenesis involved in innervation [GO:0060385]; blood vessel diameter maintenance [GO:0097746]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endothelin maturation [GO:0034959]; gene expression [GO:0010467]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; neuron projection development [GO:0031175]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of blood pressure [GO:0008217]; regulation of ERK1 and ERK2 cascade [GO:0070372]; response to cadmium ion [GO:0046686]; response to hypoxia [GO:0001666]; response to muscle stretch [GO:0035994]; response to xenobiotic stimulus [GO:0009410]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; substance P catabolic process [GO:0010814]; sympathetic neuron axon guidance [GO:0097492]
## 179                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             intracellular potassium ion homeostasis [GO:0030007]; micturition [GO:0060073]; negative regulation of cell volume [GO:0045794]; positive regulation of apoptotic process [GO:0043065]; potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to calcium ion [GO:0051592]; response to carbon monoxide [GO:0034465]; response to hypoxia [GO:0001666]; response to osmotic stress [GO:0006970]; smooth muscle contraction involved in micturition [GO:0060083]; vasodilation [GO:0042311]
## 180                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 181                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adult locomotory behavior [GO:0008344]; auditory receptor cell stereocilium organization [GO:0060088]; calcium ion transport [GO:0006816]; cell-cell adhesion [GO:0098609]; cochlea development [GO:0090102]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear auditory receptor cell differentiation [GO:0042491]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; righting reflex [GO:0060013]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]
## 182                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    G protein-coupled glutamate receptor signaling pathway [GO:0007216]; gene expression [GO:0010467]; modulation of chemical synaptic transmission [GO:0050804]; postsynaptic modulation of chemical synaptic transmission [GO:0099170]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]
## 183                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; intracellular magnesium ion homeostasis [GO:0010961]; magnesium ion transport from cytosol to endoplasmic reticulum [GO:0160176]
## 184                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion transmembrane transport [GO:0070588]; negative regulation of dendrite morphogenesis [GO:0050774]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]; positive regulation of axon extension [GO:0045773]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630]
## 185                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]
## 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 187                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of synaptic transmission [GO:0050805]; neuron-glial cell signaling [GO:0150099]; osteoblast differentiation [GO:0001649]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of growth hormone secretion [GO:0060124]; regulation of glutamate secretion [GO:0014048]; response to ethanol [GO:0045471]; response to nicotine [GO:0035094]; synaptic transmission, GABAergic [GO:0051932]
## 188                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      amino acid import across plasma membrane [GO:0089718]; amino acid transport [GO:0006865]; creatine transmembrane transport [GO:0015881]; gamma-aminobutyric acid import [GO:0051939]; neurotransmitter transport [GO:0006836]; sodium ion transmembrane transport [GO:0035725]; taurine transmembrane transport [GO:0015734]
## 189                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cell death [GO:0008219]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928]
## 190                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       zinc ion import into organelle [GO:0062111]
## 191                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]
## 192                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 193                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of mitophagy [GO:1901524]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]
## 194                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; flavonoid metabolic process [GO:0009812]
## 195                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; DNA damage response [GO:0006974]; dosage compensation by inactivation of X chromosome [GO:0009048]; endothelial to hematopoietic transition [GO:0098508]; forebrain radial glial cell differentiation [GO:0021861]; gliogenesis [GO:0042063]; innate immune response [GO:0045087]; mRNA destabilization [GO:0061157]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; oogenesis [GO:0048477]; positive regulation of cap-independent translational initiation [GO:1903679]; positive regulation of translation [GO:0045727]; primary miRNA processing [GO:0031053]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of meiotic cell cycle [GO:0051445]; regulation of T cell differentiation [GO:0045580]; RNA methylation [GO:0001510]; spermatogenesis [GO:0007283]; stem cell population maintenance [GO:0019827]
## 196                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          creatine transmembrane transport [GO:0015881]; creatinine metabolic process [GO:0046449]
## 197                                                                                                                                                                                                                                                                                                                                                                                       anterior/posterior pattern specification [GO:0009952]; astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; blood vessel development [GO:0001568]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; cell population proliferation [GO:0008283]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; cerebral cortex regionalization [GO:0021796]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; embryonic camera-type eye morphogenesis [GO:0048596]; epithelial cell development [GO:0002064]; establishment of mitotic spindle orientation [GO:0000132]; eye photoreceptor cell development [GO:0042462]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; gene expression [GO:0010467]; glandular epithelial cell differentiation [GO:0002067]; glucose homeostasis [GO:0042593]; habenula development [GO:0021986]; hindbrain development [GO:0030902]; insulin metabolic process [GO:1901142]; interkinetic nuclear migration [GO:0022027]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; learned vocalization behavior or vocal learning [GO:0098598]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; neural precursor cell proliferation [GO:0061351]; neuroblast proliferation [GO:0007405]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; olfactory bulb mitral cell layer development [GO:0061034]; oligodendrocyte cell fate specification [GO:0021778]; pallium development [GO:0021543]; pancreatic A cell development [GO:0003322]; pancreatic A cell differentiation [GO:0003310]; pituitary gland development [GO:0021983]; positive regulation of cell fate specification [GO:0042660]; positive regulation of core promoter binding [GO:1904798]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamatergic neuron differentiation [GO:0120008]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to organelle [GO:0033365]; regionalization [GO:0003002]; regulation of asymmetric cell division [GO:0009786]; regulation of cell migration [GO:0030334]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]; regulation of neuron differentiation [GO:0045664]; regulation of neuron projection development [GO:0010975]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription by RNA polymerase II [GO:0006357]; response to ethanol [GO:0045471]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; rhombomere morphogenesis [GO:0021593]; salivary gland morphogenesis [GO:0007435]; sensory neuron migration [GO:1904937]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; spinal cord development [GO:0021510]; telencephalon regionalization [GO:0021978]; transcription by RNA polymerase II [GO:0006366]; type B pancreatic cell differentiation [GO:0003309]; ventral spinal cord development [GO:0021517]
## 198                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 199                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  calcium import into the mitochondrion [GO:0036444]; mitochondrial calcium ion homeostasis [GO:0051560]; protein insertion into mitochondrial inner membrane from matrix [GO:0032979]; protein insertion into mitochondrial membrane [GO:0051204]
## 200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 intracellular cholesterol transport [GO:0032367]; plasma membrane organization [GO:0007009]; protein homotetramerization [GO:0051289]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]
## 201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]
## 202                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of myofibroblast differentiation [GO:1904761]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gene expression [GO:0010628]; response to heat [GO:0009408]
## 203                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cellular response to arsenic-containing substance [GO:0071243]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of cytoplasmic translational elongation [GO:1900248]; negative regulation of translational elongation [GO:0045900]; regulation of translation at synapse, modulating synaptic transmission [GO:0099547]
## 205                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; positive regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903235]; regulation of dopamine secretion [GO:0014059]; synaptic vesicle endocytosis [GO:0048488]
## 206                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182]
## 207                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  negative regulation of sensory perception of bitter taste [GO:1904661]; negative regulation of sensory perception of sweet taste [GO:1904657]; riboflavin transport [GO:0032218]
## 208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 209                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; regulation of calcium-dependent activation of synaptic vesicle fusion [GO:0150037]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]
## 210                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cristae formation [GO:0042407]; mitochondrial calcium ion homeostasis [GO:0051560]; neuron cellular homeostasis [GO:0070050]
## 211                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        adult locomotory behavior [GO:0008344]; anterior commissure morphogenesis [GO:0021960]; autophagy [GO:0006914]; brain development [GO:0007420]; cerebral cortex development [GO:0021987]; cerebral cortex radial glia-guided migration [GO:0021801]; corpus callosum development [GO:0022038]; detection of hot stimulus involved in thermoception [GO:0120168]; locomotory behavior [GO:0007626]; microtubule cytoskeleton organization [GO:0000226]; motor behavior [GO:0061744]; negative regulation of microtubule depolymerization [GO:0007026]; neural precursor cell proliferation [GO:0061351]; neuron projection development [GO:0031175]; neuronal stem cell population maintenance [GO:0097150]
## 212                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; bone remodeling [GO:0046849]; cellular response to alkaloid [GO:0071312]; cellular response to xenobiotic stimulus [GO:0071466]; chemical synaptic transmission [GO:0007268]; negative regulation of serotonin secretion [GO:0014063]; regulation of behavior [GO:0050795]; vasoconstriction [GO:0042310]
## 213                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; aorta development [GO:0035904]; cAMP-mediated signaling [GO:0019933]; cardiac septum development [GO:0003279]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; coronary vasculature development [GO:0060976]; establishment of endothelial barrier [GO:0061028]; heart development [GO:0007507]; heart valve development [GO:0003170]; intracellular signal transduction [GO:0035556]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of oxidative phosphorylation [GO:0090324]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of cGMP-mediated signaling [GO:0010752]; regulation of mitochondrion organization [GO:0010821]; regulation of nitric oxide mediated signal transduction [GO:0010749]; response to hydrogen sulfide [GO:1904880]; ventricular septum development [GO:0003281]
## 214                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of gene expression [GO:0010468]; regulation of protein localization [GO:0032880]; regulation of synaptic assembly at neuromuscular junction [GO:0008582]; regulation of transcription by RNA polymerase II [GO:0006357]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]
## 215                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907]
## 216                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             acute-phase response [GO:0006953]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; blood coagulation [GO:0007596]; cell surface receptor signaling pathway [GO:0007166]; cytolysis by host of symbiont cells [GO:0051838]; fibrinolysis [GO:0042730]; G protein-coupled receptor signaling pathway [GO:0007186]; ligand-gated ion channel signaling pathway [GO:1990806]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; negative regulation of proteolysis [GO:0045861]; neutrophil-mediated killing of gram-negative bacterium [GO:0070945]; platelet activation [GO:0030168]; positive regulation of blood coagulation [GO:0030194]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of insulin secretion [GO:0032024]; positive regulation of lipid kinase activity [GO:0090218]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [GO:1900738]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of blood coagulation [GO:0030193]; regulation of cell shape [GO:0008360]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to wounding [GO:0009611]
## 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 218                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; delamination [GO:0060232]; imaginal disc-derived wing expansion [GO:0048526]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; oogenesis [GO:0048477]; phototaxis [GO:0042331]; tracheal outgrowth, open tracheal system [GO:0007426]; tracheal pit formation in open tracheal system [GO:0035202]; ventral cord development [GO:0007419]; wing disc morphogenesis [GO:0007472]
## 219                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 220                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               animal organ regeneration [GO:0031100]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; calcium ion transport into cytosol [GO:0060402]; cellular response to mechanical stimulus [GO:0071260]; cellular response to UV [GO:0034644]; endocrine pancreas development [GO:0031018]; epithelial cell proliferation [GO:0050673]; establishment of localization in cell [GO:0051649]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; homeostasis of number of cells [GO:0048872]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; leukocyte homeostasis [GO:0001776]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; release of cytochrome c from mitochondria [GO:0001836]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; response to xenobiotic stimulus [GO:0009410]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068]
## 221                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          anatomical structure homeostasis [GO:0060249]; cardiac muscle tissue development [GO:0048738]; cartilage development [GO:0051216]; cell migration in hindbrain [GO:0021535]; dorsal/ventral pattern formation [GO:0009953]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fin regeneration [GO:0031101]; liver development [GO:0001889]; mesoderm development [GO:0007498]; negative regulation of endodermal cell fate specification [GO:0042664]; olfactory nerve formation [GO:0021628]; olfactory placode morphogenesis [GO:0071699]; pectoral fin development [GO:0033339]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; post-anal tail morphogenesis [GO:0036342]; posterior lateral line development [GO:0048916]; response to ethanol [GO:0045471]; skin morphogenesis [GO:0043589]
## 222                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cerebellum development [GO:0021549]; isoprenoid biosynthetic process [GO:0008299]; regulation of body fluid levels [GO:0050878]; ubiquinone biosynthetic process [GO:0006744]
## 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 225                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907]
## 226                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      methionine biosynthetic process [GO:0009086]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]
## 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; commissural neuron axon guidance [GO:0071679]; embryonic pattern specification [GO:0009880]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; forebrain neuron differentiation [GO:0021879]; hypothalamus development [GO:0021854]; neuron differentiation [GO:0030182]; otic placode formation [GO:0043049]; sensory epithelium regeneration [GO:0070654]; Wnt signaling pathway [GO:0016055]
## 228                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]
## 229                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 230                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron-glial cell signaling [GO:0150099]; synaptic transmission, GABAergic [GO:0051932]
## 231                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 232                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]
## 233                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; synaptic membrane adhesion [GO:0099560]
## 234                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to ammonium ion [GO:0071242]; cellular response to cAMP [GO:0071320]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucagon stimulus [GO:0071377]; cellular response to oleic acid [GO:0071400]; glutamine metabolic process [GO:0006541]; hepatocyte differentiation [GO:0070365]; homocysteine metabolic process [GO:0050667]; liver development [GO:0001889]; midgut development [GO:0007494]; monoatomic anion homeostasis [GO:0055081]; nitric oxide metabolic process [GO:0046209]; response to amine [GO:0014075]; response to amino acid [GO:0043200]; response to cAMP [GO:0051591]; response to dexamethasone [GO:0071548]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to growth hormone [GO:0060416]; response to lipopolysaccharide [GO:0032496]; response to oleic acid [GO:0034201]; response to starvation [GO:0042594]; response to steroid hormone [GO:0048545]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; response to zinc ion [GO:0010043]; triglyceride catabolic process [GO:0019433]; urea cycle [GO:0000050]; vasodilation [GO:0042311]
## 235                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 236                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Golgi organization [GO:0007030]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; protein N-linked glycosylation [GO:0006487]; protein secretion [GO:0009306]; regulation of response to endoplasmic reticulum stress [GO:1905897]; retina development in camera-type eye [GO:0060041]; vesicle-mediated transport [GO:0016192]
## 237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          hair cycle process [GO:0022405]; Notch signaling pathway [GO:0007219]; regulation of Notch signaling pathway [GO:0008593]; sensory perception of sound [GO:0007605]; signal transduction [GO:0007165]; tooth mineralization [GO:0034505]
## 238                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelin production [GO:1904472]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]
## 239                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 brain development [GO:0007420]; cognition [GO:0050890]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of neurotransmitter secretion [GO:0001956]; protein localization to plasma membrane [GO:0072659]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synapse organization [GO:0050807]
## 240                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ammonium homeostasis [GO:0097272]; ammonium transmembrane transport [GO:0072488]
## 241                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                histamine catabolic process [GO:0001695]; methylation [GO:0032259]
## 242                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  phosphocreatine biosynthetic process [GO:0046314]; response to heat [GO:0009408]
## 243                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       negative regulation of translation [GO:0017148]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation protein catabolic process at postsynapse [GO:0140252]
## 244                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; enzyme-linked receptor protein signaling pathway [GO:0007167]; motor neuron apoptotic process [GO:0097049]; negative regulation of P-type sodium:potassium-exchanging transporter activity [GO:1903407]; negative regulation of sodium ion export across plasma membrane [GO:1903277]; neuromuscular junction development [GO:0007528]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of motor neuron apoptotic process [GO:2000673]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of Rac protein signal transduction [GO:0035022]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; positive regulation of synaptic assembly at neuromuscular junction [GO:0045887]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of GTPase activity [GO:0043087]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein phosphorylation [GO:0001932]; regulation of synapse organization [GO:0050807]; regulation of synaptic activity [GO:0060025]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416]
## 245                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     inner ear morphogenesis [GO:0042472]; lateral semicircular canal development [GO:0060875]; regulation of transcription by RNA polymerase II [GO:0006357]; retinal pigment epithelium development [GO:0003406]
## 246                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 247                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 sodium ion transport [GO:0006814]
## 248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]
## 249                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; follicle-stimulating hormone signaling pathway [GO:0042699]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [GO:0051897]; regulation of protein kinase A signaling [GO:0010738]
## 250                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to glucose stimulus [GO:0071333]; endocrine pancreas development [GO:0031018]; gene expression [GO:0010467]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; hematopoietic stem cell homeostasis [GO:0061484]; kidney morphogenesis [GO:0060993]; mesenchyme development [GO:0060485]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of insulin secretion [GO:0032024]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translation [GO:0045727]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of DNA-templated transcription [GO:0006355]; regulation of protein stability [GO:0031647]; response to hypoxia [GO:0001666]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412]
## 251                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hypoxia [GO:0071456]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; coronary vasculature development [GO:0060976]; endocardial cushion formation [GO:0003272]; heart development [GO:0007507]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; kidney development [GO:0001822]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; neuron projection extension [GO:1990138]; olfactory bulb interneuron development [GO:0021891]; oligodendrocyte development [GO:0014003]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of gene expression [GO:0010628]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; pulmonary valve morphogenesis [GO:0003184]; regulation of dendrite morphogenesis [GO:0048814]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; synapse organization [GO:0050808]; ventricular septum development [GO:0003281]; ventricular septum morphogenesis [GO:0060412]
## 252                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]
## 253                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion regulated lysosome exocytosis [GO:1990927]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; regulation of synaptic vesicle endocytosis [GO:1900242]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119]
## 254                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         eye photoreceptor cell development [GO:0042462]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of neurogenesis [GO:0050768]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural crest formation [GO:0014029]; Notch signaling pathway [GO:0007219]; photoreceptor cell maintenance [GO:0045494]; prechordal plate formation [GO:0021501]
## 255                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  phosphocreatine biosynthetic process [GO:0046314]; response to heat [GO:0009408]
## 256                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA-mediated gene silencing by inhibition of translation [GO:0035278]; neural tube development [GO:0021915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089]
## 257                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; neurogenesis [GO:0022008]
## 258                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]
## 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      regulation of barbed-end actin filament capping [GO:2000812]
## 260                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     amine metabolic process [GO:0009308]; cellular response to copper ion starvation [GO:0035874]; putrescine metabolic process [GO:0009445]; response to antibiotic [GO:0046677]
## 261                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; central nervous system development [GO:0007417]; clustering of voltage-gated sodium channels [GO:0045162]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuronal action potential propagation [GO:0019227]; protein localization [GO:0008104]; regulation of neuron projection development [GO:0010975]; regulation of postsynapse organization [GO:0099175]; retinal ganglion cell axon guidance [GO:0031290]
## 262                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        calcium-ion regulated exocytosis [GO:0017156]; chemical synaptic transmission [GO:0007268]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sensory perception of smell [GO:0007608]
## 263                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of MAPK cascade [GO:0043408]
## 264                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  neuron cellular homeostasis [GO:0070050]; one-carbon metabolic process [GO:0006730]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]
## 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       actin filament organization [GO:0007015]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cilium assembly [GO:0060271]; nervous system development [GO:0007399]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of diacylglycerol biosynthetic process [GO:1900480]
## 266                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          anatomical structure homeostasis [GO:0060249]; cardiac muscle tissue development [GO:0048738]; cartilage development [GO:0051216]; cell migration in hindbrain [GO:0021535]; dorsal/ventral pattern formation [GO:0009953]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fin regeneration [GO:0031101]; liver development [GO:0001889]; mesoderm development [GO:0007498]; negative regulation of endodermal cell fate specification [GO:0042664]; olfactory nerve formation [GO:0021628]; olfactory placode morphogenesis [GO:0071699]; pectoral fin development [GO:0033339]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; post-anal tail morphogenesis [GO:0036342]; posterior lateral line development [GO:0048916]; response to ethanol [GO:0045471]; skin morphogenesis [GO:0043589]
## 267                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  apoptotic signaling pathway [GO:0097190]; biomineral tissue development [GO:0031214]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; growth plate cartilage chondrocyte differentiation [GO:0003418]; mitochondrial calcium ion homeostasis [GO:0051560]; negative regulation of sequestering of calcium ion [GO:0051283]; regulation of muscle contraction [GO:0006937]
## 268                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           negative regulation of neuronal signal transduction [GO:1902848]; positive regulation of circadian sleep/wake cycle, sleep [GO:0045938]
## 269                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 270                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              actin cytoskeleton organization [GO:0030036]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; cilium assembly [GO:0060271]; dendrite morphogenesis [GO:0048813]; kidney development [GO:0001822]; melanosome organization [GO:0032438]; memory [GO:0007613]; negative regulation of dendritic spine morphogenesis [GO:0061002]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; protein transmembrane transport [GO:0071806]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of synaptic vesicle exocytosis [GO:2000300]; retina development in camera-type eye [GO:0060041]
## 271                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421]; octopamine biosynthetic process [GO:0006589]
## 272                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cell population proliferation [GO:0008283]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; fibroblast migration [GO:0010761]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of DNA-templated transcription [GO:0045892]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; neuron apoptotic process [GO:0051402]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; positive regulation of bone mineralization [GO:0030501]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell population proliferation [GO:0042127]; regulation of DNA-templated transcription [GO:0006355]; regulation of neuron differentiation [GO:0045664]; regulation of transcription by RNA polymerase II [GO:0006357]; response to lipopolysaccharide [GO:0032496]; retina layer formation [GO:0010842]; roof of mouth development [GO:0060021]; Schwann cell development [GO:0014044]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; transcription by RNA polymerase II [GO:0006366]; trigeminal nerve development [GO:0021559]
## 273                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         beta-alanine transport [GO:0001762]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; glycine transport [GO:0015816]; neurotransmitter transport [GO:0006836]
## 274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               aorta development [GO:0035904]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; chemotaxis [GO:0006935]; endocardial cushion formation [GO:0003272]; heart induction [GO:0003129]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Notch signaling pathway [GO:0045747]; pulmonary valve morphogenesis [GO:0003184]; retinal ganglion cell axon guidance [GO:0031290]; ureteric bud development [GO:0001657]; ventricular septum morphogenesis [GO:0060412]
## 275                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            adult behavior [GO:0030534]; cellular response to cocaine [GO:0071314]; D-aspartate import across plasma membrane [GO:0070779]; glutathione biosynthetic process [GO:0006750]; L-aspartate import across plasma membrane [GO:0140009]; L-aspartate transmembrane transport [GO:0070778]; L-glutamate import across plasma membrane [GO:0098712]; L-glutamate transmembrane transport [GO:0015813]; monoatomic anion transmembrane transport [GO:0098656]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; neurotransmitter reuptake [GO:0098810]; positive regulation of glucose import [GO:0046326]; protein homotrimerization [GO:0070207]; response to amino acid [GO:0043200]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; telencephalon development [GO:0021537]; visual behavior [GO:0007632]
## 276                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 phosphocreatine biosynthetic process [GO:0046314]
## 277                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; monoatomic cation transport [GO:0006812]; sensory perception of sour taste [GO:0050915]
## 278                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          amino acid transport [GO:0006865]; associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid reuptake [GO:0051936]; inorganic anion import across plasma membrane [GO:0098658]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]; transport across blood-brain barrier [GO:0150104]
## 279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; cellular response to ethanol [GO:0071361]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; multicellular organism growth [GO:0035264]; postsynapse organization [GO:0099173]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of postsynaptic specialization assembly [GO:0099150]; synapse assembly [GO:0007416]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; vesicle-mediated transport [GO:0016192]
## 280                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        cell differentiation [GO:0030154]; endocrine pancreas development [GO:0031018]; floor plate development [GO:0033504]; floor plate formation [GO:0021508]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; positive regulation of DNA-templated transcription [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; Schwann cell development [GO:0014044]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; ventral spinal cord interneuron differentiation [GO:0021514]
## 281                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             L-methionine salvage from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555]
## 282                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        L-phenylalanine catabolic process [GO:0006559]; tyrosine biosynthetic process [GO:0006571]
## 283                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; centripetally migrating follicle cell migration [GO:0060269]; hematopoietic stem cell homeostasis [GO:0061484]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; negative regulation of insulin receptor signaling pathway [GO:0046627]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of plasma membrane bounded cell projection assembly [GO:0120034]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic assembly at neuromuscular junction [GO:0051124]
## 284                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 phosphocreatine biosynthetic process [GO:0046314]
## 285                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   sodium ion transmembrane transport [GO:0035725]
## 286                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]
## 287                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytoskeletal matrix organization at active zone [GO:0048789]; exocytosis [GO:0006887]; maintenance of presynaptic active zone structure [GO:0048790]; neurotransmitter secretion [GO:0007269]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; symbiont entry into host cell [GO:0046718]; vesicle-mediated transport [GO:0016192]
## 288                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; endocytosis [GO:0006897]; intracellular calcium ion homeostasis [GO:0006874]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005]
## 289                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cell population proliferation [GO:0008283]; kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell population proliferation [GO:0008284]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615]
## 290                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye development [GO:0031076]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; glandular epithelial cell maturation [GO:0002071]; intestinal epithelial cell maturation [GO:0060574]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell population proliferation [GO:0008285]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type II interferon production [GO:0032729]; post-embryonic camera-type eye development [GO:0031077]; presynapse assembly [GO:0099054]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; Spemann organizer formation [GO:0060061]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]
## 291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           chemical synaptic transmission [GO:0007268]; dense core granule priming [GO:0061789]; negative regulation of synaptic plasticity [GO:0031914]; presynaptic dense core vesicle exocytosis [GO:0099525]; regulation of neurotransmitter secretion [GO:0046928]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle priming [GO:0016082]
## 292                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion export [GO:1901660]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; cellular response to acetylcholine [GO:1905145]; cellular response to epinephrine stimulus [GO:0071872]; flagellated sperm motility [GO:0030317]; hippocampus development [GO:0021766]; intracellular calcium ion homeostasis [GO:0006874]; monoatomic ion transmembrane transport [GO:0034220]; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071878]; negative regulation of angiogenesis [GO:0016525]; negative regulation of arginine catabolic process [GO:1900082]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of cardiac muscle hypertrophy in response to stress [GO:1903243]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of citrulline biosynthetic process [GO:1903249]; negative regulation of gene expression [GO:0010629]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; negative regulation of the force of heart contraction [GO:0098736]; neural retina development [GO:0003407]; nitric oxide-cGMP-mediated signaling [GO:0038060]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of cardiac conduction [GO:1903779]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of transcription by RNA polymerase II [GO:0006357]; response to hydrostatic pressure [GO:0051599]; spermatogenesis [GO:0007283]; transport across blood-brain barrier [GO:0150104]; urinary bladder smooth muscle contraction [GO:0014832]
## 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 294                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin cytoskeleton organization [GO:0030036]; basement membrane organization [GO:0071711]; cell division [GO:0051301]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; response to bacterium [GO:0009617]; visual perception [GO:0007601]
## 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]
## 296                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 (R)-carnitine transmembrane transport [GO:1902270]; (R)-carnitine transport [GO:1900749]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; response to symbiotic bacterium [GO:0009609]; response to tumor necrosis factor [GO:0034612]; response to type II interferon [GO:0034341]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]; transport across blood-brain barrier [GO:0150104]; xenobiotic detoxification by transmembrane export across the plasma membrane [GO:1990961]
## 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin polymerization or depolymerization [GO:0008154]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]
## 298                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; regulation of metabolic process [GO:0019222]
## 299                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        axoneme assembly [GO:0035082]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; neuron migration [GO:0001764]; retina development in camera-type eye [GO:0060041]
## 300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              adult heart development [GO:0007512]; adult walking behavior [GO:0007628]; aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; blood circulation [GO:0008015]; blood vessel remodeling [GO:0001974]; cardiac septum morphogenesis [GO:0060411]; central nervous system development [GO:0007417]; chordate embryonic development [GO:0043009]; chromatin remodeling [GO:0006338]; cognition [GO:0050890]; cranial nerve development [GO:0021545]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; female genitalia development [GO:0030540]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; innervation [GO:0060384]; nose development [GO:0043584]; olfactory behavior [GO:0042048]; olfactory bulb development [GO:0021772]; olfactory nerve development [GO:0021553]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of growth hormone secretion [GO:0060123]; regulation of neurogenesis [GO:0050767]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; response to bacterium [GO:0009617]; retina development in camera-type eye [GO:0060041]; right ventricular compact myocardium morphogenesis [GO:0003226]; rRNA processing [GO:0006364]; secondary palate development [GO:0062009]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; T cell differentiation [GO:0030217]; transcription by RNA polymerase II [GO:0006366]; ventricular trabecula myocardium morphogenesis [GO:0003222]
## 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cilium assembly [GO:0060271]; convergent extension [GO:0060026]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; kidney development [GO:0001822]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; pronephros development [GO:0048793]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]
## 302                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; branching involved in salivary gland morphogenesis [GO:0060445]; camera-type eye development [GO:0043010]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; morphogenesis of an epithelial sheet [GO:0002011]; neuron projection development [GO:0031175]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of muscle cell differentiation [GO:0051149]; protein phosphorylation [GO:0006468]; regulation of basement membrane organization [GO:0110011]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; retina development in camera-type eye [GO:0060041]; retinal blood vessel morphogenesis [GO:0061304]; tissue development [GO:0009888]
## 303                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to ethanol [GO:0045471]
## 304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of glucose import [GO:0046325]; negative regulation of glycolytic process [GO:0045820]
## 305                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cerebellum development [GO:0021549]; chromatin remodeling [GO:0006338]; hematopoietic stem cell migration [GO:0035701]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; primitive hemopoiesis [GO:0060215]
## 306                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cAMP-mediated signaling [GO:0043950]
## 307                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to iron ion [GO:0071281]; cellular response to mechanical stimulus [GO:0071260]; endochondral ossification [GO:0001958]; eye development [GO:0001654]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular iron ion homeostasis [GO:0006879]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; multicellular organismal-level iron ion homeostasis [GO:0060586]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of aldosterone secretion [GO:2000860]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein secretion [GO:0050714]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular permeability [GO:0043117]; response to activity [GO:0014823]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to retinoic acid [GO:0032526]; skeletal system development [GO:0001501]; type B pancreatic cell development [GO:0003323]
## 308                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         animal organ development [GO:0048513]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of lens fiber cell differentiation [GO:1902747]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]
## 309                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       glutamate biosynthetic process [GO:0006537]
## 310                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion transmembrane transport [GO:0070588]; intracellular calcium ion homeostasis [GO:0006874]; sodium ion transport [GO:0006814]
## 311                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        amino acid transport [GO:0006865]; associative learning [GO:0008306]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid import [GO:0051939]; inorganic anion import across plasma membrane [GO:0098658]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neurotransmitter reuptake [GO:0098810]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; sodium ion import across plasma membrane [GO:0098719]; sodium ion transmembrane transport [GO:0035725]; synapse organization [GO:0050808]
## 312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; inorganic cation import across plasma membrane [GO:0098659]; potassium ion homeostasis [GO:0055075]; potassium ion import across plasma membrane [GO:1990573]; sodium ion homeostasis [GO:0055078]
## 313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein sulfhydration [GO:0044524]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; transsulfuration [GO:0019346]
## 314 actin filament organization [GO:0007015]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compartment boundary maintenance [GO:0060289]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; defense response to insect [GO:0002213]; determination of adult lifespan [GO:0008340]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; eye-antennal disc development [GO:0035214]; eye-antennal disc morphogenesis [GO:0007455]; female germ-line stem cell population maintenance [GO:0036099]; follicle cell of egg chamber development [GO:0030707]; follicle cell of egg chamber migration [GO:0007297]; follicle cell of egg chamber stalk formation [GO:0030713]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germ-line stem cell population maintenance [GO:0030718]; germ-line stem-cell niche homeostasis [GO:0060250]; germarium-derived egg chamber formation [GO:0007293]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of an epithelial fold [GO:0060571]; motor neuron axon guidance [GO:0008045]; muscle cell cellular homeostasis [GO:0046716]; muscle cell fate determination [GO:0007521]; myoblast development [GO:0048627]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of gene expression [GO:0010629]; negative regulation of lamellocyte differentiation [GO:0035204]; negative regulation of neurogenesis [GO:0050768]; nervous system process [GO:0050877]; neuroblast development [GO:0014019]; neuroblast fate determination [GO:0007400]; neuroblast fate specification [GO:0014018]; neuroblast proliferation [GO:0007405]; neuron fate determination [GO:0048664]; neuron fate specification [GO:0048665]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; peripheral nervous system development [GO:0007422]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of crystal cell differentiation [GO:0042691]; positive regulation of DNA-templated transcription [GO:0045893]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription by RNA polymerase II [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell differentiation [GO:0048056]; R7 cell differentiation [GO:0045466]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of filopodium assembly [GO:0051489]; regulation of glycolytic process [GO:0006110]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neuroblast proliferation [GO:1902692]; regulation of neurogenesis [GO:0050767]; regulation of stem cell division [GO:2000035]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; stem cell differentiation [GO:0048863]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]
## 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cellular response to light stimulus [GO:0071482]; phototransduction [GO:0007602]; visual perception [GO:0007601]
## 316                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             valine catabolic process [GO:0006574]
## 317                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     negative regulation of translation [GO:0017148]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]
## 318                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        detection of mechanical stimulus involved in sensory perception of touch [GO:0050976]; mechanosensory behavior [GO:0007638]; positive regulation of detection of mechanical stimulus involved in sensory perception of touch [GO:1905789]; positive regulation of mechanosensory behavior [GO:1905792]; potassium ion transport [GO:0006813]; response to mechanical stimulus [GO:0009612]
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                GeneOntologyIDs
## 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0000578; GO:0001502; GO:0001525; GO:0002062; GO:0005102; GO:0005109; GO:0005125; GO:0005615; GO:0005788; GO:0006915; GO:0007165; GO:0007267; GO:0007269; GO:0007416; GO:0008284; GO:0009887; GO:0009953; GO:0009986; GO:0010595; GO:0010628; GO:0014719; GO:0014834; GO:0016055; GO:0021707; GO:0021846; GO:0022009; GO:0030010; GO:0030182; GO:0030326; GO:0031012; GO:0031133; GO:0032355; GO:0035019; GO:0035115; GO:0035116; GO:0035313; GO:0035567; GO:0042127; GO:0042733; GO:0043066; GO:0043627; GO:0045165; GO:0045167; GO:0045893; GO:0045944; GO:0046330; GO:0048103; GO:0048864; GO:0050678; GO:0050768; GO:0050770; GO:0050808; GO:0051216; GO:0051247; GO:0051965; GO:0060054; GO:0060065; GO:0060066; GO:0060070; GO:0060071; GO:0060173; GO:0060856; GO:0060997; GO:0061038; GO:0062009; GO:0071560; GO:0098685; GO:0098793; GO:0098978; GO:0099175; GO:1904891; GO:1905606; GO:2000300; GO:2000463
## 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0000977; GO:0000981; GO:0005634; GO:0006357; GO:0007346; GO:0030901; GO:0050767; GO:0051726; GO:0060041; GO:0061074
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0000103; GO:0004020; GO:0004781; GO:0005524; GO:0016779; GO:0050428
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0007268; GO:0007608; GO:0017156; GO:0030276; GO:0030658; GO:0042803; GO:0045956; GO:0046982; GO:0070382; GO:0098793; GO:0098978
## 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GO:0001662; GO:0005737; GO:0019005; GO:0031146; GO:0045202; GO:0098685; GO:0098793; GO:0098978; GO:0099575; GO:2000300
## 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0002011; GO:0002088; GO:0003407; GO:0005109; GO:0005125; GO:0005615; GO:0008283; GO:0010842; GO:0016055; GO:0030182; GO:0035115; GO:0045165; GO:0045665; GO:0045686; GO:0045743; GO:0060070; GO:0060173; GO:0060219; GO:0060828; GO:0060900; GO:0061072; GO:0061303; GO:0090270; GO:0090271
## 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0003779; GO:0005200; GO:0005886; GO:0006779; GO:0007009; GO:0008091; GO:0014731; GO:0016020; GO:0030036; GO:0030054; GO:0030097; GO:0030863; GO:0030864; GO:0042995; GO:0051015; GO:0051693; GO:0098794; GO:0098978
## 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0003723; GO:0003725; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0006397; GO:0007274; GO:0008251; GO:0008285; GO:0016553; GO:0016556; GO:0021610; GO:0021618; GO:0021965; GO:0030336; GO:0035264; GO:0042802; GO:0044387; GO:0045070; GO:0045202; GO:0046872; GO:0050685; GO:0050884; GO:0051726; GO:0060384; GO:0060415; GO:0061744; GO:0097049
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005764; GO:0005765; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:1903712
## 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0000139; GO:0001772; GO:0002115; GO:0002250; GO:0003924; GO:0005509; GO:0005525; GO:0005737; GO:0005815; GO:0005886; GO:0016197; GO:0031982; GO:0032237; GO:0032588; GO:0033093; GO:0034776; GO:0045063; GO:0046330; GO:0051928
## 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0000922; GO:0001822; GO:0002251; GO:0003091; GO:0003094; GO:0005509; GO:0005615; GO:0005783; GO:0005886; GO:0005929; GO:0006629; GO:0006874; GO:0006883; GO:0006914; GO:0006915; GO:0006954; GO:0006986; GO:0007029; GO:0007157; GO:0007159; GO:0008217; GO:0008380; GO:0009410; GO:0009414; GO:0009986; GO:0010467; GO:0015747; GO:0016020; GO:0016323; GO:0016324; GO:0019864; GO:0030643; GO:0030644; GO:0032496; GO:0033209; GO:0033555; GO:0034620; GO:0034976; GO:0035809; GO:0036503; GO:0044861; GO:0045177; GO:0046720; GO:0048871; GO:0048878; GO:0050801; GO:0050829; GO:0050891; GO:0051223; GO:0055062; GO:0055064; GO:0055074; GO:0055075; GO:0055078; GO:0060073; GO:0060170; GO:0061077; GO:0070294; GO:0071918; GO:0072044; GO:0072051; GO:0072070; GO:0072218; GO:0072221; GO:0072233; GO:0072665; GO:0097190; GO:0097709; GO:0097744; GO:0098552; GO:0140367; GO:1990266
## 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005242; GO:0005546; GO:0005886; GO:0006813; GO:0008076; GO:0014861; GO:0015693; GO:0016020; GO:0034765; GO:0042802; GO:0051289; GO:0055119; GO:0060306; GO:0086002; GO:0086008; GO:0086091; GO:0090076; GO:1990573
## 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005229; GO:0005254; GO:0005783; GO:0005829; GO:0005886; GO:0034220; GO:0046983; GO:0061588; GO:0070161; GO:1902476
## 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0004937; GO:0005886; GO:0007200; GO:0007204; GO:0007267; GO:0043410; GO:0071880
## 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005954; GO:0014069; GO:0035458; GO:0043197; GO:0046427; GO:0046872; GO:0051346; GO:0060996; GO:0106310; GO:1990443; GO:2000124; GO:2001222
## 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0005308; GO:0005886; GO:0008028; GO:0015226; GO:0015718; GO:0015881; GO:0046415; GO:1902603
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0001609; GO:0002882; GO:0005886; GO:0007189; GO:0010575; GO:0010753; GO:0019934; GO:0032722; GO:0032755; GO:0043303; GO:0043306; GO:0060087; GO:0098685; GO:0098793; GO:0098978; GO:0099171
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005886; GO:0006879; GO:0006897; GO:0034755; GO:0070207; GO:0070287
## 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0000122; GO:0002088; GO:0005634; GO:0014029; GO:0021501; GO:0030509; GO:0033504; GO:0043066; GO:0043425; GO:0043565; GO:0045892; GO:0046983
## 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0000048; GO:0002682; GO:0002951; GO:0005615; GO:0005886; GO:0006508; GO:0006520; GO:0006536; GO:0006631; GO:0006691; GO:0006750; GO:0006751; GO:0007283; GO:0019344; GO:0031179; GO:0031638; GO:0036374; GO:0050727; GO:0070062; GO:0103068; GO:1901750
## 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0000165; GO:0001985; GO:0001994; GO:0001996; GO:0001997; GO:0004937; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005901; GO:0007200; GO:0007204; GO:0007512; GO:0010507; GO:0010613; GO:0031965; GO:0043410; GO:0045907; GO:0045987; GO:0046982; GO:0055117; GO:0061049; GO:0071880; GO:0097195; GO:0150099
## 28                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005216; GO:0005245; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014070; GO:0014832; GO:0015267; GO:0015278; GO:0016324; GO:0019233; GO:0030424; GO:0032421; GO:0034605; GO:0035774; GO:0042542; GO:0042802; GO:0046872; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0050974; GO:0051289; GO:0070301; GO:0070417; GO:0070588; GO:0071244; GO:0071313; GO:0097553; GO:0097604; GO:0098908; GO:1903522; GO:1903793; GO:1990760
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0003779; GO:0005829; GO:0005856; GO:0006511; GO:0016567; GO:0031463; GO:0050801; GO:0070294; GO:0070936; GO:0072156; GO:1990756
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0001786; GO:0005509; GO:0005544; GO:0005886; GO:0014059; GO:0019905; GO:0030154; GO:0030276; GO:0030424; GO:0030672; GO:0031045; GO:0042584; GO:0048488; GO:0048791; GO:0071277; GO:1903235
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004952; GO:0004993; GO:0005886; GO:0007186; GO:0007187; GO:0007191; GO:0007268; GO:0030425; GO:0030594; GO:0045211
## 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0001503; GO:0002931; GO:0004930; GO:0005178; GO:0005509; GO:0005513; GO:0005886; GO:0006874; GO:0007186; GO:0007193; GO:0007200; GO:0007254; GO:0008284; GO:0009986; GO:0010038; GO:0010628; GO:0014070; GO:0016323; GO:0016324; GO:0016597; GO:0019901; GO:0030424; GO:0032024; GO:0032782; GO:0035729; GO:0042311; GO:0042734; GO:0042803; GO:0043025; GO:0043679; GO:0044325; GO:0045907; GO:0048754; GO:0050927; GO:0051592; GO:0051924; GO:0060613; GO:0070374; GO:0070509; GO:0071305; GO:0071333; GO:0071404; GO:0071456; GO:0071774; GO:0090280; GO:0098978; GO:0099505; GO:1901653; GO:1902476
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005886; GO:0007189; GO:0007626; GO:0008289; GO:0014074; GO:0019899; GO:0032230; GO:0042755; GO:0042802; GO:0046636; GO:0050728; GO:0060080; GO:0097190; GO:0098794; GO:2001235
## 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0004303; GO:0004745; GO:0005829; GO:0006703; GO:0007601; GO:0042572; GO:0042622; GO:0052650
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0008836; GO:0009089
## 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0002009; GO:0004064; GO:0004089; GO:0005737; GO:0005829; GO:0005886; GO:0006730; GO:0008270; GO:0015670; GO:0018820; GO:0032230; GO:0032849; GO:0038166; GO:0043209; GO:0044070; GO:0045177; GO:0046903; GO:0051453; GO:0070050; GO:0070062; GO:2001150; GO:2001225
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004062; GO:0005829; GO:0008146; GO:0009812; GO:0050427
## 39                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0000302; GO:0000425; GO:0005737; GO:0005778; GO:0007605; GO:0030864; GO:0035253; GO:0043025; GO:0050910; GO:0097468; GO:0120044; GO:0120045; GO:1900063
## 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0000978; GO:0000981; GO:0001708; GO:0001822; GO:0003677; GO:0003700; GO:0005634; GO:0006357; GO:0007399; GO:0007422; GO:0009880; GO:0009952; GO:0021549; GO:0021588; GO:0021703; GO:0030878; GO:0030901; GO:0030902; GO:0030917; GO:0034672; GO:0035775; GO:0043049; GO:0043565; GO:0048596; GO:0048793; GO:0060113; GO:0060118; GO:0060271; GO:0061386; GO:0072114
## 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0001702; GO:0001944; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006865; GO:0006897; GO:0007399; GO:0008078; GO:0008203; GO:0008217; GO:0009952; GO:0010467; GO:0015026; GO:0016055; GO:0017147; GO:0033687; GO:0033690; GO:0035019; GO:0035108; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0043434; GO:0045600; GO:0045668; GO:0045669; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0048514; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060348; GO:0060349; GO:0060444; GO:0060603; GO:0060612; GO:0060764; GO:0060856; GO:0061178; GO:0061298; GO:0061299; GO:0061304; GO:0098609; GO:0110135; GO:1902262; GO:1990963
## 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004021; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853
## 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005254; GO:0005783; GO:0005886; GO:0017128; GO:0046983; GO:0051649; GO:0061588; GO:0061589; GO:0061590; GO:0061591; GO:1902476
## 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004940; GO:0005769; GO:0005886; GO:0045823; GO:0071880
## 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001964; GO:0004888; GO:0005886; GO:0006811; GO:0006821; GO:0006936; GO:0007218; GO:0008270; GO:0016594; GO:0016934; GO:0022824; GO:0030425; GO:0030594; GO:0030977; GO:0034707; GO:0043005; GO:0043025; GO:0043204; GO:0043231; GO:0045202; GO:0045211; GO:0051970; GO:0060012; GO:0060080; GO:0071230; GO:0071294; GO:0071361; GO:0097305; GO:1902476; GO:1902495
## 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 49                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001508; GO:0005221; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0016020; GO:0051260; GO:0071805
## 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:0042277; GO:0097730
## 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
## 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004021; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0045944; GO:0060219
## 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0008168; GO:0016114; GO:0032259; GO:0046872
## 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005289; GO:0005292; GO:0005739; GO:0005743; GO:0006844; GO:0015174; GO:0015227; GO:0015695; GO:0015822; GO:0089709; GO:1902616; GO:1903401; GO:1903826; GO:1990575
## 57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004890; GO:0005216; GO:0005254; GO:0005886; GO:0007214; GO:0007268; GO:0007399; GO:0007420; GO:0007612; GO:0007613; GO:0009410; GO:0009986; GO:0019098; GO:0021549; GO:0022851; GO:0030594; GO:0030659; GO:0034220; GO:0034707; GO:0035176; GO:0035612; GO:0035640; GO:0042747; GO:0042802; GO:0043005; GO:0043195; GO:0045202; GO:0045211; GO:0048666; GO:0051932; GO:0060021; GO:0060022; GO:0060077; GO:0060078; GO:0060080; GO:0060119; GO:0060384; GO:0061744; GO:0071294; GO:0071420; GO:0072347; GO:0090102; GO:0098982; GO:0099565; GO:0099634; GO:1902476; GO:1902495; GO:1902711; GO:1904315; GO:1904862
## 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005615; GO:0007218; GO:0030020; GO:0030198; GO:0062023
## 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0000785; GO:0001673; GO:0001955; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006275; GO:0007492; GO:0031965; GO:0042742; GO:0043123; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0030670; GO:0032731; GO:0035355; GO:0035663; GO:0038023; GO:0042802; GO:0045087; GO:0045121; GO:0061809; GO:0071723; GO:0071726; GO:1900227
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0002121; GO:0004995; GO:0005886; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016020
## 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0005886; GO:0008519; GO:0072488; GO:0097272
## 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0000209; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0015031; GO:0016567; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
## 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005313; GO:0005314; GO:0005886; GO:0015108; GO:0015501; GO:0015813; GO:0016324; GO:0031901; GO:0031902; GO:0033229; GO:0042883; GO:0043005; GO:0045202; GO:0046872; GO:0055038; GO:0070779; GO:0098712; GO:0140009; GO:1902476
## 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
## 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0003883; GO:0005524; GO:0005737; GO:0006241; GO:0006541; GO:0019856; GO:0030903; GO:0042802; GO:0044210; GO:0097268
## 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005509; GO:0005891; GO:0007268; GO:0008331; GO:0045202; GO:0098703
## 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0004930; GO:0005886; GO:0007186; GO:0007193; GO:0007623; GO:0008502; GO:0042562; GO:0043025; GO:0043235; GO:0046676; GO:0097159
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005886; GO:0006879; GO:0006897; GO:0034755; GO:0070207; GO:0070287
## 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001937; GO:0002232; GO:0002523; GO:0002540; GO:0004051; GO:0004052; GO:0005506; GO:0005576; GO:0005615; GO:0005635; GO:0005641; GO:0005654; GO:0005829; GO:0006691; GO:0006959; GO:0016363; GO:0016525; GO:0016787; GO:0019369; GO:0019370; GO:0019372; GO:0030501; GO:0031965; GO:0034440; GO:0034774; GO:0036336; GO:0036403; GO:0042593; GO:0042759; GO:0045598; GO:0048471; GO:0050727; GO:0050728; GO:0050796; GO:0061044; GO:0061045; GO:0106014; GO:1900015; GO:1900407; GO:1901753; GO:1903426; GO:1903573; GO:1903671; GO:1904813; GO:1904999; GO:2001301
## 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001518; GO:0005248; GO:0019228; GO:0030424; GO:0035725; GO:0086010
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0017156; GO:0017158; GO:0030276; GO:0030669; GO:0030672; GO:0031045; GO:0042802; GO:0070382; GO:0098686; GO:0099502
## 76                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005249; GO:0005251; GO:0005789; GO:0005886; GO:0008076; GO:0014059; GO:0019228; GO:0019233; GO:0021633; GO:0030027; GO:0030424; GO:0030425; GO:0031258; GO:0032809; GO:0033010; GO:0042734; GO:0043194; GO:0043204; GO:0043679; GO:0044224; GO:0045188; GO:0051260; GO:0071805
## 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0030246; GO:0050982
## 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0000139; GO:0003336; GO:0005102; GO:0005319; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006672; GO:0006869; GO:0006886; GO:0010875; GO:0016020; GO:0016887; GO:0019725; GO:0030658; GO:0031424; GO:0032379; GO:0032940; GO:0033344; GO:0033700; GO:0034040; GO:0034191; GO:0035627; GO:0042626; GO:0043129; GO:0043231; GO:0045055; GO:0045616; GO:0048286; GO:0055088; GO:0061178; GO:0061436; GO:0072659; GO:0097209; GO:0097234; GO:0140326; GO:0140359; GO:2000010
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004930; GO:0005509; GO:0005886; GO:0007166; GO:0007189; GO:0048513
## 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0002088; GO:0003382; GO:0003412; GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016324; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062; GO:0098609; GO:1904385; GO:1904754
## 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0000064; GO:0005886; GO:0006865; GO:0015171; GO:0015174; GO:0015179; GO:0015189; GO:0015807; GO:0030054; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1902475; GO:1903352; GO:1903826
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0003015; GO:0005886; GO:0005919; GO:0007391; GO:0008039; GO:0008104; GO:0008366; GO:0019991; GO:0021682; GO:0035151; GO:0045202; GO:0045216; GO:0048786; GO:0060857; GO:0061343; GO:0072553; GO:0097105
## 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0002088; GO:0003382; GO:0003412; GO:0005509; GO:0005634; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016324; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062; GO:0098609; GO:1904385; GO:1904754
## 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004930; GO:0005886; GO:0007186; GO:0008188; GO:0009582; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005737; GO:0005886; GO:0005903; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015143; GO:0015229; GO:0015882; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070837
## 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005886; GO:0007605; GO:0030425; GO:0045211; GO:0050811; GO:0060077; GO:0097112; GO:0098982; GO:0099572; GO:0099645; GO:1905702
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0045202; GO:0060219
## 88                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001508; GO:0005249; GO:0005251; GO:0005768; GO:0005789; GO:0005886; GO:0008076; GO:0014059; GO:0015271; GO:0016020; GO:0019228; GO:0019233; GO:0019894; GO:0021554; GO:0021633; GO:0021987; GO:0022038; GO:0030027; GO:0030424; GO:0030425; GO:0031258; GO:0032809; GO:0033010; GO:0034705; GO:0042734; GO:0043194; GO:0043204; GO:0043679; GO:0044224; GO:0044305; GO:0045188; GO:0045211; GO:0051260; GO:0071805; GO:0097623; GO:0098978; GO:0099508; GO:1905030
## 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001540; GO:0001666; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0022848; GO:0032720; GO:0035094; GO:0042166; GO:0042803; GO:0043005; GO:0043410; GO:0045202; GO:0045211; GO:0045766; GO:0050890
## 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005634; GO:0005829; GO:0009691; GO:0016799; GO:0102682
## 92                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0004890; GO:0005216; GO:0005254; GO:0005886; GO:0007214; GO:0007268; GO:0007399; GO:0007420; GO:0007612; GO:0007613; GO:0009410; GO:0009986; GO:0019098; GO:0021549; GO:0022851; GO:0030594; GO:0030659; GO:0034220; GO:0034707; GO:0035176; GO:0035612; GO:0035640; GO:0042747; GO:0042802; GO:0043005; GO:0043195; GO:0045202; GO:0045211; GO:0048666; GO:0051932; GO:0060021; GO:0060022; GO:0060077; GO:0060078; GO:0060080; GO:0060119; GO:0060384; GO:0061744; GO:0071294; GO:0071420; GO:0072347; GO:0090102; GO:0098982; GO:0099565; GO:0099634; GO:1902476; GO:1902495; GO:1902711; GO:1904315; GO:1904862
## 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0002682; GO:0002951; GO:0005615; GO:0005886; GO:0006536; GO:0006749; GO:0006750; GO:0006751; GO:0007283; GO:0016755; GO:0019344; GO:0031179; GO:0031638; GO:0031982; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374; GO:0050727; GO:0061017; GO:0070365; GO:0097305; GO:0097421; GO:0103068
## 94                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0000139; GO:0000421; GO:0003924; GO:0004382; GO:0005765; GO:0005794; GO:0006256; GO:0016020; GO:0017110; GO:0017111; GO:0031410; GO:0034656; GO:0036384; GO:0043273; GO:0045134; GO:0046036; GO:0046712
## 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0001937; GO:0002232; GO:0002523; GO:0002540; GO:0004051; GO:0004052; GO:0005506; GO:0005576; GO:0005615; GO:0005635; GO:0005641; GO:0005654; GO:0005829; GO:0006691; GO:0006959; GO:0016363; GO:0016525; GO:0016787; GO:0019369; GO:0019370; GO:0019372; GO:0030501; GO:0031965; GO:0034440; GO:0034774; GO:0036336; GO:0036403; GO:0042593; GO:0042759; GO:0045598; GO:0048471; GO:0050727; GO:0050728; GO:0050796; GO:0061044; GO:0061045; GO:0106014; GO:1900015; GO:1900407; GO:1901753; GO:1903426; GO:1903573; GO:1903671; GO:1904813; GO:1904999; GO:2001301
## 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          GO:0005222; GO:0005223; GO:0005262; GO:0005272; GO:0005886; GO:0006812; GO:0007165; GO:0007601; GO:0015276; GO:0017022; GO:0017071; GO:0030425; GO:0030553; GO:0032026; GO:0043194; GO:0043204; GO:0044877; GO:0045296; GO:0051591; GO:0097386; GO:0098655; GO:0098659; GO:1902495
## 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000324; GO:0005773; GO:0005774; GO:0015819; GO:0051453; GO:1903826
## 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000977; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0009887; GO:0009888; GO:0030154; GO:0030902; GO:0031016; GO:0031017; GO:0032502; GO:0035881; GO:0043565; GO:0045893; GO:0046983; GO:0048384; GO:0048666; GO:0048699
## 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006576; GO:0006805; GO:0008146; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923
## 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000209; GO:0005737; GO:0005769; GO:0005794; GO:0007399; GO:0008270; GO:0015031; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534
## 104                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000139; GO:0005200; GO:0005543; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0007416; GO:0008021; GO:0008091; GO:0016079; GO:0016081; GO:0016192; GO:0016324; GO:0016363; GO:0017158; GO:0021692; GO:0030036; GO:0030054; GO:0030534; GO:0030864; GO:0033010; GO:0035264; GO:0042995; GO:0043025; GO:0048471; GO:0051015; GO:0051693; GO:0071361; GO:0098688; GO:0098793; GO:0098918; GO:0098978; GO:0099150; GO:0099173; GO:0099186; GO:0099189
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0032870; GO:0042277; GO:1901653
## 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004014; GO:0006597; GO:0008295
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0008277; GO:0042734; GO:0042995; GO:0043235; GO:0045211; GO:0051260
## 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000064; GO:0005737; GO:0005794; GO:0005886; GO:0015189; GO:0031410; GO:0061459; GO:0097638; GO:0097639; GO:1903352
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005886; GO:0015271; GO:0022841; GO:0030322; GO:0071805
## 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0009636; GO:0009642; GO:0009986; GO:0010996; GO:0014075; GO:0019894; GO:0021549; GO:0021554; GO:0021759; GO:0022038; GO:0030673; GO:0032590; GO:0032809; GO:0035864; GO:0042734; GO:0043679; GO:0044305; GO:0044325; GO:0045211; GO:0051260; GO:0051262; GO:0071466; GO:0071774; GO:0071805; GO:0099508; GO:1901381; GO:1990089
## 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000064; GO:0001618; GO:0005290; GO:0005886; GO:0006865; GO:0009925; GO:0015171; GO:0015174; GO:0015189; GO:0015807; GO:0015819; GO:0015822; GO:0016020; GO:0016323; GO:0016324; GO:0032991; GO:0042102; GO:0061459; GO:0089718; GO:0097638; GO:0150104; GO:1903352; GO:1903810; GO:1903826
## 113                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004435; GO:0004629; GO:0005509; GO:0005737; GO:0005886; GO:0007200; GO:0016042; GO:0046488; GO:0048015; GO:0051209
## 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004066; GO:0006529; GO:0006541
## 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0003941; GO:0004794; GO:0006565; GO:0006567; GO:0009097; GO:0030170
## 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005739; GO:0005759; GO:0005829; GO:0017148; GO:0042273; GO:0043023; GO:0070130; GO:0090071; GO:0140978
## 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005262; GO:0005886; GO:0006811; GO:0006874; GO:0007166; GO:0009409; GO:0009410; GO:0014070; GO:0015267; GO:0015278; GO:0019233; GO:0032421; GO:0042802; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0051289; GO:0070301; GO:0070588; GO:0097604
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001568; GO:0001756; GO:0002042; GO:0003404; GO:0005886; GO:0007155; GO:0007411; GO:0007412; GO:0008039; GO:0009952; GO:0021654; GO:0035475; GO:0042734; GO:0046875; GO:0048013; GO:0048514; GO:0050920; GO:0098978
## 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001650; GO:0001837; GO:0003677; GO:0005654; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0016020; GO:0021849; GO:0043231; GO:0045944; GO:0050727; GO:0060232; GO:0060234
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0007605; GO:0016020; GO:0032426; GO:0120234
## 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0003690; GO:0003724; GO:0003725; GO:0003727; GO:0005524; GO:0005737; GO:0005829; GO:0009615; GO:0016887; GO:0045087; GO:0045111; GO:0051607; GO:1900245; GO:1900246
## 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000387; GO:0005229; GO:0005267; GO:0005634; GO:0005681; GO:0005829; GO:0005856; GO:0005886; GO:0006884; GO:0008289; GO:0016020; GO:0032991; GO:0034709; GO:0034715; GO:0036094; GO:0045292; GO:0071805; GO:1902476; GO:1990935
## 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005509; GO:0005886; GO:0007156; GO:0010842; GO:0016358; GO:0030425; GO:0048667; GO:0098609; GO:1904936; GO:2000171
## 126                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004062; GO:0005737; GO:0005829; GO:0006068; GO:0006805; GO:0008146; GO:0009812; GO:0044598; GO:0050427; GO:0051923
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005262; GO:0005516; GO:0005737; GO:0005886; GO:0006811; GO:0006874; GO:0007602; GO:0007608; GO:0008273; GO:0008277; GO:0009644; GO:0010628; GO:0015293; GO:0016020; GO:0016324; GO:0021630; GO:0031982; GO:0035725; GO:0036368; GO:0042756; GO:0048306; GO:0050849; GO:0050911; GO:0055074; GO:0070166; GO:0070588; GO:0071486; GO:0071805; GO:0086009; GO:0097186; GO:0098703; GO:0120199; GO:1903998; GO:1990034; GO:1990680; GO:1990834
## 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000139; GO:0002218; GO:0003924; GO:0004866; GO:0005525; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006955; GO:0030659; GO:0031410; GO:0034504; GO:0042742; GO:0042802; GO:0042803; GO:0042832; GO:0048471; GO:0050830; GO:0051607; GO:0051715; GO:0071222; GO:0071346; GO:0071347; GO:0071356; GO:0140639; GO:0140678; GO:0140973
## 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005576; GO:0007218
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0071482
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000324; GO:0005773; GO:0005774; GO:0015819; GO:0022857; GO:0051453; GO:1903826
## 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0007189
## 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001798; GO:0001934; GO:0001970; GO:0002430; GO:0002507; GO:0004866; GO:0005576; GO:0005615; GO:0006631; GO:0006935; GO:0006954; GO:0006956; GO:0006957; GO:0006958; GO:0008289; GO:0009410; GO:0009617; GO:0009986; GO:0010575; GO:0010828; GO:0010866; GO:0010884; GO:0016322; GO:0031715; GO:0032026; GO:0032355; GO:0032570; GO:0032991; GO:0035846; GO:0035886; GO:0043627; GO:0045745; GO:0045766; GO:0048260; GO:0048639; GO:0050766; GO:0051384; GO:0060041; GO:0060100; GO:0070374; GO:0097242; GO:0097278; GO:0150062; GO:0150064; GO:2000427
## 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0003341; GO:0004550; GO:0005929; GO:0006183; GO:0006228; GO:0006241; GO:0008408; GO:1902176
## 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:0048022; GO:1903712
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000976; GO:0000978; GO:0000981; GO:0003309; GO:0003310; GO:0003311; GO:0005634; GO:0006357; GO:0031018; GO:0035774; GO:0042593; GO:0045893; GO:0045944; GO:0050796; GO:0090104
## 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001955; GO:0002040; GO:0004866; GO:0004867; GO:0005615; GO:0005886; GO:0008191; GO:0015026; GO:0030198; GO:0045765; GO:0060070; GO:0090210; GO:0098552; GO:1904684; GO:1990909
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004359; GO:0005829; GO:0006541; GO:0036381; GO:0042819; GO:0042823; GO:0046982
## 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004970; GO:0005234; GO:0005886; GO:0015277; GO:0022849; GO:0045211; GO:0120169
## 143 GO:0001745; GO:0002052; GO:0002213; GO:0003682; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005783; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006110; GO:0007015; GO:0007219; GO:0007293; GO:0007297; GO:0007298; GO:0007346; GO:0007391; GO:0007400; GO:0007403; GO:0007405; GO:0007411; GO:0007422; GO:0007423; GO:0007440; GO:0007455; GO:0007474; GO:0007476; GO:0007478; GO:0007480; GO:0007498; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009950; GO:0009986; GO:0010001; GO:0010628; GO:0010629; GO:0014018; GO:0014019; GO:0016020; GO:0016318; GO:0016324; GO:0016330; GO:0016348; GO:0016360; GO:0022416; GO:0030139; GO:0030154; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0032991; GO:0035035; GO:0035153; GO:0035162; GO:0035167; GO:0035171; GO:0035172; GO:0035204; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042686; GO:0042688; GO:0042691; GO:0043525; GO:0043697; GO:0045165; GO:0045316; GO:0045466; GO:0045595; GO:0045893; GO:0045944; GO:0046331; GO:0046666; GO:0046667; GO:0046716; GO:0046843; GO:0048052; GO:0048056; GO:0048190; GO:0048477; GO:0048542; GO:0048627; GO:0048664; GO:0048665; GO:0048749; GO:0048803; GO:0048863; GO:0050699; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060289; GO:0060571; GO:0061331; GO:0061382; GO:0097150; GO:1900087; GO:1902692; GO:1990433; GO:2000035; GO:2000048
## 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0017148; GO:0030371; GO:0043161; GO:0043523; GO:0061630
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004601; GO:0005604; GO:0005615; GO:0006979; GO:0007411; GO:0010172; GO:0016203; GO:0020037; GO:0046872; GO:0048681; GO:0071711; GO:0110011; GO:0140825
## 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005267; GO:0005764; GO:0005765; GO:0005768; GO:0010008; GO:0015252; GO:0022841; GO:0035751; GO:0035752; GO:0050544; GO:0070050; GO:0071805; GO:0090385; GO:1902600
## 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004084; GO:0005739; GO:0009098; GO:0009099; GO:0050048; GO:0052654; GO:0052655; GO:0052656
## 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000122; GO:0000978; GO:0003309; GO:0003310; GO:0003700; GO:0005634; GO:0007399; GO:0017053; GO:0031018; GO:0031490; GO:0035987; GO:0046872; GO:0048732; GO:0060290
## 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0008168; GO:0016114; GO:0032259; GO:0046872
## 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004766; GO:0005829; GO:0006595; GO:0008295; GO:0042802; GO:0042803; GO:1990830
## 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004503; GO:0005507; GO:0006583; GO:0033162; GO:0042470
## 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005737; GO:0006548; GO:0019556; GO:0019557; GO:0046872; GO:0050480
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000146; GO:0003779; GO:0005524; GO:0005737; GO:0007605; GO:0008407; GO:0016459; GO:0030048; GO:0032027; GO:0035317; GO:0048800; GO:0071944; GO:0120025
## 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004062; GO:0005737; GO:0005764; GO:0008146; GO:0051923
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000149; GO:0005829; GO:0016079; GO:0019905; GO:0031201; GO:0043195; GO:0043204; GO:0046928
## 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001736; GO:0005813; GO:0005829; GO:0005929; GO:0007411; GO:0007608; GO:0015031; GO:0021772; GO:0032391; GO:0032880; GO:0034451; GO:0034464; GO:0035264; GO:0036064; GO:0045198; GO:0045444; GO:0048560; GO:0050893; GO:0051492; GO:0060122; GO:0060170; GO:0060219; GO:0060271; GO:0061326; GO:0061629; GO:0072659; GO:0097730; GO:1903251; GO:1905515
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004842; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0006511; GO:0007605; GO:0008270; GO:0010719; GO:0016274; GO:0016567; GO:0042981; GO:0043161; GO:0045732; GO:1904878; GO:1990756
## 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0008643; GO:0015293; GO:0033162; GO:0033229; GO:0042438; GO:0043474; GO:0048021; GO:0048022; GO:1903712
## 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005634; GO:0005737; GO:0005829; GO:0006338; GO:0008168; GO:0016274; GO:0031397; GO:0032259; GO:0035241; GO:0035242; GO:0042054; GO:0043022; GO:0046872; GO:1900053
## 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000002; GO:0004672; GO:0004674; GO:0005080; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0010765; GO:0032008; GO:0032869; GO:0035556; GO:0045766; GO:0045793; GO:0048854; GO:0048873; GO:0090050; GO:0106310; GO:1905564; GO:1905653; GO:2000773
## 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0002224; GO:0004888; GO:0005794; GO:0005886; GO:0006954; GO:0006955; GO:0007165; GO:0016020; GO:0030670; GO:0032755; GO:0032757; GO:0032760; GO:0034137; GO:0035354; GO:0035663; GO:0038023; GO:0042116; GO:0042495; GO:0042802; GO:0043235; GO:0045087; GO:0045121; GO:0061809; GO:0071723; GO:0071727
## 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005524; GO:0005525; GO:0005737; GO:0005739; GO:0005759; GO:0006172; GO:0007596; GO:0009142; GO:0046033; GO:0046039; GO:0046041; GO:0046051; GO:0046899
## 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004930; GO:0004983; GO:0005886; GO:0007186; GO:0016020; GO:0032870; GO:0042277
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001504; GO:0005326; GO:0005886; GO:0007601; GO:0043679; GO:0046956; GO:0050908; GO:1905130; GO:1905131
## 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0003127; GO:0005102; GO:0005245; GO:0005248; GO:0005261; GO:0005262; GO:0005267; GO:0005509; GO:0005789; GO:0005886; GO:0005929; GO:0007166; GO:0015271; GO:0016020; GO:0016055; GO:0016323; GO:0030659; GO:0034703; GO:0050982; GO:0051209; GO:0051262; GO:0051290; GO:0051371; GO:0060170; GO:0070588; GO:0071277; GO:0071805; GO:0098662
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005262; GO:0005509; GO:0005886; GO:0016020; GO:0030246; GO:0050982
## 169                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0007605; GO:0032420
## 170                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 171                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001609; GO:0001963; GO:0001973; GO:0001975; GO:0005516; GO:0005882; GO:0005886; GO:0006355; GO:0006909; GO:0006915; GO:0006954; GO:0006968; GO:0007188; GO:0007189; GO:0007205; GO:0007267; GO:0007271; GO:0007417; GO:0007596; GO:0007600; GO:0007626; GO:0008015; GO:0008285; GO:0008289; GO:0009410; GO:0014049; GO:0014057; GO:0014061; GO:0014074; GO:0016020; GO:0019899; GO:0030425; GO:0030673; GO:0031000; GO:0031802; GO:0032230; GO:0032279; GO:0035249; GO:0035810; GO:0042311; GO:0042734; GO:0042755; GO:0042802; GO:0043025; GO:0043116; GO:0043524; GO:0044877; GO:0045211; GO:0045938; GO:0046636; GO:0048143; GO:0048786; GO:0048812; GO:0050714; GO:0050728; GO:0051393; GO:0051881; GO:0051899; GO:0051924; GO:0051968; GO:0060079; GO:0060080; GO:0060134; GO:0097190; GO:0098978; GO:0099171; GO:1900273; GO:2001235
## 172                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001878; GO:0004502; GO:0005741; GO:0006569; GO:0019674; GO:0019805; GO:0034354; GO:0043420; GO:0070189; GO:0071949; GO:0072015
## 173                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0002755; GO:0005634; GO:0005737; GO:0005886; GO:0006954; GO:0008063; GO:0032731; GO:0034142; GO:0034158; GO:0035325; GO:0043123; GO:0045087; GO:0050830; GO:0051607; GO:0070976; GO:1900227
## 174                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000785; GO:0000978; GO:0000981; GO:0001228; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0007601; GO:0007605; GO:0021562; GO:0031290; GO:0042472; GO:0042491; GO:0045944; GO:0048675; GO:0050885; GO:0051402; GO:1990837
## 175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0003723; GO:0004349; GO:0004350; GO:0005524; GO:0005739; GO:0005743; GO:0006536; GO:0006561; GO:0006592; GO:0009266; GO:0019240; GO:0042802; GO:0055129
## 176                                                                                                                                                                                                                                                                                                                                                                                     GO:0001702; GO:0001756; GO:0001843; GO:0001947; GO:0002053; GO:0003151; GO:0003344; GO:0003401; GO:0005041; GO:0005769; GO:0005783; GO:0005886; GO:0006355; GO:0007204; GO:0007268; GO:0007399; GO:0008078; GO:0009880; GO:0009950; GO:0009952; GO:0010463; GO:0010976; GO:0016020; GO:0017147; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0022603; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0034185; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042475; GO:0042733; GO:0042813; GO:0043025; GO:0043065; GO:0045121; GO:0045202; GO:0045444; GO:0045599; GO:0045778; GO:0045780; GO:0045893; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050678; GO:0050680; GO:0051091; GO:0051093; GO:0051593; GO:0055008; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060412; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0060856; GO:0071542; GO:0072089; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0098609; GO:0110135; GO:1905331; GO:1990963; GO:2000051; GO:2000149; GO:2000151; GO:2000164; GO:2000166; GO:2000168; GO:2000648
## 177                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0006813; GO:0006814; GO:0006821; GO:0006883; GO:0006884; GO:0006972; GO:0007214; GO:0008511; GO:0008519; GO:0010818; GO:0015079; GO:0016323; GO:0016324; GO:0030007; GO:0030644; GO:0035264; GO:0035633; GO:0035725; GO:0035865; GO:0042995; GO:0043025; GO:0044297; GO:0045795; GO:0050910; GO:0055064; GO:0055075; GO:0055078; GO:0060444; GO:0060763; GO:0061044; GO:0071222; GO:0071944; GO:0072488; GO:0098658; GO:0098719; GO:0150003; GO:1902476; GO:1904450; GO:1904464; GO:1990573; GO:1990869
## 178                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001666; GO:0001921; GO:0004175; GO:0004222; GO:0005768; GO:0005769; GO:0005886; GO:0007411; GO:0007507; GO:0008217; GO:0008270; GO:0009410; GO:0009897; GO:0010467; GO:0010613; GO:0010814; GO:0010815; GO:0010816; GO:0016020; GO:0016485; GO:0016486; GO:0030141; GO:0031175; GO:0031982; GO:0033093; GO:0034959; GO:0035050; GO:0035994; GO:0042447; GO:0042733; GO:0042802; GO:0042803; GO:0043583; GO:0043950; GO:0045745; GO:0046686; GO:0048471; GO:0060037; GO:0060385; GO:0070372; GO:0097492; GO:0097746; GO:1902287
## 179                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001666; GO:0003779; GO:0005249; GO:0005886; GO:0005901; GO:0006813; GO:0006970; GO:0008076; GO:0015269; GO:0016020; GO:0016324; GO:0030007; GO:0034465; GO:0042311; GO:0042391; GO:0042802; GO:0043065; GO:0045211; GO:0045794; GO:0046872; GO:0051592; GO:0060072; GO:0060073; GO:0060083; GO:0071805
## 180                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 181                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001917; GO:0005509; GO:0005813; GO:0005886; GO:0005911; GO:0006816; GO:0007156; GO:0007605; GO:0007626; GO:0008344; GO:0032420; GO:0032426; GO:0042472; GO:0042491; GO:0045177; GO:0045202; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0051480; GO:0060013; GO:0060088; GO:0060091; GO:0060122; GO:0090102; GO:0098609; GO:0098683; GO:0098684
## 182                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001641; GO:0005246; GO:0005886; GO:0007216; GO:0010467; GO:0014069; GO:0019233; GO:0030424; GO:0042734; GO:0043005; GO:0043197; GO:0045211; GO:0050804; GO:0051966; GO:0097110; GO:0097449; GO:0098978; GO:0099170
## 183                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005789; GO:0010961; GO:0015444; GO:0035050; GO:0160176; GO:1990403
## 184                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0003779; GO:0005886; GO:0007204; GO:0008284; GO:0010800; GO:0015279; GO:0030182; GO:0030276; GO:0030425; GO:0030426; GO:0034703; GO:0034704; GO:0042805; GO:0043025; GO:0045666; GO:0045773; GO:0050774; GO:0051117; GO:0051402; GO:0051480; GO:0070588; GO:0070679; GO:0070782; GO:0098793; GO:1902630
## 185                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001656; GO:0001657; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0005886; GO:0006935; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035904; GO:0042802; GO:0045747; GO:0050772; GO:0050925; GO:0051964; GO:0060412; GO:0061364; GO:0070062; GO:0098609
## 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 187                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001649; GO:0004965; GO:0005615; GO:0005737; GO:0005789; GO:0005886; GO:0007193; GO:0007214; GO:0008021; GO:0008285; GO:0014048; GO:0014049; GO:0014053; GO:0016020; GO:0030673; GO:0031966; GO:0032811; GO:0033602; GO:0035094; GO:0038037; GO:0038039; GO:0042734; GO:0043025; GO:0043197; GO:0043198; GO:0043204; GO:0045211; GO:0045471; GO:0046982; GO:0050805; GO:0051932; GO:0060124; GO:0097060; GO:0098685; GO:0098793; GO:0098978; GO:0098982; GO:0099579; GO:0150047; GO:0150099; GO:1902710; GO:1902712; GO:1990430
## 188                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005283; GO:0005308; GO:0005332; GO:0005368; GO:0005369; GO:0005886; GO:0006836; GO:0006865; GO:0015185; GO:0015734; GO:0015881; GO:0016323; GO:0016597; GO:0035725; GO:0042995; GO:0051939; GO:0089718
## 189                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005654; GO:0005737; GO:0005829; GO:0008021; GO:0008219; GO:0031625; GO:0036464; GO:0042417; GO:0042734; GO:0042802; GO:0043025; GO:0046928; GO:0090083
## 190                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005886; GO:0030658; GO:0030667; GO:0046872; GO:0062111; GO:0140826
## 191                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004930; GO:0005654; GO:0005829; GO:0005886; GO:0007166; GO:0007186; GO:0007189; GO:0016020; GO:0016607
## 192                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 193                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000139; GO:0000578; GO:0001525; GO:0001540; GO:0001654; GO:0002071; GO:0002726; GO:0004930; GO:0005886; GO:0005923; GO:0007416; GO:0008285; GO:0008289; GO:0008595; GO:0009986; GO:0017147; GO:0019901; GO:0030182; GO:0030424; GO:0030425; GO:0030669; GO:0031077; GO:0031625; GO:0031901; GO:0032729; GO:0032731; GO:0032760; GO:0033077; GO:0035567; GO:0042813; GO:0043204; GO:0044877; GO:0045202; GO:0045944; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060561; GO:0060574; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0071219; GO:1901382; GO:1901524; GO:1903955; GO:2000810
## 194                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004062; GO:0005829; GO:0008146; GO:0009812; GO:0050427
## 195                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000398; GO:0001510; GO:0001734; GO:0003729; GO:0005634; GO:0005654; GO:0005794; GO:0005829; GO:0006397; GO:0006974; GO:0007283; GO:0007623; GO:0008173; GO:0009048; GO:0016556; GO:0016604; GO:0016607; GO:0019827; GO:0021861; GO:0031053; GO:0034644; GO:0036396; GO:0042063; GO:0045087; GO:0045580; GO:0045727; GO:0045746; GO:0046982; GO:0048477; GO:0051445; GO:0060339; GO:0061157; GO:0098508; GO:1902036; GO:1903679; GO:1904047; GO:1990204
## 196                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005308; GO:0005886; GO:0015292; GO:0015881; GO:0016323; GO:0046449
## 197                                                                         GO:0000122; GO:0000132; GO:0000785; GO:0000976; GO:0000978; GO:0000979; GO:0000981; GO:0001221; GO:0001227; GO:0001228; GO:0001568; GO:0001709; GO:0001755; GO:0001764; GO:0001933; GO:0002052; GO:0002064; GO:0002067; GO:0002088; GO:0003002; GO:0003309; GO:0003310; GO:0003322; GO:0003677; GO:0003680; GO:0003682; GO:0003690; GO:0003700; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006357; GO:0006366; GO:0007224; GO:0007399; GO:0007405; GO:0007406; GO:0007409; GO:0007411; GO:0007420; GO:0007435; GO:0008283; GO:0009611; GO:0009786; GO:0009950; GO:0009952; GO:0009953; GO:0010467; GO:0010468; GO:0010628; GO:0010975; GO:0019901; GO:0021510; GO:0021517; GO:0021543; GO:0021549; GO:0021593; GO:0021772; GO:0021778; GO:0021796; GO:0021798; GO:0021902; GO:0021905; GO:0021978; GO:0021983; GO:0021986; GO:0021987; GO:0022027; GO:0023019; GO:0030154; GO:0030182; GO:0030216; GO:0030334; GO:0030858; GO:0030900; GO:0030902; GO:0031490; GO:0031625; GO:0032808; GO:0032869; GO:0033365; GO:0035035; GO:0042462; GO:0042593; GO:0042660; GO:0043010; GO:0043565; GO:0044344; GO:0045165; GO:0045471; GO:0045664; GO:0045665; GO:0045893; GO:0045944; GO:0048505; GO:0048596; GO:0048708; GO:0050680; GO:0050767; GO:0060041; GO:0061034; GO:0061072; GO:0061303; GO:0061351; GO:0070410; GO:0070412; GO:0071333; GO:0071380; GO:0071466; GO:0071837; GO:0098598; GO:0120008; GO:1901142; GO:1902895; GO:1904798; GO:1904937; GO:1990830; GO:1990837; GO:2000178; GO:2001224
## 198                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 199                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005743; GO:0005759; GO:0032979; GO:0036444; GO:0043022; GO:0051204; GO:0051560
## 200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005546; GO:0005811; GO:0005829; GO:0005886; GO:0007009; GO:0008526; GO:0009898; GO:0015485; GO:0032367; GO:0051289; GO:0097038; GO:0098831; GO:0098978; GO:0099509; GO:0120020
## 201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004888; GO:0004965; GO:0005737; GO:0005886; GO:0007186; GO:0007193; GO:0007194; GO:0007214; GO:0007268; GO:0038039; GO:0043005; GO:0045211; GO:0046982; GO:0051932; GO:0150099; GO:1902710; GO:1902712
## 202                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000045; GO:0005634; GO:0005776; GO:0005829; GO:0006915; GO:0008285; GO:0009408; GO:0010508; GO:0010628; GO:0010629; GO:0016209; GO:0016605; GO:0030336; GO:0031410; GO:0034644; GO:0043065; GO:0045893; GO:0048102; GO:0048147; GO:0071361; GO:0071447; GO:0072703; GO:1904761
## 203                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0071482
## 204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000900; GO:0003730; GO:0005095; GO:0005634; GO:0005737; GO:0005840; GO:0008135; GO:0008187; GO:0032869; GO:0034599; GO:0035925; GO:0043005; GO:0043022; GO:0043023; GO:0043024; GO:0045202; GO:0045900; GO:0071243; GO:0071456; GO:0098978; GO:0099547; GO:1900248; GO:1990124; GO:2000766
## 205                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001786; GO:0005509; GO:0005544; GO:0005886; GO:0014059; GO:0019905; GO:0030154; GO:0030276; GO:0030424; GO:0030672; GO:0031045; GO:0042584; GO:0048488; GO:0048791; GO:0071277; GO:1903235
## 206                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0106310; GO:2000035; GO:2000069
## 207                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0009897; GO:0032217; GO:0032218; GO:0038023; GO:1902444; GO:1904657; GO:1904661
## 208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 209                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005886; GO:0008021; GO:0016020; GO:0017075; GO:0017124; GO:0030672; GO:0031629; GO:0031982; GO:0035544; GO:0042734; GO:0043005; GO:0043197; GO:0043679; GO:0050884; GO:0098793; GO:0098839; GO:0098978; GO:0150037; GO:1905513
## 210                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005739; GO:0005743; GO:0005758; GO:0042407; GO:0043209; GO:0051560; GO:0061617; GO:0070050
## 211                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000226; GO:0005737; GO:0005874; GO:0006914; GO:0007026; GO:0007420; GO:0007626; GO:0008344; GO:0021801; GO:0021960; GO:0021987; GO:0022038; GO:0030424; GO:0030425; GO:0030426; GO:0031175; GO:0043005; GO:0043025; GO:0044877; GO:0061351; GO:0061744; GO:0097150; GO:0120168
## 212                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004993; GO:0005886; GO:0007198; GO:0007268; GO:0014063; GO:0042310; GO:0045202; GO:0046849; GO:0050795; GO:0071312; GO:0071466
## 213                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000122; GO:0000287; GO:0003170; GO:0003279; GO:0003281; GO:0004115; GO:0004118; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0007193; GO:0007507; GO:0008270; GO:0010628; GO:0010749; GO:0010752; GO:0010754; GO:0010821; GO:0019933; GO:0019934; GO:0030424; GO:0030425; GO:0030552; GO:0030553; GO:0030911; GO:0035556; GO:0035904; GO:0036004; GO:0036006; GO:0042301; GO:0042734; GO:0042802; GO:0042803; GO:0043116; GO:0043117; GO:0043949; GO:0043951; GO:0046069; GO:0047555; GO:0048471; GO:0050729; GO:0060976; GO:0061028; GO:0071222; GO:0071260; GO:0071320; GO:0071321; GO:0071560; GO:0090324; GO:0097011; GO:0097060; GO:0097457; GO:0106072; GO:1904613; GO:1904880
## 214                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000978; GO:0000981; GO:0001228; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006357; GO:0007519; GO:0008582; GO:0008584; GO:0010468; GO:0030238; GO:0030910; GO:0032880; GO:0034504; GO:0042472; GO:0043066; GO:0043524; GO:0043565; GO:0043586; GO:0045214; GO:0045892; GO:0045893; GO:0045944; GO:0046661; GO:0048538; GO:0048699; GO:0048701; GO:0048704; GO:0050678; GO:0051451; GO:0060037; GO:0061055; GO:0061197; GO:0061551; GO:0072075; GO:0072095; GO:0072107; GO:0090190; GO:0098528; GO:1902725
## 215                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001696; GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007268; GO:0030425; GO:0030594; GO:0045202; GO:0045907
## 216                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001530; GO:0001934; GO:0004252; GO:0005102; GO:0005509; GO:0005576; GO:0005615; GO:0005788; GO:0005796; GO:0005886; GO:0006508; GO:0006953; GO:0007166; GO:0007186; GO:0007596; GO:0008083; GO:0008201; GO:0008284; GO:0008360; GO:0009611; GO:0010544; GO:0030168; GO:0030193; GO:0030194; GO:0030307; GO:0032024; GO:0032967; GO:0042730; GO:0045861; GO:0046427; GO:0048712; GO:0051281; GO:0051480; GO:0051838; GO:0051897; GO:0051918; GO:0061844; GO:0062023; GO:0070053; GO:0070062; GO:0070945; GO:0072562; GO:0090218; GO:1900016; GO:1900182; GO:1900738; GO:1990806; GO:2000379
## 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 218                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0002020; GO:0005615; GO:0007155; GO:0007419; GO:0007426; GO:0007472; GO:0008191; GO:0008270; GO:0030425; GO:0031012; GO:0035202; GO:0042331; GO:0048477; GO:0048526; GO:0051045; GO:0060232; GO:0071711
## 219                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 220                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001776; GO:0001782; GO:0001783; GO:0001836; GO:0001974; GO:0002262; GO:0002352; GO:0005739; GO:0005741; GO:0005783; GO:0005829; GO:0008053; GO:0008285; GO:0008630; GO:0009410; GO:0009620; GO:0010046; GO:0010225; GO:0010248; GO:0010332; GO:0010524; GO:0010629; GO:0014070; GO:0015288; GO:0031018; GO:0031072; GO:0031100; GO:0031334; GO:0031966; GO:0032471; GO:0033137; GO:0034644; GO:0035108; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0044325; GO:0044346; GO:0044877; GO:0045471; GO:0045862; GO:0046872; GO:0046902; GO:0046930; GO:0046982; GO:0048597; GO:0048872; GO:0050673; GO:0051087; GO:0051400; GO:0051649; GO:0051726; GO:0051881; GO:0060068; GO:0060402; GO:0070059; GO:0070242; GO:0071260; GO:0090200; GO:0090201; GO:0097145; GO:0097192; GO:1900103; GO:1901029; GO:1901030; GO:1902262
## 221                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001889; GO:0005007; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0007498; GO:0008201; GO:0008284; GO:0008543; GO:0009953; GO:0017134; GO:0018108; GO:0021535; GO:0021628; GO:0031101; GO:0031410; GO:0033339; GO:0036342; GO:0042664; GO:0043235; GO:0043406; GO:0043589; GO:0045471; GO:0045597; GO:0048738; GO:0048916; GO:0051216; GO:0060249; GO:0071699
## 222                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004659; GO:0005759; GO:0005829; GO:0006744; GO:0008299; GO:0021549; GO:0032478; GO:0046982; GO:0050878; GO:0052923; GO:0097269; GO:1990234
## 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 225                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001696; GO:0004969; GO:0004993; GO:0005886; GO:0007187; GO:0007268; GO:0030425; GO:0030594; GO:0045202; GO:0045907
## 226                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004489; GO:0009086; GO:0035999; GO:0046653; GO:0050660; GO:0050661; GO:0071949; GO:0106313
## 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001654; GO:0005109; GO:0005125; GO:0005615; GO:0009880; GO:0016055; GO:0021854; GO:0021879; GO:0030182; GO:0030900; GO:0043049; GO:0045165; GO:0060070; GO:0060898; GO:0070654; GO:0071679
## 228                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004930; GO:0004978; GO:0005737; GO:0005886; GO:0007189; GO:0019222
## 229                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004500; GO:0005507; GO:0005615; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 230                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004888; GO:0004965; GO:0005737; GO:0005886; GO:0007186; GO:0007193; GO:0007194; GO:0007214; GO:0007268; GO:0038039; GO:0043005; GO:0045211; GO:0046982; GO:0051932; GO:0150099; GO:1902710; GO:1902712
## 231                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 232                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0003779; GO:0005523; GO:0005829; GO:0005856; GO:0005865; GO:0005884; GO:0006936; GO:0007015; GO:0008344; GO:0016020; GO:0030016; GO:0030017; GO:0030239; GO:0030863; GO:0051694; GO:0070307
## 233                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0007156; GO:0007399; GO:0014069; GO:0019900; GO:0030425; GO:0043005; GO:0043025; GO:0045211; GO:0060077; GO:0097151; GO:0098982; GO:0099560; GO:0099629
## 234                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000050; GO:0001889; GO:0004087; GO:0004088; GO:0004175; GO:0005509; GO:0005524; GO:0005543; GO:0005730; GO:0005737; GO:0005739; GO:0005743; GO:0005886; GO:0006207; GO:0006541; GO:0007494; GO:0009410; GO:0009636; GO:0010043; GO:0014075; GO:0016595; GO:0019433; GO:0030955; GO:0032094; GO:0032496; GO:0032991; GO:0033762; GO:0034201; GO:0036094; GO:0042311; GO:0042594; GO:0042645; GO:0043200; GO:0044344; GO:0044877; GO:0046209; GO:0046872; GO:0048545; GO:0050667; GO:0051384; GO:0051591; GO:0055081; GO:0060416; GO:0070365; GO:0070409; GO:0071242; GO:0071320; GO:0071377; GO:0071400; GO:0071548; GO:0072341
## 235                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 236                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001889; GO:0005794; GO:0006487; GO:0007030; GO:0009306; GO:0016192; GO:0055088; GO:0060041; GO:1905897
## 237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005576; GO:0007165; GO:0007219; GO:0007605; GO:0008593; GO:0009986; GO:0022405; GO:0032420; GO:0034505; GO:0060170
## 238                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0002063; GO:0003094; GO:0004065; GO:0005509; GO:0005539; GO:0005576; GO:0005615; GO:0005783; GO:0005795; GO:0005886; GO:0008449; GO:0009611; GO:0009986; GO:0010575; GO:0014846; GO:0030177; GO:0030201; GO:0032836; GO:0035860; GO:0040037; GO:0048706; GO:0051216; GO:0060348; GO:0060384; GO:0090263; GO:0097421; GO:1904472; GO:2000345
## 239                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001956; GO:0004888; GO:0005634; GO:0005886; GO:0007186; GO:0007420; GO:0008047; GO:0008277; GO:0016020; GO:0042734; GO:0042995; GO:0045211; GO:0050807; GO:0050890; GO:0072659; GO:0098839; GO:0160079
## 240                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005886; GO:0008519; GO:0072488; GO:0097272
## 241                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001695; GO:0005737; GO:0032259; GO:0046539
## 242                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004111; GO:0005524; GO:0005615; GO:0005737; GO:0009408; GO:0046314
## 243                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000209; GO:0004842; GO:0005737; GO:0005769; GO:0005794; GO:0008270; GO:0015031; GO:0016567; GO:0017148; GO:0030371; GO:0030425; GO:0034141; GO:0042802; GO:0043161; GO:0061630; GO:0070534; GO:0098794; GO:0098978; GO:0140252
## 244                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001932; GO:0001934; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0007009; GO:0007167; GO:0007268; GO:0007416; GO:0007528; GO:0007623; GO:0009986; GO:0015031; GO:0030154; GO:0030548; GO:0032092; GO:0033691; GO:0035022; GO:0035374; GO:0036122; GO:0042030; GO:0042383; GO:0043083; GO:0043087; GO:0043113; GO:0043395; GO:0043547; GO:0044295; GO:0044325; GO:0045202; GO:0045887; GO:0045944; GO:0048018; GO:0050431; GO:0050731; GO:0050807; GO:0051491; GO:0055117; GO:0060025; GO:0061098; GO:0062023; GO:0070507; GO:0071340; GO:0086036; GO:0097049; GO:0098978; GO:1902667; GO:1903277; GO:1903407; GO:1904395; GO:2000541; GO:2000673
## 245                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000978; GO:0000981; GO:0003406; GO:0005634; GO:0006357; GO:0042472; GO:0060875
## 246                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 247                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005886; GO:0006814; GO:0015293
## 248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000244; GO:0000381; GO:0000398; GO:0005634; GO:0005687; GO:0005690; GO:0015030; GO:0016607; GO:0030622; GO:0046540; GO:0060041; GO:0071005; GO:0071011; GO:0071339; GO:0097526
## 249                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004963; GO:0005886; GO:0007186; GO:0007189; GO:0008528; GO:0008584; GO:0009755; GO:0010738; GO:0016020; GO:0042699; GO:0043235; GO:0051897; GO:0070374; GO:0071372
## 250                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000122; GO:0000976; GO:0000978; GO:0000981; GO:0001228; GO:0001666; GO:0002328; GO:0003183; GO:0003215; GO:0003289; GO:0003357; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005739; GO:0006355; GO:0007399; GO:0007420; GO:0007507; GO:0008284; GO:0008285; GO:0010467; GO:0014009; GO:0021510; GO:0021782; GO:0030182; GO:0030217; GO:0031018; GO:0031397; GO:0031647; GO:0032024; GO:0035019; GO:0035198; GO:0035910; GO:0042593; GO:0043065; GO:0043516; GO:0045588; GO:0045662; GO:0045663; GO:0045727; GO:0045893; GO:0045944; GO:0048485; GO:0048593; GO:0050821; GO:0060412; GO:0060485; GO:0060563; GO:0060993; GO:0061484; GO:0071333; GO:0090263; GO:2000761
## 251                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0002042; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0003281; GO:0005737; GO:0005886; GO:0007156; GO:0007411; GO:0007507; GO:0008046; GO:0008285; GO:0009986; GO:0010628; GO:0010629; GO:0014003; GO:0016199; GO:0021510; GO:0021836; GO:0021891; GO:0030275; GO:0030336; GO:0030424; GO:0030425; GO:0030673; GO:0030949; GO:0033116; GO:0033600; GO:0035025; GO:0035385; GO:0035904; GO:0042802; GO:0043025; GO:0045747; GO:0048814; GO:0050772; GO:0050808; GO:0050925; GO:0051964; GO:0060412; GO:0060763; GO:0060976; GO:0070100; GO:0071456; GO:1900748; GO:1990138
## 252                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000149; GO:0001778; GO:0001786; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0019905; GO:0030276; GO:0030424; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0045202; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0070062; GO:0070092; GO:0090119; GO:0090385; GO:0098686; GO:1900242; GO:1990926; GO:1990927
## 253                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000149; GO:0001778; GO:0001786; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0019905; GO:0030276; GO:0030424; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0045202; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0070062; GO:0070092; GO:0090119; GO:0090385; GO:0098686; GO:1900242; GO:1990926; GO:1990927
## 254                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000122; GO:0002088; GO:0005634; GO:0007219; GO:0007517; GO:0014029; GO:0021501; GO:0033504; GO:0042462; GO:0043066; GO:0043565; GO:0045494; GO:0045892; GO:0046982; GO:0048642; GO:0050768
## 255                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004111; GO:0005524; GO:0005615; GO:0005737; GO:0009408; GO:0046314
## 256                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000082; GO:0000209; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0021915; GO:0035198; GO:0035278; GO:0043161; GO:0051865; GO:0061630; GO:0072089; GO:2000177
## 257                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004930; GO:0005886; GO:0007166; GO:0007189; GO:0022008
## 258                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000287; GO:0005829; GO:0006563; GO:0006564; GO:0036424
## 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005634; GO:0005737; GO:0048471; GO:2000812
## 260                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005507; GO:0005615; GO:0005886; GO:0005923; GO:0008131; GO:0008201; GO:0009308; GO:0009445; GO:0035874; GO:0046677; GO:0048038; GO:0050232; GO:0052597; GO:0052598; GO:0052599; GO:0052600; GO:0097159
## 261                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001525; GO:0005576; GO:0005886; GO:0007155; GO:0007156; GO:0007411; GO:0007417; GO:0008104; GO:0010975; GO:0019227; GO:0030424; GO:0030506; GO:0031290; GO:0033268; GO:0043194; GO:0045162; GO:0045202; GO:0045211; GO:0070593; GO:0086080; GO:0098609; GO:0098632; GO:0098839; GO:0098978; GO:0099175
## 262                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0007268; GO:0007608; GO:0017156; GO:0030276; GO:0030658; GO:0042803; GO:0045956; GO:0046982; GO:0070382; GO:0098793; GO:0098978
## 263                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005886; GO:0007186; GO:0008188; GO:0015629; GO:0031628; GO:0032870; GO:0042277; GO:0043408
## 264                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0004089; GO:0005737; GO:0005829; GO:0006730; GO:0008270; GO:0032230; GO:0032849; GO:0051453; GO:0070050; GO:2001225
## 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0003779; GO:0005546; GO:0005737; GO:0005884; GO:0005925; GO:0007015; GO:0007399; GO:0008154; GO:0010592; GO:0010976; GO:0015629; GO:0030027; GO:0030424; GO:0042995; GO:0043005; GO:0051014; GO:0051015; GO:0051016; GO:0060271; GO:0071933; GO:1900480
## 266                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001889; GO:0005007; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0007498; GO:0008201; GO:0008284; GO:0008543; GO:0009953; GO:0017134; GO:0018108; GO:0021535; GO:0021628; GO:0031101; GO:0031410; GO:0033339; GO:0036342; GO:0042664; GO:0043235; GO:0043406; GO:0043589; GO:0045471; GO:0045597; GO:0048738; GO:0048916; GO:0051216; GO:0060249; GO:0071699
## 267                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001725; GO:0001786; GO:0003418; GO:0005262; GO:0005509; GO:0005544; GO:0005737; GO:0005886; GO:0005925; GO:0006816; GO:0006937; GO:0008201; GO:0012506; GO:0016020; GO:0019899; GO:0030061; GO:0031214; GO:0031982; GO:0035374; GO:0038024; GO:0042383; GO:0042470; GO:0042584; GO:0048306; GO:0048471; GO:0051015; GO:0051283; GO:0051560; GO:0070509; GO:0070588; GO:0097190
## 268                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005509; GO:0045938; GO:1902848
## 269                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 270                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001822; GO:0001934; GO:0001956; GO:0002092; GO:0005634; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0007596; GO:0007613; GO:0008089; GO:0010008; GO:0010628; GO:0014059; GO:0014069; GO:0015630; GO:0016528; GO:0030036; GO:0030424; GO:0030426; GO:0030496; GO:0030672; GO:0031083; GO:0031175; GO:0032438; GO:0033162; GO:0042383; GO:0043005; GO:0043025; GO:0043197; GO:0045211; GO:0048490; GO:0048812; GO:0048813; GO:0060041; GO:0060155; GO:0060159; GO:0060271; GO:0061002; GO:0061646; GO:0071806; GO:0098685; GO:0098686; GO:0098978; GO:1904115; GO:2000300
## 271                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004500; GO:0005507; GO:0005615; GO:0005789; GO:0006589; GO:0030667; GO:0042420; GO:0042421
## 272                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0000987; GO:0001227; GO:0001228; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0005634; GO:0005905; GO:0006355; GO:0006357; GO:0006366; GO:0007173; GO:0007399; GO:0007423; GO:0007605; GO:0008283; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010761; GO:0010763; GO:0010842; GO:0010944; GO:0014032; GO:0014044; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030501; GO:0032496; GO:0035115; GO:0035136; GO:0042059; GO:0042127; GO:0042472; GO:0042802; GO:0043066; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0051402; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:0140536; GO:1990837; GO:2000378
## 273                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001762; GO:0006836; GO:0008021; GO:0015185; GO:0015187; GO:0015812; GO:0015816; GO:0030659; GO:0042995; GO:0051939; GO:0098793; GO:0140799; GO:0140800
## 274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001656; GO:0001657; GO:0003129; GO:0003148; GO:0003180; GO:0003184; GO:0003272; GO:0005886; GO:0006935; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035904; GO:0042802; GO:0045747; GO:0050772; GO:0050925; GO:0051964; GO:0060412; GO:0061364; GO:0070062; GO:0098609
## 275                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005313; GO:0005314; GO:0005886; GO:0006750; GO:0007399; GO:0007632; GO:0008509; GO:0009410; GO:0009416; GO:0009611; GO:0009986; GO:0015175; GO:0015501; GO:0015813; GO:0016020; GO:0021537; GO:0030424; GO:0030534; GO:0030673; GO:0031982; GO:0033229; GO:0035264; GO:0042734; GO:0043197; GO:0043198; GO:0043200; GO:0044297; GO:0044306; GO:0045121; GO:0045202; GO:0046326; GO:0046872; GO:0070207; GO:0070778; GO:0070779; GO:0071314; GO:0097449; GO:0098656; GO:0098712; GO:0098796; GO:0098810; GO:0098978; GO:0140009
## 276                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004054; GO:0004111; GO:0005524; GO:0046314
## 277                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001581; GO:0005262; GO:0005886; GO:0006812; GO:0016020; GO:0030246; GO:0034703; GO:0043235; GO:0050915; GO:0050982; GO:0070062; GO:0071468
## 278                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0005332; GO:0005886; GO:0006865; GO:0007268; GO:0007613; GO:0008306; GO:0009636; GO:0009744; GO:0009986; GO:0010288; GO:0014054; GO:0014074; GO:0015185; GO:0015378; GO:0016020; GO:0030424; GO:0032229; GO:0032355; GO:0035725; GO:0042220; GO:0042734; GO:0042802; GO:0043025; GO:0045211; GO:0046872; GO:0050808; GO:0051592; GO:0051936; GO:0051939; GO:0098658; GO:0098719; GO:0098982; GO:0150104; GO:1902476
## 279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000139; GO:0005200; GO:0005543; GO:0005737; GO:0005768; GO:0005829; GO:0005886; GO:0007416; GO:0008021; GO:0008091; GO:0016079; GO:0016081; GO:0016192; GO:0016324; GO:0016363; GO:0017158; GO:0021692; GO:0030036; GO:0030054; GO:0030534; GO:0030864; GO:0033010; GO:0035264; GO:0042995; GO:0043025; GO:0048471; GO:0051015; GO:0051693; GO:0071361; GO:0098688; GO:0098793; GO:0098918; GO:0098978; GO:0099150; GO:0099173; GO:0099186; GO:0099189
## 280                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0000978; GO:0000981; GO:0005634; GO:0006357; GO:0008045; GO:0008347; GO:0014044; GO:0021508; GO:0021514; GO:0021529; GO:0021530; GO:0030154; GO:0031018; GO:0033504; GO:0045893
## 281                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005506; GO:0005634; GO:0005737; GO:0006555; GO:0010308; GO:0010309; GO:0016151; GO:0019509
## 282                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004505; GO:0005506; GO:0006559; GO:0006571
## 283                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004725; GO:0005001; GO:0005158; GO:0005925; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008594; GO:0009925; GO:0009986; GO:0030424; GO:0031252; GO:0031290; GO:0032093; GO:0045467; GO:0046627; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:0051491; GO:0060269; GO:0061484; GO:0120034; GO:1903386
## 284                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0004111; GO:0005524; GO:0046314
## 285                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001669; GO:0005737; GO:0015280; GO:0016324; GO:0031514; GO:0034706; GO:0035725
## 286                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001594; GO:0004930; GO:0005886; GO:0007186; GO:0008227; GO:0043950
## 287                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000287; GO:0003924; GO:0005525; GO:0005768; GO:0005886; GO:0006887; GO:0007269; GO:0008021; GO:0009306; GO:0016192; GO:0031489; GO:0031630; GO:0031982; GO:0032482; GO:0045202; GO:0046718; GO:0046928; GO:0048172; GO:0048786; GO:0048789; GO:0048790
## 288                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0002027; GO:0003283; GO:0005200; GO:0005739; GO:0005764; GO:0005769; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006897; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0015031; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055037; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:0140031; GO:1901018; GO:1901019; GO:1901021; GO:2001259
## 289                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0004586; GO:0005737; GO:0005829; GO:0006595; GO:0008283; GO:0008284; GO:0009446; GO:0009615; GO:0033387; GO:0042176; GO:0042803; GO:0048471
## 290                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000139; GO:0000578; GO:0001525; GO:0001540; GO:0001654; GO:0001944; GO:0002071; GO:0002726; GO:0004930; GO:0005769; GO:0005794; GO:0005886; GO:0005923; GO:0008285; GO:0008289; GO:0008595; GO:0009986; GO:0016055; GO:0017147; GO:0019901; GO:0030424; GO:0030425; GO:0031076; GO:0031077; GO:0031625; GO:0032729; GO:0032731; GO:0032760; GO:0033077; GO:0035567; GO:0042813; GO:0043204; GO:0044877; GO:0045202; GO:0045944; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060561; GO:0060574; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0071219; GO:0098978; GO:0099054; GO:1901382; GO:2000810
## 291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005509; GO:0005516; GO:0005543; GO:0005886; GO:0007268; GO:0016079; GO:0016081; GO:0016082; GO:0017075; GO:0019905; GO:0019992; GO:0030672; GO:0031594; GO:0031914; GO:0035249; GO:0042734; GO:0043195; GO:0044305; GO:0046928; GO:0061789; GO:0098688; GO:0098793; GO:0098831; GO:0099525
## 292                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0003407; GO:0005388; GO:0005516; GO:0005524; GO:0005886; GO:0005901; GO:0006357; GO:0006874; GO:0007283; GO:0010629; GO:0014832; GO:0015085; GO:0016020; GO:0016323; GO:0016525; GO:0016887; GO:0017080; GO:0019901; GO:0021766; GO:0030018; GO:0030165; GO:0030315; GO:0030317; GO:0030346; GO:0032991; GO:0034220; GO:0036126; GO:0036487; GO:0038060; GO:0043231; GO:0043537; GO:0045019; GO:0045121; GO:0046872; GO:0048787; GO:0050998; GO:0051001; GO:0051480; GO:0051599; GO:0070588; GO:0070885; GO:0071872; GO:0071878; GO:0097110; GO:0097228; GO:0097553; GO:0098703; GO:0098736; GO:0098978; GO:0150104; GO:1900082; GO:1901660; GO:1902083; GO:1902305; GO:1902548; GO:1902806; GO:1903078; GO:1903243; GO:1903249; GO:1903779; GO:1905145
## 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 294                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005201; GO:0005509; GO:0005604; GO:0005737; GO:0005912; GO:0005927; GO:0005938; GO:0007156; GO:0007157; GO:0007601; GO:0009617; GO:0030036; GO:0032154; GO:0051301; GO:0062023; GO:0070062; GO:0071711
## 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088
## 296                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005524; GO:0005737; GO:0005783; GO:0005829; GO:0005886; GO:0006814; GO:0009609; GO:0009925; GO:0015199; GO:0015226; GO:0015293; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165; GO:0031526; GO:0034341; GO:0034612; GO:0042910; GO:0060731; GO:0070062; GO:0070715; GO:0150104; GO:1900749; GO:1901235; GO:1902270; GO:1902603; GO:1990961
## 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0001726; GO:0005509; GO:0005546; GO:0005737; GO:0005902; GO:0007173; GO:0008154; GO:0008360; GO:0009617; GO:0010634; GO:0015629; GO:0030027; GO:0030041; GO:0030042; GO:0030175; GO:0030335; GO:0032233; GO:0032432; GO:0032433; GO:0035727; GO:0035729; GO:0042803; GO:0043027; GO:0051014; GO:0051015; GO:0051016; GO:0051125; GO:0051693; GO:0060327; GO:0061041; GO:0071364; GO:2000392
## 298                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004978; GO:0005737; GO:0005886; GO:0007189; GO:0019222
## 299                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001764; GO:0005829; GO:0005856; GO:0005874; GO:0005875; GO:0007399; GO:0007417; GO:0008017; GO:0019901; GO:0035082; GO:0035556; GO:0043005; GO:0060041
## 300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000785; GO:0000978; GO:0001501; GO:0001974; GO:0003007; GO:0003222; GO:0003226; GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006338; GO:0006364; GO:0006366; GO:0007417; GO:0007512; GO:0007605; GO:0007628; GO:0008015; GO:0009617; GO:0010468; GO:0010880; GO:0016887; GO:0021545; GO:0021553; GO:0021772; GO:0030217; GO:0030540; GO:0035116; GO:0035909; GO:0036302; GO:0040018; GO:0042048; GO:0042393; GO:0042472; GO:0043009; GO:0043584; GO:0045944; GO:0048752; GO:0050767; GO:0050890; GO:0060041; GO:0060123; GO:0060324; GO:0060384; GO:0060411; GO:0060429; GO:0062009; GO:0140658; GO:1990841
## 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0001822; GO:0003146; GO:0005929; GO:0007368; GO:0007601; GO:0016055; GO:0048793; GO:0060026; GO:0060271; GO:0060972; GO:0070121; GO:0097543; GO:0097546
## 302                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0002011; GO:0005102; GO:0005201; GO:0005576; GO:0005604; GO:0005606; GO:0005608; GO:0005615; GO:0005911; GO:0006468; GO:0007155; GO:0007166; GO:0007411; GO:0009887; GO:0009888; GO:0016020; GO:0030334; GO:0031012; GO:0031175; GO:0043010; GO:0043208; GO:0043256; GO:0045198; GO:0045785; GO:0045995; GO:0048514; GO:0051149; GO:0060041; GO:0060441; GO:0060445; GO:0061304; GO:0062023; GO:0098637; GO:0110011; GO:2001046
## 303                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000139; GO:0001965; GO:0005096; GO:0005903; GO:0008277; GO:0009968; GO:0030136; GO:0045471
## 304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004930; GO:0005654; GO:0005886; GO:0007186; GO:0008502; GO:0045820; GO:0046325; GO:1904408
## 305                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0000122; GO:0006338; GO:0021549; GO:0031519; GO:0035102; GO:0035701; GO:0045814; GO:0046872; GO:0060215; GO:1990841
## 306                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     GO:0001594; GO:0004930; GO:0005886; GO:0007186; GO:0008227; GO:0043950
## 307                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0000122; GO:0001501; GO:0001649; GO:0001654; GO:0001822; GO:0001938; GO:0001958; GO:0003323; GO:0005125; GO:0005615; GO:0006879; GO:0006954; GO:0006955; GO:0008083; GO:0008284; GO:0010628; GO:0014823; GO:0030182; GO:0030501; GO:0030509; GO:0030539; GO:0031666; GO:0031982; GO:0032026; GO:0032332; GO:0032349; GO:0032526; GO:0043117; GO:0045603; GO:0045666; GO:0045669; GO:0045944; GO:0046982; GO:0050679; GO:0050714; GO:0050731; GO:0051216; GO:0051384; GO:0060348; GO:0060391; GO:0060586; GO:0070700; GO:0071260; GO:0071281; GO:0071773; GO:1903392; GO:2000048; GO:2000860
## 308                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005829; GO:0005874; GO:0010719; GO:0030512; GO:0031397; GO:0032587; GO:0040037; GO:0046580; GO:0048513; GO:0070373; GO:1902747
## 309                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0004352; GO:0004354; GO:0005829; GO:0006537
## 310                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005509; GO:0005774; GO:0005886; GO:0006814; GO:0006874; GO:0015369; GO:0070588
## 311                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005283; GO:0005332; GO:0005886; GO:0006865; GO:0007612; GO:0007613; GO:0008306; GO:0009636; GO:0009744; GO:0009986; GO:0010288; GO:0014054; GO:0014070; GO:0014074; GO:0015185; GO:0015378; GO:0030424; GO:0032229; GO:0032355; GO:0035725; GO:0042220; GO:0042734; GO:0042802; GO:0043025; GO:0045211; GO:0046872; GO:0050808; GO:0051592; GO:0051939; GO:0098658; GO:0098719; GO:0098793; GO:0098810; GO:0098982; GO:1902476
## 312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0006884; GO:0008511; GO:0008519; GO:0016323; GO:0016324; GO:0046873; GO:0055064; GO:0055075; GO:0055078; GO:0071944; GO:0098659; GO:1990573
## 313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0004123; GO:0005516; GO:0005737; GO:0006629; GO:0018272; GO:0019344; GO:0019346; GO:0030170; GO:0043066; GO:0043123; GO:0044524; GO:0044540; GO:0047982; GO:0051092; GO:0070814; GO:0080146; GO:0098606
## 314 GO:0001745; GO:0002052; GO:0002213; GO:0003682; GO:0003713; GO:0004888; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005783; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006110; GO:0007015; GO:0007219; GO:0007293; GO:0007297; GO:0007298; GO:0007346; GO:0007391; GO:0007400; GO:0007403; GO:0007405; GO:0007411; GO:0007422; GO:0007423; GO:0007440; GO:0007455; GO:0007474; GO:0007476; GO:0007478; GO:0007480; GO:0007498; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009950; GO:0009986; GO:0010001; GO:0010628; GO:0010629; GO:0014018; GO:0014019; GO:0016020; GO:0016318; GO:0016324; GO:0016330; GO:0016348; GO:0016360; GO:0022416; GO:0030139; GO:0030154; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0032991; GO:0035035; GO:0035153; GO:0035162; GO:0035167; GO:0035171; GO:0035172; GO:0035204; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042686; GO:0042688; GO:0042691; GO:0043525; GO:0043697; GO:0045165; GO:0045316; GO:0045466; GO:0045595; GO:0045893; GO:0045944; GO:0046331; GO:0046666; GO:0046667; GO:0046716; GO:0046843; GO:0048052; GO:0048056; GO:0048190; GO:0048477; GO:0048542; GO:0048627; GO:0048664; GO:0048665; GO:0048749; GO:0048803; GO:0048863; GO:0050699; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060289; GO:0060571; GO:0061331; GO:0061382; GO:0097150; GO:1900087; GO:1902692; GO:1990433; GO:2000035; GO:2000048
## 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             GO:0005886; GO:0007601; GO:0007602; GO:0008020; GO:0016020; GO:0016918; GO:0033583; GO:0071482
## 316                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0005739; GO:0006574; GO:0008442; GO:0050661; GO:0051287
## 317                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0017148; GO:0030371; GO:0043161; GO:0043523; GO:0061630
## 318                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         GO:0005272; GO:0005886; GO:0006813; GO:0007638; GO:0009612; GO:0015485; GO:0032589; GO:0043005; GO:0050976; GO:1905789; GO:1905792
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      CellularComponent
## 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]
## 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     extracellular space [GO:0005615]
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 nucleus [GO:0005634]
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     extracellular space [GO:0005615]
## 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]
## 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; presynapse [GO:0098793]; SCF ubiquitin ligase complex [GO:0019005]; Schaffer collateral - CA1 synapse [GO:0098685]; synapse [GO:0045202]
## 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    extracellular space [GO:0005615]
## 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cortical cytoskeleton [GO:0030863]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]
## 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; synapse [GO:0045202]
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm [GO:0005737]; Golgi membrane [GO:0000139]; immunological synapse [GO:0001772]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]
## 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                 apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; spindle pole [GO:0000922]
## 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]
## 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             anchoring junction [GO:0070161]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]
## 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              calcium- and calmodulin-dependent protein kinase complex [GO:0005954]; dendritic spine [GO:0043197]; postsynaptic density [GO:0014069]
## 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                nucleus [GO:0005634]
## 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]
## 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 28                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              apical plasma membrane [GO:0016324]; axon [GO:0030424]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             dendrite [GO:0030425]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 P-body [GO:0000932]
## 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       apical plasma membrane [GO:0016324]; axon [GO:0030424]; axon terminus [GO:0043679]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              plasma membrane [GO:0005886]; postsynapse [GO:0098794]
## 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytosol [GO:0005829]; photoreceptor outer segment membrane [GO:0042622]
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cytosol [GO:0005829]
## 39                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ciliary rootlet [GO:0035253]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; peroxisomal membrane [GO:0005778]; stereocilium base [GO:0120044]
## 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                nucleus [GO:0005634]
## 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]
## 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           early endosome [GO:0005769]; plasma membrane [GO:0005886]
## 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               chloride channel complex [GO:0034707]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; transmembrane transporter complex [GO:1902495]
## 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 49                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           membrane [GO:0016020]; plasma membrane [GO:0005886]; voltage-gated potassium channel complex [GO:0008076]
## 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        non-motile cilium [GO:0097730]; plasma membrane [GO:0005886]
## 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               membrane [GO:0016020]
## 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                nucleus [GO:0005634]
## 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
## 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]
## 57                                                                                                                                                                                                                                                                                                                                                                        cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]
## 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]
## 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  chromatin [GO:0000785]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Golgi apparatus [GO:0005794]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 2-Toll-like receptor 6 protein complex [GO:0035355]
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 membrane [GO:0016020]; plasma membrane [GO:0005886]
## 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]
## 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        apical plasma membrane [GO:0016324]; early endosome membrane [GO:0031901]; late endosome membrane [GO:0031902]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; synapse [GO:0045202]
## 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cytoophidium [GO:0097268]; cytoplasm [GO:0005737]
## 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            synapse [GO:0045202]; voltage-gated calcium channel complex [GO:0005891]
## 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]
## 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                axon [GO:0030424]; voltage-gated sodium channel complex [GO:0001518]
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  clathrin-coated endocytic vesicle membrane [GO:0030669]; dense core granule [GO:0031045]; exocytic vesicle [GO:0070382]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 76                                                                                                                                                                                                                                                                                                                                                         axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               membrane [GO:0016020]
## 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm [GO:0005737]; cytosol [GO:0005829]; epidermal lamellar body [GO:0097209]; epidermal lamellar body membrane [GO:0097234]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        plasma membrane [GO:0005886]
## 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]
## 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cell junction [GO:0030054]; plasma membrane [GO:0005886]
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     plasma membrane [GO:0005886]; pleated septate junction [GO:0005919]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]
## 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  apical plasma membrane [GO:0016324]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]
## 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border [GO:0005903]; cytoplasm [GO:0005737]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]
## 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization [GO:0099572]
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  plasma membrane [GO:0005886]; synapse [GO:0045202]
## 88                                                                                                                                                               axon [GO:0030424]; axon initial segment [GO:0043194]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; dendrite [GO:0030425]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; juxtaparanode region of axon [GO:0044224]; lamellipodium [GO:0030027]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; neuronal cell body membrane [GO:0032809]; paranodal junction [GO:0033010]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; potassium channel complex [GO:0034705]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            acetylcholine-gated channel complex [GO:0005892]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]
## 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cytosol [GO:0005829]; nucleus [GO:0005634]
## 92                                                                                                                                                                                                                                                                                                                                                                        cell surface [GO:0009986]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; GABA-A receptor complex [GO:1902711]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; postsynaptic specialization membrane [GO:0099634]; synapse [GO:0045202]; terminal bouton [GO:0043195]; transmembrane transporter complex [GO:1902495]
## 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                extracellular space [GO:0005615]; plasma membrane [GO:0005886]; vesicle [GO:0031982]
## 94                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]
## 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; nuclear envelope [GO:0005635]; nuclear envelope lumen [GO:0005641]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; secretory granule lumen [GO:0034774]
## 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  axon initial segment [GO:0043194]; dendrite [GO:0030425]; glial cell projection [GO:0097386]; intracellular cyclic nucleotide activated cation channel complex [GO:0017071]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; transmembrane transporter complex [GO:1902495]
## 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             fungal-type vacuole [GO:0000324]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]
## 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; Golgi apparatus [GO:0005794]
## 104                                                                                                                                                                                          apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; synaptic vesicle [GO:0008021]
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cell projection [GO:0042995]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; receptor complex [GO:0043235]
## 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axolemma [GO:0030673]; axon terminus [GO:0043679]; calyx of Held [GO:0044305]; cell surface [GO:0009986]; dendrite membrane [GO:0032590]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; voltage-gated potassium channel complex [GO:0008076]
## 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                P-body [GO:0000932]
## 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 113                                                                                                                                                                                                                                                                                                                           A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
## 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]
## 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               membrane [GO:0016020]; stereocilium coat [GO:0120234]; stereocilium tip [GO:0032426]
## 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]
## 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; methylosome [GO:0034709]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; spliceosomal complex [GO:0005681]
## 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                dendrite [GO:0030425]; plasma membrane [GO:0005886]
## 126                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              apical plasma membrane [GO:0016324]; cone photoreceptor outer segment [GO:0120199]; cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; vesicle [GO:0031982]
## 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]
## 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  extracellular region [GO:0005576]
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             fungal-type vacuole [GO:0000324]; vacuolar membrane [GO:0005774]; vacuole [GO:0005773]
## 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; protein-containing complex [GO:0032991]
## 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cilium [GO:0005929]
## 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               nucleus [GO:0005634]
## 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                P-body [GO:0000932]
## 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        extracellular space [GO:0005615]; plasma membrane [GO:0005886]; side of membrane [GO:0098552]; Wnt signalosome [GO:1990909]
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytosol [GO:0005829]
## 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 143                                                                                                                                                                                                                               adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; CSL-Notch-Mastermind transcription factor complex [GO:1990433]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   basement membrane [GO:0005604]; extracellular space [GO:0005615]
## 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]
## 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                membrane [GO:0016020]; plasma membrane [GO:0005886]
## 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         mitochondrion [GO:0005739]
## 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 nucleus [GO:0005634]; transcription repressor complex [GO:0017053]
## 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytosol [GO:0005829]
## 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          melanosome [GO:0042470]; melanosome membrane [GO:0033162]
## 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cell periphery [GO:0071944]; cytoplasm [GO:0005737]; myosin complex [GO:0016459]; plasma membrane bounded cell projection [GO:0120025]
## 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cytoplasm [GO:0005737]; lysosome [GO:0005764]
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cytosol [GO:0005829]; perikaryon [GO:0043204]; SNARE complex [GO:0031201]; terminal bouton [GO:0043195]
## 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           BBSome [GO:0034464]; centriolar satellite [GO:0034451]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytosol [GO:0005829]; non-motile cilium [GO:0097730]; photoreceptor connecting cilium [GO:0032391]
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]
## 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; plasma membrane [GO:0005886]
## 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]
## 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     Golgi apparatus [GO:0005794]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]
## 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
## 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                membrane [GO:0016020]; plasma membrane [GO:0005886]
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           axon terminus [GO:0043679]; plasma membrane [GO:0005886]
## 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     basolateral plasma membrane [GO:0016323]; cation channel complex [GO:0034703]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; plasma membrane [GO:0005886]
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                membrane [GO:0016020]; plasma membrane [GO:0005886]
## 169                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          stereocilium [GO:0032420]
## 170                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                P-body [GO:0000932]
## 171                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           asymmetric synapse [GO:0032279]; axolemma [GO:0030673]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; intermediate filament [GO:0005882]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic active zone [GO:0048786]; presynaptic membrane [GO:0042734]
## 172                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          mitochondrial outer membrane [GO:0005741]
## 173                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
## 174                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]
## 176                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 177                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell projection [GO:0042995]; neuronal cell body [GO:0043025]
## 178                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; vesicle [GO:0031982]; Weibel-Palade body [GO:0033093]
## 179                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           apical plasma membrane [GO:0016324]; caveola [GO:0005901]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; voltage-gated potassium channel complex [GO:0008076]
## 180                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                P-body [GO:0000932]
## 181                                                                                                                                                                                                                                                                                                                                                                                                                                                                             apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; centrosome [GO:0005813]; cochlear hair cell ribbon synapse [GO:0098683]; kinocilium [GO:0060091]; photoreceptor inner segment [GO:0001917]; photoreceptor ribbon synapse [GO:0098684]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; synapse [GO:0045202]
## 182                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     astrocyte projection [GO:0097449]; axon [GO:0030424]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 183                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        endoplasmic reticulum membrane [GO:0005789]
## 184                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; dendrite [GO:0030425]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; presynapse [GO:0098793]
## 185                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  extracellular region [GO:0005576]
## 187 axolemma [GO:0030673]; cytoplasm [GO:0005737]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor dimeric complex [GO:0038037]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic membrane [GO:0097060]; synaptic vesicle [GO:0008021]
## 188                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               basolateral plasma membrane [GO:0016323]; cell projection [GO:0042995]; plasma membrane [GO:0005886]
## 189                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]
## 190                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]
## 191                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
## 192                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 193                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; dendrite [GO:0030425]; early endosome membrane [GO:0031901]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 194                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytosol [GO:0005829]
## 195                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; oxidoreductase complex [GO:1990204]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]
## 196                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             basolateral plasma membrane [GO:0016323]; plasma membrane [GO:0005886]
## 197                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 198                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 199                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]
## 200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; lipid droplet [GO:0005811]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; presynaptic active zone cytoplasmic component [GO:0098831]
## 201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 202                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    autophagosome [GO:0005776]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; PML body [GO:0016605]
## 203                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleus [GO:0005634]; ribosome [GO:0005840]; synapse [GO:0045202]
## 205                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 axon [GO:0030424]; chromaffin granule membrane [GO:0042584]; dense core granule [GO:0031045]; plasma membrane [GO:0005886]; synaptic vesicle membrane [GO:0030672]
## 206                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        endoplasmic reticulum membrane [GO:0005789]
## 207                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      external side of plasma membrane [GO:0009897]
## 208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 209                                                                                                                                                                                                                                                                                                                                                                                                                                                             axon terminus [GO:0043679]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]
## 210                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      MICOS complex [GO:0061617]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]
## 211                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; microtubule [GO:0005874]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]
## 212                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 plasma membrane [GO:0005886]; synapse [GO:0045202]
## 213                                                                                                                                                                                                                                                                                                                           axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; hippocampal mossy fiber [GO:0097457]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synaptic membrane [GO:0097060]
## 214                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 215                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 216                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]
## 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 218                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]
## 219                                                                                                                                                                                                                                                                                                                           A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 220                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          BAK complex [GO:0097145]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; pore complex [GO:0046930]
## 221                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 222                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cytosol [GO:0005829]; heterotetrameric polyprenyl diphosphate synthase complex [GO:0032478]; mitochondrial matrix [GO:0005759]; transferase complex [GO:1990234]
## 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   extracellular space [GO:0005615]
## 224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 225                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          dendrite [GO:0030425]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 226                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   extracellular space [GO:0005615]
## 228                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 229                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 230                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cytoplasm [GO:0005737]; G protein-coupled GABA receptor complex [GO:1902712]; G protein-coupled receptor heterodimeric complex [GO:0038039]; GABA receptor complex [GO:1902710]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]
## 231                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 232                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]
## 233                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629]
## 234                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 235                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 236                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       Golgi apparatus [GO:0005794]
## 237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]
## 238                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]
## 239                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cell projection [GO:0042995]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 240                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 241                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]
## 242                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           cytoplasm [GO:0005737]; extracellular space [GO:0005615]
## 243                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; postsynapse [GO:0098794]
## 244                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   axonal growth cone [GO:0044295]; basement membrane [GO:0005604]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; sarcolemma [GO:0042383]; synapse [GO:0045202]; synaptic cleft [GO:0043083]
## 245                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               nucleus [GO:0005634]
## 246                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 247                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; spliceosomal tri-snRNP complex [GO:0097526]; U2-type precatalytic spliceosome [GO:0071005]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]
## 249                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 250                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]
## 251                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axolemma [GO:0030673]; axon [GO:0030424]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]
## 252                                                                                                                                                                                                                                                                                                                        axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]
## 253                                                                                                                                                                                                                                                                                                                        axon [GO:0030424]; cytosol [GO:0005829]; dense core granule [GO:0031045]; early phagosome [GO:0032009]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]
## 254                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               nucleus [GO:0005634]
## 255                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           cytoplasm [GO:0005737]; extracellular space [GO:0005615]
## 256                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                P-body [GO:0000932]
## 257                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 258                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytosol [GO:0005829]
## 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]
## 260                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             bicellular tight junction [GO:0005923]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]
## 261                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axon [GO:0030424]; axon initial segment [GO:0043194]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; node of Ranvier [GO:0033268]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]
## 262                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  exocytic vesicle [GO:0070382]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; transport vesicle membrane [GO:0030658]
## 263                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      actin cytoskeleton [GO:0015629]; plasma membrane [GO:0005886]
## 264                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cytoplasm [GO:0005737]; cytosol [GO:0005829]
## 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]
## 266                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 267                                                                                                                                                                                                                                                                                                                                                                                                                                                                              chromaffin granule membrane [GO:0042584]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrial crista [GO:0030061]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; stress fiber [GO:0001725]; vesicle [GO:0031982]; vesicle membrane [GO:0012506]
## 268                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 269                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 270                                                       axon [GO:0030424]; axon cytoplasm [GO:1904115]; BLOC-1 complex [GO:0031083]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; melanosome membrane [GO:0033162]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Schaffer collateral - CA1 synapse [GO:0098685]; synaptic vesicle membrane [GO:0030672]
## 271                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; secretory granule membrane [GO:0030667]
## 272                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             clathrin-coated pit [GO:0005905]; nucleus [GO:0005634]
## 273                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; presynapse [GO:0098793]; synaptic vesicle [GO:0008021]
## 274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 axolemma [GO:0030673]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 275                                                                                                                                                                                                                                                                                                                                                                     astrocyte projection [GO:0097449]; axolemma [GO:0030673]; axon [GO:0030424]; cell body [GO:0044297]; cell surface [GO:0009986]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; membrane protein complex [GO:0098796]; membrane raft [GO:0045121]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; vesicle [GO:0031982]
## 276                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 277                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]
## 278                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]
## 279                                                                                                                                                                                          apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; parallel fiber to Purkinje cell synapse [GO:0098688]; paranodal junction [GO:0033010]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; synaptic vesicle [GO:0008021]
## 280                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               nucleus [GO:0005634]
## 281                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cytoplasm [GO:0005737]; nucleus [GO:0005634]
## 282                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 283                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      axon [GO:0030424]; basal plasma membrane [GO:0009925]; cell leading edge [GO:0031252]; cell surface [GO:0009986]; focal adhesion [GO:0005925]
## 284                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
## 285                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       acrosomal vesicle [GO:0001669]; apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; sodium channel complex [GO:0034706]
## 286                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 287                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               endosome [GO:0005768]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]
## 288                                                                                                                                                                                                                                                                                                                           A band [GO:0031672]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; intercalated disc [GO:0014704]; lysosome [GO:0005764]; M band [GO:0031430]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 289                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]
## 290                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 axon [GO:0030424]; bicellular tight junction [GO:0005923]; cell surface [GO:0009986]; dendrite [GO:0030425]; early endosome [GO:0005769]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202]
## 291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  calyx of Held [GO:0044305]; neuromuscular junction [GO:0031594]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]
## 292                                                                                                                                                                                                                                                                                                                                                                                                   basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; glutamatergic synapse [GO:0098978]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; protein-containing complex [GO:0032991]; sperm flagellum [GO:0036126]; sperm principal piece [GO:0097228]; T-tubule [GO:0030315]; Z disc [GO:0030018]
## 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  extracellular region [GO:0005576]
## 294                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adherens junction [GO:0005912]; basement membrane [GO:0005604]; cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; muscle tendon junction [GO:0005927]
## 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   extracellular space [GO:0005615]
## 296                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; brush border membrane [GO:0031526]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]
## 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       actin cytoskeleton [GO:0015629]; actin filament bundle [GO:0032432]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; ruffle [GO:0001726]
## 298                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytoplasm [GO:0005737]; plasma membrane [GO:0005886]
## 299                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; neuron projection [GO:0043005]
## 300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     chromatin [GO:0000785]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
## 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ciliary base [GO:0097546]; ciliary inversin compartment [GO:0097543]; cilium [GO:0005929]
## 302                                                                                                                                                                                                                                                                                                                                                                                                                                 basement membrane [GO:0005604]; cell-cell junction [GO:0005911]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; laminin complex [GO:0043256]; laminin-1 complex [GO:0005606]; laminin-3 complex [GO:0005608]; membrane [GO:0016020]; protein complex involved in cell-matrix adhesion [GO:0098637]
## 303                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       brush border [GO:0005903]; clathrin-coated vesicle [GO:0030136]; Golgi membrane [GO:0000139]
## 304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]
## 305                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]
## 306                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]
## 307                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             extracellular space [GO:0005615]; vesicle [GO:0031982]
## 308                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cytosol [GO:0005829]; microtubule [GO:0005874]; ruffle membrane [GO:0032587]
## 309                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               cytosol [GO:0005829]
## 310                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]
## 311                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       axon [GO:0030424]; cell surface [GO:0009986]; GABA-ergic synapse [GO:0098982]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]
## 312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]
## 313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]
## 314                                                                                                                                                                                                                               adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; CSL-Notch-Mastermind transcription factor complex [GO:1990433]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endosome [GO:0005768]; Golgi lumen [GO:0005796]; late endosome [GO:0005770]; membrane [GO:0016020]; multivesicular body [GO:0005771]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]
## 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              membrane [GO:0016020]; plasma membrane [GO:0005886]; rhabdomere membrane [GO:0033583]
## 316                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         mitochondrion [GO:0005739]
## 317                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             cytoplasm [GO:0005737]
## 318                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              neuron projection [GO:0043005]; neuron projection membrane [GO:0032589]; plasma membrane [GO:0005886]
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   MolecularFunction
## 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]
## 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]
## 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]
## 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]
## 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
## 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             actin binding [GO:0003779]; actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]
## 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               double-stranded RNA adenosine deaminase activity [GO:0003726]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA-specific adenosine deaminase activity [GO:0008251]
## 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 15                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 16                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]
## 17                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; IgG binding [GO:0019864]
## 18                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              identical protein binding [GO:0042802]; inward rectifier potassium channel activity [GO:0005242]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [GO:0086008]
## 19                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         chloride channel activity [GO:0005254]; intracellularly calcium-gated chloride channel activity [GO:0005229]; protein dimerization activity [GO:0046983]
## 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 alpha1-adrenergic receptor activity [GO:0004937]
## 21                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; metal ion binding [GO:0046872]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
## 22                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         carnitine transmembrane transporter activity [GO:0015226]; creatine transmembrane transporter activity [GO:0005308]; monocarboxylic acid transmembrane transporter activity [GO:0008028]
## 23                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       G protein-coupled adenosine receptor activity [GO:0001609]
## 24                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ferritin receptor activity [GO:0070287]
## 25                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           bHLH transcription factor binding [GO:0043425]; protein dimerization activity [GO:0046983]; sequence-specific DNA binding [GO:0043565]
## 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]; peptidyltransferase activity [GO:0000048]
## 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               alpha1-adrenergic receptor activity [GO:0004937]; protein heterodimerization activity [GO:0046982]
## 28                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; metal ion binding [GO:0046872]; monoatomic ion channel activity [GO:0005216]; osmolarity-sensing monoatomic cation channel activity [GO:1990760]; temperature-gated cation channel activity [GO:0097604]; voltage-gated calcium channel activity [GO:0005245]
## 29                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        actin binding [GO:0003779]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]
## 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]
## 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            dopamine neurotransmitter receptor activity [GO:0004952]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]
## 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          amino acid binding [GO:0016597]; calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]; integrin binding [GO:0005178]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; transmembrane transporter binding [GO:0044325]
## 34                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]
## 35                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     all-trans-retinol dehydrogenase (NAD+) activity [GO:0004745]; all-trans-retinol dehydrogenase (NADP+) activity [GO:0052650]; estradiol 17-beta-dehydrogenase [NAD(P)+] activity [GO:0004303]
## 36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              diaminopimelate decarboxylase activity [GO:0008836]
## 37                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        arylesterase activity [GO:0004064]; carbonate dehydratase activity [GO:0004089]; cyanamide hydratase activity [GO:0018820]; zinc ion binding [GO:0008270]
## 38                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 39                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]
## 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           coreceptor activity [GO:0015026]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]
## 43                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                chloride channel activity [GO:0005254]; phospholipid scramblase activity [GO:0017128]; protein dimerization activity [GO:0046983]
## 44                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## 45                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  beta1-adrenergic receptor activity [GO:0004940]
## 46                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         extracellularly glycine-gated chloride channel activity [GO:0016934]; glycine binding [GO:0016594]; neurotransmitter receptor activity [GO:0030594]; taurine binding [GO:0030977]; transmembrane signaling receptor activity [GO:0004888]; transmitter-gated monoatomic ion channel activity [GO:0022824]; zinc ion binding [GO:0008270]
## 47                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 48                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 49                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    delayed rectifier potassium channel activity [GO:0005251]; intracellularly cyclic nucleotide-activated monoatomic cation channel activity [GO:0005221]; voltage-gated potassium channel activity [GO:0005249]
## 50                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]
## 52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 G protein-coupled receptor activity [GO:0004930]
## 53                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        L-alanine:2-oxoglutarate aminotransferase activity [GO:0004021]; pyridoxal phosphate binding [GO:0030170]
## 54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]
## 56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 acyl carnitine transmembrane transporter activity [GO:0015227]; basic amino acid transmembrane transporter activity [GO:0015174]; high-affinity L-arginine transmembrane transporter activity [GO:0005289]; high-affinity lysine transmembrane transporter activity [GO:0005292]
## 57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 AP-2 adaptor complex binding [GO:0035612]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; monoatomic ion channel activity [GO:0005216]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]
## 58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             extracellular matrix structural constituent conferring tensile strength [GO:0030020]
## 59                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         chromatin binding [GO:0003682]; RNA binding [GO:0003723]
## 60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]
## 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           neuropeptide receptor activity [GO:0008188]; tachykinin receptor activity [GO:0004995]
## 62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 G protein-coupled receptor activity [GO:0004930]
## 63                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ammonium channel activity [GO:0008519]
## 64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 65                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     chloride transmembrane transporter activity [GO:0015108]; cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]
## 66                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]
## 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 69                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; high voltage-gated calcium channel activity [GO:0008331]
## 70                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           G protein-coupled receptor activity [GO:0004930]; hormone binding [GO:0042562]; melatonin receptor activity [GO:0008502]; organic cyclic compound binding [GO:0097159]
## 71                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ferritin receptor activity [GO:0070287]
## 72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]
## 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               voltage-gated sodium channel activity [GO:0005248]
## 74                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]
## 76                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 delayed rectifier potassium channel activity [GO:0005251]; voltage-gated potassium channel activity [GO:0005249]
## 77                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; G-protein alpha-subunit binding [GO:0001965]
## 78                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       ABC-type transporter activity [GO:0140359]; apolipoprotein A-I receptor binding [GO:0034191]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATPase-coupled intramembrane lipid transporter activity [GO:0140326]; ATPase-coupled lipid transmembrane transporter activity [GO:0034040]; ATPase-coupled transmembrane transporter activity [GO:0042626]; lipid transporter activity [GO:0005319]; signaling receptor binding [GO:0005102]
## 79                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               calcium ion binding [GO:0005509]; G protein-coupled receptor activity [GO:0004930]
## 80                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 calcium ion binding [GO:0005509]
## 81                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-amino acid transmembrane transporter activity [GO:0015179]; L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]
## 82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## 83                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 calcium ion binding [GO:0005509]
## 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                G protein-coupled receptor activity [GO:0004930]; neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     dehydroascorbic acid transmembrane transporter activity [GO:0033300]; L-ascorbate:sodium symporter activity [GO:0008520]; L-ascorbic acid transmembrane transporter activity [GO:0015229]; sodium ion transmembrane transporter activity [GO:0015081]; urate transmembrane transporter activity [GO:0015143]
## 86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               GABA receptor binding [GO:0050811]
## 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## 88                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; outward rectifier potassium channel activity [GO:0015271]; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1905030]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]
## 89                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       acetylcholine binding [GO:0042166]; acetylcholine receptor activity [GO:0015464]; acetylcholine-gated monoatomic cation-selective channel activity [GO:0022848]; amyloid-beta binding [GO:0001540]; chloride channel regulator activity [GO:0017081]; protein homodimerization activity [GO:0042803]; toxic substance binding [GO:0015643]
## 91                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                cytokinin riboside 5'-monophosphate phosphoribohydrolase activity [GO:0102682]; hydrolase activity, hydrolyzing N-glycosyl compounds [GO:0016799]
## 92                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 AP-2 adaptor complex binding [GO:0035612]; chloride channel activity [GO:0005254]; GABA-A receptor activity [GO:0004890]; GABA-gated chloride ion channel activity [GO:0022851]; identical protein binding [GO:0042802]; monoatomic ion channel activity [GO:0005216]; neurotransmitter receptor activity [GO:0030594]; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]
## 93                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                aminoacyltransferase activity [GO:0016755]; glutathione hydrolase activity [GO:0036374]; leukotriene C4 gamma-glutamyl transferase activity [GO:0103068]; leukotriene-C(4) hydrolase [GO:0002951]
## 94                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         CDP phosphatase activity [GO:0036384]; CTPase activity [GO:0043273]; GDP phosphatase activity [GO:0004382]; GTPase activity [GO:0003924]; nucleoside diphosphate phosphatase activity [GO:0017110]; ribonucleoside triphosphate phosphatase activity [GO:0017111]; UDP phosphatase activity [GO:0045134]
## 95                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   arachidonate 12(S)-lipoxygenase activity [GO:0004052]; arachidonate 5-lipoxygenase activity [GO:0004051]; arachidonate 8(S)-lipoxygenase activity [GO:0036403]; hydrolase activity [GO:0016787]; iron ion binding [GO:0005506]
## 96                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 98                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; cGMP binding [GO:0030553]; intracellularly cAMP-activated cation channel activity [GO:0005222]; intracellularly cGMP-activated cation channel activity [GO:0005223]; ligand-gated monoatomic ion channel activity [GO:0015276]; myosin binding [GO:0017022]; protein-containing complex binding [GO:0044877]; sodium channel activity [GO:0005272]
## 99                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
## 100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]
## 102                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 103                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]
## 104                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin filament binding [GO:0051015]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]
## 105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          adenosylmethionine decarboxylase activity [GO:0004014]
## 107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 108                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               L-arginine transmembrane transporter activity [GO:0061459]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]
## 109                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     outward rectifier potassium channel activity [GO:0015271]; potassium ion leak channel activity [GO:0022841]
## 110                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             delayed rectifier potassium channel activity [GO:0005251]; kinesin binding [GO:0019894]; transmembrane transporter binding [GO:0044325]; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential [GO:0099508]; voltage-gated potassium channel activity [GO:0005249]
## 111                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 112                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              amino acid transmembrane transporter activity [GO:0015171]; basic amino acid transmembrane transporter activity [GO:0015174]; L-arginine transmembrane transporter activity [GO:0061459]; L-histidine transmembrane transporter activity [GO:0005290]; L-lysine transmembrane transporter activity [GO:0015189]; L-ornithine transmembrane transporter activity [GO:0000064]; virus receptor activity [GO:0001618]
## 113                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 114                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             calcium ion binding [GO:0005509]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]
## 115                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]
## 116                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               L-serine ammonia-lyase activity [GO:0003941]; pyridoxal phosphate binding [GO:0030170]; threonine deaminase activity [GO:0004794]
## 117                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        mitochondrial large ribosomal subunit binding [GO:0140978]; ribosomal large subunit binding [GO:0043023]
## 118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               calcium channel activity [GO:0005262]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; intracellularly gated calcium channel activity [GO:0015278]; temperature-gated cation channel activity [GO:0097604]
## 119                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            ephrin receptor binding [GO:0046875]
## 120                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        DNA binding [GO:0003677]
## 121                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 122                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 123                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; double-stranded DNA binding [GO:0003690]; double-stranded RNA binding [GO:0003725]; RNA helicase activity [GO:0003724]; single-stranded RNA binding [GO:0003727]
## 124                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            intracellularly calcium-gated chloride channel activity [GO:0005229]; lipid binding [GO:0008289]; potassium channel activity [GO:0005267]; small molecule binding [GO:0036094]; splicing factor binding [GO:1990935]
## 125                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]
## 126                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 127                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 128                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             calcium channel activity [GO:0005262]; calcium, potassium:sodium antiporter activity [GO:0008273]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; symporter activity [GO:0015293]
## 129                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               endopeptidase inhibitor activity [GO:0004866]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; molecular function inhibitor activity [GO:0140678]; protein homodimerization activity [GO:0042803]
## 130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 131                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           G protein-coupled photoreceptor activity [GO:0008020]
## 132                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 transmembrane transporter activity [GO:0022857]
## 133                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                G protein-coupled receptor activity [GO:0004930]
## 134                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         C5L2 anaphylatoxin chemotactic receptor binding [GO:0031715]; endopeptidase inhibitor activity [GO:0004866]; lipid binding [GO:0008289]
## 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3'-5' exonuclease activity [GO:0008408]; nucleoside diphosphate kinase activity [GO:0004550]
## 136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 137                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]
## 138                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 139                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                coreceptor activity [GO:0015026]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]
## 140                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 141                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              glutaminase activity [GO:0004359]; protein heterodimerization activity [GO:0046982]; pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [GO:0036381]
## 142                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        extracellularly glutamate-gated ion channel activity [GO:0005234]; glutamate-gated calcium ion channel activity [GO:0022849]; glutamate-gated receptor activity [GO:0004970]; kainate selective glutamate receptor activity [GO:0015277]
## 143                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]; WW domain binding [GO:0050699]
## 144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 145                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              heme binding [GO:0020037]; lactoperoxidase activity [GO:0140825]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]
## 146                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          arachidonic acid binding [GO:0050544]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; proton channel activity [GO:0015252]
## 147                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 148                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       branched-chain-amino-acid transaminase activity [GO:0004084]; L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-leucine:2-oxoglutarate aminotransferase activity [GO:0050048]; L-valine transaminase activity [GO:0052655]
## 149                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 150                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]
## 151                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]
## 152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               copper ion binding [GO:0005507]; tyrosinase activity [GO:0004503]
## 153                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     imidazolonepropionase activity [GO:0050480]; metal ion binding [GO:0046872]
## 154                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        actin binding [GO:0003779]; ATP binding [GO:0005524]; microfilament motor activity [GO:0000146]; myosin light chain binding [GO:0032027]
## 155                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 156                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 157                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                RNA polymerase II-specific DNA-binding transcription factor binding [GO:0061629]
## 158                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   protein-arginine N-methyltransferase activity [GO:0016274]; ubiquitin-like ligase-substrate adaptor activity [GO:1990756]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 159                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       cysteine transmembrane transporter activity [GO:0033229]; symporter activity [GO:0015293]
## 160                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          histone methyltransferase activity [GO:0042054]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; protein-arginine omega-N monomethyltransferase activity [GO:0035241]; ribosome binding [GO:0043022]
## 161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]
## 162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; NAD+ nucleotidase, cyclic ADP-ribose generating [GO:0061809]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]
## 163                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 164                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ATP binding [GO:0005524]; GTP binding [GO:0005525]; nucleoside triphosphate adenylate kinase activity [GO:0046899]
## 165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; peptide binding [GO:0042277]
## 166                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     carcinine transmembrane transporter activity [GO:1905131]; neurotransmitter transmembrane transporter activity [GO:0005326]
## 167                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; monoatomic cation channel activity [GO:0005261]; muscle alpha-actinin binding [GO:0051371]; outward rectifier potassium channel activity [GO:0015271]; potassium channel activity [GO:0005267]; signaling receptor binding [GO:0005102]; voltage-gated calcium channel activity [GO:0005245]; voltage-gated sodium channel activity [GO:0005248]
## 168                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]
## 169                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 170                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     miRNA binding [GO:0035198]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 171                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  alpha-actinin binding [GO:0051393]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; G protein-coupled adenosine receptor activity [GO:0001609]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein-containing complex binding [GO:0044877]; type 5 metabotropic glutamate receptor binding [GO:0031802]
## 172                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      FAD binding [GO:0071949]; kynurenine 3-monooxygenase activity [GO:0004502]
## 173                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        TIR domain binding [GO:0070976]; Toll-like receptor binding [GO:0035325]
## 174                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]
## 175                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]
## 176                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               apolipoprotein binding [GO:0034185]; low-density lipoprotein particle receptor activity [GO:0005041]; toxin transmembrane transporter activity [GO:0019534]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 177                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                ammonium channel activity [GO:0008519]; potassium ion transmembrane transporter activity [GO:0015079]; sodium:potassium:chloride symporter activity [GO:0008511]
## 178                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; metalloendopeptidase activity [GO:0004222]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]
## 179                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               actin binding [GO:0003779]; calcium-activated potassium channel activity [GO:0015269]; identical protein binding [GO:0042802]; large conductance calcium-activated potassium channel activity [GO:0060072]; metal ion binding [GO:0046872]; voltage-gated potassium channel activity [GO:0005249]
## 180                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 181                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]
## 182                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          calcium channel regulator activity [GO:0005246]; group II metabotropic glutamate receptor activity [GO:0001641]; scaffold protein binding [GO:0097110]
## 183                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              P-type magnesium transporter activity [GO:0015444]
## 184                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]
## 185                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]
## 186                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 187                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             extracellular matrix protein binding [GO:1990430]; G protein-coupled GABA receptor activity [GO:0004965]; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [GO:0099579]; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential [GO:0150047]; protein heterodimerization activity [GO:0046982]
## 188                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         amino acid binding [GO:0016597]; amino acid:sodium symporter activity [GO:0005283]; creatine transmembrane transporter activity [GO:0005308]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; taurine transmembrane transporter activity [GO:0005368]; taurine:sodium symporter activity [GO:0005369]
## 189                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]
## 190                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    metal ion binding [GO:0046872]; zinc:proton antiporter activity [GO:0140826]
## 191                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                G protein-coupled receptor activity [GO:0004930]
## 192                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 193                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 194                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]
## 195                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      mRNA binding [GO:0003729]; mRNA m(6)A methyltransferase activity [GO:0001734]; protein heterodimerization activity [GO:0046982]; RNA methyltransferase activity [GO:0008173]; S-adenosyl-L-methionine binding [GO:1904047]
## 196                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       creatine transmembrane transporter activity [GO:0005308]; uniporter activity [GO:0015292]
## 197 chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; histone acetyltransferase binding [GO:0035035]; HMG box domain binding [GO:0071837]; minor groove of adenine-thymine-rich DNA binding [GO:0003680]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coregulator binding [GO:0001221]; ubiquitin protein ligase binding [GO:0031625]
## 198                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 199                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   ribosome binding [GO:0043022]
## 200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cholesterol binding [GO:0015485]; cholesterol transfer activity [GO:0120020]; phosphatidylinositol transfer activity [GO:0008526]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]
## 201                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]
## 202                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               antioxidant activity [GO:0016209]
## 203                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           G protein-coupled photoreceptor activity [GO:0008020]
## 204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            GTPase inhibitor activity [GO:0005095]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA regulatory element binding translation repressor activity [GO:0000900]; poly-pyrimidine tract binding [GO:0008187]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; ribosome binding [GO:0043022]; translation factor activity, RNA binding [GO:0008135]
## 205                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylserine binding [GO:0001786]; syntaxin binding [GO:0019905]
## 206                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    ATP binding [GO:0005524]; protein serine kinase activity [GO:0106310]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]
## 207                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           riboflavin binding [GO:1902444]; riboflavin transmembrane transporter activity [GO:0032217]; signaling receptor activity [GO:0038023]
## 208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 209                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                SH3 domain binding [GO:0017124]; syntaxin-1 binding [GO:0017075]
## 210                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 211                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 protein-containing complex binding [GO:0044877]
## 212                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      G protein-coupled serotonin receptor activity [GO:0004993]
## 213                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; GAF domain binding [GO:0036004]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; phosphate ion binding [GO:0042301]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; zinc ion binding [GO:0008270]
## 214                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]
## 215                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]
## 216                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion binding [GO:0005509]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; lipopolysaccharide binding [GO:0001530]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; thrombospondin receptor activity [GO:0070053]
## 217                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 218                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]
## 219                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 220                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 BH domain binding [GO:0051400]; heat shock protein binding [GO:0031072]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; porin activity [GO:0015288]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; protein-folding chaperone binding [GO:0051087]; transmembrane transporter binding [GO:0044325]
## 221                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]
## 222                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      all-trans-decaprenyl-diphosphate synthase activity [GO:0097269]; all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity [GO:0052923]; prenyltransferase activity [GO:0004659]; protein heterodimerization activity [GO:0046982]
## 223                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 225                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           G protein-coupled serotonin receptor activity [GO:0004993]; histamine receptor activity [GO:0004969]; neurotransmitter receptor activity [GO:0030594]
## 226                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; methylenetetrahydrofolate reductase (NAD(P)H) activity [GO:0004489]; methylenetetrahydrofolate reductase (NADPH) activity [GO:0106313]; NADP binding [GO:0050661]
## 227                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   cytokine activity [GO:0005125]; frizzled binding [GO:0005109]
## 228                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  corticotropin receptor activity [GO:0004978]; G protein-coupled receptor activity [GO:0004930]
## 229                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 230                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 G protein-coupled GABA receptor activity [GO:0004965]; protein heterodimerization activity [GO:0046982]; transmembrane signaling receptor activity [GO:0004888]
## 231                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 232                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    actin binding [GO:0003779]; tropomyosin binding [GO:0005523]
## 233                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     kinase binding [GO:0019900]
## 234                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; endopeptidase activity [GO:0004175]; glutamate binding [GO:0016595]; metal ion binding [GO:0046872]; modified amino acid binding [GO:0072341]; phospholipid binding [GO:0005543]; potassium ion binding [GO:0030955]; protein-containing complex binding [GO:0044877]; small molecule binding [GO:0036094]
## 235                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 236                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 237                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 238                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]
## 239                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        enzyme activator activity [GO:0008047]; G protein-coupled glycine receptor activity [GO:0160079]; transmembrane signaling receptor activity [GO:0004888]
## 240                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          ammonium channel activity [GO:0008519]
## 241                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             histamine N-methyltransferase activity [GO:0046539]
## 242                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 243                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         identical protein binding [GO:0042802]; translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 244                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       acetylcholine receptor regulator activity [GO:0030548]; ATPase inhibitor activity [GO:0042030]; BMP binding [GO:0036122]; calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; dystroglycan binding [GO:0002162]; heparan sulfate proteoglycan binding [GO:0043395]; receptor ligand activity [GO:0048018]; sialic acid binding [GO:0033691]; transforming growth factor beta binding [GO:0050431]; transmembrane transporter binding [GO:0044325]
## 245                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 246                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 247                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 symporter activity [GO:0015293]
## 248                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               U4atac snRNA binding [GO:0030622]
## 249                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           follicle-stimulating hormone receptor activity [GO:0004963]; G protein-coupled peptide receptor activity [GO:0008528]
## 250                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; miRNA binding [GO:0035198]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; transcription cis-regulatory region binding [GO:0000976]
## 251                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275]
## 252                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 253                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calmodulin binding [GO:0005516]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]
## 254                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    protein heterodimerization activity [GO:0046982]; sequence-specific DNA binding [GO:0043565]
## 255                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 256                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  miRNA binding [GO:0035198]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 257                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                G protein-coupled receptor activity [GO:0004930]
## 258                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           L-phosphoserine phosphatase activity [GO:0036424]; magnesium ion binding [GO:0000287]
## 259                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 260                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             copper ion binding [GO:0005507]; diamine oxidase activity [GO:0052597]; heparin binding [GO:0008201]; histamine oxidase activity [GO:0052598]; methylputrescine oxidase activity [GO:0052599]; organic cyclic compound binding [GO:0097159]; primary amine oxidase activity [GO:0008131]; propane-1,3-diamine oxidase activity [GO:0052600]; putrescine oxidase activity [GO:0050232]; quinone binding [GO:0048038]
## 261                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        ankyrin binding [GO:0030506]; cell-cell adhesion mediator activity [GO:0098632]; protein binding involved in heterotypic cell-cell adhesion [GO:0086080]
## 262                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; clathrin binding [GO:0030276]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]
## 263                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 neuropeptide receptor activity [GO:0008188]; opioid receptor binding [GO:0031628]; peptide binding [GO:0042277]
## 264                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      carbonate dehydratase activity [GO:0004089]; zinc ion binding [GO:0008270]
## 265                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                actin binding [GO:0003779]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]
## 266                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  ATP binding [GO:0005524]; fibroblast growth factor binding [GO:0017134]; fibroblast growth factor receptor activity [GO:0005007]; heparin binding [GO:0008201]
## 267                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           actin filament binding [GO:0051015]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; cargo receptor activity [GO:0038024]; chondroitin sulfate binding [GO:0035374]; enzyme binding [GO:0019899]; heparin binding [GO:0008201]; phosphatidylserine binding [GO:0001786]
## 268                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]
## 269                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 270                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 271                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              copper ion binding [GO:0005507]; dopamine beta-monooxygenase activity [GO:0004500]
## 272                                                                                                                                                                          chromatin binding [GO:0003682]; cis-regulatory region sequence-specific DNA binding [GO:0000987]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; identical protein binding [GO:0042802]; nuclear receptor corepressor activity [GO:0140536]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; transcription cis-regulatory region binding [GO:0000976]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]
## 273                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:proton antiporter activity [GO:0140800]; glycine transmembrane transporter activity [GO:0015187]; glycine:proton antiporter activity [GO:0140799]
## 274                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            axon guidance receptor activity [GO:0008046]; identical protein binding [GO:0042802]
## 275                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      cysteine transmembrane transporter activity [GO:0033229]; glutamate:sodium symporter activity [GO:0015501]; high-affinity L-glutamate transmembrane transporter activity [GO:0005314]; L-glutamate transmembrane transporter activity [GO:0005313]; metal ion binding [GO:0046872]; monoatomic anion transmembrane transporter activity [GO:0008509]; neutral L-amino acid transmembrane transporter activity [GO:0015175]
## 276                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          arginine kinase activity [GO:0004054]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 277                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]
## 278                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]
## 279                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 actin filament binding [GO:0051015]; phospholipid binding [GO:0005543]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of postsynapse [GO:0099186]; structural constituent of synapse [GO:0098918]
## 280                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 281                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         acireductone dioxygenase (Ni2+-requiring) activity [GO:0010308]; acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; iron ion binding [GO:0005506]; nickel cation binding [GO:0016151]
## 282                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              iron ion binding [GO:0005506]; phenylalanine 4-monooxygenase activity [GO:0004505]
## 283                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             heparin binding [GO:0008201]; insulin receptor binding [GO:0005158]; protein tyrosine phosphatase activity [GO:0004725]; SAM domain binding [GO:0032093]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
## 284                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]
## 285                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               ligand-gated sodium channel activity [GO:0015280]
## 286                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G protein-coupled amine receptor activity [GO:0008227]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]
## 287                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; myosin V binding [GO:0031489]
## 288                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       ATPase binding [GO:0051117]; cytoskeletal anchor activity [GO:0008093]; enzyme binding [GO:0019899]; phosphorylation-dependent protein binding [GO:0140031]; protein kinase binding [GO:0019901]; protein-macromolecule adaptor activity [GO:0030674]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; transmembrane transporter binding [GO:0044325]
## 289                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   ornithine decarboxylase activity [GO:0004586]; protein homodimerization activity [GO:0042803]
## 290                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; ubiquitin protein ligase binding [GO:0031625]; Wnt receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]
## 291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; diacylglycerol binding [GO:0019992]; phospholipid binding [GO:0005543]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]
## 292                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; calcium ion transmembrane transporter activity [GO:0015085]; calmodulin binding [GO:0005516]; metal ion binding [GO:0046872]; nitric-oxide synthase binding [GO:0050998]; nitric-oxide synthase inhibitor activity [GO:0036487]; P-type calcium transporter activity [GO:0005388]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein phosphatase 2B binding [GO:0030346]; scaffold protein binding [GO:0097110]; sodium channel regulator activity [GO:0017080]
## 293                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 294                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]
## 295                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; fucose binding [GO:0042806]
## 296                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 (R)-carnitine transmembrane transporter activity [GO:1901235]; amino-acid betaine transmembrane transporter activity [GO:0015199]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; xenobiotic transmembrane transporter activity [GO:0042910]
## 297                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]
## 298                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    corticotropin receptor activity [GO:0004978]
## 299                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]
## 300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; ATP-dependent chromatin remodeler activity [GO:0140658]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone binding [GO:0042393]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
## 301                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 302                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       extracellular matrix structural constituent [GO:0005201]; glycosphingolipid binding [GO:0043208]; signaling receptor binding [GO:0005102]
## 303                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]
## 304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      G protein-coupled receptor activity [GO:0004930]; melatonin binding [GO:1904408]; melatonin receptor activity [GO:0008502]
## 305                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]
## 306                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            G protein-coupled amine receptor activity [GO:0008227]; G protein-coupled receptor activity [GO:0004930]; trace-amine receptor activity [GO:0001594]
## 307                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        BMP receptor binding [GO:0070700]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; protein heterodimerization activity [GO:0046982]
## 308                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
## 309                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     glutamate dehydrogenase (NAD+) activity [GO:0004352]; glutamate dehydrogenase (NADP+) activity [GO:0004354]
## 310                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               calcium ion binding [GO:0005509]; calcium:proton antiporter activity [GO:0015369]
## 311                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    amino acid:sodium symporter activity [GO:0005283]; gamma-aminobutyric acid transmembrane transporter activity [GO:0015185]; gamma-aminobutyric acid:sodium:chloride symporter activity [GO:0005332]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; sodium:chloride symporter activity [GO:0015378]
## 312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    ammonium channel activity [GO:0008519]; metal ion transmembrane transporter activity [GO:0046873]; sodium:potassium:chloride symporter activity [GO:0008511]
## 313                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      calmodulin binding [GO:0005516]; cystathionine gamma-lyase activity [GO:0004123]; homocysteine desulfhydrase activity [GO:0047982]; L-cysteine desulfhydrase activity [GO:0080146]; L-cystine L-cysteine-lyase (deaminating) [GO:0044540]; pyridoxal phosphate binding [GO:0030170]; selenocystathionine gamma-lyase activity [GO:0098606]
## 314                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       calcium ion binding [GO:0005509]; chromatin binding [GO:0003682]; histone acetyltransferase binding [GO:0035035]; transcription coactivator activity [GO:0003713]; transmembrane signaling receptor activity [GO:0004888]; WW domain binding [GO:0050699]
## 315                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             G protein-coupled photoreceptor activity [GO:0008020]; retinal binding [GO:0016918]
## 316                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   3-hydroxyisobutyrate dehydrogenase activity [GO:0008442]; NAD binding [GO:0051287]; NADP binding [GO:0050661]
## 317                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 translation repressor activity [GO:0030371]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]
## 318                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cholesterol binding [GO:0015485]; sodium channel activity [GO:0005272]
cluster_1_3 <- Oral_enriched_clustered %>% dplyr::filter(GO.cluster == 1|
                                                           GO.cluster == 2|
                                                           GO.cluster == 3) %>% pull(GO.ID)

showSigOfNodes(BP_Oral, score(elim_Oral)[names(score(elim_Oral)) %in% cluster_1_3],  firstSigNodes = length(cluster_1_3), useInfo = 'all')
## Loading required package: Rgraphviz
## Loading required package: grid
## 
## Attaching package: 'grid'
## The following object is masked from 'package:topGO':
## 
##     depth
## 
## Attaching package: 'Rgraphviz'
## The following objects are masked from 'package:IRanges':
## 
##     from, to
## The following objects are masked from 'package:S4Vectors':
## 
##     from, to

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 52 
## Number of Edges = 87 
## 
## $complete.dag
## [1] "A graph with 52 nodes."
cluster_1_3_genes <- unique(unlist(genes_by_GO[cluster_1_3]))

write.csv(cluster_1_3_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Oral_enrich_BP_transport.csv",row.names=FALSE)
cluster_1_3_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_1_3_genes)

#DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Aboral_enriched_clustered %>% pull(GO.ID)])))

Aboral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)

BP_Aboral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="BP",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 8797 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 12496 GO terms and 27095 relations. )
## 
## Annotating nodes ...............
##  ( 9496 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
    BP_Aboral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 3092 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 17:  1 nodes to be scored    (0 eliminated genes)
## 
##   Level 16:  6 nodes to be scored    (0 eliminated genes)
## 
##   Level 15:  21 nodes to be scored   (0 eliminated genes)
## 
##   Level 14:  24 nodes to be scored   (0 eliminated genes)
## 
##   Level 13:  44 nodes to be scored   (175 eliminated genes)
## 
##   Level 12:  85 nodes to be scored   (236 eliminated genes)
## 
##   Level 11:  184 nodes to be scored  (238 eliminated genes)
## 
##   Level 10:  284 nodes to be scored  (291 eliminated genes)
## 
##   Level 9:   377 nodes to be scored  (334 eliminated genes)
## 
##   Level 8:   450 nodes to be scored  (625 eliminated genes)
## 
##   Level 7:   472 nodes to be scored  (816 eliminated genes)
## 
##   Level 6:   489 nodes to be scored  (1092 eliminated genes)
## 
##   Level 5:   366 nodes to be scored  (1921 eliminated genes)
## 
##   Level 4:   194 nodes to be scored  (2391 eliminated genes)
## 
##   Level 3:   78 nodes to be scored   (2465 eliminated genes)
## 
##   Level 2:   16 nodes to be scored   (2583 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (2583 eliminated genes)
BP_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Aboral_elim = c("BP_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
##  Aboral_elim
##       BP_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 118
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         Nontrivial_nodes: 3092 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 118 GO terms of 1 conditions.
##         Aboral_elim : 118 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
    BP_Results,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral.tsv"
)
  • enrichment pvalue cutoff: Aboral_elim : 0.01
  • enrich GOs (in at least one list): Aboral_elim : 118 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Aboral_elim
##       BP_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 118
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         Nontrivial_nodes: 3092 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 118 GO terms of 1 conditions.
##         Aboral_elim : 118 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 1,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Aboral,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)

ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    height=1500,
    width=700,
    "GOterms", file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral_cluster_heatmap_Wang_wardD2.png")
## quartz_off_screen 
##                 2

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Aboral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Aboral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")
Aboral_enriched_clustered <- Wang_clusters_wardD2_Aboral@enrich_GOs@data

top_cluster <- Aboral_enriched_clustered %>% arrange(Aboral_elim.pvalue) %>% head(1) %>% pull(GO.cluster)

Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == top_cluster)
##    GO.cluster    IC      GO.ID
##        <char> <num>     <char>
## 1:          9  6.30 GO:0007160
## 2:          9  4.14 GO:0007155
## 3:          9  8.23 GO:0016339
## 4:          9  6.32 GO:0007156
## 5:          9  7.39 GO:0007157
##                                                                                term
##                                                                              <char>
## 1:                                                             cell-matrix adhesion
## 2:                                                                    cell adhesion
## 3: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
## 4:                  homophilic cell adhesion via plasma membrane adhesion molecules
## 5:      heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
##                                                                                                                                       definition
##                                                                                                                                           <char>
## 1:                                                                     The binding of a cell to the extracellular matrix via adhesion molecules.
## 2: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
## 3:                   The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
## 4:                               The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
## 5:                                   The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
##    Aboral_elim.genes_frequency Aboral_elim.pvalue Aboral_elim.-log10_pvalue
##                         <char>              <num>                     <num>
## 1:              8.738% (9/103)       9.829966e-03                      2.01
## 2:            10.423% (69/662)       3.718063e-03                      2.43
## 3:              29.412% (5/17)       2.216604e-04                      3.65
## 4:            20.175% (23/114)       6.027593e-12                     11.22
## 5:             30.769% (12/39)       4.576971e-09                      8.34
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 Aboral_elim.Significant_genes
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        <char>
## 1:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Pocillopora_acuta_HIv2___RNAseq.g11876.t1;Pocillopora_acuta_HIv2___RNAseq.g12272.t1;Pocillopora_acuta_HIv2___RNAseq.g12278.t1;Pocillopora_acuta_HIv2___RNAseq.g13823.t1;Pocillopora_acuta_HIv2___RNAseq.g25351.t1;Pocillopora_acuta_HIv2___RNAseq.g28502.t1;Pocillopora_acuta_HIv2___RNAseq.g5342.t1;Pocillopora_acuta_HIv2___RNAseq.g7895.t1;Pocillopora_acuta_HIv2___TS.g10825.t1
## 2: Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.6832_t;Pocillopora_acuta_HIv2___RNAseq.g10343.t1;Pocillopora_acuta_HIv2___RNAseq.g10385.t1;Pocillopora_acuta_HIv2___RNAseq.g1119.t1;Pocillopora_acuta_HIv2___RNAseq.g11876.t1;Pocillopora_acuta_HIv2___RNAseq.g12258.t1;Pocillopora_acuta_HIv2___RNAseq.g12272.t1;Pocillopora_acuta_HIv2___RNAseq.g12278.t1;Pocillopora_acuta_HIv2___RNAseq.g12281.t1;Pocillopora_acuta_HIv2___RNAseq.g12374.t1;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g13823.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g14347.t1;Pocillopora_acuta_HIv2___RNAseq.g14375.t1;Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___RNAseq.g18125.t1;Pocillopora_acuta_HIv2___RNAseq.g18385.t1;Pocillopora_acuta_HIv2___RNAseq.g19085.t1;Pocillopora_acuta_HIv2___RNAseq.g20876.t1;Pocillopora_acuta_HIv2___RNAseq.g21477.t1;Pocillopora_acuta_HIv2___RNAseq.g21479.t1;Pocillopora_acuta_HIv2___RNAseq.g21481.t1;Pocillopora_acuta_HIv2___RNAseq.g23178.t1;Pocillopora_acuta_HIv2___RNAseq.g23210.t1;Pocillopora_acuta_HIv2___RNAseq.g23886.t1;Pocillopora_acuta_HIv2___RNAseq.g24688.t1;Pocillopora_acuta_HIv2___RNAseq.g25351.t1;Pocillopora_acuta_HIv2___RNAseq.g25739.t1;Pocillopora_acuta_HIv2___RNAseq.g25761.t1;Pocillopora_acuta_HIv2___RNAseq.g27031.t1;Pocillopora_acuta_HIv2___RNAseq.g28109.t1;Pocillopora_acuta_HIv2___RNAseq.g28196.t1;Pocillopora_acuta_HIv2___RNAseq.g28226.t2;Pocillopora_acuta_HIv2___RNAseq.g28502.t1;Pocillopora_acuta_HIv2___RNAseq.g28971.t1a;Pocillopora_acuta_HIv2___RNAseq.g29143.t2;Pocillopora_acuta_HIv2___RNAseq.g29795.t1;Pocillopora_acuta_HIv2___RNAseq.g3826.t1;Pocillopora_acuta_HIv2___RNAseq.g3939.t1;Pocillopora_acuta_HIv2___RNAseq.g5181.t1;Pocillopora_acuta_HIv2___RNAseq.g5342.t1;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g5896.t1;Pocillopora_acuta_HIv2___RNAseq.g682.t1;Pocillopora_acuta_HIv2___RNAseq.g7895.t1;Pocillopora_acuta_HIv2___RNAseq.g805.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___RNAseq.g9049.t1;Pocillopora_acuta_HIv2___RNAseq.g9253.t1;Pocillopora_acuta_HIv2___TS.g10825.t1;Pocillopora_acuta_HIv2___TS.g11002.t4;Pocillopora_acuta_HIv2___TS.g12860.t1;Pocillopora_acuta_HIv2___TS.g14528.t1a;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g17199.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g24030.t1;Pocillopora_acuta_HIv2___TS.g24743.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g30914.t1;Pocillopora_acuta_HIv2___TS.g3265.t1;Pocillopora_acuta_HIv2___TS.g5115.t2;Pocillopora_acuta_HIv2___TS.g5308.t2;Pocillopora_acuta_HIv2___TS.g8258.t1;Pocillopora_acuta_HIv2___TS.g8259.t1b
## 3:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g5308.t2
## 4:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.g10343.t1;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g16484.t1;Pocillopora_acuta_HIv2___RNAseq.g17517.t1;Pocillopora_acuta_HIv2___RNAseq.g17519.t1;Pocillopora_acuta_HIv2___RNAseq.g19085.t1;Pocillopora_acuta_HIv2___RNAseq.g23178.t1;Pocillopora_acuta_HIv2___RNAseq.g23210.t1;Pocillopora_acuta_HIv2___RNAseq.g29143.t2;Pocillopora_acuta_HIv2___RNAseq.g5181.t1;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g682.t1;Pocillopora_acuta_HIv2___RNAseq.g805.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g24743.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g5308.t2;Pocillopora_acuta_HIv2___TS.g8258.t1;Pocillopora_acuta_HIv2___TS.g8259.t1b
## 5:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              Pocillopora_acuta_HIv2___RNAseq.2533_t;Pocillopora_acuta_HIv2___RNAseq.g12987.t1;Pocillopora_acuta_HIv2___RNAseq.g14253.t1;Pocillopora_acuta_HIv2___RNAseq.g28971.t1a;Pocillopora_acuta_HIv2___RNAseq.g5388.t1;Pocillopora_acuta_HIv2___RNAseq.g8148.t1;Pocillopora_acuta_HIv2___RNAseq.g9253.t1;Pocillopora_acuta_HIv2___TS.g15590.t1;Pocillopora_acuta_HIv2___TS.g23602.t1;Pocillopora_acuta_HIv2___TS.g30706.t1;Pocillopora_acuta_HIv2___TS.g30914.t1;Pocillopora_acuta_HIv2___TS.g3265.t1
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  Aboral_elim.Significant_genes_symbol
##                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                <char>
## 1:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      Mucin-like protein;Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Mucin-like protein;Mammalian ependymin-related protein 1 (MERP-1);Mucin-like protein;Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339);Protein jagged-1 (Jagged1) (CD antigen CD339);Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module)
## 2: Hemicentin-1 (Fibulin-6) (FIBL-6);Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B);Protocadherin Fat 3 (FAT tumor suppressor homolog 3);Fibroblast growth factor receptor-like 1 (FGF receptor-like protein 1) (FGF homologous factor receptor) (FGFR-like protein) (Fibroblast growth factor receptor 5) (FGFR-5);Collagen alpha-6(VI) chain;Mucin-like protein;Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Chick receptor tyrosine phosphatase alpha) (CRYP alpha) (CRYPalpha);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28);Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR);Tissue inhibitor of metalloproteinase;Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Mucin-like protein;Hemicentin-1 (Fibulin-6) (FIBL-6);Collagen alpha-4(VI) chain;Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Melanotransferrin (Membrane-bound transferrin-like protein p97) (MTf) (CD antigen CD228);BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains);Halomucin;Melanotransferrin (Membrane-bound transferrin-like protein p97) (MTf) (CD antigen CD228);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C);Hemicentin-2;Hemicentin-2;Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta);Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha);Mammalian ependymin-related protein 1 (MERP-1);Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L);Collagen alpha-6(VI) chain;Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2);Fibulin-2 (FIBL-2);Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2];Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein];Mucin-like protein;Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form];Roundabout homolog 2;Zonadhesin;Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2);Spondin-1 (F-spondin);Roundabout homolog 2;Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339);Hemicentin-1 (Fibulin-6) (FIBL-6);Probable N-acetyltransferase camello (EC 2.3.1.-) (Xcml);Roundabout homolog 1;Protein jagged-1 (Jagged1) (CD antigen CD339);Protein turtle homolog B (Immunoglobulin superfamily member 9B);Hemicentin-1 (Fibulin-6) (FIBL-6);Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module);Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein];Collagen alpha-1(VI) chain;Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment];Hemicentin-1 (Fibulin-6) (FIBL-6);Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12);Hemicentin-2;Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Hemicentin-2;Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1)
## 3:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14)
## 4:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 3 (FAT tumor suppressor homolog 3);Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-1 (Fibulin-6) (FIBL-6);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Halomucin;Hemicentin-2;Hemicentin-2;Roundabout homolog 2;Roundabout homolog 2;Hemicentin-1 (Fibulin-6) (FIBL-6);Roundabout homolog 1;Protein turtle homolog B (Immunoglobulin superfamily member 9B);Hemicentin-1 (Fibulin-6) (FIBL-6);Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-2;Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14);Hemicentin-2;Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1)
## 5:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Hemicentin-1 (Fibulin-6) (FIBL-6);Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form];Hemicentin-1 (Fibulin-6) (FIBL-6);Hemicentin-1 (Fibulin-6) (FIBL-6);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Hemicentin-1 (Fibulin-6) (FIBL-6);Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J);Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito];Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48);Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48)
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOterms")
BP_go_terms <- BP_Aboral@graph@nodes
genes_by_GO <- genesInTerm(BP_Aboral, BP_go_terms)

cluster_6_9 <- Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == 6|GO.cluster == 9) %>% pull(GO.ID)

showSigOfNodes(BP_Aboral, score(elim_Aboral)[names(score(elim_Aboral)) %in% cluster_6_9],  firstSigNodes = length(cluster_6_9), useInfo = 'all')

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 20 
## Number of Edges = 22 
## 
## $complete.dag
## [1] "A graph with 20 nodes."
cluster_6_9_genes <- unique(unlist(genes_by_GO[cluster_6_9]))

write.csv(cluster_6_9_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Aboral_enrich_BP_adhesion.csv",row.names=FALSE)

cluster_6_9_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_6_9_genes)

cluster_1_5 <- Aboral_enriched_clustered %>% dplyr::filter(GO.cluster == 1|
                                                           GO.cluster == 2|
                                                           GO.cluster == 3|
                                                           GO.cluster == 4|
                                                           GO.cluster == 5) %>% pull(GO.ID)

showSigOfNodes(BP_Aboral, score(elim_Aboral)[names(score(elim_Aboral)) %in% cluster_1_5],  firstSigNodes = length(cluster_1_5), useInfo = 'all')
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped
## Warning in arrows(head_from[1], head_from[2], head_to[1], head_to[2], col =
## edgeColor, : zero-length arrow is of indeterminate angle and so skipped

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 309 
## Number of Edges = 601 
## 
## $complete.dag
## [1] "A graph with 309 nodes."
cluster_1_5_genes <- unique(unlist(genes_by_GO[cluster_1_5]))

write.csv(cluster_1_5_genes,"../output_RNA/differential_expression/semantic-enrichment/cluster_gene_lists/Aboral_enrich_BP_development.csv",row.names=FALSE)
cluster_1_5_genes_DE <- DE_05_SwissProt %>% filter(query %in%cluster_1_5_genes)

#DE_05_SwissProt %>% filter(query %in%unique(unlist(genes_by_GO[Aboral_enriched_clustered %>% pull(GO.ID)])))

Plotting of both tissues, pre-clustered by tissue

Custom plotting of results

clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data) 

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
  dplyr::select(cluster, Cluster.name)

clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Oral")

clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
  dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Aboral")


clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Oral")),
                                      clustered_Aboral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Aboral")))

NEW: Plotting of each tissue cluster separately

extract cluster trees

library(ggdendro)
library(patchwork)
dist_mat <- slot(Wang_clusters_wardD2_Oral, "clusters_dist")[["BMA"]]
hc <- hclust(dist_mat, method = "ward.D2")
dend <- as.dendrogram(hc)

dend_data <- ggdendro::dendro_data(dend, type = "rectangle")

dend_labels <- dend_data$labels %>%
    mutate(
    cluster = str_extract(label, "\\d+"),
    Cluster.name = str_replace(label,".*?_.*?_",""),
    Cluster.term = str_replace(label,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) 

bar_plot <- clustered_allDEGs_enrichedGO %>%  
filter(Tissue == "Oral") %>%
  arrange(as.numeric(GO.cluster)) %>%
  mutate(Cluster_label = factor(Cluster.name, levels = rev(dend_labels$Cluster.name))) %>%
  ggplot(aes(x = Cluster_label)) +
  stat_count(width = .8, fill="#FD8D3C", alpha = 0.8) +
  coord_flip() +
  theme_classic(base_size = 9) +
  scale_y_continuous(
    breaks = scales::breaks_width(2),
    expand = c(0, 0),
    limits = c(0, NA)
  ) + 
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Oral epidermis", y = "Terms in Cluster")

dend_plot <- ggplot() +
  geom_segment(
    data = dend_data$segments,
    aes(x = y, y = x, xend = yend, yend = xend),
    linewidth = 0.6,
    color = "#2C3E50"
  ) +
  scale_y_reverse(
    breaks = seq_along(dend_labels$Cluster.name),
    expand = c(0.02, 0.02)
  ) +
  scale_x_reverse(expand = c(0.02, 0)) +
  theme_void() +
  theme(
    plot.margin = margin(t = 30, r = 0, b = 22, l = 5)
  )

# Combine plots with better proportions
final <- dend_plot + bar_plot +
  plot_layout(widths = c(0.8, 3.5))

Wang_clusters_wardD2_Oral@heatmap$GOclusters_static

ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Dend_Clusters_Oral.png", final, width = 5, height = 6.5, dpi = 300)
library(ggdendro)
dist_mat <- slot(Wang_clusters_wardD2_Aboral, "clusters_dist")[["BMA"]]
hc <- hclust(dist_mat, method = "ward.D2")
dend <- as.dendrogram(hc)

dend_data <- ggdendro::dendro_data(dend, type = "rectangle")

dend_labels <- dend_data$labels %>%
    mutate(
    cluster = str_extract(label, "\\d+"),
    Cluster.name = str_replace(label,".*?_.*?_",""),
    Cluster.term = str_replace(label,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) 

bar_plot <- clustered_allDEGs_enrichedGO %>%  
filter(Tissue == "Aboral") %>%
  arrange(as.numeric(GO.cluster)) %>%
  mutate(Cluster_label = factor(Cluster.name, levels = rev(dend_labels$Cluster.name))) %>%
  ggplot(aes(x = Cluster_label)) +
  stat_count(width = .8, fill="#756BB1", alpha = 0.8) +
  coord_flip() +
  theme_classic(base_size = 9) +
  scale_y_continuous(
    breaks = scales::breaks_width(2),
    expand = c(0, 0),
    limits = c(0, NA)
  ) + 
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Aboral", y = "Terms in Cluster")

dend_plot <- ggplot() +
  geom_segment(
    data = dend_data$segments,
    aes(x = y, y = x, xend = yend, yend = xend),
    linewidth = 0.6,
    color = "#2C3E50"
  ) +
  scale_y_reverse(
    breaks = seq_along(dend_labels$Cluster.name),
    expand = c(0.02, 0.02)
  ) +
  scale_x_reverse(expand = c(0.02, 0)) +
  theme_void() +
  theme(
    plot.margin = margin(t = 30, r = 0, b = 22, l = 5)
  )

# Combine plots with better proportions
final <- dend_plot + bar_plot +
  plot_layout(widths = c(0.8, 3.5))

Wang_clusters_wardD2_Oral@heatmap$GOclusters_static

ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Dend_Clusters_Aboral.png", final, width = 5, height = 6.5, dpi = 300)

bar plots

p1 <- clustered_allDEGs_enrichedGO %>%  
filter(Tissue == "Aboral") %>%
  arrange(as.numeric(GO.cluster)) %>%
  mutate(Cluster_label = factor(Cluster.name, levels = rev(unique(Cluster.name)))) %>%
  ggplot(aes(x = Cluster_label)) +
  stat_count(width = .8, fill="#756BB1", alpha = 0.8) +
  coord_flip() +
  scale_y_continuous(breaks = scales::breaks_width(2)) +
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Aboral", y = "Terms in Cluster")

p2 <- clustered_allDEGs_enrichedGO %>%  
filter(Tissue == "Oral") %>%
  arrange(as.numeric(GO.cluster)) %>%
  mutate(Cluster_label = factor(Cluster.name, levels = rev(unique(Cluster.name)))) %>%
  ggplot(aes(x = Cluster_label)) +
  stat_count(width = .8, fill="#FD8D3C", alpha = 0.8) +
  coord_flip() +
  theme_bw(base_size = 9) +
  scale_y_continuous(breaks = scales::breaks_width(2)) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Oral epidermis", y = "Terms in Cluster")

plot <- p1 + p2 +
  plot_annotation(
    title = "Semantic Similarity Clusters of All Enriched (p < 0.01) BP GO Terms",
    theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/BP_Clusters.png", plot, width = 7, height = 6.5, dpi = 300)

NEW: Plotting of both tissues, pre-clustered by tissue

top_Oral_per_Cluster <- clustered_Oral_DEGs_enrichedGO %>% group_by(GO.cluster) %>% arrange(Oral_elim.pvalue) %>% slice(1) %>% ungroup() %>% dplyr::select(GO.cluster,GO.ID,term) %>% rename("top_sig_GO" = `GO.ID`,"top_sig_term" = `term`)

plotting_oral <- left_join(clustered_Oral_DEGs_enrichedGO,top_Oral_per_Cluster) %>%
  arrange(as.numeric(GO.cluster)) %>%
                        mutate(is_top = GO.ID == top_sig_GO,
                               pvalue = Oral_elim.pvalue,
                                term_wrapped = str_wrap(`term`, width = 25),
                                 cluster_label = factor(str_wrap(Cluster.name,
                                        width = 20), levels = unique(str_wrap(Cluster.name,
                                        width = 20)))) %>%
  add_count(GO.cluster, name = "n_terms")
## Joining with `by = join_by(GO.cluster)`
top_Aboral_per_Cluster <- clustered_Aboral_DEGs_enrichedGO %>% group_by(GO.cluster) %>% arrange(Aboral_elim.pvalue) %>% slice(1) %>% ungroup() %>% dplyr::select(GO.cluster,GO.ID,term) %>% rename("top_sig_GO" = `GO.ID`,"top_sig_term" = `term`)

plotting_aboral <- left_join(clustered_Aboral_DEGs_enrichedGO,top_Aboral_per_Cluster)%>%
                      arrange(as.numeric(GO.cluster)) %>%
                        mutate(is_top = GO.ID == top_sig_GO,
                               pvalue = Aboral_elim.pvalue,
                                term_wrapped = str_wrap(`term`, width = 25),
                                 cluster_label = factor(str_wrap(Cluster.name,
                                        width = 20), levels = unique(str_wrap(Cluster.name,
                                        width = 20)))) %>%
  add_count(GO.cluster, name = "n_terms")
## Joining with `by = join_by(GO.cluster)`
combined_plotting <- rbind(plotting_oral %>%
                                        dplyr::select(-contains("Oral")),
                                      plotting_aboral %>%
                                        dplyr::select(-contains("Aboral")))
library(ggrepel)
p_oral <- ggplot(plotting_oral, 
         aes(x = `Oral_elim.-log10_pvalue`, 
             y = reorder(GO.ID, `Oral_elim.-log10_pvalue`),
             color = factor(GO.cluster),
             size = `Oral_elim.-log10_pvalue`)) +
    geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Oral_elim.-log10_pvalue`)),
                 alpha = 0.5, linewidth = 0.8) +
    geom_point(alpha = 0.8) +
    facet_grid(cluster_label ~ ., 
               scales = "free_y", space = "free_y") +
    geom_text_repel(data = plotting_oral %>% filter(is_top),
                  aes(label = term_wrapped),
                  size = 2.5,
                  hjust = 0,
                  nudge_x = 0.3,
                  direction = "y",
                  color = "black",
                  fontface = "bold",
                  segment.color = "gray40",
                  segment.size = 0.3,
                  box.padding = 0.3,
                  max.overlaps = 30) +
    labs(title = "Oral Epidermis Tissue",
         x = "-log10(p-value)",
         y = NULL) +
    theme_minimal(base_size = 10) +
    theme(plot.title = element_text(face = "bold", size = 12),
          axis.text.y = element_text(size = 7.5),
          strip.text.y = element_text(size = 8.5, angle = 0, hjust = 0, face = "bold"),
          legend.position = "none",
          panel.spacing = unit(0.5, "lines"),
          panel.grid.major.y = element_blank(),
          panel.grid.minor = element_blank()) +
    scale_size_continuous(range = c(2, 5))

p_aboral <- ggplot(plotting_aboral, 
         aes(x = `Aboral_elim.-log10_pvalue`, 
             y = reorder(GO.ID, `Aboral_elim.-log10_pvalue`),
             color = factor(GO.cluster),
             size = `Aboral_elim.-log10_pvalue`)) +
    geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Aboral_elim.-log10_pvalue`)),
                 alpha = 0.5, linewidth = 0.8) +
    geom_point(alpha = 0.8) +
    facet_grid(cluster_label ~ ., 
               scales = "free_y", space = "free_y") +
  geom_text_repel(data = plotting_aboral %>% filter(is_top),
                  aes(label = term_wrapped),
                  size = 2.5,
                  hjust = 0,
                  nudge_x = 0.3,
                  direction = "y",
                  color = "black",
                  fontface = "bold",
                  segment.color = "gray40",
                  segment.size = 0.3,
                  box.padding = 0.3,
                  max.overlaps = 30) + 
  labs(title = "Aboral Tissue",
         x = "-log10(p-value)",
         y = NULL) +
    theme_minimal(base_size = 10) +
    theme(plot.title = element_text(face = "bold", size = 12),
          axis.text.y = element_text(size = 7.5),
          strip.text.y = element_text(size = 8.5, angle = 0, hjust = 0, face = "bold"),
          legend.position = "none",
          panel.spacing = unit(0.5, "lines"),
          panel.grid.major.y = element_blank(),
          panel.grid.minor = element_blank()) +
    scale_size_continuous(range = c(2, 5))
library(patchwork)
p2 <- p_oral + p_aboral +
  plot_annotation(
    title = "Enriched GO Terms by Semantic Cluster",
    subtitle = "Diamond = most significant term per cluster | Size = significance",
    theme = theme(plot.title = element_text(face = "bold", size = 14))
  )


ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster.pdf", p2, width = 14, height = 16)
p_oral <-ggplot(plotting_oral, 
       aes(x = `Oral_elim.-log10_pvalue`, 
           y = reorder(GO.ID, `Oral_elim.-log10_pvalue`),
           size = `Oral_elim.-log10_pvalue`)) +
  geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Oral_elim.-log10_pvalue`)),
               alpha = 0.4, linewidth = 0.6, color = "#FD8D3C") +
  geom_point(alpha = 0.7, color = "#FD8D3C") +
    facet_grid(cluster_label ~ ., 
               scales = "free_y", space = "free_y") +
    geom_text_repel(data = plotting_oral %>% filter(is_top),
                  aes(label = str_wrap(term, width = 20)),
                  size = 2,
                  hjust = 0,
                  nudge_x = 0.5,
                  nudge_y = -0.5,
                  direction = "y",
                  color = "black",
                  segment.color = "gray50",
                  segment.size = 0.5,
                  max.overlaps = 30) +
    labs(title = "Oral Epidermis Tissue",
         x = "-log10(p-value)",
         y = NULL) +
    theme_minimal(base_size = 11) +
    theme(plot.title = element_text(face = "bold", size = 12),
          axis.text.y = element_text(size = 7.5),
          strip.text.y = element_text(size = 7.5, angle = 0, hjust = 0, face = "bold"),
          legend.position = "none",
          panel.spacing = unit(.15, "lines"),
          panel.grid.major.y = element_blank(),
          panel.grid.minor = element_blank()) +
    scale_size_continuous(range = c(2, 5))

p_aboral <- ggplot(plotting_aboral, 
         aes(x = `Aboral_elim.-log10_pvalue`, 
             y = reorder(GO.ID, `Aboral_elim.-log10_pvalue`),
             color = factor(GO.cluster),
             size = `Aboral_elim.-log10_pvalue`)) +
    geom_segment(aes(xend = 0, yend = reorder(GO.ID, `Aboral_elim.-log10_pvalue`)),
               alpha = 0.4, linewidth = 0.6, color = "#756BB1") +
  geom_point(alpha = 0.7, color = "#756BB1") +
      facet_grid(cluster_label ~ ., 
               scales = "free_y", space = "free_y") +
  geom_text_repel(data = plotting_aboral %>% filter(is_top),
                  aes(label = str_wrap(term, width = 20)),
                  size = 2,
                  hjust = 0,
                  nudge_x = 0.5,
                  nudge_y = -0.5,
                  direction = "y",
                  color = "black",
                  segment.color = "gray50",
                  segment.size = 0.5,
                  max.overlaps = 30) +
  labs(title = "Aboral Tissue",
         x = "-log10(p-value)",
         y = NULL) +
   theme_minimal(base_size = 11) +
    theme(plot.title = element_text(face = "bold", size = 12),
          axis.text.y = element_text(size = 7.5),
          strip.text.y = element_text(size = 7.5, angle = 0, hjust = 0, face = "bold"),
          legend.position = "none",
          panel.spacing = unit(.15, "lines"),
          panel.grid.major.y = element_blank(),
          panel.grid.minor = element_blank()) +
    scale_size_continuous(range = c(2, 5))

p2 <- p_oral + p_aboral +
  plot_annotation(
    title = "Tissue-specific GO term enrichment patterns",
    theme = theme(plot.title = element_text(face = "bold", size = 14))
  )


ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster_colored.pdf", p2, width = 14, height = 16)
ggsave("../output_RNA/differential_expression/semantic-enrichment/All_sig_BP_terms_by_cluster_colored2.png", p2, width = 8, height = 12, dpi = 300)

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  dplyr::select(Cluster.name, Tissue) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Tissue=="Oral"),
    Aboral_terms = sum(Tissue=="Aboral"),
    .groups = "drop"
  ) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)

Both tissues together:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

BP_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Oral_elim = c("BP_Oral", "elim_Oral"),
                 Aboral_elim = c("BP_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
BP_Results
## - object class: enrich_GO_terms
## - ontology: BP
## - method: topGO
## - summary:
##  Oral_elim
##       BP_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 67
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         Nontrivial_nodes: 4469 
##  Aboral_elim
##       BP_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 118
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         Nontrivial_nodes: 3092 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 185 GO terms of 2 conditions.
##         Oral_elim : 67 terms
##         Aboral_elim : 118 terms
ViSEAGO::show_table(BP_Results)
# print the merged table in a file
ViSEAGO::show_table(
    BP_Results,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01 Aboral_elim : 0.01
  • enrich GOs (in at least one list): 185 GO terms of 2 conditions. Oral_elim : 67 terms Aboral_elim : 118 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=BP_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: BP
## - method: topGO
## - summary:
## Oral_elim
##       BP_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 67
##         feasible_genes: 9496
##         feasible_genes_significant: 712
##         genes_nodeSize: 5
##         Nontrivial_nodes: 4469 
##  Aboral_elim
##       BP_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         nodes_number: 6675
##         edges_number: 14047
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 6675
##         GO_significant: 118
##         feasible_genes: 9496
##         feasible_genes_significant: 332
##         genes_nodeSize: 5
##         Nontrivial_nodes: 3092 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 185 GO terms of 2 conditions.
##         Oral_elim : 67 terms
##         Aboral_elim : 118 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 4
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2,
    "../output_RNA/differential_expression/semantic-enrichment/DE_05_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOclusters")

Custom plotting of results

clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
  dplyr::select(cluster, Cluster.name)

cluster_map
##    cluster                                              Cluster.name
## 1        1                  Cluster 1: neuron projection development
## 2        2                           Cluster 2: cell differentiation
## 3        3               Cluster 3: anatomical structure development
## 4        4               Cluster 4: anatomical structure development
## 5        5             Cluster 5: multicellular organism development
## 6        6                      Cluster 6: sensory organ development
## 7        7               Cluster 7: anatomical structure development
## 8        8                                      Cluster 8: transport
## 9        9                                      Cluster 9: transport
## 10      10 Cluster 10: external encapsulating structure organization
## 11      11                            Cluster 11: biological_process
## 12      12                   Cluster 12: regulation of cell adhesion
## 13      13                                 Cluster 13: cell adhesion
## 14      14                             Cluster 14: secretion by cell
## 15      15                           Cluster 15: cell-cell signaling
## 16      16              Cluster 16: regulation of biological process
## 17      17                             Cluster 17: metabolic process
## 18      18                             Cluster 18: metabolic process
## 19      19              Cluster 19: multicellular organismal process
## 20      20                        Cluster 20: nervous system process
## 21      21                          Cluster 21: response to stimulus
## 22      22                       Cluster 22: immune effector process
## 23      23                            Cluster 23: biological_process

Manually fix cluster names based on GO terms inside each cluster

cluster_map_fixed <- cluster_map #%>%
  # mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
  #        )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
  left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))

write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/DE_05_clusters_named.csv")

library(DT)

# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  dplyr::select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
  mutate(
    # Clean cluster names
    #Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
    Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
    Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
  ) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Oral_terms),
    Aboral_terms = sum(Aboral_terms),
    .groups = "drop"
  ) %>%
  filter(Oral_terms + Aboral_terms > 0) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

datatable(cluster_data,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) +  #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12, hjust=0)
  ) +
  scale_y_continuous(labels = abs) +
  scale_x_discrete(position = "top") +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  #coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "right",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

p

ggsave("../output_RNA/differential_expression/semantic-enrichment/GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)

CC

Oral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)

CC_Oral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="CC",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 1542 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 1765 GO terms and 2911 relations. )
## 
## Annotating nodes ...............
##  ( 10052 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
    CC_Oral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 611 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 12:  1 nodes to be scored    (0 eliminated genes)
## 
##   Level 11:  21 nodes to be scored   (0 eliminated genes)
## 
##   Level 10:  60 nodes to be scored   (0 eliminated genes)
## 
##   Level 9:   85 nodes to be scored   (24 eliminated genes)
## 
##   Level 8:   95 nodes to be scored   (30 eliminated genes)
## 
##   Level 7:   97 nodes to be scored   (61 eliminated genes)
## 
##   Level 6:   96 nodes to be scored   (342 eliminated genes)
## 
##   Level 5:   67 nodes to be scored   (601 eliminated genes)
## 
##   Level 4:   43 nodes to be scored   (601 eliminated genes)
## 
##   Level 3:   43 nodes to be scored   (2500 eliminated genes)
## 
##   Level 2:   2 nodes to be scored    (3424 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (3424 eliminated genes)
CC_Results <- ViSEAGO::merge_enrich_terms(
    Input = list( Oral_elim = c("CC_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
##  Oral_elim
##       CC_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 17
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         Nontrivial_nodes: 611 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 17 GO terms of 1 conditions.
##         Oral_elim : 17 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
    CC_Results,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01
  • enrich GOs (in at least one list): Oral_elim : 19 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
##       CC_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 17
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         Nontrivial_nodes: 611 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 17 GO terms of 1 conditions.
##         Oral_elim : 17 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Oral,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Oral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Oral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOclusters")

Aboral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)

CC_Aboral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="CC",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 1542 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 1765 GO terms and 2911 relations. )
## 
## Annotating nodes ...............
##  ( 10052 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
    CC_Aboral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 351 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 11:  6 nodes to be scored    (0 eliminated genes)
## 
##   Level 10:  26 nodes to be scored   (0 eliminated genes)
## 
##   Level 9:   40 nodes to be scored   (0 eliminated genes)
## 
##   Level 8:   51 nodes to be scored   (7 eliminated genes)
## 
##   Level 7:   57 nodes to be scored   (19 eliminated genes)
## 
##   Level 6:   58 nodes to be scored   (431 eliminated genes)
## 
##   Level 5:   49 nodes to be scored   (850 eliminated genes)
## 
##   Level 4:   29 nodes to be scored   (1101 eliminated genes)
## 
##   Level 3:   32 nodes to be scored   (3129 eliminated genes)
## 
##   Level 2:   2 nodes to be scored    (3481 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (3481 eliminated genes)
CC_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Aboral_elim = c("CC_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
##  Aboral_elim
##       CC_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 23
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         Nontrivial_nodes: 351 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 23 GO terms of 1 conditions.
##         Aboral_elim : 23 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
    CC_Results,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral.tsv"
)
  • enrichment pvalue cutoff: Aboral_elim : 0.01
  • enrich GOs (in at least one list): Aboral_elim : 23 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Aboral_elim
##       CC_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 23
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         Nontrivial_nodes: 351 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 23 GO terms of 1 conditions.
##         Aboral_elim : 23 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Aboral,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Aboral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned many:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Aboral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")

Plotting of both tissues, pre-clustered by tissue

Custom plotting of results

clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data) 

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) #%>%
  #mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
  #dplyr::select(cluster, Cluster.name)

clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Oral")

clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) #%>%
  #mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
  #dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Aboral")


clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Oral")),
                                      clustered_Aboral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Aboral")))

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  dplyr::select(Cluster.name, Tissue) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Tissue=="Oral"),
    Aboral_terms = sum(Tissue=="Aboral"),
    .groups = "drop"
  ) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)

Both tissues together:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

CC_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Oral_elim = c("CC_Oral", "elim_Oral"),
                 Aboral_elim = c("CC_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
CC_Results
## - object class: enrich_GO_terms
## - ontology: CC
## - method: topGO
## - summary:
##  Oral_elim
##       CC_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 17
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         Nontrivial_nodes: 611 
##  Aboral_elim
##       CC_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 23
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         Nontrivial_nodes: 351 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 38 GO terms of 2 conditions.
##         Oral_elim : 17 terms
##         Aboral_elim : 23 terms
ViSEAGO::show_table(CC_Results)
# print the merged table in a file
ViSEAGO::show_table(
    CC_Results,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01 Aboral_elim : 0.01
  • enrich GOs (in at least one list): 40 GO terms of 2 conditions. Oral_elim : 19 terms Aboral_elim : 23 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=CC_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: CC
## - method: topGO
## - summary:
## Oral_elim
##       CC_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 17
##         feasible_genes: 10052
##         feasible_genes_significant: 762
##         genes_nodeSize: 5
##         Nontrivial_nodes: 611 
##  Aboral_elim
##       CC_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         nodes_number: 967
##         edges_number: 1615
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 967
##         GO_significant: 23
##         feasible_genes: 10052
##         feasible_genes_significant: 364
##         genes_nodeSize: 5
##         Nontrivial_nodes: 351 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 38 GO terms of 2 conditions.
##         Oral_elim : 17 terms
##         Aboral_elim : 23 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 4
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2,
    "../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOclusters")

Custom plotting of results

clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
  select(cluster, Cluster.name)

cluster_map
##   cluster                             Cluster.name
## 1       1          Cluster 1: extracellular matrix
## 2       2 Cluster 2: cellular anatomical structure
## 3       3       Cluster 3: intracellular organelle
## 4       4            Cluster 4: cellular_component
## 5       5                 Cluster 5: cell junction

Manually fix cluster names based on GO terms inside each cluster

cluster_map_fixed <- cluster_map #%>%
  # mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
  #        )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
  left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))

write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_clusters_named.csv")

library(DT)

# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
  mutate(
    # Clean cluster names
    #Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
    Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
    Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
  ) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Oral_terms),
    Aboral_terms = sum(Aboral_terms),
    .groups = "drop"
  ) %>%
  filter(Oral_terms + Aboral_terms > 0) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

datatable(cluster_data,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) +  #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12, hjust=0)
  ) +
  scale_y_continuous(labels = abs) +
  scale_x_discrete(position = "top") +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  #coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "right",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

p

ggsave("../output_RNA/differential_expression/semantic-enrichment/CC_GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)

MF

Oral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Oral)[selection_Oral==1]
background <- names(expressed)

MF_Oral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="MF",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 3360 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 3929 GO terms and 5138 relations. )
## 
## Annotating nodes ...............
##  ( 9061 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Oral <- topGO::runTest(
    MF_Oral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 949 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 12:  2 nodes to be scored    (0 eliminated genes)
## 
##   Level 11:  8 nodes to be scored    (0 eliminated genes)
## 
##   Level 10:  15 nodes to be scored   (9 eliminated genes)
## 
##   Level 9:   40 nodes to be scored   (35 eliminated genes)
## 
##   Level 8:   82 nodes to be scored   (62 eliminated genes)
## 
##   Level 7:   132 nodes to be scored  (563 eliminated genes)
## 
##   Level 6:   198 nodes to be scored  (1099 eliminated genes)
## 
##   Level 5:   217 nodes to be scored  (1184 eliminated genes)
## 
##   Level 4:   184 nodes to be scored  (1485 eliminated genes)
## 
##   Level 3:   52 nodes to be scored   (1485 eliminated genes)
## 
##   Level 2:   18 nodes to be scored   (1562 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (1605 eliminated genes)
MF_Results <- ViSEAGO::merge_enrich_terms(
    Input = list( Oral_elim = c("MF_Oral", "elim_Oral")))
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
##  Oral_elim
##       MF_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 31
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         Nontrivial_nodes: 949 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 31 GO terms of 1 conditions.
##         Oral_elim : 31 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
    MF_Results,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01
  • enrich GOs (in at least one list): Oral_elim : 32 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
##       MF_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 31
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         Nontrivial_nodes: 949 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
## - enrich GOs (in at least one list): 31 GO terms of 1 conditions.
##         Oral_elim : 31 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Oral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Oral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Oral,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Oral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Oral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Oral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Oral <-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Oral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Oral,
    "GOclusters")

Aboral Epidermis:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

# create viseago object
selection <- names(selection_Aboral)[selection_Aboral==1]
background <- names(expressed)

MF_Aboral <- ViSEAGO::create_topGOdata(
    geneSel=selection,
    allGenes=background,
    gene2GO=myGENE2GO_Pacuta, 
    ont="MF",
    nodeSize=5
)
## 
## Building most specific GOs .....
##  ( 3360 GO terms found. )
## 
## Build GO DAG topology ..........
##  ( 3929 GO terms and 5138 relations. )
## 
## Annotating nodes ...............
##  ( 9061 genes annotated to the GO terms. )
# perform TopGO test using elim algorithm
elim_Aboral <- topGO::runTest(
    MF_Aboral,
    algorithm ="elim",
    statistic = "fisher"
)
## 
##           -- Elim Algorithm -- 
## 
##       the algorithm is scoring 577 nontrivial nodes
##       parameters: 
##           test statistic: fisher
##           cutOff: 0.01
## 
##   Level 11:  3 nodes to be scored    (0 eliminated genes)
## 
##   Level 10:  5 nodes to be scored    (0 eliminated genes)
## 
##   Level 9:   17 nodes to be scored   (0 eliminated genes)
## 
##   Level 8:   40 nodes to be scored   (30 eliminated genes)
## 
##   Level 7:   78 nodes to be scored   (142 eliminated genes)
## 
##   Level 6:   119 nodes to be scored  (704 eliminated genes)
## 
##   Level 5:   136 nodes to be scored  (957 eliminated genes)
## 
##   Level 4:   121 nodes to be scored  (1045 eliminated genes)
## 
##   Level 3:   41 nodes to be scored   (1102 eliminated genes)
## 
##   Level 2:   16 nodes to be scored   (1571 eliminated genes)
## 
##   Level 1:   1 nodes to be scored    (1571 eliminated genes)
MF_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Aboral_elim = c("MF_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
##  Aboral_elim
##       MF_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 28
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         Nontrivial_nodes: 577 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 28 GO terms of 1 conditions.
##         Aboral_elim : 28 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
    MF_Results,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral.tsv"
)
  • enrichment pvalue cutoff: Aboral_elim : 0.01
  • enrich GOs (in at least one list): Aboral_elim : 28 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Aboral_elim
##       MF_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 28
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         Nontrivial_nodes: 577 
##  - enrichment pvalue cutoff:
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 28 GO terms of 1 conditions.
##         Aboral_elim : 28 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2_Aboral <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 2
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2_Aboral)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2_Aboral,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2_Aboral<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2_Aboral,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2_Aboral<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2_Aboral,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2_Aboral,
    "GOclusters")

Plotting of both tissues, pre-clustered by tissue

Custom plotting of results

clustered_Oral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Oral@enrich_GOs@data) 

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Oral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) #%>%
  #mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
  #dplyr::select(cluster, Cluster.name)

clustered_Oral_DEGs_enrichedGO <- clustered_Oral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Oral")

clustered_Aboral_DEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2_Aboral@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2_Aboral,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_",""),
    Cluster.term = str_replace(cluster_full,"^\\d+_",""),
    Cluster.term = str_replace(Cluster.term,"_.*$","")
  ) #%>%
  #mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) #%>%
  #dplyr::select(cluster, Cluster.name)
clustered_Aboral_DEGs_enrichedGO <- clustered_Aboral_DEGs_enrichedGO %>%
  left_join(cluster_map, by = c("GO.cluster" = "cluster")) %>%
  mutate(Tissue="Aboral")


clustered_allDEGs_enrichedGO <- rbind(clustered_Oral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Oral")),
                                      clustered_Aboral_DEGs_enrichedGO %>%
                                        dplyr::select(-contains("Aboral")))

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  dplyr::select(Cluster.name, Tissue) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Tissue=="Oral"),
    Aboral_terms = sum(Tissue=="Aboral"),
    .groups = "drop"
  ) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_clustered_separate.png", p, width = 10, height = 8, dpi = 300)

Both tissues together:

create topGO objects and perform enrichment using topGO wrapped by ViSEAGO

MF_Results <- ViSEAGO::merge_enrich_terms(
    Input = list(Oral_elim = c("MF_Oral", "elim_Oral"),
                 Aboral_elim = c("MF_Aboral", "elim_Aboral"))
)
## 'select()' returned 1:1 mapping between keys and columns

Visualize and save initial results

# display the merged table
MF_Results
## - object class: enrich_GO_terms
## - ontology: MF
## - method: topGO
## - summary:
##  Oral_elim
##       MF_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 31
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         Nontrivial_nodes: 949 
##  Aboral_elim
##       MF_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 28
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         Nontrivial_nodes: 577 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 58 GO terms of 2 conditions.
##         Oral_elim : 31 terms
##         Aboral_elim : 28 terms
ViSEAGO::show_table(MF_Results)
# print the merged table in a file
ViSEAGO::show_table(
    MF_Results,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05.tsv"
)
  • enrichment pvalue cutoff: Oral_elim : 0.01 Aboral_elim : 0.01
  • enrich GOs (in at least one list): 59 GO terms of 2 conditions. Oral_elim : 32 terms Aboral_elim : 28 terms

Semantic similarity –> Cluster: Use Wang graph-based method to identify similarity between GO terms

# initialize 
myGOs<-ViSEAGO::build_GO_SS(
    gene2GO=myGENE2GO_Pacuta,
    enrich_GO_terms=MF_Results
)
## 'select()' returned 1:1 mapping between keys and columns
myGOs <- ViSEAGO::compute_SS_distances(
    myGOs,
   distance=c("Wang")
)

myGOs
## - object class: GO_SS
## - ontology: MF
## - method: topGO
## - summary:
## Oral_elim
##       MF_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 826
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Oral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 31
##         feasible_genes: 9061
##         feasible_genes_significant: 700
##         genes_nodeSize: 5
##         Nontrivial_nodes: 949 
##  Aboral_elim
##       MF_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt
##         available_genes: 10637
##         available_genes_significant: 376
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         nodes_number: 1460
##         edges_number: 1914
##       elim_Aboral 
##         description: Custom pacuta ../output_RNA/differential_expression/semantic-enrichment/custom_GOs.txt 
##         test_name: fisher p<0.01
##         algorithm_name: elim
##         GO_scored: 1460
##         GO_significant: 28
##         feasible_genes: 9061
##         feasible_genes_significant: 329
##         genes_nodeSize: 5
##         Nontrivial_nodes: 577 
##  - enrichment pvalue cutoff:
##         Oral_elim : 0.01
##         Aboral_elim : 0.01
## - enrich GOs (in at least one list): 58 GO terms of 2 conditions.
##         Oral_elim : 31 terms
##         Aboral_elim : 28 terms
## - terms distances:  Wang

Multi Dimensional Scaling Plot of the GO-terms based on semantic similarity

# display MDSplot
ViSEAGO::MDSplot(myGOs,
                 "GOterms")

Heatmap + table of GO terms, with clusters aggregated by hclust with ward.D2 method

# GOterms heatmap with the default parameters
Wang_clusters_wardD2 <- ViSEAGO::GOterms_heatmap(
  myGOs,
  showIC = TRUE,
  showGOlabels = TRUE,
  GO.tree = list(
    tree = list(distance = "Wang", aggreg.method = "ward.D2"),
    cut = list(
      dynamic = list(
        pamStage = TRUE,
        pamRespectsDendro = TRUE,
        deepSplit = 2,
        minClusterSize = 4
      )
    )
  ),
  samples.tree = NULL
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# Display the clusters-heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOterms")
# Display the clusters-heatmap table
ViSEAGO::show_table(Wang_clusters_wardD2)
# Print the clusters-heatmap table
ViSEAGO::show_table(
    Wang_clusters_wardD2,
    "../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_cluster_heatmap_Wang_wardD2.tsv"
)

Multi Dimensional Scaling Plot of the enriched GO-terms based on semantic similarity, colored by cluster

# display colored MDSplot
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOterms")

Further summarizing the Semantic Similarity-based clusters

# calculate semantic similarities between clusters of GO terms
Wang_clusters_wardD2<-ViSEAGO::compute_SS_distances(
    Wang_clusters_wardD2,
    distance=c("max", "avg","rcmax", "BMA")
)
## 'select()' returned 1:1 mapping between keys and columns
# MDSplot - one point per cluster
ViSEAGO::MDSplot(
    Wang_clusters_wardD2,
    "GOclusters")
# GOclusters heatmap
Wang_clusters_wardD2<-ViSEAGO::GOclusters_heatmap(
    Wang_clusters_wardD2,
    tree=list(
        distance="BMA",
        aggreg.method="ward.D2"
    )
)
## 'magick' package is suggested to install to give better rasterization.
## 
## Set `ht_opt$message = FALSE` to turn off this message.
# display the GOClusters heatmap
ViSEAGO::show_heatmap(
    Wang_clusters_wardD2,
    "GOclusters")

Custom plotting of results

clustered_allDEGs_enrichedGO <- as.data.frame(Wang_clusters_wardD2@enrich_GOs@data)

cluster_map <- data.frame(cluster_full = rownames(as.matrix(slot(Wang_clusters_wardD2,"clusters_dist")[["BMA"]])))
cluster_map <- cluster_map %>% 
  mutate(
    cluster = str_extract(cluster_full, "\\d+"),
    Cluster.name = str_replace(cluster_full,".*?_.*?_","")
  ) %>%
  mutate(Cluster.name = paste0("Cluster ", cluster, ": ", Cluster.name)) %>%
  select(cluster, Cluster.name)

cluster_map
##   cluster                                  Cluster.name
## 1       1 Cluster 1: transmembrane transporter activity
## 2       2    Cluster 2: monoatomic ion channel activity
## 3       3                    Cluster 3: protein binding
## 4       4    Cluster 4: carbohydrate derivative binding
## 5       5                 Cluster 5: molecular_function
## 6       6                            Cluster 6: binding
## 7       7        Cluster 7: signaling receptor activity
## 8       8                 Cluster 8: hydrolase activity
## 9       9                 Cluster 9: catalytic activity

Manually fix cluster names based on GO terms inside each cluster

cluster_map_fixed <- cluster_map #%>%
  # mutate(Cluster.name = str_replace(Cluster.name, "Cluster 2: developmental process", "Cluster 2: cell fate determination"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 4: anatomical structure development", "Cluster 4: regeneration & tissue morphogenesis"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 5: multicellular organism development", "Cluster 5: multicellular organism pattern formation"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 9: transport", "Cluster 9: metal ion transmembrane transport"),
  #        Cluster.name = str_replace(Cluster.name, "Cluster 10: transport", "Cluster 10: amino acid & small molecule transmembrane transport"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 12: nervous system process", "Cluster 12: sensory perception"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 16: biological_process", "Cluster 16: regeneration & wound healing"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 18: secretion by cell", "Cluster 18: neurotransmitter and hormone secretion"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 24: external encapsulating structure organization", "Cluster 24: extracellular matrix organization"),
  #       Cluster.name = str_replace(Cluster.name, "Cluster 25: biological_process", "Cluster 25: cell organization and homeostasis")
  #        )
clustered_allDEGs_enrichedGO <- clustered_allDEGs_enrichedGO %>%
  left_join(cluster_map_fixed, by = c("GO.cluster" = "cluster"))

write.csv(clustered_allDEGs_enrichedGO,"../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_clusters_named.csv")

library(DT)

# Interactive table with scrolling
datatable(clustered_allDEGs_enrichedGO,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))

Plot

library(dplyr)
library(tidyr)
library(ggplot2)

# Create bidirectional data
cluster_data <- clustered_allDEGs_enrichedGO %>%
  select(Cluster.name, Oral_elim.Significant_genes, Aboral_elim.Significant_genes) %>%
  mutate(
    # Clean cluster names
    #Cluster.name = gsub("^Cluster \\d+:\\s*", "", Cluster.name),
    Oral_terms = ifelse(!is.na(Oral_elim.Significant_genes), 1, 0),
    Aboral_terms = ifelse(!is.na(Aboral_elim.Significant_genes), 1, 0)
  ) %>%
  group_by(Cluster.name) %>%
  summarise(
    Oral_terms = sum(Oral_terms),
    Aboral_terms = sum(Aboral_terms),
    .groups = "drop"
  ) %>%
  filter(Oral_terms + Aboral_terms > 0) %>%
  mutate(
    deviation = Aboral_terms - Oral_terms,
    Oral_terms = -Oral_terms  # Make negative for bidirectional plot
  ) %>%
  pivot_longer(cols = c("Oral_terms", "Aboral_terms"), 
               names_to = "Tissue", values_to = "n_terms") %>%
  mutate(Tissue = ifelse(Tissue == "Oral_terms", "Oral epidermis", "Aboral"))

datatable(cluster_data,
          options = list(
            pageLength = 10,   # rows per page
            scrollX = TRUE,    # horizontal scroll if wide
            scrollY = "400px"  # vertical scroll
          ))
# Calculate transition points for dashed lines
transition_data <- cluster_data %>%
  distinct(Cluster.name, deviation) %>%
  arrange(deviation)

oral_to_equal <- sum(transition_data$deviation >= 0) + 0.5
equal_to_aboral <- sum(transition_data$deviation > 0) + 0.5

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) +  #green: "#2E8B57"
  coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "bottom",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12),
    axis.text.y = element_text(size = 12, hjust=0)
  ) +
  scale_y_continuous(labels = abs) +
  scale_x_discrete(position = "top") +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_rightaxis.png", p, width = 10, height = 8, dpi = 300)

print(p)

# Plot
p <- ggplot(cluster_data, aes(x = reorder(Cluster.name, -deviation), y = n_terms, fill = Tissue)) +
  geom_col(width = 0.7, alpha = 0.8) +
  geom_hline(yintercept = 0, color = "black", linewidth = 0.8) +
  geom_vline(xintercept = c(oral_to_equal, equal_to_aboral), 
             color = "grey60", linetype = "dashed", linewidth = 0.6) +
  scale_fill_manual(values = c("Oral epidermis" = "#FD8D3C", "Aboral" = "#756BB1")) + #green: "#2E8B57"
  #coord_flip() +
  theme_minimal() +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.minor = element_blank(),
    legend.position = "right",
    legend.title = element_text(face = "bold"),
    axis.title = element_text(face = "bold"),
    axis.text = element_text(color = "black"),
    axis.text.x = element_text(size = 12,angle = 65, hjust = 1),
    axis.text.y = element_text(size = 12)
  ) +
  scale_y_continuous(labels = abs) +
  labs(
    x = "Gene clusters",
    y = "Number of enriched GO terms",
    title = "Tissue-specific GO term enrichment patterns",
    subtitle = "Clusters ordered by net enrichment (Oral vs. Aboral)"
  )

p

ggsave("../output_RNA/differential_expression/semantic-enrichment/MF_GO_enrichment_bidirectional_horiz.png", p, width = 12, height = 8, dpi = 300)

Combine everything into one big plot:

BP_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Aboral.tsv") %>% mutate(ontology="BP")
MF_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Aboral.tsv")   %>% mutate(ontology="MF")
CC_GOs_Aboral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Aboral.tsv") %>% mutate(ontology="CC")

BP_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/DE_05_Oral.tsv") %>% mutate(ontology="BP")
MF_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/MF_DE_05_Oral.tsv") %>% mutate(ontology="MF")
CC_GOs_Oral <- read.delim(file="../output_RNA/differential_expression/semantic-enrichment/CC_DE_05_Oral.tsv") %>% mutate(ontology="CC")

oral_combined <- rbind(BP_GOs_Oral,MF_GOs_Oral,CC_GOs_Oral) %>%
                        rename_with(~ str_replace_all(.x, "Oral_elim|\\.", "")) %>% mutate(Tissue="Oral")
aboral_combined <- rbind(BP_GOs_Aboral,MF_GOs_Aboral,CC_GOs_Aboral) %>%
                        rename_with(~ str_replace_all(.x, "Aboral_elim|\\.", "")) %>% mutate(Tissue="Aboral")

tissues_combined <- rbind(oral_combined,aboral_combined) %>%
                          mutate(freq = as.numeric(str_remove(genes_frequency,pattern="\\%.*")))
aboral_cols <- c(
  BP = "#756BB1",
  CC = "#9E9AC8",
  MF = "#CBC9E2"
)

oral_cols <- c(
  BP = "#FD8D3C",
  CC = "#FDAE6B",
  MF = "#FDD0A2"
)

top10_pval <- tissues_combined %>%
  filter(ontology=="BP") %>%
  group_by(Tissue,ontology) %>%
  slice_max(order_by = desc(pvalue), n = 30, with_ties = FALSE) %>% 
  arrange(Tissue, ontology, log10_pvalue) %>%
  ungroup() %>%
  mutate(term=str_wrap(`term`, width = 40))

p1 <- top10_pval %>% filter(Tissue == "Aboral") %>%
  mutate(term = fct_reorder(term, log10_pvalue)) %>% 
  ggplot(aes(x = term, y = log10_pvalue, fill = ontology)) +
  geom_col(width = .8, fill="#756BB1", alpha = 0.8) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
 # scale_fill_manual(values = aboral_cols) +
  theme_bw(base_size = 9) +
  #scale_y_continuous(limits = c(0, 35), expand = expansion(mult = c(0, 0.05)))+
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Aboral", y = "-log10(p-value)")

p2 <- top10_pval %>% filter(Tissue == "Oral") %>%
  mutate(term = fct_reorder(term, log10_pvalue)) %>% 
  ggplot(aes(x = term, y = log10_pvalue, fill = ontology)) +
  geom_col(width = .8, fill="#FD8D3C", alpha = 0.8) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
 # scale_fill_manual(values = oral_cols) +
 # scale_y_continuous(limits = c(0, 35), expand = expansion(mult = c(0, 0.05)))+
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
     strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Oral epidermis", y = "-log10(p-value)")

plot <- p1 + p2 +
  plot_annotation(
    title = "Top 30 enriched GO terms by p-value",
    theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/Top_BP_30.png", plot, width = 7, height = 6.5, dpi = 300)
top10_freq <- tissues_combined %>% group_by(Tissue,ontology) %>%
  slice_max(order_by = freq, n = 10, with_ties = FALSE) %>% 
  arrange(Tissue, ontology, log10_pvalue) %>%
  ungroup() %>%
  mutate(term=str_wrap(`term`, width = 40))


p1 <- top10_freq %>% filter(Tissue == "Aboral") %>%
  mutate(term = fct_reorder(term, freq)) %>% 
  ggplot(aes(x = term, y = freq, fill = ontology)) +
  geom_col(width = 0.7, alpha = 0.85) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
  scale_fill_manual(values = aboral_cols) +
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
     strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Aboral", y = "% DEGs with GO term of\nall genes with GO term")

p2 <- top10_freq %>% filter(Tissue == "Oral") %>%
  mutate(term = fct_reorder(term, freq)) %>% 
  ggplot(aes(x = term, y = freq, fill = ontology)) +
  geom_col(width = 0.7, alpha = 0.85) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
  scale_fill_manual(values = oral_cols) +
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7,color = "black"),
    strip.text = element_text(face = "bold", size = 9),
     strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "none",
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Oral epidermis", y = "% DEGs with GO term of\nall genes with GO term")


plot <- p1 + p2 +
  plot_annotation(
    title = "Top 10 enriched GO terms by frequency in tissue DEGs",
    theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/All_Onts_frq.png", plot, width = 7, height = 6.5, dpi = 300)
# Create gradient scales for each tissue
aboral_gradient <- colorRampPalette(c("#CBC9E2", "#756BB1"))(100)
oral_gradient <- colorRampPalette(c("#FDD0A2", "#FD8D3C"))(100)

p1 <- top10_freq %>% filter(Tissue == "Aboral") %>%
  mutate(term = fct_reorder(term, freq)) %>% 
  ggplot(aes(x = term, y = freq, fill = log10_pvalue)) +
  geom_col(width = 0.7, alpha = 0.85) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
  scale_fill_gradientn(colors = aboral_gradient, name = "-log10(p-value)") +
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7, color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "right",
    legend.key.height = unit(0.8, "cm"),
    legend.key.width = unit(0.3, "cm"),
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Aboral", y = "% DEGs with GO term of\nall genes with GO term")

p2 <- top10_freq %>% filter(Tissue == "Oral") %>%
  mutate(term = fct_reorder(term, freq)) %>% 
  ggplot(aes(x = term, y = freq, fill = log10_pvalue)) +
  geom_col(width = 0.7, alpha = 0.85) +
  facet_grid(ontology ~ ., scales = "free_y", space = "free_y") +
  coord_flip() +
  scale_fill_gradientn(colors = oral_gradient, name = "-log10(p-value)") +
  theme_bw(base_size = 9) +
  theme(
    panel.grid.major.y = element_blank(),
    panel.grid.major.x = element_line(color = "grey90", linewidth = 0.2),
    axis.title.y = element_blank(),
    axis.text.y = element_text(size = 7, lineheight = 0.7, color = "black"),
    strip.text = element_text(face = "bold", size = 9),
    strip.background = element_rect(fill = "white", color = "black"),
    legend.position = "right",
    legend.key.height = unit(0.8, "cm"),
    legend.key.width = unit(0.3, "cm"),
    plot.subtitle = element_text(face = "bold", size = 9, hjust = 0.5),
    panel.spacing.y = unit(0.2, "lines")
  ) + labs(subtitle = "Oral epidermis", y = "% DEGs with GO term of\nall genes with GO term")

plot <- p1 + p2 +
  plot_annotation(
    title = "Top 10 enriched GO terms by frequency in tissue DEGs",
    theme = theme(plot.title = element_text(face = "bold", size = 9, hjust = 0.5))
  )

ggsave("../output_RNA/differential_expression/semantic-enrichment/All_Onts_freq_pval.png", plot, width = 8, height = 6.5, dpi = 300)